RayPeeblesMD

PubMed

• 3 citations
  The emerging role of IL-23 in asthma and its clinical implications.
  Ashley Y Wu, R Stokes Peebles
  Expert Review of Clinical Immunology. 2023-01-01
• 2 citations
  Airway Mucus Dysfunction in COVID-19.
  Burton F Dickey, Jichao Chen, R Stokes Peebles
  American Journal of Respiratory and Critical Care Medicine. 2022-12-01
• 25 citations
  Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2.
  Mariana F Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu
  NPJ Vaccines. 2022-07-29

Journal Articles

• The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography  
  Ke, Z., Dillard, R.S., Chirkova, T., Leon, F., Stobart, C.C., Hampton, C.M., Strauss, J.D., Rajan, D., Rostad, C.A., Taylor, J.V., Yi, H., Shah, R., Jin, M., Hartert, ..., Viruses, 1/20/2018
• Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation  
  Fuseini, H., Yung, J.A., Cephus, J.Y., Zhang, J., Goleniewska, K., Polosukhin, V.V., Peebles, R.S. Jr, Newcomb, D.C., J. Immunol., 1/20/2018
• The PGI2�Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+�T Cells  
  Zhou, W., Zhang, J., Toki, S., Goleniewska, K., Johnson, M.O., Bloodworth, M.H., Newcomb, D.C., Peebles, R.S. Jr., J. Immunol., 1/20/2018
• Nasopharyngeal Lactobacillus is Associated with Childhood Wheezing Illnesses Following Acute Respiratory Syncytial Virus Infection in Infancy  
  Rosas-Salazar, C., Shilts, M.H., Tovchigrechko, A., Schobel, S., Chappell, J.D., Larkin, E.K., Gebretsadik, T., Halpin, R.A., Nelson, K.E., Moore, M.L., Anderson, L.J...., J. Allergy Clin. Immunol., 1/9/2018
• Infant Viral Respiratory Infection Nasal-Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze  
  Turi, K.N., Shankar, J., Anderson, L.J., Rajan, D., Gaston, K., Gebretsadik, T., Das, S.R., Stone, C., Larkin, E.K., Rosas-Salazar, C., Brunwasser, S.M., Moore, M.L.,�..., Am. J. Respir. Crit. Care Med., 1/7/2018
• Prostaglandins in asthma and allergic diseases  
  Peebles, R.S. Jr., Pharmacol. Ther., 1/3/2018
• -33 promotes the egress of group 2 innate lymphoid cells from the bone marrow  
  Stier, M.T., Zhang, J. Goleniewska, K., Cephus, J.Y., Rusznak, M., Wu, L. Van Kaer, L., Zhou, B., Newcomb, D.C., Peebles, R.S. Jr., J. Exp. Med., 1/1/2018
• Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell (ILC2) cytokine production in vivo  
  Toki, S., Goleniewska, K., Reiss, S., Zhang, J., Bloodworth, M.H., Stier, M.T., Zhou, W., Newcomb, D.C., Ware, L.B., Stanwood, G.D., Galli, A., Boyd, K.L., Niswender, ..., J. Allergy Clin. Immunol., 1/1/2018
• Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model  
  Toki, S., Zhou, W., Goleniewska, K., Reiss, S., Dulek, D.E., Newcomb, D.C., Lawson, W.E., Peebles, R.S. Jr., Prostaglandins Other Lipid Mediat, 1/1/2018
• Association of ST2 polymorphisms with atopy, asthma, and leukemia  
  Bloodworth, M.H., Rusznak, M., Bastarache, L., Wang, J., Denny, J.C., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2018
• Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology  
  Bloodworth, M.H., Rusznak, M., Pfister, C.C., Zhang, J., Bastarache, L., Calvillo, S.A., Chappell, J.D., Boyd, K.L., Toki, S., Newcomb, D.C., Stier, M.T., Zhou, W., Go..., J. Allergy Clin. Immunol., 1/1/2018
• Mouse Models of Viral Infection  
  Empey, K.M., Peebles, R.S. Jr, Janssen, W.J., Methods Mol. Biol., 1/1/2018
• A signaling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach  
  Petersen, C.P., Meyer, A.R., DeSalvo, C., Choi, E. Schlegel, C., Petersen, A., Engevik, A.C., Prasad, N., Levy, S.E., Peebles, R.S., Pizarro, T.T., Goldenring, J.R., Gut, 1/24/2017
