RobertJWyattMD

PubMed

• 50 citations
  Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.
  Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu
  Nature Genetics. 2023-07-01
• 29 citations
  Author Correction: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
  Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li
  Nature Communications. 2023-02-06
• Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
  Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li
  Nature Communications. 2022-11-11

Journal Articles

• Cytokines alter IgA1 O-Glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes  
  Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J, Journal of Biological Chemistry, 1/1/2014
• Novel GWAS loci for IgA nephropathy implicate immunity against intestinal pathogens  
  Nature Genetics, 1/1/2014
• IgA Nephropathy  
  Wyatt, RJ and Julian BA, New England Journal of Medicine, 6/2013
• Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy  
  Eison, TM, Hastings MC, Moldoveanu Z, PhD2, Sanders JT, Gaber L, Walker PD, Keith K. Lau KK, Julian BA, Novak J, Wyatt RJ, Clinical Nephrology, 1/1/2012
• Has the incidence of childhood steroid sensitive nephrotic syndrome changed?  
  Spencer JD, Hastings MC, Wyatt RJ, Ault BH, Clinical Nephrology, 1/1/2012
• Serum galactose-deficient IgA1 level is not associated with proteinuria in children with IgA nephropathy  
  Hastings MC, Afshan S, Sanders JT, Kane O, Lau KK, Eison TM, Moldoveanu Z, Julian BA, Novak J, Wyatt RJ, International Journal of Nephrology, 1/1/2012
• Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis  
  Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner F, Snyder HJ, Choi M, Hou P, Scolari F, Gesualdo L, Savoldi S, Amoroso A, Cusi D, Zamboli P, Julian..., PLoS Genetics, 1/1/2012
• Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system  
  Novak J, Moldoveanu Z, Julian BA, Julian BA, Raska M, Wyatt RJ, Suzuki Y, Tomino Y, Gharavi AG, Mestecky J, Suzuki H, Advances in Otorhinology, 1/1/2011
• APOL1 genetic variants are associated with susceptibility to focal segmental glomerulosclerosis and HIV-1 associated nephropathy but not IgA nephropathy in African Ame...  
  Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Mhatre AN, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Klotman ME, Cohen DJ, Appel GB, D’..., Journal of the American Society of Nephrology, 1/1/2011
• The pathophysiology of IgA nephropathy  
  Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr HB, Renfrow M, Wyatt RJ, Scolari F, Mestecky J, Gharavi AG, Julian BA, Journal of the American Society of Nephrology, 1/1/2011
• Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schonlein purpura nephritis  
  Kiryluk K, Moldoveanu Z, Sanders JT, Eison TM, Suzuki H, Julian BA, Novak J, Gharavi AG, Wyatt RJ, Kidney International, 1/1/2011
• Genome-wide association study identifies susceptibility loci for IgA nephropathy  
  Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M..., Nature Genetics, 1/1/2011
• Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis  
  Eison TM, Ault BH, Jones DP, Chesney RW, Wyatt RJ, Pediatric Nephrology, 1/1/2011
• Galactose-deficient IgA1 in African-American patients with IgA nephropathy: serum levels and heritability  
  Hastings MC, Moldoveanu Z, Julian BA, Novak J, Sanders JT, McGlothan KR, Gharavi AG, Wyatt RJ, Clinical Journal of the American Society of Nephrology, 1/1/2010
• Familial IgA nephropathy in southeastern Kentucky  
