RichardPeekMD

PubMed

• Multiancestry transferability of a polygenic risk score for diverticulitis.
  Thomas E Ueland, Jonathan D Mosley, Christopher Neylan, John P Shelley, Jamie Robinson
  BMJ Open Gastroenterology. 2024-09-23
• Gastric coinfection with thiopeptide-positivedecreases FOXM1 and pro-inflammatory biomarker expression in a murine model of-induced gastric cancer.
  Courtney Lunger, Zeli Shen, Hilda Holcombe, Anthony J Mannion, JoAnn Dzink-Fox
  Microbiology Spectrum. 2024-01-11
• 194 citations
  Helicobacter pylori infection.
  Peter Malfertheiner, M Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek
  Nature Reviews. Disease Primers. 2023-04-20

Journal Articles

• An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells  
  Wang Y, Liu L, Shen X, Peek RM, Acra SA, Li H, Ren X, Polk DB, and Yan F, Mucosal Immunology, 1/1/2017
• Helicobacter pylori-induced cell death is counteracted by NF-kappaB-mediated transcription of DARPP-32  
  Zhu S, Soutto M, Chen Z, Peng D, Romero-Gallo J, Krishna US, Belkhiri A, Washington MK, Peek RM, and El-Rifai W, Gut, 1/1/2017
• Genetic manipulation of Helicobacter pylori virulence function by host carcinogenic phenotypes  
  Suarez G, Romero-Gallo J, Sierra JC, Piazuelo MB, Krishna US, Gomez MA, Wilson KT, and Peek RM, Cancer Research, 1/1/2017
• Draft genome sequences of 13 Colombian Helicobacter pylori strains from Andean and Pacific Coast residents  
  Pazos A, Kodaman N, Piazuelo MB, Romero-Gallo J, Sobota R, Israel D, Bravo L, Morgan DM, Wilson KT, Correa P, Peek RM, Williams S, and Schneider BS, Genome Announcements, 1/1/2017
• Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood  
  Yan F, Liu L, Cao DJ, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, and Polk DB, Mucosal Immunology, 1/1/2017
• DNA transfer and Toll-like receptor modulation by Helicobacter pylori  
  Varga M and Peek RM, Current Topics in Microbiology and Immunology, 1/1/2017
• The gastric microbiome, its interaction with Helicobacter pylori and its potential role in the progression to stomach cancer  
  Noto JM and Peek RM, PLoS Pathogens, 1/1/2017
• Helicobacter pylori makes a molecular incision to gain epithelial entry  
  Noto JM and Peek RM, Cell Host and Microbe, 1/1/2017
• Different gastric microbiota compositions in two populations with high and low gastric cancer risk in Colombia  
  Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Delgado AG, Romero-Gallo J, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, and Suerbaum S, Science Reports, 1/1/2016
• EGFR regulates macrophage actication and function in bacterial infection  
  Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagomez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, and Wilson KT, Journal of Clinical Investigation, 1/1/2016
• Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system  
  Varga M, Shaffer CL, Sierra JC, Piazuelo MB, Suarez G, Romero-Gallo J, Krishna US, Gomez M, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, and Peek RM, Oncogene, 1/1/2016
• Genetic evolution of a Helicobacter pylori acid-sensing histidine kinase and gastric disease  
  Krishna US, Romero-Gallo J, Suarez G, Azah A, Krezel A, Varga M, Forsyth MH, and Peek RM, Journal of Infectious Diseases, 1/1/2016
• Hydrogen metabolism in Helicobacter pylori plays a role in gastric carcinogenesis through facilitating CagA translocation  
  Wang G, Romero-Gallo J, Benoit SL, Piazuelo MB, Dominguez RL, Morgan DR, Peek RM, and Maier RJ, mBio, 1/1/2016
• Activation of epidermal growth factor receptor in macrophages mediates feedback inhibition of M2 polarization and gastrointestinal tumor cell growth  
  Zhao G, Liu L, Peek RM, Hao X, Polk DB, Li H, and Yan F, Journal of Biological Chemistry, 1/1/2016
• TLR9 activation suppresses inflammation in response to Helicobacter pylori infection  
