Richard W Smalling MD

Cardiology•Houston, TX

Adult Congenital Heart Disease, Interventional Cardiology

Professor, Internal Medicine, University of Texas Medical School, Houston.

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6410 Fannin StSuite 600Houston, TX 77030
Phone+1 713-500-8828
Fax+1 713-500-6560

Education & Training

University of California (San Diego) Medical CenterFellowship, Cardiovascular Disease, 1978 - 1981
University of California (San Diego) Medical CenterResidency, Internal Medicine, 1975 - 1978
McGovern Medical School at UTHealthClass of 1975

Certifications & Licensure

TX State Medical License 1975 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Interventional Cardiology

Awards, Honors, & Recognition

Master Interventionalist - MSCAI Society of Cardiac Angiography and Interventions
James D. Woods Distinguished Chair in Cardiovascular Medicine UTHealth/McGovern Medical School
America's Top Doctors Castle Connolly, 2002-2014
Top Doctors:SE Texas Castle Connolly, 2013
Super Doctor SuperDoctors.com
Top MD Consumers Checkbook
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACC) American College of Cardiology
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Clinical Trials

Prostaglandin E1 (Liprostin) Treatment With Lower Limb Angioplasty for Peripheral Arterial Occlusive Disease Start of enrollment: 2003 Feb 01
Unknown status
Phase 2
Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization Start of enrollment: 2003 Sep 01
Completed
Phase 4
A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Start of enrollment: 2002 Nov 01
Completed
Phase 4
Feasibility Study of a Percutaneous Mitral Valve Repair System. Start of enrollment: 2003 Jul 01
Completed
Phase 1, Phase 2
Patent Foramen Ovale Closure or Medical Therapy After Stroke - RESPECT Trial Start of enrollment: 2003 Aug 01
Completed
Not Applicable
Counterpulsation Reduces Infarct Size Pre-PCI for AMI Start of enrollment: 2008 Dec 01
Completed
Phase 4
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk Start of enrollment: 2011 Mar 01
Completed
Not Applicable
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS Start of enrollment: 2012 Aug 01
Active, not recruiting
Not Applicable
EVEREST II Pivotal Study High Risk Registry (HRR) Start of enrollment: 2007 Feb 01
Completed
Not Applicable
The REFLECT Trial: Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation Start of enrollment: 2016 Jun 01
Completed
Not Applicable
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
ACTIVE_NOT_RECRUITING
NA
PARTNER 3 Trial - Aortic Valve-in-Valve Start of enrollment: 2017 Jan 05
Recruiting
Not Applicable
PARTNER 3 Trial - Mitral Valve in Valve Start of enrollment: 2018 Feb 01
ACTIVE_NOT_RECRUITING
NA
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. Start of enrollment: 2017 Oct 23
RECRUITING
NA
AMPLATZER PFO Occluder Post Approval Study Start of enrollment: 2018 Jan 31
ACTIVE_NOT_RECRUITING
NA
REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects Start of enrollment: 2019 Jan 14
Terminated
Not Applicable
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial Start of enrollment: 2018 Nov 30
RECRUITING
NA
MitraClip EXPAND G4 Study Start of enrollment: 2020 Jan 17
ACTIVE_NOT_RECRUITING
MitraClip REPAIR MR Study Start of enrollment: 2020 Jul 21
RECRUITING
NA
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Publications & Presentations

PubMed

Hemodynamic response of the aortic valve during dobutamine onset then progressive aortic banding.
Rob Eerdekens, Philipos K Gebremedhin, Daniel T Johnson, Richard L Kirkeeide, Gretchen L Howe
American Journal of Physiology. Heart and Circulatory Physiology. 2025-02-01
3 citations
Patent Foramen Ovale Closure in Older Patients With Stroke: Patient Selection for Trial Feasibility.
Andy Y Wang, Peter M Rothwell, Jason Nelson, Jeffrey L Saver, Scott E Kasner
Neurology. 2024-05-28
3 citations
Transmembrane stem factor nanodiscs enhanced revascularization in a hind limb ischemia model in diabetic, hyperlipidemic rabbits.
Eri Takematsu, Miles Massidda, Gretchen Howe, Julia Goldman, Patricia Felli
Scientific Reports. 2024-01-29

Journal Articles

One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart Valve
Brian Whisenant, Samir R Kapadia, Mackram F Eleid, James M Mccabe, Amar Krishnaswamy, Richard W Smalling, Charanjit S Rihal, Raj R Makkar, JAMA Cardiology
Regional Artery Specific Thresholds of Quantitative Myocardial Perfusion by PET Associated with Reduced MI and Death After Revascularization in Stable CAD
Mohammad Madjid, Igor Gregoric, Richard W Smalling, Nils P Johnson, Monica B Patel, Salman Arain, David McPherson, Pranav Loyalka, Hazim Safi, Anthony Estrera, Journal of Nuclear Medicine

Authored Content

One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart ValveJuly 2020
One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart ValveJuly 2020

Press Mentions

UTHealth Physicians Give Track Star New Lease on Life with PFO Closure ProcedureSeptember 14th, 2017
UTHealth Leads Study of Device for Minimally Invasive Repair of Aortic Aneurysms (The University of Texas Health Science Center at Houston)June 8th, 2016
Call for Accelerated Global Action to Tackle Endemic Cardiovascular Disease (World Heart Federation)June 8th, 2016
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