RajivMadathiparambilJosephMDPhD, FAAN

Neurophysiology, Sleep Medicine

Physician

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Office
931 Ridgeview Dr Ste-1100B
Allen, TX 75013
Phone+1 214-682-9595

Fax+1 214-919-4877

Since 1997 | Established Dallas area practice | Board certified in neurology | Board certified in sleep medicine | Board certified in neurophysiology (EMG/EEG) | AASM-Accredited Sleep Centers | Accredited DME/CPAP program |

RESEARCH:
Neuronatin (NNAT) is an imprinted gene | Cloned in 1994 | Subject of my 1996 PhD thesis with The University of London | Many centers worldwide working on NNAT | 72 publications on Neuronatin | Cause of Lafora body disease-a fatal human brain condition | May contribute to islet cell loss in diabetes | Promotes the spread of glioblastoma multiforme and other cancers | A review is to appear in the journal GENOMICS; linked |

University of LondonPost-Doctoral Fellowship, Cloning of Neuronatin, 1983 - 1996
University of LondonM.Phil., 1991
Beth Israel Deaconess Medical CenterFellowship, Neuroscience, 1989 - 1990
Henry Ford Health/Henry Ford HospitalResidency, Neurology, 1986 - 1990
St. John's Medical CollegeClass of 1980, MBBS

CMS Meaningful Use Stage 1 Certification eClinicalWorks EHR, eClinicalWorks LLC, 2013
Physician Recognition Award American Medical Association, 1997
Harold G. Wolff, MD Lecture Awards 1986, 1988
Postgraduate Institute of Medical Education and Research Award 1982
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PubMed

23 citations
Structure and organization of the human neuronatin gene
Dexian Dou, Rajiv Joseph
Genomics. 1996-04-15
12 citations
Further studies on platelet-mediated neurotoxicity
Rajiv Joseph, Chock Tsering, S. Grunfeld, Kma Welch
Brain Research. 1992-04-17
69 citations
Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene
Rajiv Joseph, Dexian Dou, Wayne Tsang
Brain Research. 1995-08-28

Journal Articles

Neuronatin mRNA in PC12 cells: Down regulation by nerve growth factor
Joseph R, et al, Brain Res, 1/1/1996
Cloning of human neuronatin gene and its localization to chromosome-20q112-12: the deduced protein is a novel “proteolipid”
Dou D, Joseph R, Brain Res, 1/1/1996
The structure and organization of the human neuronatin gene
Dou D, Joseph R, Genomics, 1/1/1996
Neuronatin mRNA: Alternatively spliced forms of a novel brain-specific Mammalian developmental gene
Joseph R, et al, Brain Res, 1/1/1995
Platelet secretory products may contribute to neuronal injury
Joseph R, et al, Stroke, 1/1/1991
A plasmatic factor may cause platelet activation in acute ischemic stroke
Joseph R, et al, Circ Res, 1/1/1989
Bilateral pontine gaze palsy: nuclear magnetic resonance findings in presumed multiple sclerosis
Joseph R, et al, Arch Neurol, 1/1/1985
Molecular cloning of a novel mRNA (Neuronatin) that is highly Expressed in neonatal mammalian brain
Joseph R, et al, Biochem Biophys Res Commun
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America Heart Association-NationalAmerican Heart Association National Center1992–1995
Clinical Investigator AwardNational Institutes of Health1992–1995

NNAT Discoveryhttp://www.dallasneurology.com/Research/1_NNAT%20Discovery.pdf
NNAT mRNAhttp://www.dallasneurology.com/Research/2_NNAT%20MRNA.pdf
NNAT DNAhttp://www.dallasneurology.com/Research/3_NNAT%20Human%20DNA.pdf