RobertARizzaMD

Endocrinology • Rochester, MN

Diabetes, Lipid Metabolism

Professor, Internal Medicine, Mayo Medical School

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Office
200 1st St Sw
Rochester, MN 55905
Phone+1 507-284-2511

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Endocrinology, Diabetes, and Metabolism, 1976 - 1980
Johns Hopkins UniversityResidency, Internal Medicine, 1975 - 1976
Johns Hopkins UniversityResidency, Internal Medicine, 1971 - 1973
University of Florida College of MedicineClass of 1971
The Johns Hopkins UniversityBA, Biophysics, 1967

Certifications & Licensure

MN State Medical License 1976 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Outstanding Mentorship Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, 2012
Banting Award for Distinquished Scientific Accomplishments American Diabetes Association, 2010
Honorary Fellow Royal College of Physicians of Ireland, 2009
Johns Hopkins Society of Scholars Johns Hopkins, 2008
Bruce Zimmerman Award Mayo Clinic, 2006
Banting Medal American Diabetes Association, 2006
Eric Neilsen Award for Outstanding Service to Subspecialty Medicine Association of Subspecialty Professors, Mayo Clinic, 2005
Yank D. Coble Distinguished Service to Endocrinology Award American College of Endocrinology, 2001
Outstanding Physician Clinician in Diabetes American Diabetes Association, 2000
Distinguished Service Award Department of Internal Medicine, Mayo Clinic, 1998
Distinguished Investigator Mayo Foundation, 1997
Distinguished Investigators Department of Internal Medicine, Mayo Clinic, 1996
Merit Award National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1996
Teacher of the Year - Clinical Investigator Program Mayo Clinic Committees, 1990
Elected Member The American Society for Clinical Investigation, 1987
Teacher of the Year Department of Internal Medicine, Mayo Clinic, 1982
William H. J. Summerskill Award for Outstanding Achievement in Research 1979
Upjohn Achievement Award - Number One Graduating Senior University of Florida Medical School, University of Florida, 1971
Alpha Omega Alpha University of Florida Medical School, University of Florida, 1970
Pfizer Scholarship - Most Outstanding Scholastic Record University of Florida Medical School, University of Florida, 1970
Medical Guild Academic Excellence Award University of Florida Medical School, University of Florida, 1970
Roche Award-Outstanding Academic Performance in Basic Sciences University of Florida Medical School, University of Florida, 1969
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Clinical Trials

Effects of Fats on Blood Glucose in People With and Without Type 2 Diabetes Mellitus Start of enrollment: 2004 Jul 01
Completed
Not Applicable

Publications & Presentations

PubMed

99 citations
High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs
Francisco Martínez, Robert A. Rizza, Juan C. Romero
Hypertension. 1994-04-01
26 citations
High-Fructose Feeding Elicits Insulin Resistance Without Hypertension in Normal Mongrel Dogs
E. Pamies-Andreu, M. J. Fiksen-Olsen, Robert A. Rizza, Juan C. Romero
American Journal of Hypertension. 1995-07-01
554 citations
Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin A...
Robert A. Rizza, Lawrence J. Mandarino, John E. Gerich
The Journal of Clinical Endocrinology and Metabolism. 1982-01-01

