RogerEdwardDe FilippoMDFAAP, FACS

Urology • Los Angeles, CA

Pediatric Urology

Division of Pediatric Urology Children's Hospital Los Angeles

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Office
4650 W Sunset Blvd
MS 114
Los Angeles, CA 90027
Phone+1 323-669-2247

Fax+1 323-914-2972

Summary

Chief of the Division of Urology, Children's Hospital Los Angeles
Co-Director, GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology
Associate Professor of Pediatric Urology, Keck School of Medicine, USC
Co-surgical director, CAH Comprehensive Care Clinic

Dr. De Filippo was named chief of the Division of Urology in 2014, having served interim chief since 2012, overseeing and maintaining the Division’s robust clinical and research programs. Among the many advances made during his tenure, Urology became one of the first surgical divisions at Children’s Hospital Los Angeles to implement electronic medical record-keeping in the outpatient clinic as well as in its extensive satellite network, which includes 15 offices across the Southern California region.

Currently Dr. De Filippo is researching: The development of working renal units from stem cell sources in the laboratory for eventual transplantation in animal recipients as a viable donor kidney source, the use of amniotic fluid stem cells for cell therapeutic modes of therapy in acute and chronic renal failure, FDA-approved phase II clinical trial for tissue engineering of the bladder, isolation of progenitor cells for tissue engineering and cell therapy from amniotic fluid, multipotent stem cells and progenitor cells from amniotic fluid for the treatment of alport disease, the use of multipotent stem cells from amniotic fluid for fetal therapy for alport disease as a model for fetal therapies in genetic diseases of the kidney, the use of multipotent and progenitor stem cells from amniotic fluid for diabetes and diabetic nephropathy.

GOFARR LAB

Stories like Gabriel's inspire us everyday to find new and novel therapies in our GOFARR lab.

Education & Training

Children’s Hospital Boston, Harvard Medical Schoo1999 - 2003
LA County Medical Center/USC1994 - 1999
LAC+USC Medical CenterInternship, Rotating Intern General Surgery, 1993 - 1994
Keck School of Medicine of the University of Southern CaliforniaClass of 1993, MD, Dean’s Scholar Graduate
University of Southern CaliforniaBS, Biological Sciences, Magna Cum Laude, 1984 - 1988
Loyola High SchoolHS, 1980 - 1984
University of Southern California/Los Angeles General Medical Center (USC/LA General)Residency, Urology

Certifications & Licensure

CA State Medical License 1995 - 2025
MA State Medical License 2000 - 2005
American Board of Urology Urology
American Board of Urology Pediatric Urology

Awards, Honors, & Recognition

Southern Califronia Super Doctors 2012
Top Doctors Pasadena Magazine, 2009, 2011
Southern California Super Doctors 2011
Best of Poster Stem Cell Basic Science AUA 2011
Honorable Mention Annual Audio Visual Award AUA 2010
America’s Top Surgeon, Guide to America’s Top Surgeon 2010
Top Doctors, Los Angeles Magazine 2010
Best Doctors, in the San Gabriel Valley 2008
America’s Top Urologists 2008
Laboratory awarded California Institute for Regenerative Medicine PostDoctoral Fellowship 2006
American Foundation of Urological Disease Research Scientist Award 2005
Baxter Research Award 2005
Poster Prize CHLA Research Day 2004
Von. L. Meyer Traveling Fellowship Award 2000
1st prize recipient for basic science research in tissue engineering, Clinical and Basic science research day Children’s Hospital, Boston, MA 2000
American Foundation Of Urologic Disease (AFUD) Scholarship recipient 2000
Winner of AUA/Pfizer Visiting Professorship Essay 1998
Outstanding House Officer Teaching Award 1998
Resident Teacher of the Year Award 1995
Milo Don Appleman J.R. M.D. award for outstanding graduating Senior in biological sciences 1988
Outstanding Student Scholarship award 1988
California Scholarship Federation award 1988
Collegiate Scholastic All-American award 1988
Golden Key National Honor Society 1988
Phi Beta Kappa 1988
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Publications & Presentations