  Varga MG, Piazuelo MB, Romero-Gallo J, Delgado A, Suarez GR, Whitaker ME, Krishna US, Patel RV, Skaar E, Wilson KT, Algood HMS, and Peek RM, American Journal of Physiology: GI and Liver Physiology, 1/1/2016
• Effect of diet and Helicobacter pylori infection on iron deficiency anemia and gastric ulceration in a Mongolian gerbil model  
  Beckett A, Piazuelo MB, Noto JM, Peek RM, Scott Algood HM, and Cover TL, Infection and Immunity, 1/1/2016
• BET inhibition attenuates Helicobacter pylori-induced inflammatory responses by suppressing inflammatory gene transcription and enhancer activation  
  Chen J, Wang Z, Hu X, Chen R, Romero-Gallo J, Peek RM, and Chen LF, Journal of Immunology, 1/1/2016
• Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori  
  Shimizu T, Choi E, Petersen CP, Noto JM, Romero-Gallo J, Piazuelo MB, Washington MK, Peek RM, and Goldenring JR, Journal of Pathology, 1/1/2016
• miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through the regulation of the PI3K/AKT/mTOR pathway  
  Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchheggar K, Bizama C, Espinoza JA, Peek RM, Araya JC, and Roa JC, Cellular Oncology, 1/1/2016
• The gene expression status of the PI3K/AKT/mTOR pathway in gastric cancer tissues and cell lines  
  Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Bizama C, Araya JC, Peek RM, and Roa JC, Pathology and Oncology Research, 1/1/2016
• Pathobiology of Helicobacter pylori-induced gastric cancer  
  Amieva M and Peek RM, Gastroenterology, 1/1/2016
• Pathogenic enablers: Toxic relationships in the stomach  
  Wroblewski L and Peek RM, Nature Reviews Gastroenterology and Hepatology, 1/1/2016
• Sound the alarmin: IL-33 commandeers the gastric immune response  
  Noto JM and Peek RM, Cellular and Molecular Gastroenterology and Hepatology, 1/1/2016
• The microbiome and GI Cancer  
  Wroblewski L, Peek RM, and Coburn L, Gastroenterology Clinics of North America, 1/1/2016
• New Biology to New treatment of Helicobacter pylori-induced gastric cancer  
  Peek RM, Digestive Diseases, 1/1/2016
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Books/Book Chapters

• Methods in Molecular Biology 
  Chapter: The Mongolian gerbil: a robust model of Helicobacter pylori-induced gastric inflammation and cancer 
  Page 263.0 - 280.0Noto JM, Romero-Gallo J, Piazuelo MB, and Peek RMEditors: Ivanov A.Humana Press, Totowa, NJ2016
• Principles of Mucosal Immunology 
  Chapter: Helicobacter pylori infection 
  Page 363.0 - 376.0Peek RM, Bimczok D, and Wilson KTEditors: Smith PD, MacDonald TT, and Blumberg RS.Garland Science, New York2013
• Methods in Molecular Biology: Helicobacter pylori Protocols 
  Chapter: Genetic Manipulation of a Naturally Competent Bacterium, Helicobacter pylori 
  Page 51.0 - 59.0Noto JM and Peek RMEditors: Houghton J.Humana Press, Totowa, NJ2012
• Methods in Molecular Biology: Helicobacter pylori Protocols 
  Chapter: The Helicobacter pylori cag Pathogenicity Island 
  Page 41.0 - 50.0Noto JM and Peek RMEditors: Houghton J.Humana Press, Totowa, NJ2012
• Methods in Molecular Biology: Helicobacter pylori Protocols 
  Chapter: Helicobacter pylori: an overview 
  Page 7.0 - 10.0Noto JM and Peek RMEditors: Houghton J.Humana Press, Totowa, NJ2012
• Schaecter’s Mechanisms of Microbial Disease 
  Chapter: Helicobacter pylori: Pathogenesis of a Persistent Bacterial Infection 
  Page 243.0 - 250.0Noto JM and Peek RMEditors: Engelberg C, DiRita V, and Dermody T.Lippincott Williams and Wilkins, Baltimore, MDEdition 5th,2011
• Yamada Textbook of Gastroenterology 
  Chapter: Gastritis and Gastropathy 
  Page 1005. - 1025.Washington MK and Peek RMLippincott, Williams and Wilkins2008
• The Biology of Gastric Cancer 
  Chapter: . The role of Helicobacter pylori virulence factors in rodent and primate models of disease 
