RobertLGrubbJr.MD

Neurosurgery • Saint Louis, MO

Cerebrovascular Neurosurgery, Skull Base

Professor Emeritus of Neurological Surgery, Washington University St Louis

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Office
4921 Parkview Pl
Neuroscience Center 6C
Saint Louis, MO 63110
Phone+1 314-362-3577

Fax+1 314-747-2279

Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Neurological Surgery, 1969 - 1973
Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1965 - 1967
University of North Carolina at Chapel Hill School of MedicineClass of 1965
University of North Carolina at Chapel HillA.B., Chapel Hill,, 1957 - 1961

Certifications & Licensure

MO State Medical License 1971 - 2019
NC State Medical License 1965 - 2019
American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
Distinguished Service Award Washington University School of Medicine, 2005
Donaghy Award, Cerebrovascular Section American Association of Neurological Surgeons, 2004
Grass Prize for Research Society of Neurological Surgeons, 1990
Fellow Stroke Council, American Heart Association
Alpha Omega Alpha
Phi Beta Kappa
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACS) American College of Surgeons
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Publications & Presentations

PubMed

114 citations
Intravesical rAd–IFNa/Syn3 for patients with high-grade, bacillus calmette-guerin–refractory or relapsed non–muscle-invasive bladder cancer: A phase II randomized study
Neal D. Shore, Stephen A. Boorjian, Daniel J. Canter, Kenneth Ogan, Lawrence Karsh
Journal of Clinical Oncology. 2017-10-20
853 citations
Guidelines for the Early Management of Patients With Ischemic Stroke A Scientific Statement From the Stroke Council of the American Stroke Association
Harold P. Adams, Robert J. Adams, Thomas G. Brott, Gregory J. del Zoppo, Anthony J. Furlan
Stroke. 2003-04-01
118 citations
Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types
Joshua N. Sampson, William Wheeler, Meredith Yeager, Orestis A. Panagiotou, Zhaoming Wang
Journal of the National Cancer Institute. 2015-10-12

