RichardGGorlickMD

PubMed

• Lessons learned from 20 years of preclinical testing in pediatric cancers.
  Malcolm A Smith, Peter J Houghton, Richard B Lock, John M Maris, Richard Gorlick
  Pharmacology & Therapeutics. 2024-12-01
• Retraction: Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma.
  Valerie B Sampson, Nancy S Vetter, Wendong Zhang, Pratima U Patil, Robert W Mason
  Oncotarget. 2024-10-11
• Poverty, race, ethnicity, and survival in pediatric nonmetastatic osteosarcoma: a Children's Oncology Group report.
  Lenka Ilcisin, Ruxu Han, Mark Krailo, David S Shulman, Brent R Weil
  Journal of the National Cancer Institute. 2024-10-01

Journal Articles

• Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients with Osteosarcoma  
  Richard Gorlick, MD, JAMA Oncology
• Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program  
  Attiyeh EF, Maris JM, Lock R, Reynolds CP, Kang MH, Carol H, Gorlick R, Kolb EA, Keir ST, Wu J, Landesman Y, Shacham S, Lyalin D, Kurmasheva RT, Houghton PJ, Smith MA, Pediatr Blood Cancer, 1/1/2016
• Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma  
  Yang R, Piperdi S, Zhang Y, Zhu Z, Neophytou N, Hoang BH, Mason G, Geller D, Dorfman H, Meyers PA, Healey JH, Phinney DG, Gorlick R, Clin Orthop Relat Res, 1/1/2016
• A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells  
  Shin MH, He Y, Marrogi E, Piperdi S, Ren L, Khanna C, Gorlick R, Liu C, Huang J, PLoS Genet, 1/1/2016
• Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group  
  Morris CD, Teot LA, Bernstein ML, Marina N, Krailo MD, Villaluna D, Janeway KA, DuBois SG, Gorlick RG, Randall RL, J Surg Oncol, 1/1/2016
• Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program  
  Gorlick R, Kolb EA, Keir ST, Maris JM, Lock RB, Carol H, Reynolds CP, Kang MH, Billups CA, Collins J, Kurmashev D, Kurmasheva RT, Houghton PJ, Smith MA, Pediatr Blood Cancer, 1/1/2016
• Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma  
  Koirala P, Roth ME, Gill J, Piperdi S, Chinai JM, Geller DS, Hoang BH, Park A, Fremed MA, Zang X, Gorlick R, Sci Rep, 1/1/2016
• Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group  
  Vo KT, Edwards JV, Epling CL, Sinclair E, Hawkins DS, Grier HE, Janeway KA, Barnette P, McIlvaine E, Krailo MD, Barkauskas DA, Matthay KK, Womer RB, Gorlick RG, Lessni..., Clin Cancer Res, 1/1/2016
• HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival  
  Koirala P, Roth ME, Gill J, Chinai JM, Ewart MR, Piperdi S, Geller DS, Hoang BH, Fatakhova YV, Ghorpade M, Zang X, Gorlick R, Sci Rep, 1/1/2016
• Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Gr...  
  Lagmay JP, Krailo MD, Dang H, Kim A, Hawkins DS, Beaty O, Widemann BC, Zwerdling T, Bomgaars L, Langevin AM, Grier HE, Weigel B, Blaney SM, Gorlick R, Janeway KA, J Clin Oncol, 1/1/2016
• A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma  
  Anderson PM, Bielack SS, Gorlick RG, Skubitz K, Daw NC, Herzog CE, Monge OR, Lassaletta A, Boldrini E, P�pai Z, Rubino J, Pathiraja K, Hille DA, Ayers M, Yao SL, Neboz..., Pediatr Blood Cancer, 1/1/2016
• Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, in...  
  Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KL, Butterfass-Bahloul T, Calaminus G..., Lancet Oncol, 1/1/2016
• Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis  
  Murphy B, Yin H, Maris JM, Kolb EA, Gorlick R, Reynolds CP, Kang MH, Keir ST, Kurmasheva RT, Dvorchik I, Wu J, Billups CA, Boateng N, Smith MA, Lock RB, Houghton PJ, Cancer Res, 1/1/2016
• Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group  
  Daw NC, Laack NN, McIlvaine EJ, Krailo M, Womer RB, Granowetter L, Grier HE, Marina NM, Bernstein ML, Gebhardt MC, Marcus KJ, Advani SM, Healey JH, Letson GD, Gorlick ..., Ann Surg Oncol, 1/1/2016
• Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R)  
  Geller DS, Morris J, Revskaya E, Kahn M, Zhang W, Piperdi S, Park A, Koirala P, Guzik H, Hall C, Hoang B, Yang R, Roth M, Gill J, Gorlick R, Dadachova E, Nucl Med Biol, 1/1/2016
• Future directions in the treatment of osteosarcoma  
  Bishop MW, Janeway KA, Gorlick R, Curr Opin Pediatr, 1/1/2016
• Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Gro...  
  Bishop MW, Chang YC, Krailo MD, Meyers PA, Provisor AJ, Schwartz CL, Marina NM, Teot LA, Gebhardt MC, Gorlick R, Janeway KA, Chou AJ, Pediatr Blood Cancer, 1/1/2016
• A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma  
  Mirabello L, Koster R, Moriarity BS, Spector LG, Meltzer PS, Gary J, Machiela MJ, Pankratz N, Panagiotou OA, Largaespada D, Wang Z, Gastier-Foster JM, Gorlick R, Khann..., Cancer Discov, 1/1/2015
• EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment  
  Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, B�hling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Erik..., Ann Oncol, 1/1/2015
• Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program  
  Smith MA, Reynolds CP, Kang MH, Kolb EA, Gorlick R, Carol H, Lock RB, Keir ST, Maris JM, Billups CA, Lyalin D, Kurmasheva RT, Houghton PJ, Clin Cancer Res, 1/1/2015
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis  
  Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano ..., Nat Genet, 1/1/2015
• Germline TP53 variants and susceptibility to osteosarcoma  
  Mirabello L, Yeager M, Mai PL, Gastier-Foster JM, Gorlick R, Khanna C, Pati�o-Garcia A, Sierrases�maga L, Lecanda F, Andrulis IL, Wunder JS, Gokgoz N, Barkauskas DA, Z..., J Natl Cancer Inst, 1/1/2015
• Initial testing (stage 1) of the tubulin binding agent nanoparticle albumin-bound (nab) paclitaxel (Abraxane(�)) by the Pediatric Preclinical Testing Program (PPTP)  
  Houghton PJ, Kurmasheva RT, Kolb EA, Gorlick R, Maris JM, Wu J, Tong Z, Arnold MA, Chatterjee M, Williams TM, Smith MA, Pediatr Blood Cancer, 1/1/2015
• Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and G...  
  Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, P�pai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Lets..., J Clin Oncol, 1/1/2015
• Initial testing (stage 1) of the anti-microtubule agents cabazitaxel and docetaxel, by the pediatric preclinical testing program  
  Reynolds CP, Kang MH, Maris JM, Kolb EA, Gorlick R, Wu J, Kurmasheva RT, Houghton PJ, Smith MA, Pediatr Blood Cancer, 1/1/2015
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Books/Book Chapters

