RichardSLegroMD

Obstetrics & Gynecology • Hershey, PA

Reproductive Endocrinology & Infertility

Chair and University Professor of Obstetrics & Gynecology, Penn State College of Medicine

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Office
35 Hope Drive
Stes 202204
Hershey, PA 17033
Phone+1 717-531-3503

Fax+1 717-531-4375

Education & Training

University of Southern California/Los Angeles General Medical Center (USC/LA General)Fellowship, Reproductive Endocrinology and Infertility, 1991 - 1993
UPMC Medical EducationResidency, Obstetrics and Gynecology, 1987 - 1991
Icahn School of Medicine at Mount SinaiClass of 1987

Certifications & Licensure

CA State Medical License 2007 - Present
PA State Medical License 1989 - 2024
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility
American Board of Obesity Medicine Obesity Medicine

Awards, Honors, & Recognition

Member National Academy of Medicine, 2019
Fellow, Ad Eundem Royal College of Obstetricians and Gynaecologists, 2017
America's Top Doctors Castle Connolly, 2004-2014
Fellow (FACOG) American Congress of Obstetricians and Gynecologists
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Clinical Trials

Viagra in the Treatment of Primary Dysmenorrhea Start of enrollment: 2007 May 01
Completed
Phase 1, Phase 2
Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD) Start of enrollment: 2009 Sep 01
Withdrawn
Phase 1, Phase 2
Ultrasound and Endometrial Hyperplasia Start of enrollment: 2005 Apr 01
Terminated
Not Applicable
The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function Start of enrollment: 2001 Jun 01
Completed
Obesity and Weight Loss on Reproductive Function Start of enrollment: 2005 Jun 01
Terminated
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction Start of enrollment: 2005 Jun 01
Completed
Weight Loss and Cardiovascular Disease (CVD) Prevention Via a Whole Grain Diet in Men and Women With Metabolic Syndrome Start of enrollment: 2005 Aug 01
Completed
Not Applicable
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome Start of enrollment: 2005 May 01
Completed
Not Applicable
Continuous Administration of Oral Contraceptive, Primary Dysmenorrhea Start of enrollment: 2007 Aug 01
Completed
Phase 1, Phase 2
Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Start of enrollment: 2008 Sep 01
Completed
Phase 2
Pregnancy in Polycystic Ovary Syndrome II Start of enrollment: 2009 Feb 01
Completed
Phase 3
Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis Start of enrollment: 2010 May 01
Terminated
Phase 3
Registry of Pregnancies Conceived Following Exposure to Ovulation Stimulation Medications Start of enrollment: 2009 May 01
Completed
Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation Start of enrollment: 2010 Jun 01
Completed
Phase 3
A Trial of Intravenous Fluids During Labor Start of enrollment: 2010 Apr 01
Completed
Not Applicable
Reproductive Medicine Network Biologic Specimen Repository Start of enrollment: 2010 Sep 01
Completed
Metformin for the Treatment of Premature Pubarche in Girls Start of enrollment: 2011 May 01
Terminated
Not Applicable
Stress Reduction for Overweight or Obese Women Either With Polycystic Ovary Syndrome (PCOS) or Without PCOS (Non-PCOS) Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome Start of enrollment: 2012 Jul 06
Completed
Not Applicable
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Start of enrollment: 2014 Jul 25
Completed
Phase 3
Self-Monitoring of Carbon Monoxide to Enhance Reproductive Outcomes in Women Start of enrollment: 2014 Sep 01
Terminated
Not Applicable
Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Start of enrollment: 2019 Jan 11
Completed
Phase 4
Inositol Supplementation to Treat PCOS (INSUPP-PCOS) Start of enrollment: 2020 Jan 24
Recruiting
Phase 2
Novel Subtypes of Polycystic Ovary Syndrome Start of enrollment: 2021 Jan 01
Recruiting
Roles: Contact
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Publications & Presentations

PubMed

156 citations
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He
Plos Genetics. 2018-12-01
472 citations
Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome
Richard S. Legro, Deborah A. Driscoll, Jerome F. Strauss, Janis H. Fox, Andrea Dunaif
Proceedings of the National Academy of Sciences of the United States of America. 1998-12-08
125 citations
Functional genomics of PCOS: from GWAS to molecular mechanisms.
Jan M. McAllister, Richard S. Legro, Bhavi P. Modi, Jerome F. Strauss
Trends in Endocrinology and Metabolism. 2015-03-01

Journal Articles

Bidirectional Mendelian Randomization to Explore the Causal Relationships Between Body Mass Index and Polycystic Ovary Syndrome
R Azziz, R S Legro, Human Reproduction
Vitamin D Deficiency Is Associated with Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Suneeta Senapati, Nanette Santoro, Richard S Legro, Samantha F Butts, Andrew N Hoofnagle, The Journal of Clinical Endocrinology and Metabolism
Allostatic Load, a Measure of Chronic Physiological Stress, Is Associated with Pregnancy Outcomes, but Not Fertility, Among Women with Unexplained Infertility
Valerie Baker, Peter Casson, Nanette Santoro, Wendy Vitek, Richard S Legro, Randal Robinson, G Wright Bates, Christos Coutifaris, Karl Hansen, Ruben Alvero, Esther Eis..., Human Reproduction

