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Office
5912 Hartford Way
Brighton, MI 48116Phone+1 517-376-2006
Summary
- Dr. Richard Messmann is a medical oncologist, biochemist, electrical and computer engineer and clinical research physician with over 25 years of experience in oncology drug development ranging from Phase I-III clinical studies. Dr. Messmann’s career focus is in the development of targeted diagnostic and therapeutic agents for treatment of various cancer indications.
After completing a medical oncology fellowship at the National Cancer Institute and obtaining an advanced degree in clinical trial management from Duke University, he served as Deputy Associate Director of the NIH/NCI’s Developmental Therapeutics Program (DTP). He has also held executive positions with Advanced Accelerator Applications (AAA, Novartis AG), Endocyte, Eli Lilly & Co., Michigan State University, ProNAi Therapeutics, Apexian Pharmaceuticals and Amgen Inc.
Dr. Messmann's clinical leadership of the VISION Phase 3 study of Pluvicto (177Lu-PSMA-617) resulted in the regulatory approval of the first successfully developed radio-therapeutic and radio-diagnostic for use in men with advanced metastatic castrate-resistant prostate cancer. The trial results were presented at the ASCO 2021 plenary session with a concurrent publication in the New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/nejmoa2107322).
He is currently the Executive Medical Director for Global Development of Xaluritamig (AMG 509), an Anti-STEAP1 XmAb 2+1 T-cell therapy against advanced-stage prostate cancer, early details of which were presented at the 2023 Madrid meeting of the European Society of Medical Oncology.
Education & Training
- National Institutes of Health Clinical CenterFellowship, Hematology and Medical Oncology, 1997 - 2000
- Sparrow Hospital/Michigan State UniversityResidency, Internal Medicine, 1995 - 1997
- University of MichiganResidency, Anesthesiology, 1994 - 1995
- MedStar Health/Georgetown University HospitalResidency, Anesthesiology, 1993 - 1993
- Sparrow Hospital/Michigan State UniversityInternship, Internal Medicine, 1991 - 1992
- Wayne State University School of MedicineClass of 1991
Certifications & Licensure
- MI State Medical License 1995 - 2026
- VA State Medical License 1993 - 2002
Clinical Trials
- Safety and Tolerability Study of FolateImmune in Combination With Cytokines in Patients With Refractory or Metastatic Cancer Start of enrollment: 2005 Sep 01
- Study of EC0225 for the Treatment of Refractory or Metastatic Tumors Start of enrollment: 2007 Feb 01
- A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell Carcinoma Start of enrollment: 2007 Jun 01
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Publications & Presentations
PubMed
- 948 citationsLutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.Oliver Sartor, Johann S. de Bono, Kim N. Chi, Karim Fizazi, Ken Herrmann
The New England Journal of Medicine. 2021-06-23 - 61 citationsLugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials.Ronald L Van Heertum, Robert Scarimbolo, John G Wolodzko, Barbara Klencke, Richard A. Messmann
Drug Design, Development and Therapy. 2017-06-13 - 235 citationsPhase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory NeoplasmsEdward A. Sausville, Susan G. Arbuck, Richard A. Messmann, Donna Headlee, Kenneth S. Bauer
Journal of Clinical Oncology. 2001-04-15
Press Mentions
- Apexian Pharmaceuticals Hires Richard Messmann, M.D. As Chief Medical OfficerOctober 31st, 2016
Professional Memberships
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