RichardJohnBucalaMDPhD

Summary

• Richard Bucala, MD, PhD, is Chief, Section of Rheumatology, Allergy & Immunology and the Waldemar Von Zedtwitz Endowed Professor of Medicine, Pathology, and Epidemiology & Public Health. He studies the regulation of the immune system with a focus on how protective responses can lead to immunopathology and disease. His laboratory’s main emphasis is MIF-family cytokines, their role in genetic susceptibility to disease, and their therapeutic targeting for different clinical conditions. The Bucala group is credited with the molecular cloning of MIF and discovery of its critical role in regulating glucocorticoid immunosuppression, which opened novel approaches to therapy in autoimmune inflammatory conditions. His lab also identified the MIF receptor and discovered common polymorphisms in the MIF gene, which show global population stratification. Depending on the nature of the immune or invasive provocation, variant MIF alleles protect from disease or contribute to immunopathology in autoimmunity and in different infections and chronic conditions. His laboratory developed biochips for application to genetic epidemiology studies of malaria and tuberculosis in resource-limited settings and his research is leading efforts to develop MIF-based therapies tailored to an individual’s genetic makeup. The laboratory has developed new therapies such as the anti-MIF antibody (Imalumab) and contributed to the FDA-approved anti-MIF receptor antibody (Milatuzumab). Research partnerships in structure-based drug design have led to novel small molecule MIF modulators for use in autoimmune, oncologic, and infectious diseases. The function of the MIF-like genes expressed by the parasites responsible for malaria, leishmaniasis, and helminthic infection also are under investigation. As these proteins were discovered to uniquely suppress immunologic memory, they offer new targets for vaccination against these infections.