• Anaphylaxis after zoster vaccine: implicating alpha-gal allergy as a possible mechanism  
  Stone, C.A., Hemler, J.A., Commins, S.P., Schuyler, A.J., Phillips, E.J., Peebles, R.S. Jr., Fahrenholz, J.M., J. Allergy Clin. Immunol., 1/1/2017
• STAT1 repressed cytokine producing group 2 and group 3 innate lymphoid cells during viral infection  
  Stier, M.T., Goleniewska, K., Cephus, J.Y., Newcomb, D.C., Sherrill T.P., Boyd, K.L., Bloodworth, M.H., Moore, M.L., Chen, K., Kolls, J.K., Peebles, R.S. Jr., J. Immunol., 1/1/2017
• Dietary manganese promotes Staphylococcal infection of the heart  
  Juttukonda, L.J., Berends, E.T.M., Zackular, J.P., Moore, J.L., Stier, M.T., Zhang, Y., Schmitz, J.E., Beavers, W.N., Wijers, C.D., Gilston, B.A., Kehl-Fie, T.E., Atki..., Cell Host Microbe, 1/1/2017
• Testosterone attenuates group 2 innate lymphoid cell-mediated airway inflammation  
  Cephus, J.Y., Stier, M.T., Fuseini, H., Yung, J.A., Toki, S., Bloodworth, M.H., Zhou, W., Goleniewska, K., Zhang, J., Garon, S.L., Hamilton, R.G., Poloshukin, V.V., Bo..., Cell Rep, 1/1/2017
• Is IL-1Beta inhibition the next therapeutic target in asthma?  
  Peebles, R.S. Jr., J Allergy Clin Immunol, 1/1/2017
• Advances in mechanisms of allergic diseases  
  Rothenberg, M.E., Saito, H., Peebles, R.S. Jr., J Allergy Clin Immunol, 1/1/2017
• Innate lymphoid cells and allergic disease  
  Stier, M.T., Peebles, R.S. Jr., Ann. Allergy Asthma Immunol., 1/1/2017
• Minimally invasive sampling method identifies differences in taxonomic richness of nasal microbiomes in young infants associated with mode of delivery  
  Shilts, M.H., Rosas-Salazar, C., Tovchigrechko, A., Larkin, E.K., Torralba, M., Akopov, A., Halpin, R., Peebles, R.S., Moore, M.L., Anderson, L.J., Nelson, K.E., Harte..., Microb. Ecol., 1/1/2016
• Prostaglandin I2 signaling and inhibition of group 2 innate lymphoid cell responses  
  Zhou, W., Toki, S., Zhang, J., Goleniewksa, K., Newcomb, D.C., Cephus, J.Y., Dulek, D.E., Bloodworth, M.H., Stier, M.T., Polosuhkin, V., Gangula, R.D., Mallal, S.A., B..., Am. J. Respir. Crit. Care Med., 1/1/2016
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  Bloodworth, M.H., Newcomb, D.C., Dulek, D.E., Stier, M.T., Cephus, J.Y., Zhang, J., Goleniewska, K., Kolls, J.K., Peebles, R.S. Jr., Infect. Immun., 1/1/2016
• The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation  
  Toki, S., Goleniewska, K., Reiss, S., Zhou, W., Newcomb, D.C., Bloodworth, M.H., Stier, M.T., Boyd, K.L., Polosukhin, V.V., Subramaniam, S., Peebles, R.S. Jr., Thorax, 1/1/2016
• EGFR Interacts with the fusion protein of Respiratory Syncytial Virus strain 2-20 and mediates infection and mucin expression  
  Currier, M.G., Lee, S., Stobart, C.C., Hotard, A.L., Villenave, R., Meng, J., Pretto, C.D., Shields, M.D., Nguyen, M.T., Todd, S.O., Chi, M.H., Hammonds, J., Krumm, S...., PLoS Pathog, 1/1/2016
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Books/Book Chapters

• Manual of Molecular and Clinical Laboratory Immunology 
  Chapter: Assay methods for measurement of mediators and markers of allergic inflammation 
  Page 801 - 814Schroeder, J.T., Peebles, R.S. Jr., Guerrerio, P.A.Editors: B. Detrick, J.L. Schmitz, R.G. Hamilton.American Society for Microbiology PressEdition 8th,2016
• Allergy 
  Chapter: Principles of allergy diagnosis 
  Page 129 - 146Peebles, R.S., Church, M.K., Durham, S.R.Editors: S.T. Holgate, M.K. Church, D.H. Broide, F.D. Martinez.ElsevierEdition 4th,2012
• Translational Science: from Basic to Clinical Immunology and Allergy [proceedings of the 28th symposium of the Collegium Internationale Allergologicum (CIA)]. 
