Ralph J Deberardinis MD
Clinical Biochemical Genetics, Clinical Genetics, Ph.D. Medical Genetics, Pediatric Medical Genetics
Associate Professor, Chief of Pediatric Genetics and Metabolism, University of Texas Southwestern Medical Center, Southwestern Medical School
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5323 Harry Hines BlvdDallas, TX 75390
Phone+1 214-633-1803
Fax+1 214-648-5515
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Education & Training
Children's Hospital of PhiladelphiaResidency, Pediatrics/Medical Genetics and Genomics, 2000 - 2005
Perelman School of Medicine at the University of PennsylvaniaClass of 2000
Certifications & Licensure
TX State Medical License 2008 - 2025
PA State Medical License 2001 - 2008
American Board of Medical Genetics and Genomics Clinical Biochemical Genetics- American Board of Medical Genetics and Genomics Clinical Genetics and Genomics
Clinical Trials
- An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection Start of enrollment: 2009 Aug 01
- Genetic and Metabolic Disease in Children Start of enrollment: 2015 Jun 01
Publications & Presentations
PubMed
- CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia.Junhua Lyu, Yuxuan Liu, Ningning Liu, Hieu S Vu, Feng Cai
Blood. 2025-04-03 - High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.Ling Cai, Nia G Hammond, Alpaslan Tasdogan, Massar Alsamraae, Chendong Yang
Cancer Discovery. 2025-04-02 - Lysosomal-Mitochondrial Interaction Promotes Tumor Growth in Squamous Cell Carcinoma of the Head and Neck.Avani Gopalkrishnan, Nathaniel Wang, Silvia Cruz-Rangel, Abdul Yassin-Kassab, Sruti Shiva
Molecular Cancer Research. 2025-04-01
Journal Articles
- Gain‐of‐Function Variants in the ODC1 Gene Cause a Syndromic Neurodevelopmental Disorder Associated with Macrocephaly, Alopecia, Dysmorphic Features, and Neuroimaging ...Sanjeev V Kothare, Farrah Rajabi, Annapurna Poduri, Lance H Rodan, Ralph J DeBerardinis, American Journal of Medical Genetics Part A
- Genomic Regression Analysis of Coordinated ExpressionYang Xie, Ralph J DeBerardinis, Nature
Press Mentions
Children’s Research Institute at UT Southwestern Scientists Identify Feature of Aggressive Non-Small Cell Lung CancerFebruary 19th, 2025- UTSW’s Simmons Cancer Center Awarded More Than $11.5 Million in CPRIT FundingSeptember 6th, 2024
- Children’s Research Institute at UT Southwestern Scientists Discover Kidney Cancers Rely on Mitochondrial Metabolism to MetastasizeAugust 14th, 2024
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Grant Support
- Human metabolic variation as a window into cancer initiation and progressionUT SOUTHWESTERN MEDICAL CENTER2017–2030
- Metabolic Regulators Of Tumor Cell GrowthNational Cancer Institute2011–2012
- Intermediary Metabolism In Tumor CellsNational Center For Research Resources2011
- Imaging Of Hyperpolarized Substrates In Animal Models Of CancerNational Center For Research Resources2010
- Metabolic Regulation In Growth Factor-Dependent CellsNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2010
- Metabolic Regulation In Growth Factor-Dependent CellsNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2007
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