Roy Howard Perlis MD
Director of the Center for Experimental Drugs and Diagnostics (CEDD) and Associate Director of the Psychiatric Genetics Program in Mood and Anxiety Disorders in the MGH Psychiatry Department Associate Professor of Psychiatry at Harvard Medical School and serves as a consultant to the American Psychiatric Association's bipolar treatment guidelines workshop
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15 Parkman Street Wac 812Psychiatry Outpatient DepartmentBoston, MA 02114
Phone+1 617-724-5600
Fax+1 617-724-3028
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Education & Training
Mass General Brigham/Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1997 - 2001- Mass General Brigham/Massachusetts General HospitalInternship, Internal Medicine, 1997 - 1998
Harvard Medical SchoolClass of 1997
Certifications & Licensure
MA State Medical License 1998 - 2026
American Board of Psychiatry and Neurology Psychiatry
Clinical Trials
- Effectiveness of Pramipexole for Treatment-Resistant Depression Start of enrollment: 2003 Sep 01
- Simvastatin Augmentation of Lithium Treatment in Bipolar Depression Start of enrollment: 2012 Aug 01
- Adjunctive Isradipine for the Treatment of Bipolar Depression Start of enrollment: 2013 Feb 01
Publications & Presentations
PubMed
- 1 citationsSelf-reported Health Service Utilization and Barriers to Care Among US Adults with a History of Post COVID-19 Condition.Hiten Naik, Roy H Perlis, Karen C Tran, John A Staples
Journal of General Internal Medicine. 2025-04-01 - Study Findings Question Value of Including Race in Prenatal Screening for Birth Defects.Roy Perlis, Nora Collins
JAMA. 2025-03-28 - Study Finds Most Older Adults Use Digital Health Technologies, Plus Some Surprises.Roy Perlis, Kate Schweitzer
JAMA. 2025-03-11
Journal Articles
- Psychiatry and COVID-19Roy Perlis, Donald Goff, JAMA
- Can Electronic Health Records Revive Central Nervous System Clinical Trials?Maurizio Fava, Roy H Perlis, Nature
- Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017Roy Perlis, MD, JAMA
Lectures
- Effect of Cytochrome CYP2C19 Metabolizing Activity on Antidepressant Response and Side Effects: Meta-Analysis of Data from Genome-Wide Association Studies162nd Annual Meeting, San Francisco, California, USA
- Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET NeuroimagingAmerican Psychiatric Association, 162nd Annual Meeting, San Francisco, California, USA
Authored Content
- The Time Has Come for Over-the-Counter AntidepressantsApril 2024
- Genome-Wide Association Study of Dimensional Psychopathology Using Electronic Health RecordsFebruary 2018
- High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health RecordsFebruary 2018
Press Mentions
What Happens When AI Is Used to Recommend Treatments for Patients with Bipolar Disorder?September 16th, 2024- Trust in Physicians and Hospitals During the COVID-19 Pandemic in a 50-State Survey of US AdultsAugust 26th, 2024
- Benchmarks: Mass General Research News and Notes for August 9, 2024August 9th, 2024
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Grant Support
- JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental HealthMASSACHUSETTS GENERAL HOSPITAL2024–2029
- JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental HealthMASSACHUSETTS GENERAL HOSPITAL2024–2029
- Characterization of schizophrenia liability genes in models of human microglial synaptic pruningMASSACHUSETTS GENERAL HOSPITAL2023–2028
- Depression, Isolation, and Social Connectivity Online (DISCO)MASSACHUSETTS GENERAL HOSPITAL2022–2025
- Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionMASSACHUSETTS GENERAL HOSPITAL2022–2025
- Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionMASSACHUSETTS GENERAL HOSPITAL2022–2025
- Data-driven subtyping in major depressive disorderMASSACHUSETTS GENERAL HOSPITAL2021–2025
- Patient-derived Models of Synaptic Pruning in SchizophreniaMASSACHUSETTS GENERAL HOSPITAL2019–2025
- In Vitro And In Vivo Study Of Simvastatin PLUS Lithium In Bipolar DepressionNational Institute Of Mental Health2012
- Building A Risk Stratification Model For Treatment Resistance In Major DepressiveNational Institute Of Mental Health2009–2011
- Pramipexole In Treatment-Resistant DepressionNational Institute Of Mental Health2003–2007
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