  Chapter: 13 inhibits IL-17A and IL-22 produced by polarized human Th17 cells 
  Page 173 - 177Newcomb, D.C., Peebles, R.S.Editors: G. Marone, M. Triggiani, A. Genovese.Pacini Editore S.p.A., Pisa, Italy2012
• Allergens and Respiratory Pollutants: The Role of Innate Immunity 
  Chapter: The intersection of Respiratory Syncytial Virus infection, innate immunity and allergic lung disease 
  Page 229 - 239Chi, M.H., Moore, M.L., Peebles, R.S. Jr.Editors: M.A.Williams.Biohealthcare Publishing, Ltd., Oxford, United Kingdom2011
• Lung Biology in Health and Disease 
  Chapter: Overview of the infection, allergy and asthma relationship. Asthma Infections. R.J. Martin and E.R Sutherland, editors 
  Page 1 - 16Newcomb, D.C., Peebles, R.S. Jr.Editors: C. Lenfant.Informa Healthcare2010
• Middleton�s Allergy: Principles and Practice 
  Chapter: Lipid mediators of hypersensitivity and inflammation 
  Page 203 - 221Peebles, R.S. Jr., Boyce, J.A.Editors: N.F. Adkinson, Jr., B.S. Bochner, W.W. Busse, S.T. Holgate, R.F. Lemanske, Jr., and F.E.R. Simons.Mosby2009
• COX-2 Inhibitors 
  Chapter: Effects on the lungs: role of COX-2 inhibitors 
  Peebles, R.S. Jr., Hashimoto, K.Editors: M. Pairet, J. van Ryn.Birkheuser Verlag, Switzerland2004
• New Perspectives in the Monitoring of Lung Inflammation: Analysis of Exhaled Breath Condensate 
  Chapter: The role of leukotrienes and prostanoids in airway inflammation 
  Page 149 - 165Dworski, R., Peebles, R.S. Jr., Sheller, J.R.Editors: P. Montuschi.CRC Press, Boca Raton, FL2004
• Manual of Clinical Laboratory Immunology 
  Chapter: In vivo diagnostic allergy testing methods 
  Norman, P.S., Peebles, R.S.Editors: N.R. Rose, R.G. Hamilton, B. Detrick.American Society for Microbiology PressEdition 5th,1997
• Allergy and Allergic Diseases 
  Chapter: Late-phase reactions in the nose 
  Page 1139 - 1160Peebles, R.S., Togias, A.Editors: A.B. Kay.Blackwell Science, Ltd., Victoria, Austral1997
• Current Therapy of Infectious Disease 
  Chapter: Hypersensitivity to antibiotics 
  Page 617 - 621Peebles, R.S., Adkinson, N.F.Editors: D. Schlossberg.Mosby-Year Book, St. Louis, MO1996
• Human Basophils and Mast Cells: Clinical Aspects 
  Chapter: Role of mast cells and basophils in rhinitis 
  Page 60 - 83Peebles, R.S., Togias, A.G.Editors: G. Marone.Karger, Basel1995
• Inflammation: Mediators and Pathways 
  Chapter: Pharmacologic regulation of adhesion molecule function and expression 
  Page 29 - 96Peebles, R.S., Bochner, B.S., Schleimer, R.P.Editors: Ruffolo Jr., M.A. Hollinger.CRC Press, Boca Raton, FL1995
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Abstracts/Posters

• The mediating role of the upper airway and gut microbiomes in the association of common early-life exposures with childhood wheezing illnesses
  Rosas-Salazar C, Tang Z, Shilts MH, Gebretsadik T, Moore ML, Peebles R.S., Das RS, Hartert TV, Am. J. Respir. Crit. Care Med, 1/1/2018
• Testosterone decreases and ovarian hormones increase house dust mite-induced dual type 2 and IL-17A-mediated airway inflammation
  Fuseini, H., Cephus, J., Yung, J.A., Goleinewska, K., Peebles, R.S. Jr., Newcomb, D.C., J. Allergy Clin. Immunol., 1/1/2018
• TSLP and IL-33 reciprocally regulate each other�s lung protein expression and receptor expression in ILC2 following aeroallergen challenge in mice
