RodneyLeeLevineMDPhD

Neonat/Perinatology • Bethesda, MD

Senior Investigator, National Heart, Lung, and Blood Institute, NIH

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Office
50 S Drive Msc 8012
Bethesda, MD 20892
Phone+1 301-496-2310

Education & Training

University of ColoradoFellowship, Neonatal-Perinatal Medicine, 1974 - 1977
University of ColoradoResidency, Pediatrics, 1973 - 1976
Stanford University School of MedicineClass of 1973
Stanford UniversityA.B., Biology, 1968
Stanford UniversityB.S., Chemistry, 1968

Certifications & Licensure

MD State Medical License 1985 - 2026
CO State Medical License 1974 - 2005
American Board of Pediatrics Pediatrics
American Board of Pediatrics Neonatal-Perinatal Medicine

Awards, Honors, & Recognition

Fellow Society for Free Radical Biology and Medicine, 2012
Award of Merit National Institutes of Health, 2011
Norman Kretchmer Visiting Professor and Kretchmer Memorial Lecturer Stanford University School of Medicine, 2006
Postdoctoral Fellows Award for Research Mentoring National Heart, Lung, and Blood Institute, 2004
The Fleming Lecturer Southwestern University, 2001
Jerry Elliot Memorial Lecture South Central Conference on Perinatal Research, 2000
Dorothy Dillon Eweson Lecture American Federation for Aging Research, Presented to the Oxygen Society, 1999
The Surgeon General's Exemplary Service Medal United States Public Health Service, 1993
Outstanding Service Medal (NIH Director's Award) for "Fundamental contributions to an understanding of the role of metal ion catalyzed oxygen free radical damage to proteins in pathological disorders" United States Public Health Service, 1993
Handy Memorial Lectureship Medical Center of Delaware/American Academy of Pediatrics, 1992
Commendation Medal "For scientific accomplishments" United States Public Health Service, 1989
Lubchenco Lectureship University of Colorado Health Sciences Center, 1988
The Housestaff Award for Excellence in Teaching Walter Reed Army Medical Center, 1982
Young Investigator Award American Academy of Pediatrics, Section on Perinatal Pediatrics, 1981
Ross Award in Research, "For his contribution to Research in Pediatrics", Western Society for Pediatric Research, 1976
Harold K. Faber Award Stanford University School of Medicine, "For outstanding accomplishments in the field of Pediatrics.",, 1973
Alpha Omega Alpha Stanford University, 1972
Lloyd Dinklespiel Award to the Outstanding Graduate Stanford University, 1968
Award of Merit American Chemical Society, 1968
Sigma Xi Award Stanford University, 1968
Phi Lambda Upsilon Stanford University, 1968
Phi Beta Kappa Stanford University, 1966
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Publications & Presentations

PubMed

Oxidation of CaMKIIα cysteines inhibits autonomous activation induced by phosphorylation.
Nathália Rocco-Machado, Max Deng, Yi He, Rodney L Levine
Archives of Biochemistry and Biophysics. 2024-12-12
Corrigendum to "Loss of methionine sulfoxide reductases increases resistance to oxidative stress" [Free Radic. Biol. Med. 145 (2019) 374-384].
Lo Lai, Junhui Sun, Sreya Tarafdar, Chengyu Liu, Elizabeth Murphy
Free Radical Biology & Medicine. 2024-08-01
Lactate oxidation in Paracoccus denitrificans.
Geumsoo Kim, Raul Covian, Lanelle Edwards, Yi He, Robert S Balaban
Archives of Biochemistry and Biophysics. 2024-06-01

