Robert Owen Messing MD

PubMed

• A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal.
  Adriana Gregory-Flores, Ivan Jm Bonet, Stève Desaivre, Jon D Levine, Stanton F McHardy
  JCI Insight. 2025-04-22
• Effects of a protein kinase C epsilon inhibitor on insulin signalling in lipid-treated HepG2 hepatocytes and glucose tolerance in fat-fed mice.
  Miguel L Agoncillo, Zhongmin Gao, Harmannus C De Kraker, Stanton F McHardy, Robert O Messing
  European Journal of Pharmacology. 2025-03-05
• Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review.
  Shaunna L Clark, Emily E Hartwell, Doo-Sup Choi, John H Krystal, Robert O Messing
  Alcohol, Clinical & Experimental Research. 2025-01-01

Journal Articles

• Identification of lipocalin-2 as a PKC delta phosphorylation substrate in neutrophils  
  Weng Y-C, Wang G, Messing R O, Chou W-H, J Biomed Sci, 1/1/2015
• Generation and characterization of ATP analog-specific protein kinase Cdelta  
  Kumar V, Weng YC, Geldenhuys WJ, Wang D, Han X, Messing RO, Chou WH, J Biol Chem, 1/1/2015
• Ligand requirements for involvement of PKCepsilon in synergistic analgesic interactions between spinal mu and delta opioid receptors  
  Schuster DJ, Metcalf MD, Kitto KF, Messing RO, Fairbanks CA, Wilcox GL, Br J Pharmacol, 1/1/2015
• Alcohol dependence: molecular and behavioral evidence  
  Trudell JR, Messing RO, Mayfield J, Harris RA, Trends Pharmacol Sci, 1/1/2014
• Deletion of Prkcz increases intermittent ethanol consumption in mice  
  Lee AM, Zou ME, Lim JP, Stecher J, McMahon T, Messing RO, Alcohol Clin Exp Res, 1/1/2014
• Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area  
  Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A, Alcohol Clin Exp Res, 1/1/2013
• Quo vadis? Peering into the future  
  Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR, Ann Neurol, 1/1/2013
• Have the Annals editors added value?  
  Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL, Ann Neurol, 1/1/2013
• Protein kinase C epsilon Is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs  
  Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL, J Neurosci, 1/1/2013
• Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake  
  Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW, Nat Neurosci, 1/1/2013
• PKC epsilon phosphorylation of the sodium channel NaV18 increases channel function and produces mechanical hyperalgesia in mice  
  Wu D-F, Chandra D, McMahon T, Wang D, Dadgar J, Kharazia VN, Liang Y-J, Waxman SG, Dib-Hajj SD, Messing RO, J Clin Invest, 1/1/2012
• Responses to ethanol in C57BL/6 versus C57BL6 x 129 hybrid mice  
  Lim JP, Zou ME, Janak PJ, Messing RO, Brain and Behavior, 1/1/2012
• Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase c delta  
  Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW, Biophys J, 1/1/2012
• Fighting decision fatigue  
  Stewart AF, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR, Johnston SC, Hauser SL, Ann Neurol, 1/1/2012
• Protein kinase C epsilon modulates nicotine consumption and reward signals in the nucleus accumbens  
  Lee AM and Messing RO, Proc Natl Acad Sci USA, 1/1/2011
• PKC delta is a novel regulator of cisplatin nephrotoxicity and effective target for renoprotection during cancer therapy  
  Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z, J Clin Invest, 1/1/2011
• Should the reorganization of addiction-related research across all the national institutes of health be structural?-The devil is truly in the details  
  Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD, Alcohol Clin Exp Res, 1/1/2011
• GABAA receptor trafficking is regulated by PKC epsilon and the N-ethylmaleimide-sensitive factor  
  Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO, J Neurosci, 1/1/2010
• PKC-delta promotes renal tubular cell apoptosis associated with proteinuria  
  Li X, Pabla N, Wei Q, Dong G, Messing RO, Wang C-Y, Dong Z, J Amer Soc Nephrol, 1/1/2010
• The substrates and binding partners of protein kinase C epsilon  
  Newton PM, Messing RO, Biochem J, 1/1/2010
• The N-type calcium channel is a novel target for treating alcohol use disorders  
  Newton PM and Messing RO, Channels, 1/1/2009
• Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala  
  Bajo M, Cruz MT, Siggins GR, Messing R, Roberto M, Proc Nat Acad Sci USA, 1/1/2008
• A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference self-administration and reinstatement  
  Newton PM, Zeng L, Wang V, Connolly J, Wallace MJ, Kim CK, Shin HS, Belardetti F, Snutch TP, Messing RO, J Neurosci, 1/1/2008
• Protein kinase C delta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current  
  Choi D-S, Wei W, Deitchman JK, Kharazia VN, Lesscher HMB, McMahon T, Wang D, Qi Z-H, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO, J Neurosci, 1/1/2008
• Hypertensive encephalopathy and the blood-brain barrier: is deltaPKC a gatekeeper? (Commentary)  
  Chou W-H, Messing RO, J Clin Invest, 1/1/2008
• Join now to see all