  Lavigne K, Woodford SY, Barker C, Julian BA, Novak J, Moldoveanu Z, Gharavi AG, Wyatt RJ, Clinical Nephrology, 1/1/2010
• Invited commentary: Prevention and treatment of kidney disease in Henoch-Schoenlein purpura  
  Hastings MC, Eison TM, Wyatt RJ, Evidence-Based Child Health: A Cochrane Review Journal, 1/1/2010
• Genetic studies of IgA nephropathy: past, present, and future  
  Kiryluk K, Julian BA, Wyatt RJ, Scolari F, Zhang H, Novak J, Gharavi AG, Pediatric Nephrology, 1/1/2010
• Pathogenesis of Henoch-Schoenlein purpura nephritis  
  Lau KK, Suzuki H, Novak J, Wyatt RJ, Pediatric Nephrology, 1/1/2010
• Control of aquaporin 2 expression in collecting ducts of quail kidneys  
  Lau KK, Yang Y, Cook GA, Wyatt RJ, Nishimura H, General and Comparative Endocrinology, 1/1/2009
• Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity  
  Suzuki H, Fan R, Zhang Z, Brown R, Hall S, Julian BA, Chatham WW, Suzuki Y, Wyatt RJ, Moldoveanu Z, Lee JY, Robinson J, Tomana M, Tomino Y, Mestecky J, Jan Novak J, Journal of Clinical Investigation, 1/1/2009
• IgA nephropathy and Henoch-Schoenlein purpura nephritis  
  Sanders JT, Wyatt RJ, Current Opinion in Pediatrics, 1/1/2008
• IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1  
  Suzuki H, Moldoveanu Z, Hall S, Brown R, Vu HL, Novak L, Julian BA, Tomana M, Wyatt RJ, Edberg JC, Alarcon GS, Kimberly RP, Tomino Y, Mestecky J, Novak J, Journal of Clinical Investigation, 1/1/2008
• Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy  
  Gharavi AG, Moldoveanu Z, Wyatt RJ, Barker CV, Woodford SY, Lifton RJ, Mestecky J, Novak J, Julian BA, Journal of the American Society of Nephrology, 1/1/2008
• Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy  
  Mestecky J, Tomana M, Moldoveanu Z, Julian BA, Suzuki H, Matousovic K, Renfrow MB, Novak L, Wyatt RJ, Novak J, Kidney Blood Press Res, 1/1/2008
• Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal disease  
  Julian BA, Wittke S, Novak J, Coon JJ, Zurbig P, Schiffer E, Haubitz M, Moldoveanu Z, Calcatera SM, Wyatt RJ, Sykora J, Sladkova E, Hes O, Mischak H, McGuire BM, Electrophoresis, 1/1/2007
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Books/Book Chapters

• Pathogenesis and Treatment in IgA Nephropathy 
  Chapter: Heterogeneity of Aberrant O-glycosylation of IgA1 in IgA Nephropathy. 
  Novak, J., Takahashi, K., Suzuki, H., Reily, C., Stewart, T., Ueda, H., Yamada, K., Moldoveanu, Z., M. Hastings, C., Wyatt, R.J., Mestecky, J., Raska, M., Julian, B.A....Editors: Tomino, Y..Springer, Tokyo, Japan2015
• Recent Advances in IgA Nephropathy 
  Chapter: Clinicopathologic Findings 
  Page 83 - 106Julian BA, Wyatt RJEditors: K.N. Lai.World Scientific, Hong Kong2009
• Pediatric Nephrology for the Primary Care Physician 
  Chapter: Glomerular Diseases 
  Page 173 - 192Hastings MC, Wyatt RJEditors: A.J. Barakat and R.W. Chesney.American Academy of Pediatrics2009
• IgA Nephropathy Today, Contributions to Nephrology 
  Chapter: IgA Nephropathy: A Clinical Overview 
  Page 19 - 26Julian BA, Wyatt RJ, Matousovic K, Moldoveanu Z, Mestecky J, Novak JEditors: Tomino Y.Karger, Basel, Switzerland2007
• Contributions to Nephrology 
  Chapter: IgA nephropathy and Henoch-Schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. 
  Page 134 - 138Novak J, Moldoveanu Z, Renfrow MB, Yanagihara T, Suzuki H, Raska M, Hall S, Brown R, Huang W-Q, Goepfert A, Kilian M, Poulsen K, Tomana M, Wyatt RJ, Julian BA, Mestecky JKarger, Basel, Switzerland2007
• Contributions to Nephrology 
  Chapter: Characterization of IgG antibodies specific for galactose-deficient IgA. 