Journal Articles

The safety of airplane travel in patients with symptomatic carotid occlusion
Reynolds, MR, Kamath, AA, Grubb, RL, Powers, WJ, Adams, HP, Derdeyn, CP, J Neurol Neurosurg Psychiat, 1/1/2014
Codeletions at 1p and 19q predict a lower pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas
Lin, AL, Liu, J, Evans, J, Leuthardt, EC, Dacey, RG, Dowling, JL, Kim, AH, Zipfel, GJ, Grubb, RL, Jr, Huang, J, Robinson, CG, Simpson, JR, Linette, GP, Chicoine, MR, T..., Neuro-Oncology, 1/1/2014
EC-IC bypass for ischemic cerebrovascular disease: What have we learned from the Carotid Occlusion Surgery Study?
Reynolds, MR, Derdeyn, CP, Grubb, RL, Jr, Powers, WJ, Zipfel, GJ, Neurosurg Focus, 1/1/2014
Management of Atypical Cranial Meningiomas, Part 2: Predictors of Progression and the Role of Adjuvant Radiation after Subtotal Resection
Sun, SQ, Cai, C, Murphy, RKJ, DeWees, T, Dacey, RG, Grubb, RL, Rich, KM, Zipfel, GJ, Dowling, JL, Leuthardt, EC, Leonard, JR, Evans, J, Simpson, JR, Robinson, CG, Perr..., Neurosurgery, 1/1/2014
Intravenous t-Marshall, RMPA therapy is an independent risk factor for symptomatic intracerebral hemorrhage following carotid endarterectomy
Vellimana, AK, Yarbrough, CK, Blackburn, S, Strom, RG, Pilgram, TK, Lee, J-M, Grubb, RL, Jr, Rich, KM, Chicoine, MR, Dacey, RG, Jr, Derdeyn, CP, Zipfel, GJ, Neurosurgery, 1/1/2014
Response to editorial “EC-IC bypass graft for cerebral ischemia”
Grubb, RL, Jr, Powers, WJ, Clarke, WR, Adams, HP, Jr, Derdeyn, CP, J Neurosurg, 1/1/2013
Investigating the mechanisms of peri-operative ischemic stroke in the Carotid Occlusion Surgery Study
Reynolds, MR, Grubb, RL, Jr, Clarke, WR, Zipfel, GJ, Adams, HP, Jr, Powers, WJ, Derdeyn, CP for the COSS Investigators, J Neurosurg, 1/1/2013
Are routine imaging and intensive care unit admission necessary in mild traumatic brain injury?
Washington, CW, Grubb, RL, Jr, J Neurosurg, 1/1/2013
Impact of epilepsy surgery on seizure control and quality of life: A 26-year follow-up study
Mohammed, H, Kaufman, CB, Limbrick, DD, Steger-May, K, Grubb, RL, Jr, Rothman, SM, Weisenberg, J, Munro, R, Smyth, MD, Epilepsia, 1/1/2012
Technical, angiographic and clinical outcomes of Neuroform 1,2, 2 Treo and 3 devices in stent-assisted coiling of intracranial aneurysms
Kadkhodayan, Y, Somogyi, CT, Cross, DT, III, Derdeyn, CP, Zipfel, GJ, Chicoine, MR, Rich, KM, Grubb, RL, Jr, Dacey, RG, Jr, Moran, CJ, J NeuroIntervent Surg, 1/1/2012
Oligodendrogliomas in children
Creach, KM, Rubin, JB, Leonard, JR, Limbrick, DD, Smyth, MD, Dacey, RG, Jr., Rich, KM, Dowling, JL, Grubb, RL, Jr., Linette, GP, King, AA, Michalski, JM, Park, TS, Per..., J Neurooncol, 1/1/2012
Are routine repeat imaging and intensive care unit admission necessary in mild traumatic brain injury?
Washington, CW, Grubb, RL, Jr, J Neurosurg, 1/1/2012
Cerebral hemodynamics and cognitive impairment:Impac-- baseline data from the RECON trial