  Page 403.0 - 424.0Israel DA and Peek RMEditors: Fox JG, Wang TC, and Giraud A.Springer Press2008
• Digestive Disease Self-Education Program V (DDSEP V) 
  Chapter: Acid diseases of the esophagus and stomach 
  Peek RM and Shaker R2008
• Cytokines in the genesis and treatment of cancer 
  Chapter: Helicobacter pylori, Cytokines, and Cancer 
  Page 3.0 - 26.0Peek RMEditors: Caliguri M and Lotze M.Humana Press2007
• Physiology of the Gastrointestinal tract 
  Chapter: Mechanisms of Helicobacter pylori-induced gastric inflammation 
  Page 1091. - 1114.Israel DA and Peek RMEditors: Johnson LR.Elsevier PressEdition 4th,2006
• Schaecter’s Mechanisms of Microbial Disease 
  Chapter: Helicobacter pylori: Pathogenesis of a “Slow” Bacterial Infection 
  Page 243.0 - 250.0Peek RMEditors: Engelberg C, DiRita V, and Dermody T.Lippincott Williams and WilkinsEdition 4th,2006
• Rapid Reference to Dyspepsia 
  Editors: El-Omar E and Peek RM.Elsevier Limited, London, UK2003
• Microbial pathogenesis and the intestinal epithelial cell 
  Chapter: Application of microarray analysis to the investigation of host-pathogen interactions 
  Page 121.0 - 140.0Israel DA and Peek RMEditors: Hecht GA.ASM press, Washington DC2003
• Helicobacter pylori 
  Chapter: Restriction and modification systems 
  Page 269.0 - 276.0Donahue JP, and Peek RMEditors: Hazell S, Mendz G, Mobley H.ASM press, Washington DC2001
• Mechanisms of Microbial Disease 
  Chapter: Helicobacter pylori, peptic ulcer disease and gastric cancer 
  Peek RM, and Blaser MJEditors: Eisenstein B., Engelberg C..Williams and Wilkins1997
• Helicobacter pylori: Techniques for Clinical Diagnosis and Basic Research 
  Chapter: Reverse transcription-Polymerase chain reaction (RT-PCR) for bacterial and host gene expression in human gastric mucosa 
  Page 163.0 - 173.0Peek RM, Miller GG, and Blaser MJEditors: Lee, A., Megraud, F..W.B. Saunders Ltd1995
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Abstracts/Posters

• Geospatial analyses identify a clustering of diffuse gastric cancers and related risk exposures in Central America
  Cherry CB, Escamilla V, Dominguez R, Schneider BS, Gulley M, Tavera G, Williams S, Israel D, Piazuelo MB, Wilson KT, Peek RM, Emch M, and Morgan DR, DDW meeting, Chicago, IL, 1/1/2017
• Gastric intestinal metaplasia type III and prospective risk of gastric cancer in Colombia
  Piazuelo MB, Camargo MC, Mera R, Delgado A, Bravo J, Peek RM, Correa P, Morgan DR, Bravo L, and Wilson KT, DDW meeting, Chicago, IL, 1/1/2017
• A Lactobacillus Rhamnosus GG (LGG)-derived protein promotes intestinal development via activation of EGF receptor in intestinal epithelial cells
  Shen X, Liu L, Polk DB, Peek RM, Acra S, He F, and Yan F, DDW meeting, Chicago, IL, 1/1/2017
• Carcinogenic host microenvironments target and modify key pathogenic loci within Helicobacter pylori
  Noto JM, Chopra A, Loh, J, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett A, Cover TL, Mallal S, Israel DA, and Peek RM, DDW meeting, Chicago, IL, 1/1/2017
• Genetic manipulation of Helicobacter pylori cag+ type 4 secretion system function by gastric cancer phenotypes
  Suarez G, Romero-Gallo J, Sierra C, Piazuelo MB, Krishna U, Gomez M, Wilson KT, and Peek RM, DDW meeting, Chicago, IL, 1/1/2017
• Helicobacter pylori genetic ancestry in Central America is consistent with disrupted co-evolution, implications for cancer
  Tavera G, Dominguez R, Bartlett J, Schneider BS, Cherry CB, Israel D, Romero-Gallo J, Mera R, Piazuelo MB, Peek RM, Wilson KT, Williams S, and Morgan DR, DDW meeting, Chicago, IL, 1/1/2017
• Inhibition of epidermal growth factor receptor activation as a strategy to prevent Helicobacter pylori-induced epithelial inflammatory responses, DNA damage, and gastr...