Journal Articles

An Increase in Chromogranin A-positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis
Robert A Rizza, Antoinette Moran, Journal of the Endocrine Society
Paradigm Shifts in Nocturnal Glucose Control in Type 2 Diabetes
Robert A Rizza, Ananda Basu, Rita Basu, The Journal of Clinical Endocrinology and Metabolism
Insulin Pulse Amplitude and Frequency Do Not Determine Rates of Endogenous Glucose Production in Nondiabetic Subjects
Varghese RT, Andrews JC, Shah M, Piccinini F, Dalla Man C, Rizza RA, Cobelli C, Vella A, Diabetologia, 1/1/2015
The Oral Minimal Model Method
Cobelli C, Man CD, Toffolo G, Basu R, Vella A, Rizza R, Diabetes, 1/1/2014
Glp-1 Antagonism Alters the Rate of Gastrointestinal Transit but Not the Rate of Meal Appearance after Roux-en-y Gastric Bypass in Diabetic and Non-diabetic Subjects
Shah M, Law JH, Piccinini F, Dalla Man C, Sathananthan M, Giesler PD, Camilleri M, Rizza RA, Cobelli C, Vella A, Diabetologia, 1/1/2013
Preparedness of the CTSA's Structural and Scientific Assets to Support the Mission of the National Center for Advancing Translational Sciences (NCATS)
CTSA Principal Investigators, Shamoon H, Center D, Davis P, Tuchman M, Ginsberg H, Califf R, Stephens D, Mellman T, Verbalis J, Nadler L, Shekhar A, Ford D, Rizza R, S..., Clin Transl Sci, 1/1/2012
"Hyperoxia Blunts Counterregulation during Hypoglycaemia in Humans: Possible Role for the Carotid Bodies": Errata
Wehrwein EA, Basu R, Basu A, Curry TB, Rizza RA, Joyner MJ, The Journal of Physiology, 1/1/2011
Reply from Erica A Wehrwein, Rita Basu, Ananda Basu, Timothy B Curry, Robert A Rizza and Michael J Joyner
Wehrwein EA, Basu R, Basu A, Curry TB, Rizza RA, Joyner MJ, J Physiol (Lond)., 1/1/2011
Modelling Non-Steady State Metabolism from Arteriovenous Data
Manesso E, Toffolo GM, Basu R, Rizza RA, Cobelli C, IEEE Transactions on Biomedical Engineering, 1/1/2010
Erratum to "Hyperoxia Blunts Counterregulation during Hypoglycemia in Humans: Possible Role for the Carotid Bodies?" by Erica a Wehrwein, Rita Basu, Ananda Basu, Timot...
Wehrwein E, Basu R, Basu A, Curry T, Rizza R, Joyner MJ., J Physiol, 1/1/2010
Commentary on the Results and Clinical Implications of the PROactive Study
Rizza R, Henry R, Kahn R, Clinical Diabetes, 1/1/2006
Effects of Age and Sex on Postprandial Glucose Metabolism: Differences in Glucose Turnover, Insulin Secretion, Insulin Action, and Hepatic Insulin Extraction [Erratum]
Basu R, Dalla Man C, Campioni M, Basu A, Klee G, Toffolo G, Cobelli C, Rizza RA, Diabetes, 1/1/2006