PubMed

8 citations
Treatment of a ureteral stricture following failed management with ureteral wall stent.
Roger E. De Filippo, Eric A. Kurzrock, John P. Stein, Donald G. Skinner
The Journal of Urology. 1998-08-01
28 citations
Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration.
Stefano Da Sacco, Roger E. De Filippo, Laura Perin
Current Opinion in Organ Transplantation. 2011-02-01
84 citations
Human Amniotic Fluid as a Potential New Source of Organ Specific Precursor Cells for Future Regenerative Medicine Applications
Stefano Da Sacco, Sargis Sedrakyan, Francesco Boldrin, Stefano Giuliani, PierPaolo Parnigotto
The Journal of Urology. 2010-03-01

Journal Articles

Single Injection of Stem Cells Derived From Amniotic Fluid Delays Progression of Kidney Failure in a Mouse Model of Alport Syndrome.
Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Lemley K Warburton D, De Filippo RE, Perin L, J Am Soc Nephrol
Shorter androgen receptor CAG repeat lengths associated with cryptorchidsm risk among hispanic white boys.
Davis-Dao C, Koh CJ, Hardy BE, Chang A, Kim SS, De Filippo R, Hwang A, Pike MC, Carroll JD, Coetzee GA, Vandenberg D, Siegmund K, Cortessis VK, J Clinical Endocrinology & Metabolism
Regenerative medicine of the kidney.
Perin L, Da Sacco S, De Filippo RE, Adv Drug Deliv Rev. 63(4-5):379-87
Bioengineering a vaginal replacement utilizing a small biopsy of autologous tissue.
Dorin RP, Atala A, De Filippo RE, Seminars in Reproductive Medicine (1): 38-44
Laparoendoscopic Single-site Nephrectomy in Pediatric Patients: Initial Clinical Series of Infants to Adolescents.
Koh CJ, De Filippo RE, Chang AY, Hardy BE, Berger A, Eisenberg M, Patil M, Aron M, Gill IS, Desai MM, Urology 76(6):1457-61
Protective Effect of Human Amniotic Fluid Stem Cells in Acute Tubular Necrosis.
Perin L, Giuliani S, Sedrakyan S, Da Sacco S, Carraro G, Liron S, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE, PluS One Science 5(2):e9357
The systemic characterization of human amniotic fluid: a potential new source of organ specific precursor cells for future regenerative medicine applications.
Da Sacco S, Sedrakyan S, Boldrin F, Parnigotto PP, Habibian R, Warburton D, De Filippo RE* , Perin L, J.Urology 183(3): 1193-1200
Complimentary roles of sonography and magnetic resonance imaging in the assessment of fetal urinary tract anomalies.
.Barseghyan K, Jackson HA, Chmait R, De Filippo RE, Miller DA, J. Ultrasound Med
Human amniotic fluid stem cells can integerate and differntiate into epithelial lung lineages.
.Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Driscoll B, Turcatel G, De Langhe SP, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D, Stem Cells (11): 2902-11
Stem/Progenitor cells in lung development, injury, repair, and regeneration.
Warburton D, Perin L, De Filippo R, Bellusci S, Shi W, Driscoll B, Proc. Am Thoracic Soc (6):703-6
Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer.
Tuazon E, Banks K, Koh CJ, De Filippo RE, Chang A, Hardy BE, Cortessis VK, J Urol. 180(2):783-4
Bladder and external urethral sphincter function after prenatal closure of myelomeningocele.
Koh CJ, De Filippo RE, Borer JG, Khoshbin S, Bauer SB, J Urol
New Surgical Tecniques in Pediatric Urology.
De Filippo R, Bauer S, Current Opinion in Urology
Minimally Invasive Endoscopic Treatment of Vesicoureteral Reflux and Urinary Incontinence.
De Filippo R, Atala A, Journal of Laparoendoscopic & Advanced Surgical Techniques (Part B). 4 179-188
A giant urethral diverticulum presenting as a scrotal mass in an adult male.
De Filippo RE, Kurzrock EA, Stein JP, et al, BJU Int. 83 (4): 522-523
Imaging of ureteroceles Using Volumetric MR Urography.
Kokorowski P, Jackson H, Moats R, Schiel L, Berkeley, Hardy B,, Dialogues in Pediatric Urology 28 (3): 15
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Books/Book Chapters