  Page 129 - 133Suzuki H, Moldoveanu Z, Hall S, Brown R, Julian BA, Wyatt RJ, Tomana M, Tomino Y, Novak J, Mestecky JKarger2007
• Clinical Pediatric Nephrology 
  Chapter: IgA Nephropathy and Henoch Schonlein Purpura Nephritis 
  Page 213 - 222Wyatt RJ, Lau KK, Novak J, Gaber LWEditors: Kerr K, Makker SP, Schnapper HM.Taylor and Francis Medical Books, London, United Kingdom2006
• Essence of Ambulatory Pediatrics 
  Chapter: Hematuria-Proteinuria Evaluation 
  Wyatt RJEditors: JA Stockman and J Lohr.WB Saunders, Orlando, FL2001
• Clinical Management of Infections in Immunocompromised Infants and Children 
  Chapter: Infections in the Child with Renal Disease 
  Page 242 - 258Ault BH, Jones DP and Wyatt RJEditors: CC Patrick.Lippincott Williams and Wilkins, Philadelphia, PA2001
• Examining competing interests. 
  Chapter: Health Policy Report: Evaluation of TennCare 
  Page 440 - 443Tamburo R, Barnard M, DiBari M, Wyatt R, Mirvis DEditors: JB Thomison.Tennessee Medicine, Nashville TN1999
• Current Therapy in Nephrology and Hypertension 
  Chapter: Henoch-Schonlein Purpura 
  Page 172 - 174Wyatt RJ and Kagy LEditors: RJ Glassock.CV Mosby, Philadelphia, PAEdition 4th,1998
• Mediguide to Nephrology 
  Chapter: IgA Nephropathy 
  Page 1 - 6Julian BA and Wyatt RJEditors: HH Malluche.Lawrence Dellacourt Publications, Inc., New York, NY1996
• Infections in Immunocompromised Infants and Children 
  Chapter: Infections of the Child with Renal Disease 
  Page 311 - 321Matsell DG, Chesney RW, Wyatt RJ and Novello ACEditors: C.C. Patrick.Churchill Livingston, Inc., New York, NY1992
• Comprehensive Pediatrics 
  Chapter: Pediatric Nephrology 
  Page 612 - 646Roy S III, Stapleton FB and Wyatt RJEditors: JG Hughes and RL Summitt.CV Mosby Co., St. Louis, MOEdition 7th,1990
• IgA Nephropathy 
  Chapter: The future--a pediatric perspective. 
  Page 240 - 254Hogg RJ, Rifai A, Splawski JB and Wyatt RJEditors: AR Clarkson.Martinus Nijhoff, Boston, MA1987
• Progress in Allergy 
  Chapter: Regulatory Factor Deficiencies: P 
  Page 339 - 343Wyatt RJEditors: K Rother and U Rother.Karger, Basel, Switzerland1987
• Glomerulonephritis 
  Chapter: C3NeF in Glomerulonephritis 
  Page 227 - 236West CD, Wyatt RJ and Forristal JEditors: Y Yoshitoshi and Y Ueda.University Park Press, Baltimore, MD1979
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Abstracts/Posters

• Pathogenic role of aberrantly-glycosylated IgA1 and corresponding autoantibodies in patients with Henoch-Schoenlein purpura nephritis.
  Suzuki H, Moldoveanu Z, Julian BA, Suzuki Y, Tomino Y, Wyatt RJ, Novak J, Journal of the American Society of Nephrology, 1/1/2014
• Abnormal cytokine signaling cytokine in IgA1-secreting cells that promotes production of galactose-deficient IgA1 in patients with IgA nephropathy can be controlled by...
  K, HuangZ-Q, Raska M, Anderson J, Suzuki H, Reily CR, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Mestecky J, Tomino Y, Gharavi AG, Julian BA, Willey CD, Novak J, Thirteenth International Symposium on IgA Nephropathy, Nanjing, China, 1/4/2013
• Quantitative GWAS for Gal-deficient IgA1 Highlights Genetic Variants in the Glycosylation Pathway.
  Kiryluk K, Li Y, Hou P, Xie J, Moldoveanu Z, Raska M, Yamada K, Julian BA, Wyatt RJ, Suzuki H, Scolari F, Berthoux F, Eitner F, Floege J, Chen N, Zhang H, Novak J, Gha..., Thirteenth International Symposium on IgA Nephropathy, Nanjing, China, 1/4/2013
• Surveillnace biopsies in pediatric renal transplant recipients.
  Atherton JG, Hastings MC, Kane OG, Delos Santos NM, Eison TM, Wyatt RJ, Walker P, Ault BH, Journal of Investigative Medicine, 1/1/2013
• Cytokines accentuate synthesis of galactose-deficient IgA1 in IgA nephropathy by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
  Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2013
• Galactose deficient IgA1 production enhanced by abnormal cytokine signaling in IgA1-secreting cells can be controlled by STAT inhibitors.