Diabetes Mellitus and Outcome after Successful Percutaneous Coronary Revascularization: The Mayo Clinic Experience 1979-1998
Hasdai D, Rizza RA, Grill DE, Scott CG, Garratt KN, Holmes DR Jr, Heart Drug, 1/1/2001
Treatment of Diabetes Mellitus by Diet Alone versus Oral Hypoglycemics versus Insulin and Outcome after Successful Percutaneous Coronary Revascularization
Hasdai D, Rizza RA, Grill DE, Scott CG, Garratt KN, Holmes DR Jr., Heart Drug, 1/1/2001
Profiles of the Endocrine Clinic: the Mayo Clinic
Brennan MD, Miner KM, Rizza RA, J Clin Endocrinol Metab, 1/1/1998
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Gavin JR, Alberti KGMM, Davidson MB, Defronzo RA, Drash A, Gabbe SG, Genuth S, Harris MI, Kahn R, Keen H, Knowler WC, Lebovitz H, Maclaren NK, Palmer JP, Raskin P, Riz..., Diabetes Care, 1/1/1997
Effect of Acute Hyperglycemia on Colorectal Motor and Sensory Function in Humans
Maleki D, Camilleri M, Zinsmeister AR, Rizza RA, Am J Physiol Gastrointest Liver Physiol, 1/1/1997
Pregnancy Outcomes in IDDM in the Diabetes Control and Complications Trial
The DCCT Research Group, Am J Ob Gyn, 1/1/1996
Use of Bioelectrical Impedance Analysis Measurements in Patients with Diabetes
Leiter L, the DCCT Research Group, American Journal of Clinical Nutrition, 1/1/1996
Effects of Intensive Diabetes Therapy on Neuropsychological Functions in Adults in the Diabetes Complications and Control Trial
The DCCT Research Group, Ann Int Med, 1/1/1996
Influence of Intensive Diabetes Treatment on Quality of Life Outcomes in the Diabetes Control and Complications Trial
The DCCT Research Group, Diabetes Care, 1/1/1996
Lifetime Benefits of Intensive Therapy as Practiced in the Diabetes Control and Complications Trial: An Economic Evaluation
The DCCT Research Group, JAMA, 1/1/1996
Measurement of Plasma Calcitonin Gene-related Peptide Concentration in Healthy Humans and Patients with Type II Diabetes Mellitus: Responses to Meal Ingestion and Hype...
Bradford CW, Heath H III, Rizza RA, Butler PC, Endocrinol Metab, 1/1/1995
Lack of Correlation between Sodium-lithium Countertransport Activity and Insulin Action in Non-insulin-dependent Diabetes Mellitus
Alzaid AA, Dinneen SF, Turner ST, Rizza RA, Endocrinology & Metabolism, 1/1/1995
The Relationship of Glycemic Exposure (HbA1c) To the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications Trial
The DCCT Research Group, Diabetes, 1/1/1995
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Books/Book Chapters

