PriscillaKaliopiBrastianosMD

PubMed

• Thrombosis, brain metastasis formation, and the perivascular metastatic niche-Novel insights from the tumor microvascular circulation.
  Christopher Alvarez-Breckenridge, Priscilla K Brastianos, Daniel P Cahill
  Neuro-Oncology. 2024-11-04
• NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.
  Kathryn L Eschbacher, Quynh T Tran, Evgeny A Moskalev, Sarah Jenkins, Karen Fritchie
  Brain Pathology. 2024-11-01
• 1 citations
  Central nervous system metastases in advanced non-small cell lung cancer: A review of the therapeutic landscape.
  Michael Weller, Jordi Remon, Stefan Rieken, Philipp Vollmuth, Myung-Ju Ahn
  Cancer Treatment Reviews. 2024-11-01

Journal Articles

• Toward Precision Medicine in Brain Metastases  
  Priscilla Brastianos, MD, Thieme
• The Dual PI3K/mTOR-pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases  
  Priscilla K Brastianos, Daniel P Cahill, Clinical Cancer Research
• DMD Genomic Deletions Characterize a Subset of progressive/higher-grade Meningiomas with Poor Outcome  
  Ganesh M Shankar, Sandro Santagata, Priscilla K Brastianos, Daniel P Cahill, Acta Neuropathologica
• Profiles of Brain Metastases: Prioritization of Therapeutic Targets  
  Raymond Sawaya, Zoran Gatalica, Isabella C Glitza, John V Heymach, Michael E Salacz, Michael A Davies, Amy B Heimberger, Nuhad K Ibrahim, Jianjun Zhang, Sherise D Ferg..., International Journal of Cancer
• Brain Metastasis from Squamous Cell Carcinoma of the Head and Neck: A Review of the Literature in the Genomic Era Related  
  Priscilla K Brastianos, Joshua B Bederson, Raj K Shrivastava, Journal of Neurosurgery
• Genomic sequencing of meningiomas reveals oncogenic SMO and AKT1 mutations  
  Brastianos, P.K., Horowitz, P., Santagata, S., Jones, R., McKenna, A., Getz, G., Ligon, K., Palescandolo, E., Hummelen, P., Ducar, M., Raza, A., Sunkavalli, A., MacCon..., Nature Genetics, 1/1/2013
• Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma  
  Abedalthagafi, M., Linda Bi, W.L., Aizer, A.A., Merrill, P.H., Brewster, R., Agarwalla, P.K., Listewnik, M.L., Dias-Santagata, D., Thorner, A.R., Hummelen, P.V., Bra..., Neuro-Oncology, 1/28/2016
• Case-based Review: meningioma  
  Fogh, S.E., Johnson, D.R., Barker, F.G., Brastianos, P.K., Clarke, J.L., Kaufmann, T.J., Obemdorfer, S., Preusser, M., Raghunathan, A., Santagata, S., Theodosopoulos, ..., Neurooncol Pract, 1/1/2016
• Management of Brain Metastases in Patients with Melanoma  
  Chukwueke, U., Batchelor, T., Brastianos, P, J Oncol. Pract, 1/1/2016
• Alectinib Dose Escalation Reinduces Central Nervous System Responses in Patients with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer Relapsing on Stand...  
  Gainor, J.F., Chi, A.S., Logan, J., Hu, R., Oh, K.S., Brastianos, P.K., Shih, H.A., Shaw, A.T., J Thoracic Oncol, 1/1/2016
• Clinical Activity of Alectinib in Advanced RET-Rearranged Non-Small-Cell Lung Cancer  
  Lin, J.J., Kennedy, E., Sequist, L.V., Brastianos, P.K., Goodwin, K.E., Stevens, S., Wanat, A.C., Stober, L.L., Digumarthy, S.R., Engelman, J.A., Shaw, A.T., Gainor, J.F., J. Thorac Oncol, 1/1/2016
