RajRMakkarMD

Interventional Cardiology

Vice President, Cardiovascular Innovation and Intervention; Associate Director of the Smidt Heart Institute for Interventional Technologies; Executive Director of Cardiac Interventional Services; Director of Interventional Cardiology Division; Director of the Interventional Cardiology Research Program

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Office
8700 Beverly Blvd
West Hollywood, CA 90048
Phone+1 310-423-3977

Fax+1 310-423-0106

Education & Training

Cedars-Sinai Medical CenterFellowship, Interventional Cardiology, 1996 - 1997
Cedars-Sinai Medical CenterFellowship, Cardiovascular Disease, 1993 - 1996
Wayne State University School of MedicineResidency, Internal Medicine, 1990 - 1993
KM School of PG Medicine and ResearchResidency, 1987 - 1990
Gujurat UniversityMB, BS, 1981 - 1987
N.H.L Municipal Medical CollegeClass of 1987

Certifications & Licensure

CA State Medical License 1993 - 2027
MI State Medical License 1993 - 1994
American Board of Internal Medicine Interventional Cardiology
National Board of Physicians and Surgeons Interventional Cardiology

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

Heart Disease of the Small Arteries in Women and Men Start of enrollment: 2005 Nov 01
Recruiting
Not Applicable
Randomized Evaluation of Intracoronary Transplantation of Bone Marrow Stem Cells in Myocardial Infarction Start of enrollment: 2005 Jul 01
Completed
Phase 1
Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Start of enrollment: 2012 Nov 13
Terminated
Phase 1, Phase 2
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).
ACTIVE_NOT_RECRUITING
NA
ABSORB III Randomized Controlled Trial (RCT) Start of enrollment: 2012 Dec 01
Completed
Not Applicable
Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
ACTIVE_NOT_RECRUITING
NA
The REFLECT Trial: Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation Start of enrollment: 2016 Jun 01
Completed
Not Applicable
Portico Next Generation Approval Study Start of enrollment: 2019 Sep 17
ACTIVE_NOT_RECRUITING
NA
2019-06 TRISCEND Study Start of enrollment: 2020 May 06
ACTIVE_NOT_RECRUITING
NA
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Publications & Presentations

PubMed

Implications of an off-hours setting in patients undergoing transcatheter edge-to-edge repair for mitral regurgitation.
Alon Shechter, Aakriti Gupta, Danon Kaewkes, Homa Taheri, Takashi Nagasaka
American Heart Journal. 2025-04-01
Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory.
Omar K Khalique, Syed Zaid, Gilbert H L Tang, Mohamed Abdel-Wahab, Miriama Akodad
Journal of the American College of Cardiology. 2025-03-18
2 citations
Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials.
Rohin K Reddy, James P Howard, Michael J Mack, Michael J Reardon, Troels Højsgaard Jørgensen
Journal of the American College of Cardiology. 2025-03-11

Journal Articles

One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart Valve
Brian Whisenant, Samir R Kapadia, Mackram F Eleid, James M Mccabe, Amar Krishnaswamy, Richard W Smalling, Charanjit S Rihal, Raj R Makkar, JAMA Cardiology
Original Investigation Stroke After Surgical Versus Transfemoral Transcatheter Aortic Valve Replacement in the PARTNER Trial
Eugene H Blackstone, Vinod H Thourani, Howard C Herrmann, David J Cohen, Martin B Leon, Michael J Mack, Raj R Makkar, Samir R Kapadia, Susheel K Kodali, Lars G Svensso..., ScienceDirect
Clinical Research Commissural Alignment of Bioprosthetic Aortic Valve and Native Aortic Valve Following Surgical and Transcatheter Aortic Valve Replacement and Its Imp...
Raj Makkar, MD, ScienceDirect
Focus on Stroke Risk and Prevention Debris Heterogeneity Across Different Valve Types Captured by a Cerebral Protection System During Transcatheter Aortic Valve Replac...
Martin B Leon, Roxana Mehran, Renu Virmani, Susheel Kodali, Samir R Kapadia, Raj Makkar, ScienceDirect
Impact of Aortic Root Anatomy and Geometry on Paravalvular Leak in Transcatheter Aortic Valve Replacement with Extremely Large Annuli Using the Edwards SAPIEN 3 Valve
Omar K Khalique, Raj R Makkar, Norihiko Kamioka, Vasilis Babaliaros, Joseph A Kozina, Saif Anwaruddin, Dinesh Jagasia, Howard C Herrmann, Sukhdeep S Basra, Molly A Sze..., JACC: Cardiovascular Imaging
Early Leaflet Thrombosis Is It Benign?
Raj Makkar, Tarun Chakravarty, JACC: Cardiovascular Imaging
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Lectures

Making the Case for… - Clinical Trial Updates, Anatomic Considerations, and Optimizing Procedural Outcomes
CRF Transcatheter Cardiovascular Therapeutics - Annual Symposium 2019 - Miami, FL - 9/26/2019
PARTNER 3 Low-Risk Computed Tomography Substudy: Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves
CRF Transcatheter Cardiovascular Therapeutics - Annual Symposium 2019 - Miami, FL - 9/27/2019
Prevention and Management of Bioprosthetic Valve Thrombosis
CRF Transcatheter Valve Therapy (TVT) - Structural Heart Disease Summit - Chicago, IL - 6/13/2019
The Next TAVR vs. SAVR Randomized Trial Should Be in Patients With Bicuspid Aortic Valves
CRF Transcatheter Valve Therapy (TVT) - Structural Heart Disease Summit - Chicago, IL - 6/13/2019
Thrombosis of a Transcatheter or Surgical Bioprosthetic Valve
CRF Transcatheter Valve Therapy (TVT) - Structural Heart Disease Summit - Chicago, IL - 6/13/2019
2 Illustrative Cases – A Case-Based Discussion
CRF Transcatheter Valve Therapy (TVT) - Structural Heart Disease Summit - Chicago, IL - 6/13/2019
Bicuspid Aortic Valve: TAVR Is as Good as SAVR
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Outcomes of Transcatheter Aortic Valve Replacement with Balloon-Expandable Sapien3 Valve in Bicuspid Aortic Stenosis: An analysis of the STS/ACC TVT Registry
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
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Authored Content

Impact of Pulmonary Artery Dilatation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve ReplacementNovember 2021
One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart ValveJuly 2020
One-Year Outcomes of Mitral Valve-in-Valve Using the SAPIEN 3 Transcatheter Heart ValveJuly 2020
Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves PARTNER 3 Cardiac Computed Tomography SubstudyJune 2020
Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves PARTNER 3 Cardiac Computed Tomography SubstudyJune 2020
Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves PARTNER 3 Cardiac Computed Tomography SubstudyJune 2020
Subclinical Leaflet Thrombosis in Transcatheter and Surgical Bioprosthetic Valves PARTNER 3 Cardiac Computed Tomography SubstudyJune 2020
Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve ReplacementJanuary 2020
1-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients with Severe Mitral Annular CalcificationApril 2018
1-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients with Severe Mitral Annular CalcificationApril 2018
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Press Mentions

Trilogy Valve Demonstrates Safety and Effectiveness in Treating Aortic RegurgitationMarch 30th, 2025
Strike Two: BHF PROTECT-TAVI Throws Cold Water on Embolic ProtectionMarch 30th, 2025
More ALIGN-AR Data Bolster Potential for a Dedicated AR DeviceMarch 30th, 2025
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