Marshall, RS, Festa, JR, Cheung, Y-KK, Chen, R, Pavol, MA, Derdeyn, CP, Clarke, WR, Videen, TO, Grubb, RL, Jr., Adams, HP, Powers, WJ, Lazar, RM, Neurology, 1/1/2012
Response to “EC-IC bypass for stroke: Is it the end of the line or a bump in the road?” EC-IC Bypass for Stroke in 2012 “It was deja vu all over again”
Powers, WJ, Clarke, WR, Adams, HP, Jr., Derdeyn, CP, Grubb, RL, Jr., Neurosurgery, 1/1/2012
Platelet transfusion: An unnecessary risk for mild traumatic brain injury patients on antiplatelet therapy
Washington, C, Schuerer, DJE, Grubb, RL, Jr, J Trauma, 1/1/2011
Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic ischemia: The Carotid Occlusion Surgery Study: A randomized trial
Powers, WJ, Clarke, WR, Grubb, RL, Jr, Videen, TO, Adams, HP, Jr, Derdeyn, CP for the COSS investigators, JAMA, 1/1/2011
Clinical features and outcome in North American adults with idiopathic basal arterial occlusive disease without moya-moya collaterals
Goyal, MS, Hallemeier, CL, Zipfel, GJ, Rich, KM, Grubb, RL. Jr., Chicione, MR, Moran, CJ, Cross, DT, III, Dacey, RG, Jr., Derdeyn, CP, Neurosurgery, 1/1/2010
Cranial dural arteriovenous fistulas: asymptomatic cortical venous drainage portends less aggressive clinical course
Strom, RG, Botros, JA, Refai, D, Moran, CJ, Cross, DT, III, Chicione, MR, Grubb. RL. Jr., Rich, KM, Derdeyn, CP, Dacey, RG, Jr., Zipfel, GJ, Neurosurgery, 1/1/2009
Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity with functional magnetic resonance imaging: initial exper...
Zhang, D, Johnston, JM, Fox, MD, Leuthardt, EC, Grubb, RL, Jr., Chicione, MR, Smyth, MD, Snyder, AZ, Raichle, ME, Shimony, JS, Neurosurgery, 1/1/2009
Cerebral hemodynamics as a predictor of stroke in adult patients with moyamoya disease A prospective observational study
Zipfel, GJ, Sagar, J, Miller, JP, Videen, TO, Grubb, RL. Jr., Dacey, RG, Jr., Derdeyn, CP, Neurosurgery Focus, 1/1/2009
Patterns of infarction in hemodynamic failure
Derdeyn, CP, Carpenter, DA, Videen, TO, Grubb, RL, Jr., Powers, WJ, Cerebrovasc Dis, 1/1/2007
No effect of low-dose statin treatment on cerebral blood flow in humans with atherosclerotic cerebrovascular disease
Derdeyn, CP, Carpenter, DA, Videen, TO, Grubb, RL, Jr., Powers, WJ, J Cereb Blood Flow Metab, 1/1/2007
A review of spinal injuries in the invasive cardiologist: II, Prevention and Treatment
Fadl, YY, Ellenbogen, KA, Grubb, RL Jr, Khoo-Summer, L, Lindsay, BD, Pacing Clin Electrophysiol, 1/1/2007
A review of spinal injuries in the invasive cardiologist: I, Biomechanics and pain generation
Fadl, YY, Ellenbogen, KA, Grubb, RL Jr, Khoo-Summers, L, Lindsay, BD, Pacing Clin Electrophysiol, 1/1/2007
Guidelines for the early management of adults with ischemic stroke
Adams, HP, Jr., del Zoppo, G, Alberts, MJ, Bhatt, DL, Brass, L, Furlan, A, Grubb, RL, Jr., Higashida, RT, Jauch, EC, Kidwell, C, Lyden, PD, Morgenstern, LB, Quereshi, ..., Stroke, 1/1/2007
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Books/Book Chapters