Glenn’s Urologic Surgery.
Dorin RP; De Filippo REEdition 7,
Hinman’s Atlas of Pediatric Urologic Surgery.
Page 1117 - 1118Dorin RP; De Filippo REEdition 2,
Pediatric Urology: Surgical Complications and Management.
Page 2276 - 2277Dorin RP; De Filippo RE
Pediatric Endourology Techniques.
Page 1077 - 1078Dorin RP; De Filippo RE
Diseases of the Kidney and Urinary Tract, vols 1-3.
Page 2415 - 2416Liu, J, De Filippo REEdition 8,
Koh C Campbell-Walsh Urology, Volumes (1-4).
Page 2201 - 2202Kokorowski P, De Filippo RE
Amniotic Fluid Stem Cells.
Chapter: Embryonic Stem Cells – Differentiation and Pluripotent Alternatives
Page 493 - 506Carraro G, Garcia OH, Perin L, De Filippo R, and Warburton WEditors: Michael S. Kallos.Open Access Publisher InTech, Rijeca, Croatia
issue Engineering of the Reproductive System.
Chapter: Principles of Regenerative Medicine
Page 955 - 980Da Sacco S, Perin L, De Filippo REditors: Anthony Atala, Robert Lanza, James Thomson, and Robert Nerem.Academic Press, San Diego, CaliforniaEdition 2,
Stem cells in kidney regeneration.
Chapter: Biomaterials and tissue engineering in Urology
Sedrakyan S, Perin L, De Filippo REEditors: ohn Denstedt and Anthony Atala.CRC Press LLC, Boca Raton, FL
Characterization of human amniotic fluid stem cells and their pluripotential capability. Vol. 86
Chapter: Methods Cell Biol.
Page 85 - 99Perin L. Sedrakyan S, Da Sacco S, De Filippo REditors: Jennie P. Mather.Elsevier London, UK
Tissue Engineering of the Reproductive Tract.
Chapter: Principles of Regenerative Medicine
Giuliani S, Perin L, Sedrakyan S, and De Filippo REEditors: Anthony Atala, Robert Lanza, James Thomson, and Robert Nerem.Academic Press, Burlington MA
Bladder Exstrophy, Cloacal Exstrophy, Epispadias, Epispadias, Myelomeningocele, and Imperforate Anus.
Chapter: Urology Pearls of Wisdom: Congenital Disorders of the Lower Urinary Tract
De Filippo RE, Atala AEditors: David A. Levy.Boston Medical Publishing, Corp., Boston, MA
Epithelial Cell Culture: Vaginal Cell Reconstruction.
Chapter: Methods of Tissue Engineering
Page 273 - 275De Filippo RE, Atala AEditors: Anthony Atala and Robert P. Lanza.Academic Press, San Diego, California
Research in Urologic Surgery.
Chapter: Surgical Research
Page 1107 - 1118De Filippo RE, Atala AEditors: Wiley W. Souba and Douglas W. Wilmore.Academic Press, San Diego, California
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Abstracts/Posters