• A New Patient-Derived Orthotopic Malignant Meningioma Model Treated with Oncolytic Herpes Simplex Virus  
  Nigim, F., Esaki, S., Hood, M., Lelic, N., James, M.F., Ramesh, V., Stemmer-Rachamimov, A., Cahill, D.P., Brastianos, P.K., Rabkin, S.D., Martuza, R.L., Wakimoto, H, Neuro Oncol, 1/1/2016
• Rapid Intraoperative Molecular Characterization of Glioma  
  Shankar, G.M., Francis, J.M., Rinne, M.L., Ramkissoon, S.H., Huang, F.W., Venteicher, A.S., Akama-Garren, E.H., Kang, Y.J., Lelic, N., Kim, J.C., Brown, L.E., Charbonn..., JAMA Oncology, 1/15/2015
• PLEKHA5: A Key to Unlock the Blood-Brain Barrier  
  Eisele, S.C., Gill, C.M., Shankar, G.M., Brastianos, P.K., Clinical Cancer Research, 1/1/2015
• Systemic therapy of brain metastases  
  Brastianos, H.C., Cahill, D.P., Brastianos, P.K, Current Neurology and Neuroscience Reports, 1/1/2015
• Ipilimumab and craniotomy in patients with melanoma and brain metastases: a case series  
  Jones, P.S., Cahill, D.P., Brastianos, P.K., Flaherty, K.T., Curry, W.T., Neurosurg Focus., 1/1/2015
• Genomic profiling of brain metastases: current knowledge and new frontiers  
  Neagu, M.R., Gill, C.M., Batchelor, T.T., Brastianos, P.K., CCO, 1/1/2015
• Management of brain metastases in the era of targeted and immunomodulatory therapies  
  Brastianos, P.K., Cahill, D.P., Oncology, 1/1/2015
• BRAF V600E mutations in papillary craniopharyngioma  
  Brastianos, P.K., Santagata, S.S, Eur J Endrocrinol, 1/1/2015
• BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology  
  Shankar, G.M., Lelic, N, Gill, C.M., Thorner, A.T., Hummelen, P.V., Wisoff , J.H., Loeffler, J.S., Brastianos, P.K., Shin, J.H., Borges, L.F., Butler, W.E., Zagzag, D...., Acta Neuropathologica, 1/1/2015
• Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy  
  Brastianos, P.K., Shankar, G.M., Gill, C.M., Taylor-Weiner, A., Nayyar, N., Panka, D.J., Sullivan, R., Frederick, D.T., Abedalthagafi, M., Jones, P., Dunn, I., Nahed, ..., JNCI, 1/1/2015
• Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets  
  Brastianos, P.K., Carter, S.L. Santagata, S., Cahill, D.P., Taylor-Weiner, A., Jones, R.T., Van Allen, E.M., Lawrence, M.S., Horowitz, P.M., Cibulskis, K., Ligon, K., ..., Cancer Discovery, 1/1/2015
• Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making  
  Calligaris, D., Feldman, D.R., Norton, I., Brastianos, P.K., Dunn, I.F., Santagata, S., Agar, N.Y., Int J Mass Spectrom, 1/1/2015
• Alectinib Salvages CNS Metastases in ALK-Positive Lung Cancer Patients Previously Treated with Crizotinib and Ceritinib  
  Gainor, J.F., Sherman, C.A., Willoughby, K., Logan, J., Kennedy, E., Brastianos, P.K., Chi, A.S., Shaw, A.T., J. Thorac Oncol, 1/18/2014
• ASCO Guideline for Management of Brain Metastases from HER2-Positive Breast Cancer: An Important Framework  
  Brastianos, P.K., & Cahill, D.P., ASCO Post, 1/1/2014
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Books/Book Chapters

