Richard Frank Loeser Jr. MD

PubMed

• The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical develo...
  Morten Asser Karsdal, Lucio C Rovati, Jeyanesh Tambiah, Olga Kubassova, Christoph Ladel
  Osteoarthritis and Cartilage Open. 2025-06-01
• Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype.
  Rachel Gagliardi, Drew W Koch, Richard Loeser, Lauren V Schnabel
  Journal of Orthopaedic Research. 2025-02-01
• 1 citations
  Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.
  Nicole E Kramer, Seyoun Byun, Philip Coryell, Susan D'Costa, Eliza Thulson
  Cell Genomics. 2025-01-08

Journal Articles

• Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults with Knee Osteoarthritis  
  Richard Loeser Jr., MD, JAMA
• Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better?  
  Richard F Loeser, Ali Guermazi, Mary F Lyles, Arthritis Care & Research
• Sufficient Vitamin K Status Combined with Sufficient Vitamin D Status Is Associated with Better Lower Extremity Function: A Prospective Analysis of Two Knee Osteoarthr...  
  Richard Loeser Jr., MD, Arthritis Care & Research
• Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities  
  Long DL, Ulici V, Chubinskaya S, Osteoarthritis Cartilage, 1/1/2015
• Osteoarthritic changes in vervet monkey knees correlate with meniscus degradation and increased matrix metalloproteinase and cytokine secretion  
  Stone AV, Vanderman KS, Willey JS, Long DL, Register TC, Shively CA, Stehle JR, Ferguson CM, Osteoarthritis Cartilage, 1/1/2015
• The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes  
  Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP, Osteoarthritis Cartilage, 1/1/2015
• Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent  
  Greene MA, Loeser RF, Osteoarthritis Cartilage, 1/1/2015
• The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study  
  Shea MK, Kritchevsky S, Hsu F, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C; for the Health ABC Study, Osteoarthritis Cartilage, 1/1/2015
• Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis  
  Beavers KM, Beavers DP, Newman JJ, Anderson AM, Nicklas BJ, Lyles MF, Miller GD, Milhalko SL, Messier SP, Osteoarthritis Cartilage, 1/1/2015
• Redox regulation of Rac1 by thiol oxidation  
  Hobbs AG, Mitchell LE, Arrington ME, Gunawardena HP, DeCristo MJ, Chen X, Cox AD, Campbell SL, Free Radic Biol Med, 1/1/2015
• Integrins and chondrocyte-matrix interactions in articular cartilage  
  Loeser RF, Matrix Biol, 1/1/2014
• Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor-1 and osteogenic protein-1  
  Gandhi U, Long DL,Yin W, Chubinskaya S, Arthritis Rheum, 1/1/2014
• Influence of alignment and knee joint loading in osteoarthritic gait  
  Messier SP, Pater M, Beavers DP, Legault C, Hunter DJ, DeVita P, Osteoarthritis Cartilage, 1/1/2014
• The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese, older adults with osteoarthritis  
  Beavers DP, Beavers KM, Walton NR, Lyles MF, Nicklas BJ, Shapses SA, Newman JJ, Messier SP, Osteoarthritis Cartilage, 1/1/2014
• Stress inducible gene nuclear protein-1 (NUPR1/p8) regulates MMP-13 expression in human articular chondrocytes  
  Yammani RR, Loeser RF, Arthritis Rheum, 1/1/2014
• Knee-joint loading in knee osteoarthritis: Influence of abdominal and thigh fat  
  Messier SP, Beavers DP, Carr JJ, Khajanchi S, Legault C, Hunter DJ, DeVita P, Med Sci Sports Exer, 1/1/2014
• Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis  
  Stone AV, Vanderman K, Long DL, Clark SC, Ferguson CM, Osteoarthritis Cartilage, 1/1/2014
• Osteoarthritis Year in Review 2013: Biology  
  Loeser RF, Osteoarthritis Cartilage, 1/1/2013
• Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults with Knee Osteoarthritis: The IDEA Ra...  
  Messier SP, Mihalko, SL, Legault, Miller GD, Nicklas, BJ, DeVita P, Ph.D., Beavers D, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr J, Guermazi A, JAMA, 1/1/2013
• Strength Training for Arthritis Trial (START): Design and Rationale  
  Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, DeVita P, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, BMC Musculoskeletal Disorders, 1/1/2013
• Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage  
  Willey JS, Long DL, Vanderman KS, Int J Radiat Bio, 1/1/2013
• Rac1 is required for matrix metalloproteinase-13 production by chondrocytes in response to fibronectin fragments  
  Long DL, Willey JS, Arthritis Rheum, 1/1/2013
• The Effects of aging on the development of osteoarthritis  
  Loeser RF, HSS Journal, 1/1/2012
• Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular cho...  
  Yammani RR, Loeser RF, Arthritis Res Ther, 1/1/2012
• Effects of aging on articular cartilage homeostasis  
  Lotz M, Loeser RF, Bone, 1/1/2012
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Books/Book Chapters