Neurosurgery at Washington University. A Century of Excellence.
Grubb, RL JrQuest Graphics, St. Louis, MO2011
Stroke: Pathophysiology, Diagnosis and Management
Chapter: Extracranial-intracranial bypass for cerebral ischemia.
Page 1437 - 1446Grubb, RL, JrEditors: Mohr, JP, Choi, D, Grotta, JC, Weir, B, Wolf, PA.Churchill Livingstone, Philadelphia, PA2004
Update in Intensive Care and Emergency Medicine, Vol. 37: Cerebral Blood Flow, Mechanisms of Ischemia, Diagnosis and Therapy
Chapter: Cerebral hemodynamics and stroke risk in patients with complete carotid artery occlusion. Is there a role for cerebral revascularization.
Page 277 - 297Grubb, RL Jr., Powers, WJEditors: Pinsky, MR.Springer Verlag, Berlin2002
Cerebrovascular Disease: Momentum at the End of the Second Millennium (Proceedings of the 21st Princeton Stroke Conference)
Chapter: Cerebral hemodynamics and stroke risk.
Grubb, RL Jr., Derdeyn, CP, Fritsch, SM, Powers, WJEditors: Choi, DW, Dacey, RG, Jr., Hsu, CY, Powers, WJ.Futura Publishing, Armonk, NY2001
Carotid Artery Surgery
Chapter: Ischemic complications of carotid endarterectomy.
Page 471 - 478Taylor, CL, Selman, WR, Grubb, RL, Jr., Ratcheson, RAEditors: Loftus, CM, Kresowik, TF.Thieme, New York, NY2000
Operative Neurosurgical Techniques
Chapter: Surgical Therapy for Diseases of the Extracranial Carotid Artery.
Page 890 - 890Ratcheson, RA and Grubb, RL,JrEditors: Schmidek, H.H. and Sweet, W.H..W.B. Saunders Co., Philadelphia, PAEdition 3rd,1995
The Practice of Neurosurgery
Chapter: Nuclear Medicine and Positron Emission Tomography.
Page 137 - 157Grubb, RL,Jr.Editors: Tindall, GT, Cooper, PR, Barrow, DL.Williams and Wilkins, Baltimore, MD1995
Neurosurgical Operative Atlas (Volume 3)
Chapter: Pre auricular infratemporal fossa approach to tumors involving the lateral cranial base.
Page 33 - 40Grubb, RL,Jr. and Smith, PGEditors: Rengachary, SS and Wilkins, RH.Williams and Wilkins, Baltimore, MD1993
Brain Surgery: Complication Avoidance and Management
Chapter: Spontaneous cerebral hemorrhage.
Page 1251 - 1269Grubb, RL,JrEditors: Apuzzo, MLJ.Churchill Livingstone, New York, NY1993
Operative Neurosurgical Techniques
Chapter: Surgical therapy of diseases of the extracranial carotid artery.
Page 753 - 764Ratcheson, RA and Grubb, RL,JrEditors: Schmidek, HH and Sweet, WH.Grune and Stratton, New York, NYEdition 2nd,1987
Cerebral Blood Flow: Physiologic and Clinical Aspects
Chapter: CBF CMRO2 relationships in cerebral ischemia and subarachnoid hemorrhage in man.
Page 378 - 401Powers, WJ and Grubb, RL,JrEditors: Wood, JH.McGraw Hill, New York, NY1987
Clinical Neurosurgery
Chapter: Management of the patient with carotid occlusion and a single ischemic event.
Page 251 - 280Grubb, RL,Jr1986
Clinical Neurosurgery
Chapter: Biography of Sidney Goldring, M.D.
Grubb, RL,Jr1986
Stroke and the Extracranial Vessels
Chapter: Superficial temporal middle cerebral cortical artery anastomosis.
Page 255 - 263Ratcheson, RA and Grubb, RL,JrEditors: Smith, RR.Raven Press, New York, NY1984
Stroke and the Extracranial Vessels
Chapter: Cerebral metabolism and blood flow PET Scanning.
