RobertMartinBookchinMD

PubMed

• 11 citations
  The Effects of Erythrocyte Membranes on the Nucleation of Sickle Hemoglobin
  Alexey Aprelev, Maria Rotter, Zipora Etzion, Robert M. Bookchin, Robin W. Briehl
  Biophysical Journal. 2005-04-01
• 56 citations
  Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells.
  Zipora Etzion, Teresa Tiffert, Robert M. Bookchin, Virgilio L. Lew
  The Journal of Clinical Investigation. 1993-11-01
• 87 citations
  Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles
  Virgilio L. Lew, Austin R. Hockaday, Maria-Isabel Sepulveda, Andrew P. Somlyo, Avril V. Somlyo
  Nature. 1985-06-13

Journal Articles

• Oxidative status of valinomycin-resistant normal, beta-thalassemia and sickle red blood cells  
  Amer, J., Etzion, Z. Bookchin, R.M. and Fibach, E., Biochim. Biophys. Acta, 1/1/2006
• Ion transport in the mechanism of sickle cell dehydration  
  Lew, V.L. and R.M Bookchin, Physiol. Rev., 1/1/2005
• The effects of erythrocyte membranes on the nucleation of sickle hemoglobin  
  Aprelev, A. Rotter, M.A., Etzion, Z., Bookchin, R.M., Briehl, R.W., and F.A. Ferrone, Biophys.J., 1/1/2005
• Sickle red cell dehydration: mechanisms and interventions (Review)  
  Bookchin, R.M., and V.L. Lew, V.L., Curr. Opin. Hematol., 1/1/2002
• Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids  
  Li, X., Briehl, R.W., Bookchin, R.M., Josephs, R., Wei, B., Manning, J.M., and F.A. Ferrone, J. Biol. Chem., 1/1/2002
• Dehydration response of sickle cells to sickling-induced Ca2+ permeabilization  
  Lew, V.L., Etzion, Z., and R.M. Bookchin, Blood, 1/1/2002
• Normal Ca2+ extrusion by the Ca2+ pump of intact red blood cells exposed to high glucose concentrations  
  Raftos, J.E., Edgley, A., Bookchin, R.M., Etzion, Z., Lew, V.L., and T. Tiffert, Am. J. Physiol., 1/1/2001
• Identification and characterization of a newly recognized population of high-Na+, low-K+, low-density sickle and normal red cells  
  Bookchin R.M., Etzion Z., Sorette M., Mohandas N., Skepper J.N., Lew V.L., Proc. Natl. Acad. Sci. U S A, 1/1/2000
• Polymer structure and solubility of deoxyhemoglobin S in the presence of high concentrations of volume-excluding 70-kDa dextran Effects of non-s hemoglobins and inhibi...  
  Bookchin R.M., Balazs T., Wang Z., Josephs R., Lew V.L., J. Biol. Chem., 1/1/1999
• Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability  
  Lew, V.L., Ortiz, O.E., and R.M. Bookchin, J. Clin. Invest., 1/1/1997
• HbC compound heterozygotes [HbC/Hb Riyadh and HbC/Hb N-Baltimore with opposing effects on HbC crystallization  
  Hirsch, R.E., Witowska, E., Shafer, F., Lin, M., Balazs, T., Bookchin, R.M., and R.L. Nagel, Br. J. Haematol., 1/1/1997
• Measurement of the distribution of anion exchange function in normal human red cells  
  Raftos, J.E., Bookchin, R.M., and V.L. Lew, J.Physiol., 1/1/1997
• Distribution of chloride permeabilities in normal human red cells  
  Raftos, J.E., Bookchin, R.M., and V.L. Lew, J.Physiol., 1/1/1996
• K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemia red blood cells  
  Etzion, Z., Lew, V.L. and R.M. Bookchin, Am.J.Physiol., 1/1/1996
• A recombinant sickle hemoglobin triple mutant with independent inhibitory effects on polymerization  
  Himanen, J., Mirza, U.A., Chait, B.T., Bookchin, R.M., and J.M. Manning, J.Biol.Chem., 1/1/1996
• Pathophysiology of sickle cell anemia (Review)  
  Bookchin, R.M., and V.L. Lew, V.L., Hematol. Oncol. Clin. North Am., 1/1/1996
• Generation of normal human red cell volume, hemoglobin content and membrane area distributions, by "birth" or regulation?  
  Lew, V.L., Raftos, J.E., Sorette, M, Bookchin, R.M., and M. Narla, Blood, 1/1/1995
• Osmotic effects of water compartments in protein polymers  
  Lew, V.L., Balazs, T. and R.M. Bookchin, Cell Biochemistry and Function, 1/1/1995
• Measurement of the hemoglobin concentration in deoxyhemoglobin S polymers and characterization of the polymer water compartment  
  Bookchin, R.M., Balazs, T. and V.L. Lew, J. Mol. Biol., 1/1/1994
• Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ buffering of sickle cell anemia red cells  
  Etzion, Z., Tiffert, T., Bookchin, R.M., and V.L. Lew, J. Clin. Invest., 1/1/1993
• The distribution of intracellular calcium chelator (fura2) in a population of intact human red cells  
  Biochim. Biophys. Acta Bio-Membr., 1/1/1993
• Composition of the hemoglobin S polymer  
  Bookchin, R.M., Balazs, T. and V.L. Lew, Am. J. Hematol., 1/1/1993
• Effects of deoxygenation on active and passive Ca2+ transport and cytoplasmic Ca2+ buffering in normal human red cells  
  Tiffert, T., Etzion, Z., Bookchin, R.M. and V.L. Lew, J. Physiol. (Lond.), 1/1/1992
• Role of reticulocyte transport heterogeneity in the generation of mature sickle cells with different volumes  
  Lew, V.L., and R.M. Bookchin, Biochemical Society Transactions, 1/1/1992
• The osmotic effects of protein polymerization Analysis of volume changes in sickle cell anemia red cells following deoxy-hemoglobin S polymerization  
  Lew, V.L., and R.M. Bookchin, J. Membr. Biol., 1/1/1991
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Books/Book Chapters