Books/Book Chapters

• Harrison’s Principles of Internal Medicine 
  Chapter: Biology of psychiatric disorders. 
  Messing RO, Nestler EJEditors: Kasper, Braunwald, Fauci, Hauser, Longo, Jameson.McGraw-Hill, New York, NYEdition 19th,2015
• Handbook of Clinical Neurology; Alcohol and the Nervous System. Vol. 125 (3rd series) 
  Chapter: Peripheral systems: neuropathy. 
  Page 513 - 525Maiya RP, Messing ROEditors: E.V. Sullivan and A. Pfefferbaum.Elsevier2014
• Encyclopedia of Life Sciences 
  Chapter: Alcoholism. 
  Messing RO, Diamond INature Publishing Group, London2005
• Protein Kinase C Protocols. Methods in Molecular Biology series. 
  Chapter: Genetic approaches to studying protein kinase C. 
  Page 233 - 453Messing ROEditors: Newton.Humana Press, Totowa, NJ2003
• Pathophysiology of Disease: An Introduction to Clinical Medicine 
  Chapter: Chapter 7. Nervous system disorders. 
  Page 143 - 188Messing ROEditors: McPhee, Lingappa, Ganong.McGraw-Hill, New York, NYEdition 4th,2003
• Protein Kinase C Protocols. Methods in Molecular Biology series. 
  Chapter: Animal models to study the function of PKC isozymes. 
  Page 455 - 473Messing RO, Choi D-SEditors: Newton.Humana Press, Totowa, NJ2003
• Harrison’s Principles of Internal Medicine 
  Chapter: Biology of addiction. 
  Page 2557 - 2560Messing ROEditors: Braunwald, Fauci, Kasper, Hauser, Longo, Jameson.McGraw-Hill, New York, NYEdition 15th,2001
• Ethanol and Intracellular Signaling: From Molecules to Behavior. NIAAA Research Monograph 35. 
  Chapter: Protein kinase C delta and epsilon in neuronal responses to chronic ethanol exposure. 
  Page 173 - 183Messing ROPublic Health Service, National Institutes of Health2000
• Cecil Textbook of Medicine 
  Chapter: Nutritional diseases of the nervous system. 
  Page 2039 - 2041Messing ROEditors: Bennett and Plum.W.B. Saunders, Philadelphia, PAEdition 20th,1996
• Pathophysiology of Disease: An Introduction to Clinical Medicine 
  Chapter: Nervous system disorders. 
  Page 69 - 105Messing ROEditors: McPhee, Lingappa, Ganong, Lange.Appleton & Lange, Norwalk, CT1995
• Proceedings of the 86th Nobel Symposium: Toward a Molecular Basis of Alcohol Use and Abuse 
  Chapter: Protein kinase C and adaptation to ethanol. 
  Page 29 - 38Roivainen R, Hundle BH, Messing ROEditors: Janson, Jörvall, Rydberg, Terenius, Vallee.Birkhauser Verlag, Basel1994
• Alcohol, Cell Membranes, and Signal Transduction in Brain 
  Chapter: Mechanisms that mediate ethanol-induced increases in dihydropyridine-sensitive calcium channels. 
  Page 169 - 174Messing ROEditors: Alling, Sun.Plenum, New York, NY1993
• The Molecular and Genetic Basis of Neurological Disease 
  Chapter: Molecular biology of alcohol dependence. 
  Page 129 - 142Messing RO, Diamond IEditors: Rosenberg, Prusiner, DiMauro, Barchi, Kunkel.Butterworth-Heinemann, Boston, MA1993