Page 89 - 98Grubb, RL,Jr. and Ratcheson, RAEditors: Smith, RR.Raven Press, New York, NY1984
Eleventh International Symposium on Cerebral Blood Flow and Metabolism
Chapter: The value of regional cerebral blood volume measurements in the diagnosis of cerebral ischemia.
Page 598 - 599Powers, W, Martin, W, Herscovitch, P, Raichle, ME, and Grubb, RL,JrEditors: Bes, A, Makenzie, ET, Seylaz, J.Raven Press, New York, NY1983
Current Techniques in Operative Neurosurgery
Chapter: Surgical therapy of diseases of the extracranial carotid artery.
Page 671 - 687Ratcheson, RA and Grubb, RL,JrEditors: Schmidek, H.Grune and Stratton, New York, NYEdition 2nd,1982
Clinical Management of Intracranial Aneurysms
Chapter: Cerebral hemodynamics and metabolism in subarachnoid hemorrhage.
Page 163 - 176Grubb, RL, JrEditors: Hopkins, LN and Long, DM.Raven Press, New York, NY1982
Tenth International Symposium on Cerebral Blood Flow and Metabolism
Chapter: Effects of hemorrhagic and drug induced hypotension on cerebral oxygen utilization and blood flow.
Page 182 - 183Grubb, RL,Jr. and Raichle, MEEditors: Raichle, ME, Grubb, RL,Jr., Ter Pogossian, MM.Raven Press, New York, NY1981
Tenth International Symposium on Cerebral Blood Flow and Metabolism
Chapter: Measurement of regional cerebral oxygen consumption by positron emission tomography.
Page 7 - 8Raichle, ME, Larson, KB, Markham, J, Depresseux, JC, Grubb, RL, Jr., and Ter Pogossian, MMEditors: Raichle, ME, Grubb, RL,Jr., Ter Pogossian, MM.Raven Press, New York, NY1981
Tenth International Symposium on Cerebral Blood Flow and Metabolism
Chapter: Measurement of local cerebral blood flow in man with positron emission tomography.
Page 19 - 20Raichle, ME, Markham, J, Larson, KE, Grubb, RL,Jr., and Welch, MJEditors: Raichle, ME, Grubb, RL,Jr., Ter Pogossian, MM.Raven Press, New York, NY1981
Cerebral Metabolism and Neural Function
Chapter: Strategies for measurement of cerebral metabolism using positron emission tomography.
Page 388 - 397Raichle, ME, Laux, BE, Grubb, RL,Jr., and Larson, KBEditors: Passonnaeu, JV, Hawkins, RA, Lust, WD, Welch, FA.Williams and Wilkins, Baltimore, MD1980
Cerebral Arterial Spasm: Proceedings of the Second International Workshop
Chapter: Cerebral hemodynamics and metabolism in subarachnoid hemorrhage and vasospasm.
Page 341 - 349Grubb, RL,JrEditors: Wilkins, R.Williams and Wilkins, Baltimore, MD1980
Cerebral Blood Flow and Metabolism
Chapter: Regional cerebral metabolism with position emission tomography: correction for tracer egress from tissue.
Page 204 - 205Raichle, ME, Welch, MJ, Grubb, RL,Jr., Larson, KB, Laux, B, and Ter Pogossian, MMEditors: Gotoh, F, Nagai, H, Tazaki, Y.Munksgaard, Copenhagen1979
Cerebral Blood Flow and Metabolism
Chapter: Regional cerebral blood flow and oxygen utilization in superficial temporal middle cerebral artery anastomosis patients.
Page 502 - 503Grubb, RL,Jr., Ratcheson, RA, Raichle, ME, Kliefoth, AB, and Gado, MHEditors: Gotoh, F, Nagai, H, Tazaki, Y.Munksgaard, Copenhagen1979
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Abstracts/Posters