Journal Articles

Stereospecific oxidation of calmodulin by methionine sulfoxide reductase A
Lim JC, Kim G, and Levine RL, Free Radical Biology and Medicine, 1/1/2013
Quantification of protein carbonylation
Wehr N and Levine RL, Methods in Molecular Biology, 1/1/2013
Regulation of the actin-activated MgATPase activity of Acanthamoeba myosin II by phosphorylation of serine 639 in motor domain loop 2
Liu X, Lee D-Y, Cai S, Yu S-H, Shu S, Levine RL, and Korn ED, Proceedings of the National Academy of Sciences USA, 1/1/2013
In vitro oxidative inactivation of human presequence protease
Teixeira PD, Pinho CM, Branca R, Lehtiö J, Levine RL, and Glaser E, Free Radical Biology and Medicine, 1/1/2012
Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A
Lim JC, Gruschus JM, Ghesquière B, Kim G, Piszczek G, Tjandra N, and Levine RL, Journal of Biological Chemistry, 1/1/2012
A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A
Lim JC, Gruschus JM, Berlett BS, Kim G, Piszczek G, Tjandra N, and Levine RL, Journal of Biological Chemistry, 1/1/2012
Wanted and wanting: Antibody against methionine sulfoxide
Wehr NB and Levine RL, Free Radical Biology and Medicine, 1/1/2012
Methionine sulfoxide reductase contributes to meeting dietary methionine requirements
Zhao H, Kim G, and Levine RL, Archives of Biochemistry and Biophysics, 1/1/2012
Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-gamma2
Mitterberger MC, Kim G, Rostek U, Levine RL, and Zwerschke W, Experimental Cell Research, 1/1/2012
Quantitation of protein carbonylation by dot blot
Wehr NB and Levine RL, Analytical Biochemistry, 1/1/2012
Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusion injury
Zhao H, Sun J, Deschamps AM, Kim G, Liu C, Murphy E, and Levine RL, American Journal of Physiology - Heart and Circulatory Physiology, 1/1/2011
Methionine sulfoxide reductase A is a stereospecific methionine oxidase
Lim JC, You Z, Kim G, and Levine RL, Proceedings of the National Academy of Sciences, 1/1/2011
Iron regulatory protein 2 turnover through anon-proteasomal pathway
Chang AHK, Jeong J, and Levine RL, Journal of Biological Chemistry, 1/1/2011
Deuteration of Escherichia coli Enzyme INtr alters its stability
Piszczek G, Lee JC, Tjandra N, Lee C-R, Seok Y-J, Levine RL, and Peterkofsky A, Archives of Biochemistry and Biophysics, 1/1/2011
Group B streptococcus, phospholipids, and pulmonary hypertension
Curtis J, Kim G, Wehr NB, and Levine RL, Journal of Perinatology, 1/1/2011
Small-molecule antioxidant proteome-shields in Deinococcus radiodurans
Daly MJ, Gaidamakova EK, Matrosova VY, Kiang JG, Fukumoto R, Lee D-Y, Wehr NB, Viteri GA, Berlett BS, and Levine RL, PLoS ONE, 1/1/2010
Transgenic mice overexpressing methionine sulfoxide reductase A: Characterization of embryonic fibroblasts
Zhao H, Kim G, Liu C, and Levine RL, Free Radical Biology and Medicine, 1/1/2010
Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A
Kim G, Cole NB, Lim JC, Zhao H, and Levine RL, Journal of Biological Chemistry, 1/1/2010
Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
Guyot N, Bergsson G, Butler MW, Greene CM, Weldon S, Kessler E, Levine RL, O'Neill, Biological Chemistry, 1/1/2010
Characterization of a covalent polysulfane bridge in Cu, Zn superoxide dismutase
You Z, Cao X, Taylor AB, Hart PJ, and Levine RL, Biochemistry, 1/1/2010
Oxidative stress causes reversible changes in mitochondrial permeability and structure
Cole NB, Daniels MP, Levine RL, and Kim G, Experimental Gerontology, 1/1/2010
Earl R. Stadtman
Levine RL and Bohr VA, Mechanisms of Ageing and Development, 1/1/2010
ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine
Stevens LA, Levine RL, Gochuico BR, and Moss J, Proceedings of the National Academy of Sciences, 1/1/2009
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation
Weldon S, McNally P, McElvaney NG Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, and Taggart CC, Journal of Immunology, 1/1/2009
Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin
Klamt F, Zdanov S, Levine RL, Pariser A, Zhang Y, Zhang B, Freedberg D, Yu L-R, Veenstra TD, and Shacter E, Nature Cell Biology, 1/1/2009
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Books/Book Chapters