  Yamada K, Huang ZQ, Raska M, Anderson J, Suzuki H, Reily C, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Mestecky JF, Tomino Y, Gharavi AG, Julian BA, Wiley CD..., Journal of the American Society of Nephrology, 1/1/2013
• Effects of leukemia inhibitory factor and oncostatin M on IgA1- producing cells from patients with IgA nephropathy.
  Yamada, K, Huang ZQ, Raska M, Moldoveanu Z, Suzuki H, Suzuki Y, Kiryluk K, Wyatt RJ, Tomino Y, Julian BA, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2013
• Urinary tract abnormalities in CD151 trafficking deficient transgenic mice.
  Kane O, Zhang F, Wyatt RJ, Ault BH, Zhang XA, Journal of Investigative Medicine, 1/1/2012
• Analysis of germline VH sequences of IgG autoantibodies specific for galactose-deficient IgA1 in patient with IgA nephropathy.
  Huang ZQ, Raska M, Zhang, Zhixin (Jason), Suzuki H, Hall SD, Wyatt RJ, Julian BA, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2012
• Role of N-acetylgalctosaminyl transferases in the synthesis of aberrant IgA1 O-glycans in IgA nephropathy.
  Raska M, Yamada K, Stewart TJ, Stuchlova-Horynova M, Huang ZQ, Suzuki H, Moldoveanu Z, Julian BA, Wyatt RJ, Mestecky JF, Renfrow MB, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2012
• Cytokine-mediated dysregulation of specific glycosyltransferases contributes to aberrant glycosylation of IgA1 in patients with IgA nephropathy.
  Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2012
• IL-6 increases production of galactose-deficient IgA1 by IgA1-secreting cells from IgA nephropathy patients through STAT3 signaling pathways.
  Yamada K, Huang ZQ, Suzuki H, Raska M Moldoveanu Z, Suzuki Y, Julian BA, Wyatt RJ, Tomino Y, Mestecky JF, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2012
• Mesangial IgG deposition is not associated with outcome in pediatric IgA nephropathy.
  Hastings MC, McGlothan KR, Eison TM, Delos Santos NM, Ault BH, Wyatt RJ, Journal of the American Society of Nephrology, 1/1/2011
• Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.
  Kiryluk K, Li Y, Rohanizadegan M, Sanna-Cherchi S, Choi M, Scolari F, Gesualdo L, Savoldi S, Amoroso A, Julian BA, Novak J, Wyatt RJ, Metzger M, Stengel B, Thibaudin L..., Journal of the American Society of Nephrology, 1/1/2011
• APOL1 genetic variants are associated with susceptibility to focal segmental glomerulosclerosis and HIV-1 associated nephropathy but not IgA nephropathy in African Ame...
  Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Imus P, Mhatre AN, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Cohen DJ, Appel GB, D’Agat..., Journal of the American Society of Nephrology, 1/1/2011
• Distinct in vitro and in vivo phenotypes of KCNJ5 mutations in hereditary hypertension.
  Scholl UI, Nelson-Williams CJ, Yue P, Wyatt RJ, Dillon MJ, Couch R, Hammer LA, Wang WH, Lifton RP, Journal of the American Society of Nephrology, 1/1/2011
• Effect of gp130 Cytokines on IgA1-Producing Cells from Patients with IgA Nephropathy.
  Yamada K, Raska M, Moldoveanu Z, Suzuki H, Kiryluk K, Julian BA, Wyatt RJ, Tomino Y, Mestecky JF, Gharavi AG, Novak J, Journal of the American Society of Nephrology, 1/1/2011
• Absence of mesangial IgG deposits in childhood IgA nephropathy (IgAN) is associated with normal serum levels of galactose-deficient IgA1 (Gd-IgA1).
  Eison TM, Hastings MC, Moldoveanu Z, Sanders JT, Lau KK, Julian BA, Novak J, Wyatt RJ, Pediatric Academic Societies, 1/1/2011
• Serum galactose-deficient IgA1 (Gd-IgA1) levels in children with hematuria.