  Sierra C, Asim M, Verriere T, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado A, Barry D, Peek RM, Gobert A, and Wilson KT, DDW meeting, Chicago, IL, 1/1/2017
• The role of Nod1 in targeting the immune response towards Helicobacter pylori in a genetic model of gastric carcinogenesis
  Suarez G, Romero-Gallo J, Piazuelo MB, Sierra C, Delgado A, Washington MK, Wilson KT, and Peek RM, 19th International Workshop on Campylobacter, Helicobacter and related organisms, Nantes, France, 1/1/2017
• Helicobacter pylori expands and functionally activates a novel gastric stem cell population in a cag pathogenicity island-dependent manner
  Wroblewski LE, Romero-Gallo J, Goldenring JR, Coffey RJ, Amieva MR, Powell AE, and Peek RM, 19th International Workshop on Campylobacter, Helicobacter and related organisms, Nantes, France, 1/1/2017
• Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments
  Noto JM, Chopra A, Loh, J, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett A, Wilson KT, Cover TL, Mallal S, Israel DA, and Peek RM, 19th International Workshop on Campylobacter, Helicobacter and related organisms, Nantes, France, 1/1/2017
• The ornithine decarboxylase inhibitor difluoromethylornithine effectively reduces Helicobacter pylori virulence and induction of inflammation and carcinogenesis
  Sierra C, Suarez G, Piazuelo MB, Hansen LM, Peek RM, Solnick JV, Gobert A, and Wilson KT, 19th International Workshop on Campylobacter, Helicobacter and related organisms, Nantes, France, 1/1/2017
• Biopsy sampling of the incisura angularis for the diagnosis of gastric precancerous lesions
  Piazuelo MB, Camargo MC, Mera R, Bravo JC, Bravo LE, Delgado AG, Schneider BG, Peek RM, Morgan DR, Correa P, and Wilson KT, DDW meeting, San Diego, CA, 1/1/2016
• H. pylori antibiotic resistance in Central America: implications for patient care, gastric cancer prevention, and antibiotic stewardship
  Ortiz V, Dominguez R, Cherry C, Estevez D, Israel DA, Krishna U, Romero-Gallo J, Piazuelo MB, Wilson KT, Peek RM, and Morgan DR, DDW meeting, San Diego, CA, 1/1/2016
• H. pylori cagY rearrangements modify function of the cag type 4 secretion system in response to oncogenic changes in the gastric microenvironment
  Suarez G, Romero-Gallo J, and Peek RM, DDW meeting, Washington, DC, 1/1/2015
• Role of an acid sensing histidine kinase in H. pylori pathogenesis
  Azah A, Krishna U, Varga MG, Romero-Gallo J, Forsyth MH, Suarez G, and Peek RM, DDW meeting, Washington, DC, 1/1/2015
• Role of Helicobacter pylori–induced hypoxia-inducible factor 1alpha in the altitude enigma of gastric carcinogenesis
  Noto JM, Zabaleta J, Piazuelo MB, Correa P, and Peek RM, DDW meeting, Washington, DC, 1/1/2015
• Toll-like receptor 9 suppresses the progression to H. pylori-induced injury and cancer
  Varga MG, Piazuelo MB, Suarez G, Romero-Gallo J, Gomez M, Washington MK, and Peek RM, DDW meeting, Washington, DC, 1/1/2015
• Helicobacter pylori cag+ strains stimulate expansion of Lrig1+ progenitor cells within the gastric mucosa in a strain-specific manner
  Wroblewski L, Romero-Gallo J, Goldenring JR, Coffey RJ, Amieva MR, Peek RM, and Powell AE, DDW meeting, Washington, DC, 1/1/2015
• Hif-1a stabilization suppresses Helicobacter pylori-induced inflammation
  Noto JM, Romero-Gallo J, Piazuelo MB, Taylor CT, and Peek RM, FASEB Science Research Conference: Gastrointestinal Tract XVI: Epithelia, Microbes, Inflammation and Cancer, Steamboat Springs, CO, 1/1/2015
• Expression of a novel tight junction protein, claudin-18, is dysregulated in gastric cancer and in response to H. pylori in a cag-dependent manner
  Wroblewski LE, Romero-Gallo J, Delgado A, Piazuelo MB, Correa P, and Peek RM, FASEB Science Research Conference: Gastrointestinal Tract XVI: Epithelia, Microbes, Inflammation and Cancer, Steamboat Springs, CO, 1/1/2015