Goldman's Cecil Medicine
Chapter: Hypoglycemia/Pancreatic Islet Cell Disorders
Page 1499 - 1505Vella A, Rizza RA, Service FJEditors: Goldman L; Schafer AI.Elsevier/Saunders, PhiladelphiaEdition 24th,2012
Clinical Dilemmas in Diabetes
Vella A, Rizza RAWiley-Blackwell, Chichester; Hoboken2011
Endocrinology: Adult and Pediatric
Chapter: Classification and Diagnosis of Diabetes Mellitus
Page 735 - 743Dinneen SF, Rizza RAEditors: Jameson JL; et al.Saunders/Elsevier, PhiladelphiaEdition 6th,2010
Textbook of Diabetes
Chapter: Metabolic Disturbances in Diabetes
Page 215 - 216Vella A, Rizza RAEditors: Holt RIG; et al.Wiley-Blackwell, Chichester; HobokenEdition 4th,2010
Pharmacology and Therapeutics: Principles to Practice
Chapter: Diabetes Mellitus
Page 557 - 570Rizza RA, Vella AEditors: Waldman SA, Terzic A.Saunders/Elsevier, Philadelphia2009
Cecil Medicine
Chapter: Hypoglycemia/Pancreatic Islet Cell Disorders
Page 1760 - 1766Rizza RA, Service FJEditors: Goldman L, Ausiello D.Saunders Elsevier, PhiladelphiaEdition 23rd,2008
Neurological Therapeutics: Principles and Practice
Chapter: Diabetic Polyneuropathy
Page 2261 - 2267Dyck PJ, Rizza RAEditors: Noseworthy JH.Informa Healthcare, AbingdonEdition 2nd,2006
Neurological Therapeutics : Principles and Practice
Chapter: Diabetic Polyneuropathy
Page 2001 - 2006Dyck PJ, Rizza RAEditors: Noseworthy JH.Martin Dunitz, London2003
Early Diagnosis and Treatment of Endocrine Disorders
Chapter: Type 1 Diabetes
Page 69 - 86Kudva YC, Basu R, Rizza RAEditors: Bar RS.Humana Press, Totowa2003
Type 1 Diabetes: Etiology and Treatment
Chapter: Surgery for the Patient with Type 1 Diabetes
Page 361 - 371Vella A, Rizza RAEditors: Sperling MA.Humana Press, Totowa2003
Textbook of Diabetes
Chapter: Metabolic Disturbances in Diabetes Mellitus
Vella A, Rizza RAEditors: Pickup JC, Williams G.Blackwell Science, MaldenEdition 3rd,2003
Encyclopedia of Foods: A Guide to Healthy Nutrition
Rizza RA, Go VLW, McMahon MM, Harrison GG, Nelson JK, Kuhnert KAEditors: Rizza RA, et al.Academic Press, San Diego2002
Endocrinology
Chapter: Classification and Diagnosis of Diabetes Mellitus
Page 756 - 762Dinneen SF, Rizza RAEditors: DeGroot LJ, et al.W. B. Saunders Co., PhiladelphiaEdition 4th,2001
Influence of Intensive Diabetes Treatment on Body Weight and Composition of Adults With Type 1 Diabetes in the Diabetes Control and Complications Trial.
The DCCT Research Group2001
Neurological Therapeutics: Principles and Practice. Peripheral Nerve Disorders
Chapter: Diabetic Polyneuropathy
Dyck PJ, Rizza RAEditors: J.H. Noseworthy, P.J. Dyck.Martin Dunitz Publishers2001
Cecil Textbook of Medicine
Chapter: Hypoglycemia/pancreatic Islet Cell Disorders
Page 1285 - 1292Rizza RA, Service FJEditors: Goldman L, Bennett JC.W. B. Saunders Company, PhiladelphiaEdition 21st,2000
The Effect of Intensive Diabetes Therapy on Measures of Autonomic Nervous System Function in the DCCT
The DCCT Research Group1998
Early Worsening of Diabetic Retinopathy in the Diabetes Control and Complications Trial
The DCCT Research Group1998
The Diabetes Annual/11
Chapter: Preface
Marshall SM, Home PD, Rizza RAEditors: Marshall SM, et al.Elsevier, Amsterdam1998
The Diabetes Annual/11
Marshall SM, Home PD, Rizza RAElsevier, Amsterdam1998
Handbook of Physiology, the Endocrine Pancreas and Regulation of Metabolism
Chapter: Type 1 Diabetes Mellitus (IDDM), Part IV. Integrated Hormonal Responses to Physiological Challenges
Rizza RA, Jensen MD, Nair KSEditors: Jefferson and Cherrington.Oxford University Press1997
Hypoglycemia in the DCCT
The DCCT Research Group1997
Clustering of Long-term Complications in Families with Diabetes in the Diabetes Control and Complications Trial
The DCCT Research Group1997
Clinical Research in Diabetes and Obesity: Volume I: Methods, Assessment, and Metabolic Regulation
Chapter: Preface
Drazin B, Rizza REditors: Drazin B, Rizza R.Humana Press, Totowa1997
Clinical Research in Diabetes and Obesity: Volume I: Methods, Assessment, and Metabolic Regulation
Draznin B, Rizza RHumana Press, Totowa1997
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Abstracts/Posters

