RichardEugeneFryeMD

Child Neurology • Phoenix, AZ

Neurodevelopmental Disabilities

Professor, Child Health, University of Arizona COM

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Office
1919 E Thomas Rd
Phoenix, AZ 85016
Phone+1 602-933-0970

Fax+1 602-933-4253

Education & Training

Boston Children’s Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Child Neurology, 2000 - 2003
University of Miami/Jackson Health SystemResidency, Pediatrics, 1998 - 2000
Georgetown University School of MedicineClass of 1998

Certifications & Licensure

AZ State Medical License 2017 - 2025
CA State Medical License 2023 - 2025
FL State Medical License 2005 - 2025
KY State Medical License 2018 - 2019
AR State Medical License 2011 - 2018
TX State Medical License 2007 - 2017
MA State Medical License 2003 - 2005
American Board of Pediatrics Pediatrics
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Clinical Trials

Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders Start of enrollment: 2010 Jul 01
Completed
Not Applicable
A Folinic Acid Intervention for Autism Spectrum Disorders Start of enrollment: 2012 May 01
Terminated
Phase 2
Mitochondrial Dysfunction in Phelan-McDermid Syndrome Start of enrollment: 2012 May 01
Completed
Mitochondrial Dysfunction in Autism Spectrum Disorder Start of enrollment: 2012 Oct 16
Active, not recruiting
Etiology and Early Diagnosis of Neurodevelopmental Disorders Start of enrollment: 2012 May 01
Active, not recruiting
Efficacy and Safety of Trichuris Suis Ova (TSO) as Compared to Placebo in Autism Spectrum Disorder Start of enrollment: 2014 May 01
Terminated
Phase 2
An Exploratory Open Label Study of EPI-743 (Vincerinone TM) in Children With Autism Spectrum Disorder Start of enrollment: 2014 Oct 31
Withdrawn
Phase 2
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder Start of enrollment: 2020 Feb 01
Active, not recruiting
Phase 2
High-Frequency Transdermal Neuromodulation to Decrease Anxiety and Improve Sleep in ASD Start of enrollment: 2019 May 21
Completed
Not Applicable
Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium Start of enrollment: 2020 Sep 22
Recruiting
Phase 2
Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism Start of enrollment: 2020 Oct 08
Recruiting
Phase 2
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders Start of enrollment: 2024 Jul 01
Not yet recruiting
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

125 citations
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.
Shannon Rose, Sirish C. Bennuri, Jakeira E. Davis, Rebecca Wynne, John Slattery
Translational Psychiatry. 2018-02-02
564 citations
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Daniel A. Rossignol, Richard E. Frye
Molecular Psychiatry. 2012-03-01
164 citations
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder
Richard E. Frye, Stepan Melnyk, Derrick F. MacFabe
Translational Psychiatry. 2013-01-22

Press Mentions

Stealth’s Phase III Elamipretide in Mitochondrial Myopathy Has Experts Wary While FDA Approval DebatedJune 17th, 2019
Phoenix Children’s Earns $1 Million in Grants for Autism ResearchJanuary 12th, 2019
Neurologist Andrew Zimmerman Fired by DOJ for Change of OpinionJanuary 9th, 2019
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Grant Support

Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2006–2009
Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2005