• The Helicobacter pylori cag secretion system suppresses inflammation via translocation of DNA into host cells
  Varga MG, Shaffer CL, Piazuelo MB, Sierra JC, Suarez G, Romero-Gallo J, Krishna US, Gomez M, Skaar EP, Correa P, Wilson KT, Hajifrangiskou M, and Peek RM, 18th International Workshop on Campylobacter, Helicobacter and related organisms, Rotorua, New Zealand, 1/1/2015
• The molecular evolution of Nod1-dependent immune suppression induced by Helicobacter pylori within the stomach
  Suarez G, Romero-Gallo J, Piazuelo MB, Philpott D, and Peek RM, 18th International Workshop on Campylobacter, Helicobacter and related organisms, Rotorua, New Zealand, 1/1/2015
• H. pylori compromises cellular response to oncogenic stress
  Wei J, Noto JM, Zaika E, Washington MK, Correa P, El-Rifai W, Peek RM, and Zaika A, DDW meeting, Chicago, IL, 1/1/2014
• Helicobacter pylori suppresses hepcidin, a master regulator of iron homeostasis, in a cag-dependent manner
  Noto JM, Piazuelo MB, Delgado A, Correa P, and Peek RM, DDW meeting, Chicago, IL, 1/1/2014
• The Helicobacter pylori peptidoglycan deacetylase PgdA mediates intracellular bacterial survival, autophagy, and disease
  Suarez G, Romero-Gallo J, Piazuelo MB, Williams J, Greenfield L, Jones NL, and Peek RM, DDW meeting, Chicago, IL, 1/1/2014
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Lectures

• Helicobacter pylori and complications of gastroesophageal reflux 
  Nashville, TN - 1/1/2000
• Helicobacter pylori and gastric epithelial cell cycle events 
  Nagoya, Japan - 1/1/2000
• Helicobacter pylori and the cell cycle 
  Cleveland, OH - 1/1/1999
• Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle 
  Royal Free University, Amsterdam, the Netherlands - 1/1/1999
• Helicobacter pylori and reflux disease: paradox revealed 
  Nashville, TN - 1/1/1999
• The paradox of H. pylori and complications of gastroesophageal reflux disease 
  Vanderbilt University School of Medicine, Nashville, TN - 1/1/1999
• Helicobacter pylori and complications of gastroesophageal reflux disease 
  New Orleans, LA - 1/1/1998
• Helicobacter pylori and upper GI tract disease 
  Murfreesboro VA Medical Center, Murfreesboro, TN - 1/1/1998
• Helicobacter pylori and reflux disease 
  Baptist-Montclair Hospital, Birmingham, AL - 1/1/1998
• Helicobacter pylori and gastroduodenal disease 
  Asheville, NC - 1/1/1997
• Helicobacter pylori-induced duodenal ulceration 
  Cleveland, OH - 1/1/1997
• Pathogenesis of H. pylori-induced peptic ulceration 
  Vanderbilt University School of Medicine, Nashville, TN - 1/1/1997
• Food-borne illnesses 
  Nashville, TN - 1/1/1997
• The role of H. pylori in upper gastrointestinal complications 
  Chattanooga, TN - 1/1/1997
• Helicobacter pylori and disease 
  Nashville, TN - 1/1/1996
• Microbial virulence and cancer 
  Steamboat Springs, CO - 1/11/2013
• Novel treatment strategies for Helicobacter pylori 
  University of Pittsburgh, Pittsburgh, PA - 1/21/2010
• Helicobacter pylori and gastric cancer: An axis of evil 
  College of William and Mary, Williamsburg, VA - 1/12/2013
• Impact of iron deficiency on H. pylori virulence and gastric carcinogenesis 
  Oxford, UK - 1/15/2013
• Helicobacter pylori Symposium 2012 
  Vina del Mar, Chile - 1/28/2012
• Helicobacter pylori and gastric cancer: past success inform future directions 
  Uniformed Services University of the Health Sciences, Bethesda, MD - 1/19/2012
• H. pylori and gastric cancer 
  Tokyo, Japan - 1/14/2012
• Best of AGA at DDW 2012 
  Amsterdam, The Netherlands - 1/20/2012
• Screening Strategies in Minority Populations: How do we personalize the approach? 
  San Diego, CA - 1/19/2012
• Concepts in Gastric Ulcers, Cancer and H. pylori 
  San Diego, CA - 1/19/2012
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