RamnikJosephXavierMD

Gastroenterology • Boston, MA

Associate Professor, Medicine, Massachusetts General Hospital, Harvard Medical School

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Office
55 Fruit St
Blk 4
Boston, MA 02114
Phone+1 617-724-6007

Fax+1 617-724-6832

Education & Training

Massachusetts General HospitalFellowship, Gastroenterology, 1992 - 1996
Massachusetts General HospitalResidency, Internal Medicine, 1990 - 1992
Massachusetts General HospitalInternship, Internal Medicine, 1989 - 1990
University of Zimbabwe Huggins SOMClass of 1986

Certifications & Licensure

MA State Medical License 1991 - 2025
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Fellow (AGAF) American Gastroenterological Association, 2010
Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.
Zher Yin Tan, Joel K A Adade, Xiebin Gu, Cody J S Hecht, Michael Salcius
Cell Chemical Biology. 2025-03-20
The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin.
Ranad Humeidi, Noriko Oshiro-Rapley, Xiebin Gu, Joon Soo An, Ashwin N Ananthakrishnan
Journal of the American Chemical Society. 2025-03-11
Trajectories of microbiome-derived bile acids in early life - insights into the progression to islet autoimmunity.
Santosh Lamichhane, Alex M Dickens, Tanja Buchacher, Evita Tianai Lou, Vincent Charron-Lamoureux
Medrxiv. 2025-02-24

Journal Articles

Investigating Fatigue in IBD Patients
Francis P Colizzo, Hamed Khalili, John J Garber, Ramnik J Xavier, Clinical Gastroenterology and Hepatology
Temporal Development of the Gut Microbiome in Early Childhood from the TEDDY Study
Richard E Lloyd, Marian Rewers, William Hagopian, Ramnik J Xavier, Nature
The Human Gut Microbiome in Early-Onset Type 1 Diabetes from the TEDDY Study
Ramnik J Xavier, Marian J Rewers, William A Hagopian, Nature
Antigen Discovery and Specification of Immunodominance Hierarchies for MHCII-Restricted Epitopes
Ramnik Xavier, MD, Nature
Circadian Clock Protein BMAL1 Regulates IL-1β in Macrophages via NRF2
Ramnik Xavier, MD, Proceedings of the National Academy of Sciences
Circadian Clock Protein BMAL1 Regulates IL-1β in Macrophages via NRF2
Ramnik Xavier, MD, Proceedings of the National Academy of Sciences
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte–Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease
Lee A Denson, Bruce J Aronow, Barbara S Kirschner, Joshua D Noe, Melvin B Heyman, Ramnik J Xavier, Robert N Baldassano, Jeffrey S Hyams, Subra Kugathasan, Wallace V Cr..., Inflammatory Bowel Diseases
A Role for Bacterial Urease in Gut Dysbiosis and Crohn’s Disease
Marc Yudkoff, Josephine Ni, Lindsey Albenberg, Ramnik J Xavier, James D Lewis, Robert N Baldassano, Science Magazine
Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases
Hamed Khalili, John J Garber, Ramnik J Xavier, Ashwin N Ananthakrishnan, Vijay Yajnik, Journal of Crohn's and Colitis
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Authored Content

Investigating Fatigue in IBD PatientsFebruary 2020

Press Mentions

Congrats to the 44 Mass General Investigators Named to the Highly Cited Researchers List for 2022December 8th, 2022
Congrats to the 44 Mass General Investigators Named to Clarivate Analytics’ Highly Cited Researchers List for 2022November 22nd, 2022
Bacterial BullseyeJuly 25th, 2022
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Grant Support

GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of diseaseMASSACHUSETTS GENERAL HOSPITAL2024–2029
GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of diseaseMASSACHUSETTS GENERAL HOSPITAL2024–2029
GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of diseaseMASSACHUSETTS GENERAL HOSPITAL2024–2029
GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of diseaseMASSACHUSETTS GENERAL HOSPITAL2024–2029
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesBROAD INSTITUTE, INC.2023–2028
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesBROAD INSTITUTE, INC.2023–2028
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesBROAD INSTITUTE, INC.2023–2028
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesBROAD INSTITUTE, INC.2023–2028
Identification and Characterization of Microbial Metabolites in ImmunityBROAD INSTITUTE, INC.2022–2027
Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHSBROAD INSTITUTE, INC.2022–2026
Determinants of inception of inflammation in inflammatory bowel diseasesMASSACHUSETTS GENERAL HOSPITAL2021–2026
Determinants of inception of inflammation in inflammatory bowel diseasesMASSACHUSETTS GENERAL HOSPITAL2021–2026
Determinants of inception of inflammation in inflammatory bowel diseasesMASSACHUSETTS GENERAL HOSPITAL2021–2026
Determinants of inception of inflammation in inflammatory bowel diseasesMASSACHUSETTS GENERAL HOSPITAL2021–2026
Center for the Study of Inflammatory Bowel Disease at Massachusetts General HospitalMASSACHUSETTS GENERAL HOSPITAL1997–2026
Center for the Study of Inflammatory Bowel Disease at Massachusetts General HospitalMASSACHUSETTS GENERAL HOSPITAL1997–2026
Research Training In Digestive DiseasesNational Institute Of Diabetes And Digestive And Kidney Diseases2011
Bioinformatics CoreNational Institute Of Allergy And Infectious Diseases2011
Toll-Like Receptors And The Intestinal EpitheliumNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Systems Biology Of Crohn'S DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Role Of CARMA1 In Inflammatory Lung DiseaseNational Heart, Lung, And Blood Institute2008–2011
Genetics, Genes, And Pathways In Inflammatory Bowel Disease (IBD)National Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
Intracellular Epithelial Sensors Of Intestinal BacteriaNational Institute Of Diabetes And Digestive And Kidney Diseases2009
Genomic Approaches To Host-Pathogen InteractionsNational Institute Of Allergy And Infectious Diseases2006–2009
SAM68 As Adaptor Molecule In T Cell Signal TransductionNational Institute Of Allergy And Infectious Diseases1997–2001