ReisaAnneSperlingMD

Director, Center for Alzheimer's Research and Treatment & Co-Director, Neuroimaging Core, Massachusetts Alzheimer's Disease Research Center & Professor of Neurology, Harvard Medical School

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Office
75 Francis St
Brigham & Women's Hospital
Boston, MA 02115
Phone+1 617-732-8060

Fax+1 617-264-5212

Education & Training

Beth Israel Deaconess Medical Center/Harvard Medical SchoolResidency, Neurology, 1992 - 1995
Brigham and Women's HospitalInternship, Internal Medicine, 1991 - 1992
Harvard Medical SchoolClass of 1991

Certifications & Licensure

MA State Medical License 1995 - 2026

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Dominantly Inherited Alzheimer Network (DIAN) Start of enrollment: 2009 Jan 01
Recruiting
Implications of Amyloid Pathology Start of enrollment: 2008 Nov 01
Unknown status
Evolution of Memory Related Activity Start of enrollment: 2006 May 01
Unknown status
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study Start of enrollment: 2015 Sep 08
Completed
18F-AV-1451 PET Imaging in Participants Enrolled in the LEARN Study Start of enrollment: 2016 Aug 01
Completed
Phase 1
Alzheimer Prevention Trials (APT) Webstudy Start of enrollment: 2017 Dec 20
Recruiting
TRC-PAD Program: In-Clinic Trial-Ready Cohort Start of enrollment: 2019 Jun 04
Active, not recruiting
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Publications & Presentations

PubMed

Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer's disease.
Colin Birkenbihl, Madison Cuppels, Rory T Boyle, Hannah M Klinger, Oliver Langford
Brain Informatics. 2025-01-27
Depressive Symptoms and Amyloid Pathology.
Wietse A Wiels, Julie E Oomens, Sebastiaan Engelborghs, Chris Baeken, Christine A F von Arnim
JAMA Psychiatry. 2025-01-22
Identifying cognitive test scores associated with early tau burden in Alzheimer's disease.
Caitlin M Terao, Madeline Wood Alexander, R Philip Chalmers, Silina Z Boshmaf, Jane Paterson
Alzheimer's & Dementia. 2025-01-14

Journal Articles

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease
Reisa Sperling, Michael S Rafii, Gary Romano, JAMA Neurology
Short-Term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment
Jeffrey M Burns, Keith A Johnson, Reisa A Sperling, Jason Karlawish, JAMA Neurology
Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease
Hyun-Sik Yang, Reisa Sperling, Matthew Schrag, Richard Mayeux, JAMA Neurology
Association of Factors with Elevated Amyloid Burden in Clinically Normal Older Individuals
Reisa A Sperling, Eric Siemers, Keith A Johnson, JAMA Neurology
Nonlinear Distributional Mapping (NoDiM) for Harmonization Across Amyloid-PET Radiotracers☆
Jasmeer P Chhatwal, Reisa A Sperling, Keith A Johnson, ScienceDirect
Dissecting the Genetic Relationship Between Cardiovascular Risk Factors and Alzheimer’s Disease
Christine M Glastonbury, Fanny M Elahi, Reisa A Sperling, William P Dillon, Lindsay A Farrer, Rahul S Desikan, Christopher P Hess, James B Brewer, Bradley T Hyman, Kri..., Acta Neuropathologica
Neurogenetic Contributions to Amyloid Beta and Tau Spreading in the Human Cortex
Reisa A Sperling, Keith A Johnson, Nature
Dedifferentiation of Caudate Functional Connectivity and Striatal Dopamine Transporter Density Predict Memory Change in Normal Aging
Reisa A Sperling, Keith A Johnson, Proceedings of the National Academy of Sciences
Anticholinergic Amnesia Is Mediated by Alterations in Human Network Connectivity Architecture
Reisa A Sperling, Brendon P Boot, Keith A Johnson, Dorene Rentz, Jasmeer P Chhatwal, Cerebral Cortex
Association of Anxiety with Subcortical Amyloidosis in Cognitively Normal Older Adults
Reisa A Sperling, Nancy J Donovan, Keith A Johnson, Dorene M Rentz, Nature
Age-Related Increases in Tip-of-the-Tongue Are Distinct from Decreases in Remembering Names: A Functional MRI Study
Dorene M Rentz, Reisa A Sperling, Kathryn V Papp, Cerebral Cortex
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Authored Content

Short-Term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive ImpairmentAugust 2020
Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer DiseaseJune 2020
Association of Factors with Elevated Amyloid Burden in Clinically Normal Older IndividualsApril 2020
Sex, Amyloid, and APOE ε4 and Risk of Cognitive Decline in Preclinical Alzheimer's Disease: Findings from Three Well-Characterized CohortsMay 2018
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Press Mentions

Experts Challenge New Diagnostic Criteria for Alzheimer’s DiseaseNovember 6th, 2024
Experts Challenge New Diagnostic Criteria for Alzheimer’sNovember 6th, 2024
Depressive Symptoms Associated with Amyloid Accumulation Early in Alzheimer’s Disease, Even Before Cognitive Changes Are ApparentOctober 29th, 2024
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Grant Support

Evolution Of Memory Related FMRI Activation Over The Course Of MCI And ADNational Institute On Aging2012
Implications Of Amyloid Deposition In Clinically Normal Older IndividualsNational Institute On Aging2009–2012
Mentoring Imaging Research In Early ADNational Institute On Aging2010–2011
Impact Of Amyloid On The Aging BrainNational Institute On Aging2010–2011
Evolution Of Memory-Related FMRI Activation Over The Course Of MCI And ADNational Institute On Aging2006–2010
Alzheimer'S Disease Neuroimaging Initiative (ADNI)National Center For Research Resources2007–2008
Trial Of Simvastatin To Slow The Progression Of Alzheimer'S DiseaseNational Center For Research Resources2005–2008
Trial Of Simvastation To Slow The Progression Of Alzheimer'S DiseaseNational Center For Research Resources2006
Reducing Homocysteine To Slow Cognitive Decline In Alzheimer'S DiseaseNational Center For Research Resources2006
Reducing Homocysteine To Slow Cognitive Decline In Alzheimer'SNational Center For Research Resources2005
Assessment Measures For Alzheimer'S Disease: Primary Prevention TrialsNational Center For Research Resources2005
Trial Of Simvastatin To Slow Progression Of Alzheimer'SNational Center For Research Resources2004
Efficacy And Safety Of Ly451395 In Probable Alzheimer'SNational Center For Research Resources2004
Face-Name Association: FMRI Studies In Aging &Mild ADNational Institute Of Neurological Disorders And Stroke2000–2004
Functional Magnetic Resonance Imaging (FMRI)National Institute On Aging2002