• Alcohol and Seizures: Basic Mechanisms and Clinical Concepts 
  Chapter: Calcium channel changes during alcohol withdrawal. 
  Page 60 - 67Greenberg DA, Messing RO, Marks SS, Carpenter CLEditors: Porter, Mattson, Cramer, Diamond.F.A. Davis, Philadelphia, PA1990
• Neurology and General Medicine 
  Chapter: Alcohol and the nervous system. 
  Page 533 - 548Messing RO, Greenberg DAEditors: Aminoff M.Churchill Livingstone, New York, NY1989
• The Calcium Channel: Structure, Function, and Implications. 
  Chapter: Alcohol, neurodegenerative disorders, and calcium channel antagonist receptors. 
  Page 541 - 546Greenberg DA, Messing RO, Marks SS, Carpenter CL, Watson DLEditors: Morad, Nayler, Kazda, Schramm.Springer-Verlag, Berlin, Heidelberg1988
• Needed: A catalyst for Change. 
  Chapter: Alcohol and the nervous system 
  Page 721 - 734Messing ROEditors: Aminoff M.Churchill Livingstone, PhiladelphiaEdition 4,
• Harrison’s Principles of Internal Medicine. 
  Chapter: Biology of psychiatric disorders 
  Page 3522 - 3528Messing RO, Rubenstein JH, Nestler EJEditors: Longo, Fauci, Kasper, Hauser, Jameson, Loscalzo.McGraw-Hill, New YorkEdition 18,
• Pathophysiology of Disease: An Introduction to Clinical Medicine. 
  Chapter: Nervous system disorders 
  Page 141 - 182Lomen-Hoerth C,Messing ROEditors: McPhee, Lingappa, Ganong, Lange.McGraw-Hill, New YorkEdition 5,
• Pathophysiology of Disease: An Introduction to Clinical Medicine. 
  Chapter: Nervous system disorders 
  Page 124 - 154Messing ROEditors: McPhee, Lingappa, Ganong, Lange.Appleton & Lange, Norwalk, CTEdition 2,
• Neurology and General Medicine. 
  Chapter: Alcohol and the nervous system 
  Page 533 - 548Messing RO, Greenberg DAEditors: Aminoff M. Churchill Livingstone, New York
• Alcohol and Seizures: Basic Mechanisms and Clinical Concepts. 
  Chapter: Calcium channel changes during alcohol withdrawa 
  Page 60 - 67Greenberg DA, Messing RO, Marks SS, Carpenter CEditors: Porter, Mattson, Cramer.Diamond, Philadelphia
• The Molecular and Genetic Basis of Neurological Disease. 
  Chapter: Molecular biology of alcohol dependence 
  Page 129 - 142Messing RO, Diamond IEditors: Rosenberg, Prusiner, DiMauro, Barchi, Kunkel.Butterworth-Heinemann, Boston
• Alcohol, Cell Membranes, and Signal Transduction in Brain. 
  Chapter: Mechanisms that mediate ethanol-induced increases in dihydropyridine- sensitive calcium channels 
  Page 169 - 174Messing ROPlenum, New York
• Proceedings of the 86th Nobel Symposium: Toward a Molecular Basis of Alcohol Use and Abuse. 
  Chapter: Protein kinase C and adaptation to ethanol 
  Page 29 - 38Roivainen R, Hundle BH, Messing ROEditors: Janson, Jörvall, Rydberg, Terenius, Vallee.Birkhäuser , Basel
• Join now to see all