• Principles and Practice of Pediatric Oncology 
  Chapter: Osteosarcoma: Biology, Diagnosis, Treatment and Remaining Challenge 
  Gorlick R, Bielack S, Teot L, Meyer J, Randall L, Marina NEditors: Pizzo P, Poplack D.Lippincott, Philadelphia, PA2011
• Manual of Pediatric Hematology and Oncology 
  Chapter: Malignant Bone Tumors 
  Dubois S, Janeway K, Gorlick R, Marina NEditors: Lanzkowsky P.Elsevier, Burlington, MAEdition 5th,2011
• Rudolph's Pediatrics 
  Chapter: Osteosarcoma 
  Gorlick R, Meyers PEditors: Rudolph AM, Rudolph C, First L, Lister G, Gershon AA.McGraw-Hill, New York, NYEdition 22nd,2011
• Pediatric Hematology and Oncology 
  Chapter: Bone Tumours 
  Gorlick R, Persioglou M, Whelan JEditors: Estlin E, Gilbertson R, Wynn R.Wiley-Blackwell, Hoboken, NJ2010
• Molecularly Targeted Therapy for Childhood Cancer 
  Chapter: Molecularly Targeted Therapy in Osteosarcoma 
  Ricafort R, Gorlick REditors: Arceci R, Houghton PJ.Springer, New York, NY2010
• Cancer in Children and Adolescents 
  Chapter: Cancer in Children and Adolescents 
  Marina N, Gorlick R, Bielack SEditors: Carroll WL , Finlay JL.Jones & Bartlett, Sudburry, MA2010
• Pediatric and Adolescent Osteosarcoma 
  Chapter: Current Concepts on the Molecular Biology of Osteosarcoma 
  Gorlick REditors: Jaffe N, Bruland OS, Bielack S.Springer, New York, NY2009
• American Academy of Pediatrics Textbook of Pediatric Care 
  Chapter: Leukemias 
  Kolb EA, Gorlick REditors: McInerny TK, Adam HM, Campbell DE, Kamat DK, Kelleher KJ.American Academy of Pediatrics, Elk Grove Village, IL2009
• Nathan and Oski's Oncology of Infancy and Childhood 
  Chapter: Osteosarcoma 
  Janeway K, Gorlick R, Bernstein MLEditors: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG.Saunders-Elsevier, Philadelphia, PA2009
• Cancer Medicine 
  Chapter: Bone Tumors 
  Gorlick R, Toretsky J, Marina N, Wolden S, Randall RL, Gebhardt M, Teot L, Bernstein MEditors: Holland J, Frei E.BC Decker, Hamilton, OntarioEdition 6th,2003
• Encyclopedia of Cancer 
  Chapter: Bone Tumors 
  Gorlick R, Meyers PAEditors: Bertino JR.Academic Press, San Diego, CAEdition 2nd,2002
• Orthopedic Knowledge Update: Musculoskeletal Tumors 
  Chapter: General Principles of Chemotherapy 
  Meyers PA, Gorlick REditors: Menendez LR.American Academy of Orthopaedic Surgeons, Rosemont, IL2002
• Methotrexate 
  Chapter: Methotrexate, its mechanism of action in malignant disease and mechanisms of resistance by malignant cells 
  Gorlick REditors: Cronstein BN, Bertino JR.Birkh�user Verlag, Basel, Switzerland2000
• Antifolate drugs: Basic research and clinical practice 
  Chapter: Clinical pharmacology and resistance to dihyrdrofolate reductase inhibitors 
  Gorlick R, Bertino JREditors: Jackman AL.The Humana Press, Totowa, NJ1999
• Drug resistance in the treatment of cancer 
  Chapter: Resistance mechanisms to antimetabolites 
  Goker E, Gorlick R, Bertino JREditors: Pinedo H, Giaccone G.Cambridge University Press, Cambridge1998
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Lectures