• Proceedings of the Symposium on Oxidative Stress in Thalassemia-Etiology and Prevention 
  Chapter: Increase in high-Na+, low-K+, "valinomycin-resistant" red cells in Hb E/Beta-thalassemia, Beta-thalassemia intermedia, and sickle cell anemia-a possible result of oxidative membrane damage? 
  Bookchin, R.M and Z. EtzionEditors: S. Fucharoen and E.A. Rachmilewitz.2002
• Sickle Cell Disease and Thalassemias: New Trends in Therapy 
  Chapter: Magnesium therapy for sickle cell anemia: a new rationale. 
  Page 545 - 546Bookchin, R.M., Tiffert, J.T., Davies,S.C., Vichinsky, E. and V.L. LewEditors: Y. Beuzard, B. Lubin, and J. Rosa.John Libbey and Co., Ltd., London1995
• Encyclopedia of Human Biology, Volume 6 
  Chapter: Red cell calcium. 
  Bookchin, R.M., and Lew, V.L.Editors: R. Dulbecco.Academic Press, New York1991
• The Red Cell Membrane: A Model for Solute Transport 
  Chapter: Mechanisms of red cell dehydration in sickle cell anemia. Application of an integrated red cell model. 
  Page 443 - 461Bookchin, R.M., O.E. Ortiz, and V.L. LewEditors: B.U. Raess, and G. Tunnicliffe.Humana Press, Clifton, NJ1989
• The Red Cell Membrane: A Model for Solute Transport 
  Chapter: Need and applications of integrated red cell models. 
  Page 19 - 34Lew, V.L., C.J. Freeman, O.E. Ortiz, and R.M. BookchinEditors: B.U. Raess, and G. Tunnicliffe.Humana Press, Clifton, NJ1989
• The Red Cell. Seventh Ann Arbor Conference 
  Chapter: Predictions and tests of a new integrated reticulocyte model: Implications for dehydration of sickle cells. 
  Page 615 - 627Bookchin, R.M., O.E. Ortiz, C.J. Freeman and V.L. LewEditors: G.J. Brewer.Alan R. Liss, New York1989
• Pathophysiological Aspects of Sickle Cell Vaso-Occlusion 
  Chapter: Activation of calcium-dependent potassium channels in deoxygenated sickled red cells. 
  Page 193 - 200Bookchin, R.M., O.E. Ortiz, and V.L. LewEditors: R.L. Nagel.Alan R. Liss, New York1987
• Approaches to the Therapy of Sickle Cell Anaemia 
  Chapter: Red cell calcium transport and mechanisms of dehydration in sickle cell anemia. 
  Page 291 - 300Bookchin, R.M., O.E. Ortiz, and V.L. LewEditors: Y. Beuzard, S. Charache, and F. Galacteros.1986
• Intracellular Calcium Regulation 
  Chapter: The state of calcium in sickle cell anemia red cells. 
  Page 327 - 334Bookchin, R.M., O.E. Ortiz, A. Hockaday, M.I. Sepulveda, and V.L. LewEditors: H. Bader, K. Gietzen, J. Rosenthal, R. Rudel, and H.U. Wolf.Manchester University Press, Wolfeboro, NH1986
• Cellular and Molecular Aspects of Aging: The Red Cell as a Model 
  Chapter: Elevated red cell calcium: Innocent bystander or kiss of death. 
  Page 369 - 375Bookchin, R.M., V.L. Lew, and E.F. Roth,Jr.Editors: J.W. Eaton.Alan R. Liss, New York1985
• The Red Cell. Proceedings of the Sixth International Conference on Red Cell Metabolism and Function 
  Chapter: Silent Intracellular calcium in sickle cell anemia red cells. 
  Page 17 - 28Bookchin, R.M., O.E. Ortiz, and V.L. LewEditors: G.J. Brewer.Alan R. Liss, New York1984
• The Red Cell: Fifth Ann Arbor Conference 
  Chapter: Abnormal vesiculation and calcium transport by "one-step" inside-out vesicles from sickle cell anemia red cells. Comparisons with transport by intact cells. 
