RamaKMallampalliMD
Pulmonology • Columbus, OHCritical Care Medicine, Pleural Disease
Chair of Internal Medicine, Physician in Chief of Medicine, The Ohio State University Wexner Medical Center
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Office
395 W 12th Avenue, Room 392
Department of Internal Medicine
Columbus, OH 43210Phone+1 614-293-8724Fax+1 614-293-6656
Summary
- Dr. Mallampalli’s research in the area of pulmonary molecular and cell biology as it relates to acute lung injury (ALI) and the mechanisms of sepsis. He is an internationally recognized investigator in the area of ubiquitin-mediated proteolysis as it relates to inflammation and injury. His research program discovered a unique model for the molecular behavior of ubiquitin E3 ligase subunits that control inflammation. Dr. Mallampalli’s laboratory designed, synthesized, and tested the first-in-class genus of oral ubiquitin E3 ligase (F box) inhibitors that block inflammation in preclinical models of ALI and multi-organ failure that are FDA approved for Phase 1 studies. He currently leads an NIH Program Project grant in ALI and a Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage II (CADETII) award to develop drug therapies for inflammatory lung illness.
Education & Training
University of Iowa Hospitals and ClinicsFellowship, Pulmonary Disease and Critical Care Medicine, 1988 - 1991
Hennepin HealthcareChief Residency, Internal Medicine, 1987 - 1988- Hennepin HealthcareResidency, Internal Medicine, 1985 - 1988
- Hennepin HealthcareInternship, Internal Medicine, 1984 - 1987
- Hennepin HealthcareInternship, Transitional Year, 1984 - 1985
University of Wisconsin School of Medicine & Public HealthClass of 1984
Certifications & Licensure
OH State Medical License 2019 - 2026
PA State Medical License 2009 - 2021
IA State Medical License 1988 - 2014
MN State Medical License 1985 - 1990- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Critical Care Medicine
- American Board of Internal Medicine Pulmonary Disease
Awards, Honors, & Recognition
- Distinguished Alumnus Award University of Iowa Carver College of Medicine, 2020
- Permanent Member NHLBI Program Project Review Committee
- Harrington Scholar-Innovator Harrington Discovery Institute, 2016
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Publications & Presentations
PubMed
- Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain.Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yajie Liu
Biorxiv. 2024-11-13 - Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants.Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yajie Liu
Biorxiv. 2024-09-05 - 8 citationsNeutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants.Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng
Cell Reports. 2024-08-27
Press Mentions
New Research-Funding Record Set by Ohio State College of MedicineNovember 21st, 2024- Cleveland VA, Ohio State Join Clinical Trials Testing Experimental COVID-19 Vaccines in HumansSeptember 2nd, 2020
- Tiny Coils Improve Quality of Life for Patients with Severe EmphysemaMay 15th, 2016
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Grant Support
- F box-Induced Acute Lung Injury and ParkinNational Heart, Lung, & Blood Institute2016–2020
- Signaling Mechanisms by Which Mitochondria Regulates Fibrosis in the LungNational Heart, Lung, & Blood Institute2016–2020
- Epigenetic Regulation in Acute Lung InjuryNational Heart, Lung, & Blood Institute2015–2019
- Novel F Box Immunomodulator for Lung Allograft RejectionHarrington Discovery Institute2016–2018
- Mechanisms of Lung Homeostatis by F box ProteinsNational Heart, Lung, & Blood Institute2014–2018
- Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 1National Heart, Lung, & Blood Institute2014–2018
- Regulation of F Box Proteins in Acute Lung InjuryNational Heart, Lung, & Blood Institute2014–2018
- Translational Training Program in Pulmonary Biology and MedicineNational Heart, Lung, & Blood Institute2013–2018
- Regulation of Innate Immunity by F-Box ProteinsNational Heart, Lung, & Blood Institute2013–2018
- A New Genus of Ubiquitin-Based Anti-Inflammatories for COPDNational Heart, Lung, & Blood Institute2014–2017
- Novel F Box Anti-Inflammatories for COPDFlight Attendants Medical Research Institute2014–2017
- Cardiolipin, Pneumonia, And A Novel Cardiolipin PUMPVeterans Affairs2010–2012
- Septic Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2010–2012
- Cardiolipin Induced Lung Injury And FIC1National Heart, Lung, And Blood Institute2010–2012
- Mechanisms Of Lung Phospholipid HomeostasisNational Heart, Lung, And Blood Institute2009–2011
- Tnf-Alpha Control Of A Surfactant Enzyme In Lung InjuryNational Heart, Lung, And Blood Institute2009–2010
- Adenoviral Induced Acute Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2009–2010
- Tnf-Alpha Control Of A Surfactant Enzyme In Lung InjuryNational Heart, Lung, And Blood Institute2006–2009
- Adenoviral Induced Acute Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2006–2009
- Regulation Of Surfactant Synthesis In AsthmaNational Heart, Lung, And Blood Institute2005–2008
- Transcriptional Regulation Of A Surfactant EnzymeNational Heart, Lung, And Blood Institute2002–2005
- Regulation Of Cytidylytransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute2002–2005
- Tnfalpha-Lipoprotein Control Of A Surfactant EnzymeNational Heart, Lung, And Blood Institute2001–2004
- Transcriptional Regulation Of A Surfactant EnzymeEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2003
- Regulation Of Sufactant Synthesis By TNF In Adult LungNational Heart, Lung, And Blood Institute1998–2002
- Regulation Of Cytidylyltransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute1998–2000
- Regulation Of Cytidylyltransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute1996–1997
Professional Memberships
- Member
- The American Society for Clinical InvestigationMember
- American Society for MicrobiologyMember
- American College of Chest Physicians, FellowMember
- Amercian Society for Biochemsitry and Molecular BiologyFellow
- Society for Pediatric ResearchMember
- Central Society for Clinical ResearchMember
- American Federation for Medical ResearchMember
- Iowa Medical societyMember
- Biochemical SocietyMember
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