Insulin Action in Noninsulin Dependent Diabetes Mellitus: Results of a Randomized Crossover Trial Comparing Sulphonylurea Therapy with Exogeneous Insulin
Firth RG, Bell PM, Rizza RA, British Diabetes Association, Sheffield, England, 1/1/1986
Improvement in Insulin Action on Hepatic and Periphreal Tissues: A Major Postreceptor Effect of Chronic Sulfonylurea Therapy
Mandarino L, Rizza RA, Gerich JE, European Association for the Study of Diabetes, Oslo, Norway, 1/1/1983

Press Mentions

Mayo Clinic Q and a: Metabolic Syndrome and Lifestyle ChangesMarch 6th, 2023
SPECIAL REPORT-Drugmakers Pushed Aggressive Diabetes Therapy. Patients Paid the PriceNovember 4th, 2021
How Dehydration May Affect Type 2 Diabetes Management and RiskJuly 29th, 2021
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Grant Support

Mayo Clinic Center For Translational Science ActivitiesNational Center For Research Resources2011
CTSA Infrastructure For Pediatric ResearchNational Center For Research Resources2006–2011
CTSA Infrastructure For Clinical TrialsNational Center For Research Resources2006–2011
CTSA Infrastructure For AIDS ResearchNational Center For Research Resources2006–2011
Mechanisms Of Insulin Resistance In ManNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2011
Comparative Medicine Core Facility Infrastructure ImprovementNational Center For Research Resources2010
Mayo Clinic Center For Clinical And Translational ResearchNational Center For Research Resources2006–2010
Investigations On GluconeogenesisNational Center For Research Resources2007–2008
Ctsa/Ncra Community Engagement SupplementNational Center For Research Resources2007
Ctsa: K12 ComponentNational Center For Research Resources2006
General Clinical Research CenterNational Center For Research Resources2005–2006
Mechanisms Of Postprandial Hyperglycemia In HumansNational Center For Research Resources2005
Effects Of Free Fatty Acids On Endogenous Glucose ProductionNational Center For Research Resources2005
Insulin Effect On Gluconeogenesis In Type 2 DiabetesNational Center For Research Resources2004
Effect Of Type 2 Diabetes On Insulin Stimulated Splanchnic Glucose UptakeNational Center For Research Resources2004
Diabetes Prevention Trial - Type I Diabetes (Dpt-1)National Center For Research Resources2004
Comparison Of The Dual And Triple Tracer MethodNational Center For Research Resources2004
Mechanisms Of Insulin Resistance In ManNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2003
Incretin Hormone GLP-1, Mode Of Glucose Delivery &UptakNational Center For Research Resources2000–2002
Glucagon And Glucose Release, Glycogenolysis And Gluconeogenesis In DiabetesNational Center For Research Resources2000–2002
NON Insulin Dependent Diabetes Mellitus On Muscle &Splanchnic GlucoseNational Center For Research Resources1999–2002
Effects Of Glucagon On Carbohydrate Metabolism In Type 2 Diabetes MellitusNational Center For Research Resources1999–2002
Effects Of GLP On Glucose EffectivenessNational Center For Research Resources1999–2002
Effects Of GLP 1 On Insulin Action In Diabetic &Non Diabetic SubjectsNational Center For Research Resources1999–2002
Effect Of Androgen Replacement On Carbohydrate MetabolismNational Institute On Aging1998–2002
Diabetes Prevention Trial--Type I DiabetesNational Center For Research Resources1996–2002
Mechanisms Of Insulin ResistanceNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2000
Effects Of Glucagon On Glucose ToleranceNational Center For Research Resources1999
Non-Insulin Dependent Diabetes Mellitus--Glucose Stimulating Own Uptake/ReleaseNational Center For Research Resources1998–1999
Evaluation Of New Method To Measure Insulin Action And Glucose EffectivenessNational Center For Research Resources1998–1999
Method To Measure Insulin Action And Glucose Effectiveness In HumansNational Center For Research Resources1997–1999
Effects Of Overnight Insulin Infusion In Insulin Action In NIDDMNational Center For Research Resources1996–1999
Effects Of Glucagon On Hepatic Glucose Release, Glycogenolysis, GluconeogenesisNational Center For Research Resources1996–1999
Effects Of Nocturnal Increase In Growth Hormone On Breakfast ToleranceNational Center For Research Resources1994–1999
Mechanisms Of Insulin Resistance In ManNational Center For Research Resources1985–1999