• Moving beyond the plateau of outcomes in sarcoma, Current Knowledge and Future Directions in the Treatment of Bone Sarcomas, Focusing on Clinical Trials and Surgical a... 
  Shanghai, China - 1/30/2016
• Beyond the plateau � Scaling new peaks in treating sarcomas! 
  Mumbai, India - 1/14/2015
• Osteosarcoma: Biology and Laboratory Approaches to Identifying New Therapy 
  Tata Memorial Hosptial, Mumbai, India - 1/12/2015
• Osteosarcoma: Children's Oncology Group Clinical Trials 
  New York, NY - 1/3/2015
• Advances in Pediatric Bone Tumors: Osteosarcoma and Ewing Sarcoma 
  New York, NM - 1/2/2015
• Osteosarcoma: Current Status and Potential Routes to Progress 
  Columbia University, New York, NY - 1/28/2014
• Children's Oncology Group Osteosarcoma Phase 2 Clinical Trials 
  Berlin, Germany - 1/16/2014
• Molecular Pathogenesis of Osteosarcoma 
  Bronx, NY - 1/2/2014
• Osteosarcoma: Progress and Vision for Osteosarcoma Therapy 
  St. Jude Children's Cancer Research Hospital, Memphis, TN - 1/13/2013
• Clinical translation in Ewing sarcoma 
  Madrid, Spain - 1/9/2013
• Osteosarcoma: Challenges for Future Progress 
  Texas Children's Hospital, Baylor University, Houston, TX - 1/8/2012
• Pediatric Oncologic Emergencies 
  Jacobi Medical Center and North Central Bronx Hospital, Bronx, NY - 1/6/2012
• Osteosarcoma: Its Biology Needs to Guide its Treatment 
  University Of Medicine And Dentistry Of New Jersey, Robert Wood Johnson Medical School, New Brunswic - 1/17/2011
• Osteosarcoma: Its Biology Needs to Define its New Treatment 
  The Albert Einstein College of Medicine Price Center, LeFrak Auditorium, Bronx, NY - 1/16/2011
• Osteosarcoma: Progress in Biological Understanding and Treatment 
  Stanford University, Stanford, CA - 1/14/2011
• Osteosarcoma: Clinical Trials 
  New York, NY - 1/8/2011
• Recognizing and Treating Bone Tumors 
  Jacobi Medical Center and North Central Bronx Hospital, Bronx, NY - 1/8/2011
• Osteosarcoma: Biology and Therapy 
  The University of Texas MD�Anderson Cancer Center, Children's Cancer Hospital, Houston, TX - 1/8/2010
• Signaling in Pediatric Cancer Comes to the Clinic 
  Chicago, IL - 1/5/2010
• Osteosarcoma: Its Biology Needs to Define New Treatment 
  Georgetown University Hospital and Lombardi Comprehensive Cancer Center, Georgetown, DC - 1/5/2010
• Issues in Understanding the Molecular Biology and Improving Clinical Outcomes of Osteosarcoma 
  The Animal Medical Center, New York, NY - 1/29/2009
• Osteosarcoma: Biology Needs to Define New Therapies 
  Yokohama, Japan - 1/17/2009
• Current Concepts on the Molecular Biology of Osteosarcoma 
  Stuttgart, Germany - 1/14/2009
• Issues in Designing Clinical Studies of the IGF1 Receptor 
  Chicago, IL - 1/30/2008
• Concepts on the Molecular Biology, Drug Resistance and New Therapeutics in Osteosarcoma and New Directions in Osteosarcoma Chemotherapy 
  Seoul, Korea - 1/20/2008
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