  Eison TM, Sanders JT, Hastings MC, Moldoveanu Z, Ault BH, Julian BA, Novak J, Wyatt RJ, Pediatric Academic Societies, 1/1/2011
• Clinical Features and Outcome of Biopsied Henoch-Schonlein Purpura Nephritis (2000-2009).
  Eison TM, Hastings MC, Lau KK, Delos Santos NM , Ault BH, Jones DP,1 Wyatt RJ, Pediatric Nephrology, 1/1/2011
• Gd-IgA1: A screening test for pediatric IgA nephropathy.
  Sanders JS, Moldoveanu Z, Somes G, Hastings MC, Huang W-Q, Walker S, Hancox O, Novak J, Wyatt RJ, American Journal of Kidney Diseases, 1/1/2010
• Genome-wide association study (GWAS) identifies five new susceptibility loci for IgA nephropathy (IgAN).
  Gharavi AG, Kiryluk K, Choi M, Li Y, Xie J, Hou P, Sanna-Cherchi S, Novak J, Wyatt RJ, Julian BA, Savoldi S, Allegri L, Ghiggeri GM, Magistroni R, Salvadori M, Boscutt..., Journal of the American Society of Nephrology, 1/1/2010
• Serial measurement of galactose-deficient IgA1 (Gd-IgA1) in children.
  Hastings MC, Sanders JT, Moldoveanu Z, Novak J, Julian BA, Wyatt RJ, Journal of the American Society of Nephrology, 1/1/2010
• Biological activities of IgA1-containing immune complexes from pediatric patients with IgA nephropathy (IgAN).
  Novak J, Raskova-Kafkova L, Suzuki H, Tomana M, Matousovic K, Brown RT, Hall SD, Sanders JT, Eison TM, Moldoveanu Z, Novak L, Novak Z, Mayne R, Julian BA, Mestecky JF,..., Journal of the American Society of Nephrology, 1/1/2010
• Gd-IgA1: Galactose-deficient IgA1 in normal pediatric subjects.
  Sanders JS, Moldoveanu Z, Huang W-Q, Walker S, Hancox O, Novak J, Wyatt RJ, Pediatric Academic Societies, 1/1/2010
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Lectures

• IgA nephropathy: Contributions to its understanding from the LBCH/UTHSC group. 
  Children’s Foundation Research Institute, Memphis, TN - 1/19/2014
• IgA nephropathy and Henoch Schoenlein purpura. 
  University of West Virginia, Morgantown, WV - 1/17/2014
• IgA nephropathy (anti-Gd1-IgA1, sCD89, sCD71, etc.) 
  Amsterdam, the Netherlands - 1/3/2014
• IgA Nephropathy: The First 15 Years (1969-1984). 
  University of Alabama at Birmingham - 1/11/2013
• IgA Nephropathy – Pathogenic Mechanisms for the Most Common Chronic Glomerular Disease. 
  University of Tennessee Health Sciences Center - 1/7/2011
• IgA Nephropathy. 
  Washington, DC - 1/17/2005
• Genetic Influences in the Pathogenesis of IgA nephropathy. 
  University of Tennessee Health Sciences Center - 1/14/2004
• Treatment of IgA Nephropathy. 
  Chicago, IL - 1/19/2002
• Update on IgA Nephropathy: Treatment of IgA Nephropathy. 
  Toronto, Canada - 1/15/2000
• Urinary Tract Infection" and "IgA Nephropathy - Pediatric Long Term Outcome/Treatment Strategies. 
  St. Jude Children's Research Hospital, Memphis, TN - 1/25/1996
• Epidemiology of IgA nephropathy: Genetic influence vs selection bias. 
  Washington, DC - 1/4/1996
• The Complement System in IgA Nephropathy: Genetic and Functional Aspects. 
  Nancy, France - 1/2/1992
• Role for Specific Complement Phenotypes and Deficiencies in the Clinical Expression of IgA Nephropathy. 
  1/18/1990
• Genetic Influences in the Pathogenesis and Clinical Expression of IgA Nephropathy. 
  Toronto, Canada - 1/27/1989
• Regional Variation in C4 Phenotype in Patients with IgA Nephropathy. 
  Cincinnati, OH - 1/7/1989
• Activation in IgA Nephropathy. 
  Washington, DC - 1/17/1988
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