  Toki, S., Zhou, B., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2018
• Glucagon-like peptide 1 receptor (GLP-1R) signaling attenuates RSV-induced type 2 response and immunopathology
  Peebles, R.S. Jr., Bloodworth, M.H., Zhang, J., Hotard, A., Moore, M.L., Hartert, T.V., Niswender, K., D., J. Allergy Clin. Immunol., 1/1/2017
• Glucagon-like peptide 1 receptor (GLP-1R) signaling inhibits aeroallergen-induced IL-33 release and reduced group 2 innate lymphoid cells (ILC2) activation in vivo
  Toki, S., Goleniewska, K., Reiss, S., Zhang, J., Bloodworth, M.H., Stier, M.T., Zhou, W., Newcomb, D.C., Boyd, K., L., Niswender, K., D., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2017
• IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow
  Stier, M.T., Goleniewska, K., Zhang, J. Peebles, R.S. Jr, J. Allergy Clin. Immunol., 1/1/2017
• Female mice have increased house dust mite induced airway inflammation compared to male mice
  Fuseini, H., Cephus, J.Y., Yung, J., Zhang, J., Goleniewska, K., Peebles, R.S.�Jr, Newcomb, D.C., J. Allergy Clin. Immunol., 1/1/2017
• Testosterone attenuates group 2 innate lymphoid cell-mediated airway inflammation
  Cephus, J.Y., Stier, M.T., Fuseini, H., Toki, S., Bloodworth, M.H., Zhou, W., Goleniewska, K., Zhang, J., Boyd, K.L.,�Peebles, R.S.�Jr, Newcomb, D.C., J. Allergy Clin. Immunol., 1/1/2017
• Ovarian hormones increase Alternaria extract induced ILC2 activation
  Newcomb, D.C., Cephus, J.Y., Stier, M.T., Bloodworth, M.H., Fuseini, H. Zhou, W., Toki, S., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2016
• TSLP neutralization inhibits ILC2 activation induced by multiple pathogenic clinical isolates of RSV
  Stier, M.T., Toki, S., Newcomb, D.C., Bloodworth, M.H., Hartert, T.V., Moore, M.L. Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2016
• Prostaglandin I2 receptor (IP) signaling increases regulatory T (Treg) cell induction and function and renders T effector (Teff) cells more susceptible to Treg-mediate...
  Bloodworth, M.H., Goleniewska, K., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2016
• Ovarian hormones increase IL-17A production from Th17 cells through an IL-23R and Let-7f mediated pathway in severe asthma
  Newcomb, D.C., Cephus, J.Y., Peebles, R.S. Jr., Dulek, D.E., Boswell, M., Langley, E.W., Feldman, A.S., Fahrenholz, J.M., Zhou, W., Goleniewska, K., J. Allergy Clin. Immunol., 1/1/2015
• Respiratory syncytial virus induces IL-13+ group 2 innate lymphoid cells via TSLP
  Stier, M.T., Toki, S., Goleniewska, K., Moore, M.L., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2015
• TSLP signaling pathway is required for COX inhibition-induced augmentation of allergic airway inflammation
  Zhou, W., Zhang, J. Toki, S., Goleniewska, K., Reiss, S., Zhou, B., McKenzie, A., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2015
• Exogenous PGI2 protection against respiratory syncytial virus (RSV)-induced IL-13-producing Th2 cells and ILC2
  Bloodworth, M.H., Toki, S., Goleniewska, K., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2015
• Deficiency of thymic stromal lymphopoietin (TSLP) receptor signaling reduced IL-33 protein expression and the number of lung group 2 innate lymphoid cells (ILC2) follo...