• Advances in Geroscience 
  Chapter: Osteoarthritis in the Elderly 
  Page 309 - 353Loeser RF, Lotz MKEditors: Sierra, F and Kohanski R.Springer Science+Business Media, New York2015
• Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management 
  Chapter: Aging and Posttraumatic Arthritis 
  Page 165 - 183Ferguson CM, Lotz MKEditors: Olson SA and Guilak F.Springer Science+Business Media, New York2015
• Cecil Textbook of Medicine 
  Chapter: Connective Tissue Structure and Function 
  Page 1659 - 1662Loeser RFEditors: Goldman L, Schafer, AI.Saunders Elsevier, PhiladelphiaEdition 24th,2011
• Osteoarthritis Research Society International (OARSI) Primer 
  Chapter: Inflammation and OA 
  Otero M, Goldring MBEditors: Henrotin Y, Hunter D, Kawaguchi H.2011
• Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology 
  Chapter: Computational modeling of the effects of oxidative stress on the IGF-1 signaling pathway in human articular chondrocytes 
  Page 71 - 78Marcott PF, Fetrow JS, Allen EEACM, New York2010
• Hazzard's Principles of Geriatric Medicine and Gerontology 
  Chapter: Aging of the Muscles and Joints 
  Page 1355 - 1368Loeser RF, Debono OEditors: Hazzard WR, Halter JB, Ouslander JG, Tinetti M, Asthana S, High K, Studenski, S.McGraw Hill, Inc., N.Y.Edition 6th,2009
• Osteoarthritis, A Companion to Rheumatology 
  Chapter: Aging Cartilage and Osteoarthritis Cartilage: Differences and Shared Mechanisms 
  Page 77 - 84Loeser RFEditors: Sharma L, Berenbaum F.Mosby, PhiladelphiaEdition 1st,2007
• Principles of Geriatric Medicine and Gerontology 
  Chapter: Aging of the Muscles and Joints 
  Page 905 - 918Loeser RF, Debono OEditors: Hazzard WR, Blass JP, Halter JB, Ouslander JG, Tinetti M.McGraw Hill, Inc., N.Y.Edition 5th,2003
• Principles of Geriatric Medicine and Gerontology 
  Chapter: Aging and the Musculoskeletal System 
  Loeser RF, Debono OEditors: Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander JG.McGraw Hill, Inc., N.Y.1999
• Clinics in Geriatric Medicine 
  Chapter: Musculoskeletal and Connective Tissue Disorders 
  Page 401 - 661Loeser RFEditors: Richard F. Loeser.W.B. Saunders, Philadelphia, PA1998
• Handbook of Nutrition in the Aged 
  Chapter: Vitamin K and Vitamin K-Dependent Proteins in the Elderly: Implications for Bone and Cartilage Biology 
  Page 263 - 280Wallin R, Sadowski JEditors: Ronald R. Watson.CRC Press, Boca Raton, FLEdition 2nd,1993
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Abstracts/Posters

• Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments
  Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Osteoarthritis and Cartilage, 1/1/2015
• Mitochondrial reactive oxygen species promote hyperoxidation of peroxiredoxins and inhibit pro-survival IGF-1 signaling in human articular chondrocytes
  Collins JA, Poole L, Furdui C, Nelson K, Osteoarthritis and Cartilage, 1/1/2015
• Ulici V, Long D, Osteoarthritis and Cartilage, 1/1/2015
• Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent
  Greene MA, Loeser RF, Osteoarthritis and Cartilage, 1/1/2015
• 1 Deletion of Macrophage Migration Inhibitory Factor Reduces Severity of Osteoarthritis in Mice
  Greene M., Roland A, Pritzker L., Carlson C., Bucala R., Miller R., Osteoarthritis Research Society International, Paris France, 1/1/2014
• Changes in joint loads, leptin and MMP-3 subsequent to long-term intensive weight loss and exercise: secondary outcomes from the intensive diet and exercise for arthri...
  Messier SP, DeVita P, Nicklas BJ, Beavers D, Miller GD, Hunter DJ, Eckstein F, Guermazi A, Osteoarthritis Research Society International, Paris France, 1/1/2014
• Redox Regulation of Cell Signaling in Chondrocytes Stimulated with Fibronectin Fragments
  Wood S, Reisz J, Yammani R, Klomsiri C, Poole L, Furdui Cristina, Orthopedic Research Society, 1/1/2014
• Effects of Osteoarthritis on Meniscus Cell Response to Osteogenic Protein 1 (OP1/ BMP7)
  Vanderman KS, Chubinskaya SG, Ferguson CM, Orthopedic Research Society, 1/1/2014
• Direct comparison of the effects of fibronectin fragment stimulation on chondrocytes and meniscal cells
  Long DL, Stone A, Transactions of the Orthopedic Research Society, 1/1/2013
• Function of the chondrocyte PI-3 kinase-Akt pathway is stimulus dependent
  Greene M, Loeser RF, Transactions of the Orthopedic Research Society, 1/1/2013
• Nuclear Protein-1 (Nupr1) regulates matrix metalloproteinase -13 expression in human articular chondrocytes
  Yammani R, Loeser RF, Transactions of the Orthopedic Research Society, 1/1/2013
• Inflammatory factors associated with injury stimulate early osteoarthritis pathways in the meniscus
  Stone AV, Long DL, Yammani R, Ferguson CM, Transactions of the Orthopedic Research Society, 1/1/2013
• Function of the chondrocyte PI-3 kinase-Akt pathway is stimulus dependent
  Loeser RF, Greene M, Arthritis Rheum, 1/1/2012
• A systems biology approach to elucidating pathways active during the development of osteoarthritis
  Olex AL, Westwood B, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS, Arthritis Rheum, 1/1/2012
• Transcriptional regulation during the development of surgically-induced OA in mice
  Olex AL, McNulty M, Carlson, CS, Callahan M, Ferguson C, Fetrow JS, Osteoarthritis and Cartilage, 1/1/2012
• Regulation of chondrocyte MMP-13 production by the GTPase Rac1
  Long DL, Loeser RF, Transactions of the Orthopedic Research Society, 1/1/2011
• Changes in gene expression with age and osteoarthritis in the mouse knee joint
  Olex A, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS, Osteoarthritis and Cartilage, 1/1/2011
• Aging and oxidative stress reduce the chondrocyte response to IGF-1 and OP-1
  Gandhi U, Chubinskaya S, Osteoarthritis and Cartilage, 1/1/2011
• The Effects of Age on Disease Severity and Gene Expression in the Destabilized Medial Meniscus (DMM) Model of OA in Mice
  Olex, A, Chou, J, McNulty, MA, Carlson, CS, Callahan, M, Ferguson, C, Fetrow, JS, Transactions of the Orthopedic Research Society, 1/1/2010
• Using gene microarrays to discover skeletal muscle mechanisms underlying clinical responses to diet and exercise interventions
  Fetrow J, Chou J, Nicklas B, Kritchevsky SB, Gerontological Society of America, 1/1/2010
• Reduction in articular cartilage lesions in older adult mice overexpressing catalase targeted to mitochondria
  McNulty MA, Treuting PM, Carlson CS, Osteoarthritis Cartilage, 1/1/2009
• Reactive oxygen species inhibit IGF-I induction of chondrocyte proteoglycan synthesis through differential regulation of PI-3 kinase-Akt and MEK-ERK MAPK signaling pat...
  Loeser RF, Yin W, Osteoarthritis Cartilage, 1/1/2009
• Reactive oxygen species contribute to IGF-I resistance in osteoarthritic chondrocytes through inhibition of the IRS-I-PI3 Kinase-Akt signaling pathway
  Loeser RF, Yin W, Arthritis Rheum, 1/1/2009
• Arthritis Rheum
  Long D, Blake S, Song X-Y, Lark M, Arthritis Rheum, 1/1/2007
• The IGF-I signaling inhibitor TRB3 is increased in OA chondrocytes
  Cravero JD, Carlson CS, Osteoarthritis and Cartilage, 1/1/2007
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Lectures