Lectures

• Calcium Signaling Toolkit- Integrators and Targets of Alcohol: Introduction 
  San Antonio, TX - 1/1/2015
• Protein Kinase C Epsilon Inhibitors to Treat Alcohol Dependence and Pain 
  University of Texas, Austin, TX - 1/1/2015
• Protein kinase C phosphorylation of GABA-A receptors in responses to ethanol. 
  Bellvue, WA - 1/1/2014
• Molecular Signaling and Crosstalk 
  Galveston, TX - 1/1/2014
• Neuroadaptations that Promote Alcohol Drinking Despite Adverse Circumstances 
  University of Texas, Austin, TX - 1/1/2014
• Dell Medical School Update 
  University of Texas, Austin, TX - 1/1/2014
• Addiction 
  New Orleans, LA - 1/1/2013
• Dell Medical School: Update and Research Perspective 
  University of Texas, Austin, TX - 1/1/2013
• Drinking Despite Aversive Consequences: Circuits and Receptors 
  University of Texas, Austin, TX - 1/1/2013
• Mining Nociceptor Signaling for Pain Therapeutics 
  Boston, MA - 1/1/2012
• PKC Epsilon Signaling in Addiction and Pain 
  Medical University of South Carolina, Charleston, SC - 1/1/2012
• Neurobiology and Treatment of Addiction 
  UCSF, San Francisco, CA - 1/1/2012
• PKC Epsilon is a Drug Target for Pain 
  UCSF, San Francisco, CA - 1/1/2012
• Fyn Kinase, NMDA Receptor Function, and Alcohol Response: A Translational Neuroscience Perspective 
  Atlanta, GA - 1/1/2011
• PKC Regulation of Cyc-loop Receptors in Models of Alcohol and Nicotine Addiction 
  Chicago, IL - 1/1/2011
• PKC Epsilon Regulation of Cys-Loop Receptors in Alcohol and Nicotine Addiction 
  Univ. of Texas at Austin - 1/1/2011
• PKC Regulation of Cys-loop Receptors in Alcohol and Nicotine Addiction 
  University of North Carolina, Chapel Hill, NC - 1/1/2011
• Protein Kinase C Regulation of Ethanol Actions at GABA-A Receptors 
  Vienna, Austria - 1/1/2011
• Alcoholic Polyneuropathy is Worsened by Binge Drinking and is PKC epsilon-dependent. 
  Volterra, Italy - 1/1/2011
• Protein Kinase C Epsilon as a Drug Target for Pain, Anxiety and Alcoholism 
  Abbott Park, IL - 1/1/2010
• Regulation of Neuropeptide Signaling by PKC Isozymes in the Amygdala 
  Paris, France - 1/1/2010
• PKC Epsilon Regulation of GABA-A Receptor Trafficking and Function 
  Rosalind Franklin University of Medicine and Science, North Chicago, IL - 1/1/2010
• Sibling Rivalry: Opposing Regulation of Anxiety and Alcohol Responses by PKC Delta and Epsilon 
  University Medical Center, Utrecht, The Netherlands - 1/1/2010
• PKC Regulation of Cys-loop Receptors Modifies Behavioral Responses to Alcohol and Nicotine 
  University of Michigan, Ann Arbor, MI - 1/1/2010
• Rival Siblings: Protein Kinase Delta and Epsilon in Anxiety and Responses to Ethanol 
  University ofChicago, Chicago, IL - 1/1/2010
• Join now to see all