  Toki, S., Goleniewska, K., Reiss, S., Zhou, B., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2015
• Generation of human hybridomas secreting naturally-occurring IgE MAbs using memory B-cells from atopic and asthmatic patients
  Smith, S.A., Hovarth, D., Steven-Smith, C., Newcomb Baker, D.C., Peebles, R., J. Allergy Clin. Immunol., 1/1/2014
• Prostaglandin I2 receptor IIP) signaling inhibits Alternaria-induced IL-5 and IL-13 expression through group 2 innate lymphoid cells (ILC2)
  Toki, S., Goleniewska, K., Reiss, S., Zhou, W., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2014
• Respiratory syncytial virus induced IL-25 and IL-33 production in the lungs
  Stier, M.T., Goleniewska, K., Peebles, R.S., J. Allergy Clin. Immunol., 1/1/2014
• Epidermal growth factor receptor (EGFR) mediates cell fusion and infectivity of respiratory syncytial virus (RSV)
  Lee, S., Currier, M.G., Hotard, A.L., Meng, J., Pretto, C., Power, U.F., Villenave, R., Shields, M.D., Chi, M.H., Peebles, R.S., Moore, M.L., J. Allergy Clin. Immunol., 1/1/2014
• FeNo decreases significantly during improved symptom control in pediatric patients after acute asthma exacerbations necessitating emergency department care
  Karlin, E.M., Gebretsadik, T., Langley, E.W., Hartert, T.V., Peebles, R.S. Jr., Arnold, D.H., J. Allergy Clin. Immunol., 1/1/2014
• 17-Beta estradiol positively correlates with IL-17A+ CCR6+ memory CD4+ T cells in patients with severe asthma
  Newcomb Baker, D.C., Cephus, J.Y., Feldman, A.S., Frey, N., Cooper, K., Fahrenholz, J.M., Peebles, R.S., J. Allergy Clin. Immunol., 1/1/2014
• IL-4 signaling attenuates gamma-delta T cell IL-17A protein expression
  Harintho, M.S., Newcomb Baker, D.C., Cephus, J.Y., Goleniewska, K., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2014
• Prostaglandin I2 (PGI2) inhibits IL-33-induced Type 2 cytokine response by mouse CD4 cells
  Zhou, W., Zhang, J., Goleniewska, K., Peebles, R.S. Jr., J. Allergy Clin. Immunol., 1/1/2014
• 17Beta-estradiol increases IL-17A protein expression from mouse CD4+ Th17 differentiated cells
  Cephus, J.Y., Newcomb Baker, D.C., Boswell, M., Goleniewska, K., Peebles, R.S., J. Allergy Clin. Immunol., 1/1/2014
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Lectures

• GLP-1R signaling inhibits of allergic airway inflammation 
  Research Triangle Park, NC, 2017; Chicago, IL, 2017; - 1/26/2018
• Respiratory syncytial virus-induced mucus expression 
  Lucerne, Switzerland - 1/19/2018
• Allergy Skin Testing and Rhinitis 
  1/13/2018
• The Overlap of Asthma and COPD (ACOS) is a Distinct Syndrome that Changes Treatment and Patient Outcomes 
  1/3/2018
• Asthma/COPD Overlap Syndrome (ACOS) With and Without Occupational Causes 
  Orlando, FL - 1/2/2018
• Updates in immunology relevant to the practicing allergist 
  Greensboro, GA - 1/29/2017
• Asthma 
  Multiple locations, 2014, 2015, 2016, 2017 - 1/26/2017
• COPD 
  1/26/2017
• PGI2 Regulation of Allergic Inflammation 
  1/21/2017
• GLP-1R signaling inhibits ILC2 stimulation and allergic airway inflammation 
  1/21/2017
• T-cell development, TCR diversity, CD4 subsets, Cytotoxic T-cells, NK cells 
  1/20/2017
• Innate lymphoid cells in viral lung infections 
  Washington, DC - 1/19/2017
• GLP-1R signaling regulation of allergic airway inflammation 
  Multiple locations, 2016, 2017 - 1/17/2017
• Prostacyclin Inhibition of ILC2 Function 
  Atlanta, GA - 1/5/2017
• Role of COX in the regulation of allergic inflammation 
  University of California-Davis, Davis, CA, 2016; Cincinnati, OH - 1/18/2016
• Treatment Choices for Asthma/COPD Overlap Syndrome 
  San Francisco, CA - 1/13/2016
• Innate Immune Dysfunction and the Development of Antiviral Adaptive Immunity 
  Los Angeles, CA - 1/7/2016
• Glucagon like peptide-1 receptor signaling inhibits both lung innate and adaptive immunity mediated allergic inflammation to inhaled aeroallergen 
  Charleston, SC - 1/6/2016
• Prostaglandin Regulation of Asthma 
  San Francisco, CA - 1/5/2016
• How to Apply for and Obtain an NIH Grant for the New Investigator 
  Houston, TX, 2015; Los Angeles, CA, 2016 - 1/4/2016
• Innate Immunity is the Major Contributor to Ongoing Asthma and Represents the Best Therapeutic Targets 
  Houston, TX - 1/21/2015
• Prostacyclin Maintains Control Over ILC2 Responses in the Lung 
  Houston, TX - 1/21/2015
• Asthma/COPD Overlap Syndrome 
  1/18/2015
• Eicosanoids, Non-steroidal Anti-inflammatory Agents and Acetaminophen 
  1/14/2015
• Pulmonary Function Testing 
  Multiple locations, 2002, 2010, 2013, 2015 - 1/10/2015
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Other

• PLoS One. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis 
  Zhou, W., Dowell, D.R., Huckabee, M.M., Newcomb, D.C., Boswell, M.G., Goleniewska, K., Lotz, M.T., Toki, S., Yin, H., Yao, S., Natarajan, C., Wu, P., Sriram, S., Breye...
  1/1/2012