Redox Proteomics: from Protein Modifications to Cellular Dysfunction and Diseases
Chapter: Chemical modification of proteins by reactive oxygen
Stadtman ER and Levine RLEditors: Dalle-Donne I, Scaloni A, and Butterfield DA.Wiley Interscience, New York2006
Redox Proteomics: from Protein Modifications to Cellular Dysfunction and Diseases
Chapter: Carbonylated proteins and their implication in physiology and pathology species
Levine RL and Stadtman EREditors: Dalle-Donne I, Scaloni A, and Butterfield DA.Wiley Interscience, New York2006
The Science of Geriatrics
Chapter: Modification of proteins during aging
Page 75 - 94Levine RL, and Stadtman EREditors: Morley JE, Armbrecht HJ, Coe RM, and Vellas B.Serdi Publisher/Springer Publishing Company, Paris/New York2000
Methods in Molecular Biology, volume 99: Stress Response: Methods and Protocols
Chapter: Determination of carbonyl groups in oxidized proteins
Page 15 - 24Levine RL, Wehr N, Williams, JA, Stadtman, ER, and Shacter, EEditors: Keyse SM.Humana Press, Totowa, NJ2000
Free Radicals: A Practical Approach
Chapter: Determination of carbonyl groups in oxidized proteins
Page 159 - 170Shacter E, Williams JA, Stadtman ER, and Levine, RLEditors: Punchard N, and Kelly, F.Oxford University Press, Oxford1996
Handbook of the Biology of Aging
Chapter: Protein modifications with aging
Page 184 - 197Levine RL, and Stadtman EREditors: Schneider EL, and Rowe JW.Academic Press, OrlandoEdition 4th ,1996
The Biology of Aging
Chapter: Oxidation of proteins during aging
Page 73 - 81Levine RL, and Stadtman, EREditors: Sprott RL, Warner HR, and Williams TF.Springer Publishing, New York1993
Frontiers and New Horizons in Amino Acid Research
Chapter: Regulation of Escherichia coli glutamine synthetase
Page 27 - 39Stadtman, ER, Chock, PB, Rhee, SG, and Levine RLEditors: Takai, K.Elsevier, Amsterdam1992
Oxidative Damage and Repair: Chemical, Biological, and Medical Aspects
Chapter: Metalcatalyzed oxidation of glutamine synthetase: Determinants of proteolytic susceptibility
Page 373 - 379Levine RL, Climent I, Farber JM, Shames BD, Sahakian JA, and Rivett AJEditors: Davies KJA.Pergamon Press, New York1992
Oxygen Radicals in Biology and Medicine
Chapter: Oxidative modification of glutamine synthetase: Covalent and conformational changes which control susceptibility to proteolysis
Page 541 - 544Levine RL, and Rivett AJEditors: Simic MA, Taylor KA, Ward JF, and von Sonntag C.Plenum, New York1989
Medical, Biochemical, and Chemical Aspects of Free Radicals
Chapter: Mixed function oxidation of glutamine synthetase: Correlation of chemical and biochemical alterations
Page 1195 - 1202Levine RL, and Rivett AJEditors: Hayaishi O, Niki E, Kondo, M, and Yoshikawa, T.Elsevier, Amsterdam1989
Current Trends in the Study of Intracellular Protein Degradation II
Chapter: Proteolysis induced by metal-catalyzed oxidation
Page 347 - 360Levine RLEditors: Grisolia S, and Knecht E.Springer International, Vienna1989
Modification of Proteins during Aging
Chapter: Age-related alterations of enzymes may involve mixed-function oxidation reactions
Oliver CN, Ahn B, Wittenberger ME, Levine RL, and Stadtman, EREditors: Adelman RC and Dekker EE.Alan R. Liss, New York1985
ADP-Ribosylation of Proteins
Chapter: Characterization of NAD:arginine mono(ADP-ribosyl transferases in turkey erythrocytes: Determinants of substrate specificity
Page 512 - 517Moss J, West RE Jr, Osborne JC Jr, and Levine RLEditors: Althaus FR, Hilz H, and Shall S.Springer-Verlag, Berlin1985
Molecular Basis of Aging
Chapter: Oxidative inactivation of key metabolic enzymes during aging
Oliver CN, Fulks R, Levine RL, Fucci L, Rivett AJ, Roseman JE, and Stadtman EREditors: Roy AK, and Chatterjee B.Academic Press, New York1984
Affinity Chromatography and Biological Recognition
Chapter: Tyrosine phosphate and tyrosine sulfate in proteins
Page 401 - 403Martensen TM, Levine RL, and Sliwkowski MXEditors: Chaiken IM, Wilchek M, and Parikh I.Academic Press, New York1983
Hyperbilirubinemia in the Newborn, Report of the Eighty-Fifth Ross Conference on Pediatric Research
Editors: Levine RL, and Maisels MJ.Ross Laboratories, Columbus, Ohio1983
Hyperbilirubinemia in the Newborn, Report of the Eighty-Fifth Ross Conference on Pediatric Research
Chapter: Bilirubin and the blood-brain barrier
Page 125 - 129Levine RLEditors: Levine RL, and Maisels MJ.Ross Laboratories, Columbus, Ohio1983
Hyperbilirubinemia in the Newborn, Report of the Eighty-Fifth Ross Conference on Pediatric Research
Chapter: The toxicology of bilirubin
Page 39 - 44Levine RLEditors: Levine RL, and Maisels MJ.Ross Laboratories, Columbus, Ohio1983
Cytochrome P-450,Biochemistry, Biophysics, and Environmental Implications
Chapter: Inactivation of key metabolic enzymes by P450-linked mixed function oxidation systems
Page 531 - 538Oliver C, Fucci L, Levine R, Wittenberger M, and Stadtman EREditors: Hietanen E, Laitinen M, and Hanninen O.Elsevier-Biomedical Press, Amsterdam1982
Experiences in Biochemical Perception
Chapter: Regulation of glutamine synthetase degradation
Page 233 - 249Oliver CN, Levine, RL, and Stadtman, EREditors: Ornston LN.Academic Press, New York1982
Metabolic Interconversion of Enzymes
Chapter: Regulation of glutamine synthetase degradation
Page 259 - 268Oliver CN, Levine, RL, and Stadtman, EREditors: Holzer H.Springer-Verlag, Berlin1981
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Other