Evaluation Of A New Method To Measure Insulin Action And Glucose EffectivenessNational Center For Research Resources1997
Effects Of Endurance Training On Muscle Protein Synthesis In Women And MenNational Center For Research Resources1996–1997
Impact Of Glucose On Glucose Uptake In Controls And NIDDMNational Center For Research Resources1996
Alterations In Insulin Secretion, Insulin Action, And Diabetes And Blood GlucoseNational Center For Research Resources1994–1996
Impact Of Glucose PER SE On Glucose Uptake In Controls And NIDDMNational Center For Research Resources1995
Effect Of Sulfonylurea (GLIPIZIDE) On Growth Hormone Secretion In HumansNational Center For Research Resources1995
Growth Hormone To Treat Hypoglycemia In Patients With Metastatic InsulinomasNational Center For Research Resources1994–1995
Effects Of Physiologic Changes In Glucagon On Carbohydrate ToleranceNational Center For Research Resources1993–1995
Mechanisms Of Insulin Resistance In ManNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1995
Comparison Of Rate Of Onset Of Insulin Action In NIDDM And Nondiabetic ControlNational Center For Research Resources1993–1994
Characterization Of GI Motility In DiabetesNational Center For Research Resources1993–1994
Assessment Of Contribution Of Insulin Secretion And Insulin Action CarbohydratesNational Center For Research Resources1993–1994
Effects Of Early Morning Increases In Cortisol On Breakfast ToleranceNational Center For Research Resources1992–1994
Blood Draws For Radioimmunoassay And Radioenzymatic StandardsNational Center For Research Resources1992–1993
Validation And Application Of Nonsteady-State EquationsNational Center For Research Resources1990–1993
Characterization Of GI Motility In Patients With DiabetesNational Center For Research Resources1989–1993
Feasibility Study--Effect Of Somatostatin On Meal-Induced Insulin SecretionNational Center For Research Resources1992
Assessment Of Insulin Action In NIDDM Using Variable Insulin InfusionsNational Center For Research Resources1992
Assessment Of Contribution Of Insulin Secretion And Insulin ActionNational Center For Research Resources1992
Treatment Of Abnormal Insulin Kinetics And Insulin ResistanceNational Center For Research Resources1991
Bibliography ManagementNational Center For Research Resources1991
Effect Of Meal Composition On Treatment Of HypoglycemiaNational Center For Research Resources1990–1991
Postprandial Metabolism In Niddm--Hepatic Glucose CyclingNational Center For Research Resources1989–1991
Gastric Inhibitory Polypeptide (GIP) In Health And DiseaseNational Center For Research Resources1989–1991
Standardization Of Radioimmuno And Radioenzymatic AssaysNational Center For Research Resources1987–1991
Use Of Human Ultralente For Basal Insulin DeliveryNational Center For Research Resources1990
Effect Of Meal Composition On Treatment Of HypoclycemiaNational Center For Research Resources1989
Effect Of Ultralente On Postprandial Carbohydrate DisposalNational Center For Research Resources1987–1989
Futile Cycling--Hyperinsulinemia, Hyperglycemia, And Diabetes MellitusNational Center For Research Resources1988
Are Isotopes Of Glucose, Leucine, And Palmitate Irreversible TracersNational Center For Research Resources1988
Futile Cycling In Man--Effects Of IDDMNational Center For Research Resources1986
Effects Of Insulin And Sufonylurea Therapy In Insulin ActionNational Center For Research Resources1986
Effects Of Insulin Action Using Variable And Constant InfusionNational Center For Research Resources1986
Effects Of Tolinase On Insulin Action In Non-Insulin Dependent DiabetesNational Center For Research Resources1985–1986
Effects Of Hyperinsulinemia On Insulin ActionNational Center For Research Resources1985–1986
Effects Of Growth Hormone On Insulin ActionNational Center For Research Resources1985–1986
Effects Of Exercise On Insulin ActionNational Center For Research Resources1985–1986
Effects Of Acromegaly On Insulin ActionNational Center For Research Resources1985–1986
Effects Of Acanthosis Nigricans On Insulin ActionNational Center For Research Resources1985–1986
Effect Of Reversal Of Hyperinsulinemia On Insulin ActionNational Center For Research Resources1985–1986
Effect Of Hyperinsulinemia On Catecholamine MetabolismNational Center For Research Resources1985–1986
Mechanisms Of Insulin Resistance In ManNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985