RobertLouisFerrisMDPhD

Otolaryngology (ENT) • Raleigh, NC

Associate Professor of Otolaryngology, University Pittsburgh

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Office
2901 Blue Ridge Rd
Ste 201
Raleigh, NC 27607
Phone+1 984-974-6484

Fax+1 412-621-1449

Education & Training

Johns Hopkins UniversityResidency, Otolaryngology - Head and Neck Surgery, 1996 - 2001
Johns Hopkins University/Bayview Medical CenterInternship, Transitional Year, 1995 - 1996
Johns Hopkins University School of MedicineClass of 1995

Certifications & Licensure

NC State Medical License 2024 - 2026
PA State Medical License 2001 - 2024
MD State Medical License 1996 - 2002
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2011-2014
America's Top Doctors for Cancer Castle Connolly, 2010-2013
Fellow (FACS) American College of Surgeons
Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
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Clinical Trials

Vaccine Therapy in Treating Patients With Head and Neck Cancer Start of enrollment: 2005 Sep 01
Completed
Phase 1
Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer Start of enrollment: 2007 Nov 01
Completed
Phase 2
Study of HF10 in Patients With Refractory Head and Neck Cancer or Solid Tumors With Cutaneous and/or Superficial Lesions Start of enrollment: 2009 Aug 01
Completed
Phase 1
ERBITUX® Followed by Adjuvant Treatment With Chemoradiation and ERBITUX® for Locally Advanced Head and Neck Squamous Cell Carcinoma Start of enrollment: 2011 Feb 01
Completed
Phase 2
A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer Start of enrollment: 2013 Apr 01
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer Start of enrollment: 2014 Jan 22
ACTIVE_NOT_RECRUITING
PHASE2
Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer Start of enrollment: 2013 Apr 09
Completed
Phase 1
SBRT With Cetuximab +/- Docetaxel Followed by Adjuvant Cetuximab +/- Docetaxel in Recurrent, Previously-Irradiated SCCHN Start of enrollment: 2013 Jul 03
Completed
Phase 2
Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA Start of enrollment: 2016 Sep 01
Withdrawn
Phase 1
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer Start of enrollment: 2018 Nov 16
COMPLETED
PHASE2
HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma Start of enrollment: 2020 Jul 06
ACTIVE_NOT_RECRUITING
PHASE2
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) Start of enrollment: 2022 Oct 06
TERMINATED
PHASE3
Roles: Principal Investigator
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Publications & Presentations

PubMed

Dysfunctional CD11cCD21extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.
Ayana T Ruffin, Allison N Casey, Sheryl R Kunning, Ian P MacFawn, Zhentao Liu
Science Translational Medicine. 2025-02-19
Evaluation of radiomics as a predictor of efficacy and the tumor immune microenvironment in anti-PD-1 mAb treated recurrent/metastatic squamous cell carcinoma of the h...
Dan P Zandberg, Serafettin Zenkin, Murat Ak, Priyadarshini Mamindla, Vishal Peddagangireddy
Head & Neck. 2025-01-01
1 citations
Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients.
Ronan W Hsieh, William E Gooding, Marci Nilsen, Mark Kubik, Zahra Kelly
Clinical Otolaryngology. 2025-01-01

Journal Articles

P16 as a Prognostic Biomarker for Nonoropharyngeal Squamous Cell Cancers: Avatar or Mirage?
Robert Ferris, MD, Journal of the National Cancer Institute
Staged Reconstruction (Delayed-Immediate) of the Maxillectomy Defect Using CAD/CAM Technology
Matthew M Hanasono, Mario G Solari, Robert L Ferris, Sebastian Brooke, Mark W Kubik, Matilda Dhima, Journal of Reconstructive Microsurgery

Lectures

Head and Neck Cancers. Integrating Immunotherapy Into Clinical Practice: Changes Over the Past Year (Part 2)
2018 ASCO Annual Meeting - Chicago, Illinois - 05/31/2018

Press Mentions

Dysfunctional B Cells: New Cancer Immunotherapy TargetFebruary 20th, 2025
Scientists Identify a New Cancer Immunotherapy Target: Dysfunctional B CellsFebruary 19th, 2025
UPMC ‘S Cancer Center to Expand Clinical ResearchFebruary 7th, 2023
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Grant Support

Immune Activation By Cetuximab In Head And Neck Cancer PatientsNational Institute Of Dental &Craniofacial Research2010–2011
Chemokine Signals In Head And Neck Cancer ProgressionNational Cancer Institute2006–2010
Direct Measurement Rates Synthesis Turnover T-Lymphocytes Head/Neck CancerNational Center For Research Resources2005