Physiological control of mammalian pyrimidine metabolism: Studies on carbamyl phosphate synthetase and aspartate transcarbamylase. Ph.D. Thesis: Stanford University
Levine RL
1/1/1973

Grant Support

Regulation Of Iron Regulatory Protein 2National Heart, Lung, And Blood Institute2011
Protein CarbonylationNational Heart, Lung, And Blood Institute2011
Oxidative Modification Of ProteinsNational Heart, Lung, And Blood Institute2010–2011
Biochemical Basis Of Stress Resistance Of Deinococcus RadioduransNational Heart, Lung, And Blood Institute2010–2011
Fate Of Oxo-Histidine Containing ProteinsNational Heart, Lung, And Blood Institute2010
Metal-Catalyzed Oxidation Of ProteinsNational Heart, Lung, And Blood Institute2009
Metal-Catalyzed Oxidation Of ProteinsNational Heart, Lung, And Blood Institute1990–2008
Function Of Carbonic Anhydrase IIINational Heart, Lung, And Blood Institute2001
Metal Catalyzed Oxidation Of ProteinsNational Heart, Lung, And Blood Institute1996–1997
Oxidation Of ProteinsNational Heart, Lung, And Blood Institute1995
Mixed-Function Oxidation Of ProteinsNational Heart, Lung, And Blood Institute1985–1988