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Office
200 1st St SW
Rochester, MN 55905Phone+1 507-284-2511
Summary
- The research goals of Robert J. Pignolo, M.D., Ph.D., are to understand the mechanisms underlying skeletal aging, and to use insights from rare bone diseases to inform new ways of studying and treating conditions of skeletal dysfunction. Dr. Pignolo's work has relevance to stem cell biology, regenerative medicine and the influence of micro-environmental effects on cellular aging.
Areas of focus include: aging of bone, mesenchymal stem cell biology, circulating osteogenic precursor (COP) cells, and disorders of extraskeletal bone formation.
The work performed by Dr. Pignolo has tremendous clinical implications for age-related osteoporosis, fractures, various conditions of disease-associated bone loss, rare bone diseases such as FOP, common conditions of heterotopic bone formation, frailty and sarcopenia.
Education & Training
- University of Pennsylvania Health SystemFellowship, Geriatric Medicine (Internal Medicine), 2001 - 2003
- Drexel University College of Medicine/Hahnemann University HospitalResidency, Internal Medicine, 1998 - 2001
- MCP-Hahnemann College of MedicineClass of 1998
Certifications & Licensure
- MN State Medical License 2016 - 2025
- PA State Medical License 1999 - 2016
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Geriatric Medicine
Awards, Honors, & Recognition
- Regional Top Doctor Castle Connolly, 2014
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Clinical Trials
- An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects Start of enrollment: 2014 Jul 14
Publications & Presentations
PubMed
- 13 citationsPalovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.Robert J Pignolo, Geneviève Baujat, Edward C Hsiao, Richard Keen, Amy Wilson
Journal of Bone and Mineral Research. 2022-10-01 - 10 citationsGaretosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial.Maja Di Rocco, Eduardo Forleo-Neto, Robert J Pignolo, Richard Keen, Philippe Orcel
Nature Medicine. 2023-10-01 - 14 citationsThe natural history of fibrodysplasia ossificans progressiva: A prospective, global 36-month study.Robert J Pignolo, Geneviève Baujat, Matthew A Brown, Carmen De Cunto, Edward C Hsiao
Genetics in Medicine. 2022-12-01
Journal Articles
- Diagnosis and Management of Pseudohypoparathyroidism and Related Disorders: First International Consensus StatementRobert Pignolo, Ashley H Shoemaker, Michael A Levine, Nature
Press Mentions
- Nanoparticle Vaccines ExplainedFebruary 16th, 2022
- Retrospective Study Finds That Cancer Drug Also Lowers Blood GlucoseNovember 9th, 2021
- Retrospective Study Finds That Cancer Drug Also Lowers Blood GlucoseNovember 8th, 2021
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Grant Support
- Molecular Genetics Of Progressive Osseous HeteroplasiaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
- Histology CoreNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
- Osteoporosis And Osteoblast Differentiation In Mouse Models Of Accelerated AgingNational Institute On Aging2007–2011
- Circulating Osteogenic Cells In Aging And DiseaseNational Institute On Aging2005–2007
Professional Memberships
- Member
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