  Page 163 - 182Bookchin, R.M., C. Raventos, and V.L. LewEditors: G.J. Brewer.Alan R. Liss, New York1981
• Contemporary HematologyOncology 
  Chapter: Molecular and cellular aspects of sickling. 
  Page 31 - 37Bookchin, R.M., and R.L. NagelEditors: R. Silber, A.S. Gordon, J. LoBue, and F. Muggia.Plenum Medical Book Co., New York1981
• Red Blood Cell and Lens Metabolism 
  Chapter: Structure-function relations in the hemoglobinopathies. 
  Page 321 - 338Bookchin, R.M., and R.L. NagelEditors: S.K. Srivastava.Elsevier-North Holland, New York1980
• Membrane Transport in Erythrocytes 
  Chapter: Ca-sensitivity modulation. 
  Page 196 - 207Lew, V.L., R.M. Bookchin, A.M. Brown, and H.G. FerreiraEditors: U.V. Lassen, H.H. Ussing, and J.O. Wieth.Munksgaard, Copenhagen1980
• Development of Therapeutic Agents for Sickle Cell Disease 
  Chapter: Evaluation of functional effects of antisickling agents on red cells. 
  Page 47 - 56Bookchin, R.M., R.L. Nagel, and E.F. Roth,Jr.Editors: J. Rosa, Y. Beuzard, and J. Hercules.Elsevier-North Holland, New York1979
• Development of Therapeutic Agents for Sickle Cell Disease 
  Chapter: Nitrogen mustards as antisickling agents. 
  Page 119 - 126Roth, E.F., Jr., D. Elbaum, R.M. Bookchin, and R.L. NagelEditors: J. Rosa, Y. Beuzard, and J. Hercules.Elsevier-North Holland, New York1979
• Clinical and Biochemical Aspects of Hemoglobin Abnormalities 
  Chapter: Functional abnormalities of whole blood in sickle cell anemia. 
  Page 57 - 66Bookchin, R.M., Y. Ueda, R.L. Nagel, and L.C. LandauEditors: W.S. Caughey.Academic Press, New York1978
• Molecular Interactions of Hemoglobin 
  Chapter: Studies on the supramolecular structure of the hemoglobin S polymer. 
  Page 201 - 207Nagel, R.L., and R.M. BookchinEditors: D. Labie, C. Poyart, and J. Rosa.INSERM, Paris1978
• Clinical and Biochemical Aspects of Hemoglobin Abnormalities 
  Chapter: Areas of interaction in Hb S polymer. 
  Page 195 - 204Nagel, R.L., and R.M. BookchinEditors: W.S. Caughey.Academic Press, New York1978
• Proceedings of Symposium of Sickle Cell Disease 
  Chapter: Some covalent and non-covalent inhibitors of sickling. 
  Page 347 - 360Nagel, R.L., E.F. Roth,Jr., D. Elbaum, R.M. Bookchin, and J. HarringtonEditors: J.I. Hercules, G.L. Cottam, M.R. Waterman, and A.N. Schechter.DHEW1976
• Sickle Cell Anemia and Other Hemoglobinopathies 
  Chapter: Mechanism of hemoglobin S gelation. Structural restrictions to supramolecular models of the polymerization of hemoglobin S. 
  Page 51 - 66Nagel, R.L., and R.M. BookchinEditors: R.D. Levere.Academic Press, New York1975
• Molecular Pathology 
  Chapter: Molecular aspects of structural mutants of human hemoglobins. 
  Page 547 - 582Nagel, R.L., and R.M. BookchinEditors: R.A. Good, S.B. Day, and J.J. Yunis.Charles C. Thomas, Springfield1975
• The Detection of Hemoglobinopathies 
  Chapter: Determination of the minimum gelling concentration as a measure of sickling tendency. 
  Page 79 - 81Bookchin, R.M.Editors: R.M. Schmidt, T.H.J. Huisman, and H. Lehmann.CRC Press, Cleveland1974
• Symposium on Sickle Cell Disease 
  Chapter: Molecular interactions of sickling hemoglobins. 
  Page 140 - 154Bookchin, R.M., and R.L. NagelEditors: H. Abramson, J. Bertles, and D. Wethers.C.V.Mosby, St.Louis1973
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