RaymondLComenzoMD

Oncology • Boston, MA

Hematologic Oncology

Lecturer, Pathology, Tufts Medical Center

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Office
800 Washington St
Boston, MA 02111
Phone+1 617-636-5000

Education & Training

Tufts Medical CenterFellowship, Hematology and Medical Oncology, 1989 - 1992
Boston University Medical CenterResidency, Internal Medicine, 1986 - 1989
Boston University School of MedicineClass of 1986

Certifications & Licensure

MA State Medical License 1988 - 2025
NY State Medical License 1998 - 2010
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Pathology Blood Banking/Transfusion Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
Boston Magazine Castle Connolly, 2009-2013
America's Top Doctors for Cancer Castle Connolly, 2009-2013
Super Doctor SuperDoctors.com
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Clinical Trials

Thalidomide, Doxorubicin, and Dexamethasone in Treating Patients With Untreated Stage II or Stage III Multiple Myeloma Start of enrollment: 2000 Aug 01
Completed
Phase 2
Melphalan and Filgrastim to Stimulate Peripheral Stem Cells in Patients With Multiple Myeloma Start of enrollment: 2000 Aug 01
Completed
Phase 2
Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102) Start of enrollment: 2003 Dec 01
Completed
Phase 3
Melphalan, Thalidomide, and Dexamethasone in Treating Patients With Newly Diagnosed, Previously Untreated Primary Systemic Amyloidosis Start of enrollment: 2002 May 01
Completed
Phase 2
Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis Start of enrollment: 2010 Nov 01
Completed
Phase 3
Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis Start of enrollment: 2013 Jan 01
Completed
Phase 2
Phase 1/2, Open Label, Dose Escalation Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2013 Apr 01
Completed
Phase 1, Phase 2
A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis Start of enrollment: 2013 Feb 01
Completed
Phase 1
Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL Amyloidosis Start of enrollment: 2015 Aug 01
Completed
The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2016 Mar 01
Completed
Phase 2
Trial of Venetoclax (ABT-199) and Dexamethasone for Relapsed or Refractory Systemic AL Amyloidosis Start of enrollment: 2017 Jan 01
Terminated
Phase 1
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Publications & Presentations

PubMed

Gene Expression Sets and Renal Profiling from the Renal AL Amyloid Involvement and NEOD00 (RAIN) Trial.
Cindy Varga, Felix Eichinger, Viji Nair, Abhijit S Naik, Samih H Nasr
Kidney International Reports. 2024-09-01
Renal Response Criteria for Clinical Trials in Amyloid Light Chain Amyloidosis.
Nelson Leung, Raymond Comenzo, Julian Gillmore, Andrea Havasi, Efstathios Kastritis
Kidney International Reports. 2024-07-01
26 citations
Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial.
Morie A Gertz, Adam D Cohen, Raymond L Comenzo, Efstathios Kastritis, Heather J Landau
Blood. 2023-10-05

Abstracts/Posters

In Systemic Light-Chain Amyloidosis Complete and Very Good Partial Responses Are Not Enough: Involved Free Light Chain (iFLC) Levels < 10mg/L Are Associated with Optim...
Raymond L Comenzo, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
B-Cell Maturation Antigen (BCMA) in Systemic Light-Chain Amyloidosis (AL): Association with Disease Activity and Its Modulation with Gamma-Secretase Inhibition
Raymond L Comenzo, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Primary Results from the Phase 3 Tourmaline-AL1 Trial of Ixazomib-Dexamethasone Versus PhysicianÍs Choice of Therapy in Patients (Pts) with Relapsed/Refractory Primary...
Raymond L Comenzo, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Results of the Phase 3 VITAL Study of NEOD001 (Birtamimab) Plus Standard of Care in Patients with Light Chain (AL) Amyloidosis Suggest Survival Benefit for Mayo Stage ...
Raymond L Comenzo, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

Untangling Amyloidosis 2019
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Seeking AL Amyloidosis Very Early: The SAVE Trial - Identifying Clonal Lambda Light Chain Genes in Patients with MGUS or Smoldering Multiple Myeloma
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

What Is Causing the National Blood Shortage?March 4th, 2022
What Doctors Want You to Know About the Potential Link Between COVID-19 and Blood TypeJune 24th, 2020
Experimental Drug Shows Promise for Rare Genetic Disorder – WebMDFebruary 11th, 2019