Lectures

Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
Guided Posters: Reproductive Endocrinology
ENDO 2019 - New Orleans, LA - 3/25/2019
An International Initiative to Improve Outcomes in PCOS: Evidence-Based Guidelines and Multifaceted Translation
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/20/2018

Authored Content

Fertility-Related Quality of Life, Gonadal Function, and Erectile Dysfunction in Male Partners of Couples with Unexplained InfertilityMarch 2019
Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018
Transfer of Fresh Versus Frozen Embryos in Ovulatory WomenJanuary 2018

Press Mentions

Weight Loss May Not Aid Fertility Treatment in Obese WomenJanuary 27th, 2022
Weight Loss May Not Bring Fertility Benefits for Obese WomenJanuary 24th, 2022
Weight Loss May Not Affect Fertility Treatment SuccessJanuary 24th, 2022
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Grant Support

Treatment Of Hyperandrogenism Vs. Insulin Resistance In Infertile PCOS WomenEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2012
A Randomized Trial Of Letrozole VS Clomiphene In Infertile Women With PCOSEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2011
Treatment Of Hyperandrogenism VS Insulin Resistance In Infertile PCOS WomenNational Center For Research Resources2009
Pregnancy In Polycystic Ovary Syndrome IINational Center For Research Resources2009
Hyperandrogenism And Insulin Resistance In The Ontogeny Of PCOSNational Center For Research Resources2009
24hr Blood Pressure Monitoring In Patients At Risk For Hypertension In PregnancyNational Center For Research Resources2008–2009
Development Of A Screening Test For Endometrial Hyperplasia In An At Risk CohortNational Center For Research Resources2007–2009
Atorvastatin For Treatment Of PCOS Women With Elevated LDL CholesterolNational Center For Research Resources2007–2009
Continuous Glucose Monitoring In Pregnant Women With Polycystic Ovary SyndromeNational Center For Research Resources2005–2009
Genotyping Families Of Women With PCOSNational Center For Research Resources2004–2009
Phenotyping Kindreds Of Familial PCOSNational Center For Research Resources1997–2009
The Treatment Of Dysmenorrhea: Effects Of Sildenafil And Oral ContraceptivesFogarty International Center2006–2008
Racial Differences In Circulating Sex Steroids: Mechanisms And Effect On BoneNational Center For Research Resources2005–2008
Effect Of Lifestyle Intervention &Metformin In Polycystic Ovary SyndromeNational Center For Research Resources2005–2008
Meals Of Varying Fat &Fiber Content Effect On Postprandial Testosterone ConcNational Center For Research Resources2007
Effect Of Meals Of Varying Fat &Fiber Content On Postprandial TestosteroneNational Center For Research Resources2006–2007
Insulin Resistance Markers In ChildrenNational Center For Research Resources2004–2007
Effects Of Meals Of Varying Fat&Fiber Content On Postprandial Testosterone ConcNational Center For Research Resources2006
Trial Of Clomiphene Citrate, Metformin &Combined Clom/Metf In Infertility PCOSNational Center For Research Resources2005–2006
Effects Of Continuous Admin Of A Monophasic Oral Contraceptive On Bleeding DaysNational Center For Research Resources2005–2006
Insulin Resistance In Pcos--Sequelae And TreatmentEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2005
Trial Of Clomiphene Citrate/Metformin In PCOS InfertilitNational Center For Research Resources2004
Continuous Dose Of Oral Contracetive On Bleeding DaysNational Center For Research Resources2004
Atorvastatin Treatment Of PCOS Women With Ldl/CholesteroNational Center For Research Resources2004
Effect Of Continuous Vs. Sequential Oral ContraceptionEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2004
Cooperative Multicenter Reproductive Medicine NetworkEunice Kennedy Shriver National Institute Of Child Health &Human Development2000–2004
Exercise On Insulin Tolerance In Women With PCOSNational Center For Research Resources2000–2002
Phenotyping Kindrids Of Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Phenotype And Genotype In Familial Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genotyping Families Of Women With Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Assessing Safety/Efficacy Of Troglitazone In Pcos--Polycystic Ovary SyndromeNational Center For Research Resources1998–2002
Genetics Of Familial Polycystic Ovary SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–2000
Effects Of 3 Oral Contraceptives On Various Metabolic ParametersNational Center For Research Resources1998–1999
Bone Density In Women With Polycystic Ovary SyndromeNational Center For Research Resources1998–1999
Insulin Action In The Polycystic Ovary SyndromeNational Center For Research Resources1997–1999