• Vitamin K Insufficiency and Osteoarthritis 
  Chicago, IL - 1/1/2015
• Aging, Oxidative Stress and the Development of Osteoarthritis 
  Multiple Locations, 2010, 2012, 2014 - 1/1/2015
• Aging and Osteoarthritis: What’s the Mechanistic Link? 
  Multiple Locations, 2011, 2014 - 1/1/2015
• The Role of Aging in the Development of Osteoarthritis 
  University of Liverpool, UK, 2012; University of Kansas Medical Center, Kansas City, KS, 2015 - 1/1/2015
• Osteoarthritis Update: from Etiology to Management 
  Multiple Locations, 2002, 2013, 2014 - 1/1/2015
• Osteoarthritis as a Whole Joint Disorder 
  Chicago, IL - 1/1/2014
• Redox Regulation of Cell Signaling in Chondrocytes and Matrix Destruction in Osteoarthritis 
  Girona, Spain - 1/1/2014
• Redox Regulation of Chondrocyte Integrin Signaling 
  Ohio State University, Columbus, OH - 1/1/2014
• Osteoarthritis: 2014 Update 
  St. Louis, MO - 1/1/2014
• Aging and Osteoarthritis: What’s the Link 
  Paris, France - 1/1/2014
• Redox Regulation of Chondrocyte Signaling 
  San Antonio, TX - 1/1/2013
• Aging, Redox Signaling, and the Development of Osteoarthritis 
  Penn Center for Musculoskeletal Disorders, University of Pennsylvania, Philadelphia, PA - 1/1/2013
• Cartilage Pathogenesis in Osteoarthritis 
  Les Diablerets, Switzerland - 1/1/2013
• Year in Review 2013: Biology of OA 
  Philadelphia, PA - 1/1/2013
• Inflammation and Osteoarthritis 
  Bethesda, MD - 1/1/2013
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  Rush Medical College, Chicago, IL - 1/1/2013
• Disease Mechanisms That Impact the Joint: Age 
  Chicago, IL - 1/1/2012
• Mechanisms Linking Aging to the Development of Osteoarthritis 
  Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC - 1/1/2012
• The Chondrocyte Senescent Secretory Phenotype and its Role in the Development of Osteoarthritis 
  Madrid Spain - 1/1/2011
• Redox Regulation of IGF-I and Integrin Signaling in Chondrocytes 
  New York University School of Medicine, New York - 1/1/2011
• OA and Aging 
  Chicago, IL - 1/1/2011
• Effect of Aging on Cartilage Matrix and Chondrocytes 
  Chicago, IL - 1/1/2011
• The Effect of Aging on the Development of Osteoarthritis 
  New York, NY - 1/1/2011
• Chondrocyte Homeostasis 
  San Diego, CA - 1/1/2011
• Aging and Osteoarthritis: Lessons from Animal Models 
  University of California San Diego, La Jolla, CA - 1/1/2011
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