Surgical results of the Carotid Occlusion Surgery Study (COSS).
Grubb, RL, Jr, Powers, WJ, Clarke, WR, Adams, HP, Jr, Videen, TO, Derdeyn, CP, J Neurosurg, 1/1/2011
Long-term outcome in North American adults with moya-moya phenomenom.
Hallemeier, CL, Derdeyn, CP, Rich, KM, Grubb, RL, Jr., Chicoine, MR, Moran, CJ, Cross, DT III, Zipfel, GJ, Dacey, RG, Jr, Stroke, 1/1/2006
Combined surgical resection and gamma knife radiosurgery for cerebral metastases.
Lusis, EA, Limbrick, D, Chicoine, M, Simpson, J, Rich, KM, Dacey, RG, Dowling, JL, Grubb, RL, Filiput, EA, Dryzmala, R, Malyapa, R, Neuro-Oncology, 1/1/2004
Long-term outcome after angioplasty for symptomatic CA stenosis.
Derdeyn, CP, Moran, CJ, Cross, DT, Rich, KM, Grubb, RL Jr., Chicione, MR, Dacey, RG, J Neurosurg, 1/1/2002
Procedural thrombus and postprocedural ischemic events after treatment of intracranial aneurysms with GDC.
Derdeyn, CP, Cross, DT, Moran, CJ, Pilgram, T, Grubb, RL Jr., Rich, KM, Chicione, MR, Dacey, RG, J Neurosurg, 1/1/2002
Effects of acute intracerebral hemorrhage on hemispheric blood flow and metabolism.
Zazulia, AR, Diringer, MN, Videen, TO, Adams, RE, Yundt, K, Aiyagari, V, Grubb, RL Jr., Powers, WJ, Stroke, 1/1/2001
Peri-clot CMRO2 as a measure of ongoing tissue injury after acute intracerebral hemorrhage.
Zazulia, AR, Diringer, MN, Videen, TO, Adams, RE, Yundt, K, Aiyagari, V, Grubb, RL Jr., Powers, WJ, Neurology, 1/1/2001
Hyperventilation of traumatic brain injury patients lowers cerebral blood flow below 20 ml/100g/min without impairing regional cerebral metabolism.
Diringer, MN, Zazulia, AR, Videen, TO, Grubb, RL Jr., Aiyagari, V, Powers, WJ, Neurology, 1/1/2001
Absence of selective deep white matter ischemia in chronic carotid disease.
Derdeyn, CP, Simmons, NR, Videen, TO, Yundt, KD, Fritsch, SM, Carpenter, DA, Grubb, RL Jr., Powers, WJ, Stroke, 1/1/2000
Time-related changes in cerebral blood volume in patients with increased oxygen extraction fraction.
Derdeyn, CP, Videen, TO, Yundt, KD, Carpenter, DA, Fritsch, SM, Grubb, RL Jr, Powers, WJ, Stroke, 1/1/2000
Effect of hyperventilation on cerebral hemodynamics and oxygen metabolism following acute brain injury.
Diringer, MN, Yundt, KD, Videen, TO, Adams, RE, Zazulia, AR, Deibert, EM, Aiyagari, V, Dacey, RG Jr., Grubb, RL Jr., Powers, WJ, Stroke, 1/1/2000
Benign prognosis of asymptomatic carotid occlusion.
Powers, WJ, Derdeyn, CP, Yundt, KD, Carpenter, DA, Fritsch, SM, Videen, TO, Spitznagel, EL, Grubb, RL Jr, Stroke, 1/1/1999
PET screening prior to EC/IC bypass for symptomatic carotid occlusion: A cost effectiveness analysis.
Derdeyn, CP, Gage, BF, Grubb, RL Jr., Powers, WJ, Stroke, 1/1/1999
Increased oxygen extraction fraction in symptomatic patients with complete carotid artery occlusion predicts a subsequent increased incidence of ipsilateral ischemic s...
Grubb, RL Jr., Powers, WJ, Derdeyn, CP, Yundt, KD, Carpenter, DA, Videen, TO, Fritsch, SM, J Neurosurg, 1/1/1998
Temporal stability of hemodynamic stage in patients with carotid occlusion.
Derdeyn, CP, Yundt, KD, Videen, TO, Grubb, RL Jr., Carpenter, DA, Powers, WJ, J Neurosurg, 1/1/1998
A comparison of BOLD MRI and PET OEF measurements on patients with carotid artery occlusion.
Lin, W, Derdeyn, CP, Celik, A, Grubb, RL, Jr., Powers, WJ, Haacke, EM, Annual Meeting Society of Magnetic Resonance in Medicine, 1/1/1998
Temporal stability of hemodynamic stage in patients with carotid occlusion.
Derdeyn, CP, Yundt, KD, Videen, TO, Grubb, RL Jr., Carpenter, DA, Powers, WJ, J Cereb Blood Flow Metab, 1/1/1997
The effects of vasospasm (VSP) on cerebral oxygen metabolism.
Carpenter, DA, Tempel, LW, Grubb, RL,Jr., Raichle, ME, and Powers, WJ, Stroke, 1/1/1989
Border zone hemodynamics cerebrovascular disease.
Carpenter, DA, Grubb, RL,Jr., and Powers, WJ, Neurology, 1/1/1989
Cerebral hemodynamic measurements do not predict early stroke risk.
Grubb, RL,Jr., Powers, WJ, and Tempel, L, Neurosurgery, 1/1/1988
Prognosis of medically treated hemodynamic cerebral ischemia. A PET study.
Powers, WJ, Tempel, LW, and Grubb, RL,Jr, J Nucl Med, 1/1/1988
Clinical correlates of cerebral hemodynamics.
Powers, WJ, Tempel, LW, Grubb, RL,Jr., and Raichle, ME, Stroke, 1/1/1987
The hemodynamic effects of carotid stenosis on the cerebral circulation.
Powers, WJ, Press, GA, Grubb, RL,Jr., Gado, M, and Raichle, ME, Stroke, 1/1/1986
Regional cerebral blood flow and metabolism in reversible ischemia due to vasospasm.
Powers, WJ, Grubb, RL,Jr., Baker, RP, Mintun, M, and Raichle, ME, Stroke, 1/1/1985
Positron emission tomography to assess cerebral perfusion.
Powers, WJ, Raichle, ME, and Grubb, RL,Jr, Lancet, 1/1/1985
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