Ralph R Weichselbaum MD
D.K. Ludwig Professor of Rad and Cellular Oncology, University of Chicago Medicine
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5758 S Maryland AveMc9006Chicago, IL 60637
Phone+1 773-702-0817
Fax+1 773-834-7233
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Education & Training
Mass General Brigham/Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Radiation Oncology, 1972 - 1975
Alameda Health System-Highland HospitalInternship, Internal Medicine, 1971 - 1972
University of Illinois College of MedicineClass of 1971
Certifications & Licensure
CA State Medical License 1973 - Present
IL State Medical License 1984 - 2026
MA State Medical License 1972 - 2009
American Board of Radiology Therapeutic Radiology
Awards, Honors, & Recognition
- Elected Member Institute of Medicine, 1997
- Super Doctor SuperDoctors.com
Publications & Presentations
PubMed
- Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7immunorad conference.Pierre-Antoine Laurent, Fabrice André, Alexandre Bobard, Desiree Deandreis, Sandra Demaria
Oncoimmunology. 2025-12-01 - Metal-organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy.Wangqing Bian, Xiaomin Jiang, Jinhong Li, Langston Tillman, Chaoyu Wang
Chemical Science. 2025-03-19 - Nanoparticle-Mediated Toll-Like Receptor Activation and Dual Immune Checkpoint Downregulation for Potent Cancer Immunotherapy.Jing Liu, Zhihao Zhao, Richard Zanni, Xiaomin Jiang, Ralph R Weichselbaum
ACS Nano. 2025-03-11
Journal Articles
- The Change of Soluble Programmed Cell Death-Ligand 1 in Glioma Patients Receiving Radiotherapy and Its Impact on Clinical OutcomesRalph Weichselbaum, MD, Frontiers in Immunology
- Classification for Long-Term Survival in Oligometastatic Patients Treated with Ablative Radiotherapy: A Multi-Institutional Pooled AnalysisJulian C Hong, A William Blackstock, Joseph K Salama, Paul Okunieff, Michael T Milano, James J Urbanic, Ralph R Weichselbaum, Johnny Kao, Max W Sung, Steven J Chmura, PLoS One
Press Mentions
UChicago Medicine Names Radiation Oncology LeaderDecember 6th, 2024- Ralph Weichselbaum, MD, Appointed University of Chicago Health System Leader for Radiation and Cellular OncologyDecember 4th, 2024
- Ludwig Chicago Nanotechnology Induces Therapeutic Immune Responses Against Multiple Types of TumorsOctober 29th, 2022
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Grant Support
- Genetically-engineered Bacteria Overcome Therapy ResistanceUNIVERSITY OF CHICAGO2024–2029
- Genetically-engineered Bacteria Overcome Therapy ResistanceUNIVERSITY OF CHICAGO2024–2029
- Genetically-engineered Bacteria Overcome Therapy ResistanceUNIVERSITY OF CHICAGO2024–2029
- Nanoscale Coordination Polymers of Cyclic-di-nucleotides and Peptide Antigens for Effective Therapy of Metastatic Colorectal CancerUNIVERSITY OF CHICAGO2023–2028
- Dynamics of Immune Response in Irradiated Rectal CancerWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- Dynamics of Immune Response in Irradiated Rectal CancerWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- A Digital Twin for rectal cancer to guide adaptive radiotherapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- A Digital Twin for rectal cancer to guide adaptive radiotherapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- Dynamics of Immune Response in Irradiated Rectal CancerWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- Dynamics of Immune Response in Irradiated Rectal CancerWEILL MEDICAL COLL OF CORNELL UNIV2022–2027
- Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapyUNIVERSITY OF CHICAGO2021–2026
- Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapyUNIVERSITY OF CHICAGO2021–2026
- Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapyUNIVERSITY OF CHICAGO2021–2026
- In vivo CRISPR-screening of novel cancer cell-intrinsic targets that sensitize to local ionizing radiation, and possible combination with systemic checkpoint blockade.UNIVERSITY OF CHICAGO2022–2025
- Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersUNIVERSITY OF CHICAGO2020–2025
- Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersUNIVERSITY OF CHICAGO2020–2025
- Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersUNIVERSITY OF CHICAGO2020–2025
- P-3: Radiation Inducible Tnf-A Therapy For Prostate CancerNational Cancer Institute2011–2012
- Radiation Enhancement Of HSV Anti-Tumor EffectsNational Cancer Institute2009–2011
- P-3: Radiation Inducible Tnf-A Therapy For Prostate CancerNational Cancer Institute2010
- Radiation Inducible Tnf-A Therapy For Prostate CancerNational Cancer Institute2009
- Mechanisms Of Resistance To Radio Inducible Gene TherapyNational Cancer Institute2005–2009
- DNA Damage Targeted Gene Therapy In Head &Neck CancerNational Cancer Institute2005–2009
- Gene Therapy For Extension Of Vein Graft PatencyNational Heart, Lung, And Blood Institute2003–2005
- Design Of Genetically Engineered HSV For Cancer TherapyNational Cancer Institute1997–2001
- Training Program In Environmental Biology (NRSA)National Cancer Institute1993–2000
- Pilot--Gene Therapy In Oral CancersNational Institute Of Dental &Craniofacial Research1996–1999
- Novel Methods Of Tumor Cell RadiosensitizationNational Cancer Institute1995–1998
- 3D Dose Escalation For Prostate CancerNational Cancer Institute1994–1996
- Radiation Gene Induction--Applications To Gene TargetingNational Cancer Institute1993–1995
- Assays Of Tumor Response To RadiotherapyNational Cancer Institute1986–1994
- 3-Dose Escalation Study For Prostate CancerNational Cancer Institute1993
- X-RAY &Molecular Probes Of RetinoblastomaNational Cancer Institute1988–1992
- Environmental BiologyNational Cancer Institute1988–1992
- X-RAY And Molecular Probes Of RetinoblastomaNational Cancer Institute1988–1990
- Training Program In Environmental BiologyNational Cancer Institute1986–1987
Professional Memberships
- Member
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