• Central Nervous System Metastasis, the Biological Basis and Clinical Consideration 
  Chapter: Leptomeningeal Carcinomatosis 
  Page 187 - 201Brastianos, P.K., Brastianos, H.C., Eichler, AEditors: Palmieri, D..Springer, New York, NY2013
• Encyclopedia for Neurological Sciences 
  Chapter: Primary CNS Lymphoma 
  Page 971 - 977Brastianos, P.K., & Batchelor, T.T.Editors: Aminoff, M.J., and Daroff, R.B..2013
• Primary Central Nervous System Tumors: Pathogenesis and Therapy 
  Chapter: Pineal Region Tumors 
  Page 435 - 457Brastianos, H., Brastianos, P.K., Blakeley, JEditors: Norden, A., Reardon, D., Wen, P.Humana Press, New York, NY2011
• Now What: Patient Encounters in Internal Medicine 
  Chapter: Thrombocytopenia 
  Brastianos, P.K.Editors: Garibaldi, B..Lippincott Williams & Williams, Baltimore, MD2010
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Abstracts/Posters

• Genetic characterization demonstrates high frequency of clinically actionable mutations in SMO and AKT1 in skull base meningiomas
  Brastianos, P.K., Society for Neuro-Oncology International Meningioma Meeting, Toronto, ON, Canada, 1/1/2016
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Metastasis-specific Mutations
  Brastianos, P.K., Clonal Evolution Symposium, AACR National Meeting, Philadelphia, PA, 1/1/2015
• Modes of metastasis in human and murine cancer revealed by whole exome sequencing
  Carter, S.L., Brastianos, P.K., Mcfadden, D.G., Papagiannokopoulos, T., Taylor-Weiner, A., Cibulskis, K., Jacks, T., Hahn, W.C., Getz, G, American Association for Cancer Research, San Diego, CA, 1/1/2014
• Exome sequencing reveals BRAF mutations in papillary craniopharyngiomas
  Brastianos, P.K., Taylor-Weiner, A., Manley, P.E., Jones, R.T., Dias-Santagata, D., Thorner, A., Rodrigues, F., Bernardo, L., Schubert, L., Stewart, C., Kieran, M., Lo..., Society for Neuro-Oncology, Miami, FL, 1/1/2014
• Genomic characterization of meningiomas
  Brastianos, P.K., Horowitz, P., Santagata, S., Jones, R.T., McKenna, A., Ligon, K., Palescandolo, E., Hummelen, P., Getz, G., Hahn, W.C., Dunn, I.F., Beroukhim, R, American Association for Cancer Research, Washington, DC, 1/1/2013
• Genomic characterization of meningiomas
  Brastianos, P.K., Horowitz, P., Santagata, S., Jones, R.T., McKenna, A., Ligon, K., Palescandolo, E., Hummelen, P., Getz, G., Hahn, W.C., Dunn, I.F., Beroukhim, R, American Society of Clinical Oncology, Chicago, IL, 1/1/2012
• Discovery of Novel Oncogenic SMO and AKT1 Mutations in Meningiomas
  Horowitz, P., Brastianos, P.K., Santagata, S., Jones, R., McKenna, A., Getz, G., Ligon, K.L., Palescandolo, E., Ducar, M., MacConaill, L., Stemmer-Rachamimov, A., Loui..., American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, 1/1/2012
• Novel Oncogenes Discovered in Meningiomas Through Deep Sequencing
  Horowitz, P., Brastianos, P.K., Santagata, S., Jones, R., McKenna, A., Getz, G., Ligon, K.L., Palescandolo, E., Ducar, M., MacConaill, L., Stemmer-Rachamimov, A., Loui..., New England Neurosurgical Society Annual Meeting, Brewster, MA, 1/1/2012
• Novel Oncogene Discovery in Meningiomas
  Horowitz, P.M., Brastianos, P., Santagata, S., Jones, R., McKenna, A., Getz, G., Ligon, K.L., Palescandolo, E., Van Hummelen, P., Hahn, W., Dunn, I.F., Beroukhim, R, Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 1/1/2012
• Massively parallel sequencing of formalin-fixed paraffin-embedded tissues
  Erlich, R.L., Palescandolo, E., Jones, R.T., Sunkavalli, A., Raza, A., Ducar, M., Hatton, C., Go, C., Roden, C., Hanna, M., Mills, A., Adusumilli, R., Kumar, P., Brast..., Beyond the Genome Meeting, Boston, MA, 1/1/2012
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Lectures

• Will There Ever Be Progress for Leptomeningeal Carcinomatosis: An Update on the Multidisciplinary... 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/4/2019
• How Can We Apply Precision Medicine to Craniopharyngioma and Meningioma? 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
• Phase II study of pembrolizumab in leptomeningeal carcinomatosis. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018
• When cancer spreads to the brain: shifting clinical paradigms in central nervous system metastases 
  San Diego, CA - 1/1/2016
• Meningioma: Treatment and Quality of Life 
  Las Vegas, NV - 1/1/2016
• Genomic evolution of brain metastases 
  Multiple Locations, 2016 - 1/1/2016
• Development of Precision Medicine Approaches in Meningiomas 
  Boston, MA, 2016; Toronto, ON, Canada, 2016 - 1/1/2016
• Evolving clinical paradigms in metastatic brain tumors: genomics as a tool 
  Multiple Locations, 2016 - 1/1/2016
• Shifting clinical paradigms in primary and metastatic brain tumors: unleashing the power of genomics to clinical care 
  Multiple Locations, 2016 - 1/1/2016
• Shifting clinical paradigms of rare tumors using genomics 
  Boston, MA - 1/1/2016
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets 
  Multiple Locations, 2015, 2016 - 1/1/2016
• Emerging Paradigms for the Optimal Management of Brain Metastases 
  San Diego, CA - 1/1/2016
• Evolving Clinical Paradigms in Meningiomas, Craniopharyngiomas and Brain Metastases: Genomics as a Tool 
  Multiple Locations, 2014, 2015, 2016 - 1/1/2016
• Targeted Medical Therapy for Meningiomas 
  Las Vegas, NV - 1/1/2016
• Genomic profiling of brain metastases and emerging therapies for brain metastases 
  Scottsdale, AZ - 1/1/2016
• Targeted therapy for meningioms in the US 
  Scottsdale, AZ - 1/1/2016
• Emerging Targeted Therapies for Meningiomas & Craniopharyngiomas 
  Xian, China, 2016; Hangzhou, China, 2016 - 1/1/2016
• Shifting Clinical Paradigms in Brain Metastases 
  Multiple Locations, 2015, 2016 - 1/1/2016
• Development of Precision Medicine Approaches for Meningiomas 
  Toronto, ON, Canada - 1/1/2016
• Shifting Clinical Paradigms in Brain Metastases: Genomics as a tool 
  Toronto, ON, Canada - 1/1/2016
• Shifting Clinical Paradigms in Brain Tumors 
  Toronto, ON, Canada - 1/1/2016
• Management of brain metastases 
  1/1/2016
• Genomics of Meningiomas and Brain Metastases 
  Toronto, ON, Canada - 1/1/2016
• Genomics of craniopharyngiomas 
  1/1/2016
• Genetics and Heterogeneity 
  Heidelberg, Germany - 1/1/2016
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Other

• Identification of PIN1 inhibitors as possible therapeutic agents against Alzheimer’s disease (Thesis) 
  Brastianos, P.K, University of British Columbia
  1/2/2002