Malignant Potentai of the cryptorchid testis associated with bilateral occurrence, persistent non-descent, and advanced age at repair: Results of a Comprehensive Me...
Kimberly Banks, Ellenie Tuazon, Chester Koh, Roger De Filippo, Andy Chang, Kiros Berhane, Victoria K Cortessis, American Urologic Association National Meeting, Orlando
Volumetric 3D Magnetic Resonance Urography: A New Imaging Modality that enhances the Diagnosis of Various Conditions in Pediatric Urology.
Paul Kokorowski, Stefano Giuliani, Hollie Jackson, Rex Moats, Lee Schiel, Dawn Berkeley, Brian Hardy, Roger E. De Filippo, British Association of Paediatric Surgeons 53rd International Congress
Imaging of Ureteroceles Using Volumetric MR Urography.
Paul Kokorowski, Hollie Jackson, Rex Moats, Brian Hardy, Roger E. De Filippo, Society for Fetal Urology
Volumetric 3D Magnetic Resonance Urography: A New Imaging Modality that enhances the Diagnosis of Various Conditions in Pediatric Urology.
.Paul Kokorowski, Steve Kim, Hollie Jackson, Rex Moats, Lee Schiel, Dawn Berkeley, Brian Hardy, Roger E. De Filippo, American College of Surgeons
Precursors Isolated from Embryonic Stem Cell Culture: Potential use for Tissue Regeneration.
Paul Kokorowski, Laura Perin, Federico Tozzi, Casey Brewer, Sargis Sedrakyan, Stefano Da Sacco, Roger E. De Filippo, International Society for Stem Cell Research
Inverted 3D Volumetric Imaging for Enhanced Visualization of Ureteroceles and Ectopic Ureters in Pediatric Patients.
Paul Kokorowski, Steve Kim, Hollie Jackson, Rex Moats, Lee Schiel, Dawn Berkeley, Brian Hardy, Roger E. De Filippo, American College of Surgeons
Subpopulations in Human Amniotic Fluid: A Source of Progenitor Cells for Structure Specific Tissue Regeneration.
Stefano Da Sacco, Laura Perin, Sargis Sedrakyan, Casey Brewer, Paul Kokorowski, Francesco Boldrin, Pier Paolo Parnigotto, David Warburton, Roger E. De Filippo., American College of Surgeons
In Vitro Expansion of Embryonic Stem Cells for Progenitor Isolation as a Source of Cells for Tissue Regeneration.
Paul Kokorowski, Laura Perin, Federico Tozzi, Casey Brewer, Sargis Sedrakyan, Stefano Da Sacco, Roger E. De Filippo, American College of Surgeons
Renal Subpopulations in Human Amniotic Fluid: A Novel Source of Structure Specific Progenitor Cells for Tissue Regeneration.
tefano Da Sacco, Laura Perin, Sargis Sedrakyan, Casey Brewer, Paul Kokorowski, Francesco Boldrin, Pier Paolo Parnigotto, David Warburton, Roger E. De Filippo, American Academy of Pediatrics
Comprehensive Meta-Analysisi of Cryptorchidismtestis cancer association reveals a strong secular trend and notable modification by histologic type of ...
Kimberly Banks, Ellenie Tuazon, Chester Koh, Roger De Filippo, Andy Chang, Kiros Berhane, Victoria K Cortessis, American Urologic Association National Meeting, Orlando
Single Injection of Stem Cells Derived from Amniotic Fluid Slows Down the Progression of Kidney Failure in a Mouse Model of Alport Syndrome.
Laura Perin, Sargis Sedrakyan, Stefano Da Sacco, Astgik Petrosyan, Liron Shiri, Kevin V. Lemley, Roger De Filippo, Podium, American Society of Nephrology National Meeting, Philadelphia
Renal Subpopulations in Human Amniotic Fluid: A novel source of structure specific progenitor cells for tissue regeneration.
Roger De Filippo, Laura Perin, Sargis Sedrakyan, Francesco Boldrin, Pier Paolo Parnigoto, David Warburton, American Society for Clincial Investigation, Chicago
Transmesenteric Robotic-Assisted Laparoscopic Pyeloplasty: A Simple Approach for Pediatric Ureteropelvic Junction Obstruction Repair.
Roger De Filippo, Andy Chang, Craig Peters, Chester Koh, Society of Laparoendoscopic Surgeons (Podium), Boston
The Role of Amniotic Fluid Stem Cells in Acute Tubular Necrosis.
Roger E. De Filippo, Laura Perin Stefano Giuliani, Sargis Sedrakyan, and Stefano Da Sacco, American Academy of Pediatrics (Poster), Washington DC
Amniotic Fluid Stem Cells and therapeutic options in Alport Syndrome as a model for chronic kidney disease.
Roger E. De Filippo, Wake Forest Institute of Regenerative Medicine Annual Retreat, North Carolina
Simplified Technique for Robotic-Assisted Laparoscopic Extravesical Ureteral Reimplantation in Children
Philip H. Kim, Mukul B. Patil, Justin H. Lee Brian E. Hardy, Chester J. Koh, Roger E. De Filippo, Andy Y. Chang, Craig A. Peters, American Urological Association National Meeting, San Francisco
Shorter Androgen Receptor CAG Repeat Lengths Are Associated with Cryptorchidism Among Hispanic.
Carol Davis-Dao, Chester Koh, MD, Brian E. Hardy, MD2, Andy Chang, Roger E. De Filippo, Andrew Hwang, MD3, Steve S. Kim, MD, Malcolm Pike, Gerhard Coetze..., MA 2011, Boston
Protective Effect of Human Amniotic Fluid Stem Cells In Acute Tubular Necrosis.
Laura Perin, Sargis Sedrakyan, Stefano Da Sacco, Shiri Liron, Kevin Lemley, David Warburton, and Roger E. De Filippo, American Academy of Pediatrics MA 2011, Boston
Amniotic Fluid Stem Cells and Chronic Kidney Disease.
Sargis Sedrakyan, Laura Perin, Stefano DaSacco, Liron Shiri, Kevin Lemley, Roger De Filippo, American Urological Association National Meeting, Washington DC
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