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Office
200 1st St SW
Rochester, MN 55905Phone+1 507-284-2511
Summary
- I am a critical care clinician investigator with an interest in mechanical ventilation and its sequelae, including the prevention and treatment of severe and refractory hypoxemia, the acute respiratory distress syndrome (ARDS), and post-intensive care syndrome (PICS) and recovery after ICU discharge. I am the director of the Mayo Clinic medical ICU (MICU) and physician champion of the Mayo Clinic Intensive Care Recovery Program (MCIRP).
My clinical research focuses on the continued pursuit of truly personalized approach to non-invasive and invasive mechanical ventilation in patients with acute respiratory failure or the acute respiratory distress syndrome (ARDS). By employing sound, physiologically-based techniques tailored to individual patient lung mechanics it is my belief that we can minimize or prevent ventilator-induced (VILI) or patient self-inflicted (P-SILI) lung injury and reduce overall mortality in these conditions.
My basic and translational work attempts to understand how lung cells injure and repair in response to deforming stress. Potential translational interventions include osmolar agents (inhaled), redox signaling, the adenylate cyclase axis (particularly soluble AC), and associated receptor signaling.
Educational endeavors include the development of mechanical ventilation education for residents, fellows, and staff at the Mayo Clinic and as co-director of the international Mayo Mechanical Ventilation Conference and various organizations and societies.
Education & Training
- Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Pulmonary Disease and Critical Care Medicine, 2008 - 2011
- Mayo Clinic College of MedicinePost-Doctoral Fellowship, 2007 - 2009
- Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 2004 - 2007
- New York Medical CollegeClass of 2004
Certifications & Licensure
- FL State Medical License 2021 - 2025
- WI State Medical License 2013 - 2025
- MN State Medical License 2005 - 2024
- NH State Medical License 2019 - 2021
- GA State Medical License 2015 - 2020
- VT State Medical License 2019 - 2020
- American Board of Internal Medicine Critical Care Medicine
- American Board of Internal Medicine Pulmonary Disease
Clinical Trials
- EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures Start of enrollment: 2012 Oct 31
- Safety Study of Inhaled Saline in Acute Lung Injury Start of enrollment: 2013 Oct 01
- Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial Start of enrollment: 2015 Jun 01
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Publications & Presentations
PubMed
- 105 citationsMechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.Fan Wang, Kaitlyn R. Knutson, Constanza Alcaino, David R. Linden, Simon J. Gibbons
The Journal of Physiology. 2017-01-01 - 20 citationsPhysiology-guided management of hemodynamics in acute respiratory distress syndrome.Gustavo A. Cortes-Puentes, Richard A. Oeckler, John J. Marini
Annals of Translational Medicine. 2018-07-05 - 33 citationsRisk Factors for Dexmedetomidine-Associated Hemodynamic Instability in Noncardiac Intensive Care Unit Patients.Calvin Ice, Heather A. Personett, Erin Frazee, Ross A. Dierkhising, Rahul Kashyap
Anesthesia and Analgesia. 2016-02-01
Journal Articles
- Alveolar Microstrain and the Dark Side of the LungRichard Oeckler, MD, BioMed Central
Press Mentions
- Mayo Clinic Experts Urge 'Household Holiday': Keep Thanksgiving Gathering to a MinimumNovember 25th, 2020
- Debate Will Argue Pros and Cons of Low Tidal Volumes and Driving Pressures Outside ARDSOctober 21st, 2020
- LIVE Updates from COVID-19 Conference: First Session Begins, Experts Discuss Respiratory Effects, Critical Care in PatientsJuly 27th, 2020
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Grant Support
- Hypercapnia Modulation of Alveolar Cell Repair in the Ventilator-Injured LungParker B. Francis Fellowship2012–2015
Professional Memberships
- Member
- Member
- Fellow
- Sigma XiMember
- American Physiological SocietyMember
- The Royal Society of MedicineFellow
External Links
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