RichardCharlesSheltonMD

Charles B. Ireland Professor & Vice Chair for Research, Department of Psychiatry, University of Alabama at Birmingham (UAB)

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Office
1717 6th Ave S
Birmingham, AL 35233
Phone+1 800-822-8816

Education & Training

National Institutes of Health Clinical CenterResidency, Psychiatry, 1983 - 1985
Brigham and Women's Hospital/Harvard Medical SchoolResidency, Psychiatry, 1980 - 1983
University of Louisville School of MedicineInternship, Transitional Year, 1979 - 1980
University of Louisville School of MedicineClass of 1979

Certifications & Licensure

AL State Medical License 2012 - 2024
TN State Medical License 1985 - 2014
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression Start of enrollment: 2004 Jul 01
Completed
Phase 3
The Effectiveness of Sertraline in Patients Who Have Had Inadequate Response to Escitalopram Start of enrollment: 2004 Jun 01
Completed
Phase 3
Sertraline vs. Venlafaxine XR Start of enrollment: 2002 Apr 01
Completed
Phase 3
Medication, Weight Gain and GI Hormones Start of enrollment: 2007 Jan 01
Completed
Phase 4
A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder Start of enrollment: 2008 Mar 01
Completed
Phase 2
Does Risperidone Consta Reduce Relapse and Rehospitalization in Bipolar Disorder? Start of enrollment: 2007 Nov 01
Completed
Phase 4
Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIs Start of enrollment: 2008 Jul 01
Completed
Phase 2
Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation Start of enrollment: 2010 May 01
Completed
Phase 4
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) Start of enrollment: 2011 Feb 01
Completed
Phase 2, Phase 3
Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support) Start of enrollment: 2010 Nov 01
Completed
Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression Start of enrollment: 2013 Apr 01
Completed
Not Applicable
Genomics Used to Improve DEpression Decisions Start of enrollment: 2014 Apr 01
Completed
Not Applicable
Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDD Start of enrollment: 2016 Jan 01
Completed
Not Applicable
MicroRNA Correlates of Childhood Maltreatment and Suicidality Start of enrollment: 2021 Feb 26
Recruiting
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis.
Anna L Wrobel, Megan Turner, Olivia M Dean, Michael Berk, Louisa G Sylvia
Psychiatry Research. 2024-12-01
5 citations
Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial.
George I Papakostas, Madhukar H Trivedi, Richard C Shelton, Dan V Iosifescu, Michael E Thase
Molecular Psychiatry. 2024-08-01
2 citations
Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study pro...
Brandon M Kitay, Eva Murphy, Matthew Macaluso, Philip R Corlett, Rachel Hershenberg
Psychiatry Research. 2023-12-01

Journal Articles

Other

Bipolar disorder in adults: Treating major depression with antidepressants
Shelton RC, Bobo WV
http://www.uptodate.com/contents/bipolar-disorder-in-adults-treating-major-depression-with-antidepre
UpToDate, Wolters Kluwer Health - 2013-02-01
Bipolar disorder in adults: Treating major depression with second-generation antipsychotics
Shelton RC, Bobo WV
http://www.uptodate.com/contents/bipolar-disorder-in-adults-treating-major-depression-with-second-ge
UpToDate, Wolters Kluwer Health - 2013-03-13

Press Mentions

'Conclusive Answer' on Antidepressants in Pregnancy and Kids' Epilepsy RiskMay 11th, 2022
More Seasonal Affective Disorder This Winter? 'It's Obvious This Year Is Different'January 27th, 2021
Allergan’s Phase III Botox Trial for Depression Pushed to H2 2019December 10th, 2018
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Grant Support

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in AdolescentsNational Institute of Mental Health2022–2027
MicroRNA Correlates of Childhood Maltreatment and SuicidalityNational Institute of Mental Health2020–2025
MicroRNA Mediators of Early Life Stress Vulnerability and ResilienceNational Institute of Mental Health2017–2020
A Double-Blind, Proof-of-Concept (POC) Trial of Low Field Magnetic Stimulation (LFMS) Augmentation of Antidepressant Therapy in Treatment-Resistant Depression (TRD)National Institute of Mental Health/Massachusetts General Hospital (subaward)2011–2016
2/2-Ziprasidone Augmentation Of Ssris For Treatment-Resistant Depression (TRD)National Institute Of Mental Health2008–2011
Signal Transduction In DepressionNational Institute Of Mental Health2006–2008
Molecular Neurobiology Of DepressionNational Institute Of Mental Health1999–2003
Depression--Psychopathology Beyond The ReceptorsNational Institute Of Mental Health1996–2002
Comparison Of Mazaperine, Risperidone, And PlaceboNational Center For Research Resources1997
Slep Deprivation And Circadian Rhythm In DepressionNational Center For Research Resources1996
Rapid Response To Antidepressants In Sleep DeprivationNational Center For Research Resources1994–1996
Alprazolam Concentration Response To Lactate Induced Panic AttackNational Center For Research Resources1994–1996
Rapid Response To Antidepressants By Sleep DeprivationNational Institute Of Mental Health1990–1994
Activity Monitoring In DepressionNational Center For Research Resources1991
Pharmacological Investigation Of Neuronal Calcium ChannelsNational Center For Research Resources1987–1989