Robert Louis Ferris MD PhD

Otolaryngology (ENT)•Raleigh, NC

Associate Professor of Otolaryngology, University Pittsburgh

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2901 Blue Ridge RdSte 201Raleigh, NC 27607
Phone+1 984-974-6484
Fax+1 412-621-1449

Education & Training

Johns Hopkins UniversityResidency, Otolaryngology - Head and Neck Surgery, 1996 - 2001
Johns Hopkins University/Bayview Medical CenterInternship, Transitional Year, 1995 - 1996
Johns Hopkins University School of MedicineClass of 1995

Certifications & Licensure

NC State Medical License 2024 - 2026
PA State Medical License 2001 - 2026
MD State Medical License 1996 - 2002
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2011-2014
America's Top Doctors for Cancer Castle Connolly, 2010-2013
Fellow (FACS) American College of Surgeons
Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
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Clinical Trials

Vaccine Therapy in Treating Patients With Head and Neck Cancer Start of enrollment: 2005 Sep 01
Completed
Phase 1
Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer Start of enrollment: 2007 Nov 01
Completed
Phase 2
Study of HF10 in Patients With Refractory Head and Neck Cancer or Solid Tumors With Cutaneous and/or Superficial Lesions Start of enrollment: 2009 Aug 01
Completed
Phase 1
ERBITUX® Followed by Adjuvant Treatment With Chemoradiation and ERBITUX® for Locally Advanced Head and Neck Squamous Cell Carcinoma Start of enrollment: 2011 Feb 01
Completed
Phase 2
A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer Start of enrollment: 2013 Apr 01
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer Start of enrollment: 2014 Jan 22
ACTIVE_NOT_RECRUITING
PHASE2
Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer Start of enrollment: 2013 Apr 09
Completed
Phase 1
SBRT With Cetuximab +/- Docetaxel Followed by Adjuvant Cetuximab +/- Docetaxel in Recurrent, Previously-Irradiated SCCHN Start of enrollment: 2013 Jul 03
Completed
Phase 2
Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA Start of enrollment: 2016 Sep 01
Withdrawn
Phase 1
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer Start of enrollment: 2018 Nov 16
COMPLETED
PHASE2
HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma Start of enrollment: 2020 Jul 06
ACTIVE_NOT_RECRUITING
PHASE2
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) Start of enrollment: 2022 Oct 06
TERMINATED
PHASE3
Roles: Principal Investigator
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Publications & Presentations

PubMed

Dysfunctional CD11cCD21extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.
Ayana T Ruffin, Allison N Casey, Sheryl R Kunning, Ian P MacFawn, Zhentao Liu
Science Translational Medicine. 2025-02-19
Evaluation of radiomics as a predictor of efficacy and the tumor immune microenvironment in anti-PD-1 mAb treated recurrent/metastatic squamous cell carcinoma of the h...
Dan P Zandberg, Serafettin Zenkin, Murat Ak, Priyadarshini Mamindla, Vishal Peddagangireddy
Head & Neck. 2025-01-01
1 citations
Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients.
Ronan W Hsieh, William E Gooding, Marci Nilsen, Mark Kubik, Zahra Kelly
Clinical Otolaryngology. 2025-01-01

Journal Articles

P16 as a Prognostic Biomarker for Nonoropharyngeal Squamous Cell Cancers: Avatar or Mirage?
Robert Ferris, MD, Journal of the National Cancer Institute
Staged Reconstruction (Delayed-Immediate) of the Maxillectomy Defect Using CAD/CAM Technology
Matthew M Hanasono, Mario G Solari, Robert L Ferris, Sebastian Brooke, Mark W Kubik, Matilda Dhima, Journal of Reconstructive Microsurgery

Lectures

Head and Neck Cancers. Integrating Immunotherapy Into Clinical Practice: Changes Over the Past Year (Part 2)
2018 ASCO Annual Meeting - Chicago, Illinois - 05/31/2018

Press Mentions

Combination Immunotherapy Before Surgery May Increase Survival in People with Head and Neck CancerMarch 13th, 2025
Dysfunctional B Cells: New Cancer Immunotherapy TargetFebruary 20th, 2025
Scientists Identify a New Cancer Immunotherapy Target: Dysfunctional B CellsFebruary 19th, 2025
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Grant Support

Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCCUNIVERSITY OF PITTSBURGH AT PITTSBURGH2024–2029
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesUNIVERSITY OF PITTSBURGH AT PITTSBURGH2016–2028
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesUNIVERSITY OF PITTSBURGH AT PITTSBURGH2016–2028
Identifying cellular and molecular signatures from distinct T cell receptor clonotypes associated with favorable immune checkpoint inhibitor responses in HNSCCsUNIVERSITY OF PITTSBURGH AT PITTSBURGH2022–2027
Head and Neck Cancer SPOREUNIVERSITY OF PITTSBURGH AT PITTSBURGH2004–2027
Exploration of Contemporary Modifiable Exposures and Cancer in Beauty SalonsUNIVERSITY OF PITTSBURGH AT PITTSBURGH1997–2025
Cancer Center Support GrantUNIV OF NORTH CAROLINA CHAPEL HILL1997–2025
Cancer Center Support GrantUNIVERSITY OF PITTSBURGH AT PITTSBURGH1997–2025
Optimization of anti-LANA CD8+ as an therapeutic immunogen (Immune/Microenvironment)UNIVERSITY OF PITTSBURGH AT PITTSBURGH1997–2025
Cancer Center Support GrantUNIV OF NORTH CAROLINA CHAPEL HILL1997–2025
Immune Activation By Cetuximab In Head And Neck Cancer PatientsNational Institute Of Dental &Craniofacial Research2010–2011
Chemokine Signals In Head And Neck Cancer ProgressionNational Cancer Institute2006–2010
Direct Measurement Rates Synthesis Turnover T-Lymphocytes Head/Neck CancerNational Center For Research Resources2005

Robert Louis Ferris MD PhD

Dr. Ferris is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Press Mentions

Grant Support

Professional Memberships

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