PhilipAPhilipMD

PubMed

• 1232 citations
  Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-05...
  Charles S. Fuchs, Toshihiko Doi, Raymond Jang, Kei Muro, Taroh Satoh
  JAMA Oncology. 2018-05-10
• 325 citations
  Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.
  Shadan Ali, Aamir Ahmad, Sanjeev Banerjee, Subhash Padhye, Kristin Dominiak
  Cancer Research. 2010-05-01
• 141 citations
  Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer.
  Shadan Ali, Khaldoun Almhanna, Wei Chen, Philip A. Philip, Fazlul H. Sarkar
  American Journal of Translational Research. 2011-01-01

Journal Articles

• A Rapid Method for the Determination of Acetylation Phenotype Using Dapsone.  
  Philip, P.A., Roberts, M.S., Rogers, H.J, British Journal of Clinical Pharmacology. 17:465-69, 1984
• Genetically Determined Debrisoquine Oxidation Capacity in Bladder Cancer.  
  Cartwright, R.A, Philip, P.A., Rogers H.J., Glashan, R.W, Carcinogenesis. 5: 1191-92, 1984
• Influence of Age, Sex and Body Weight on the Dapsone Acetylation Phenotype.  
  Philip, P.A., Gayed, S.L., Roger, H.J., Crome, P, British Journal of Pharmacology. 23:709-713, 1987
• Curable Metastatic Cancer in Young Women.  
  Ledermann, J.A., Crawford, S.M., Philip, P.A., Bagshawe, K.D, British Medical Journal. 295: 399-452, 1987
• Acetylator Status and its Relationship to Breast Cancer and Other Diseases of the Breast.  
  Philip, P.A., Rogers, H.J., Millis, R.R., Rubens, R.D., Cartwright, R.A, European Journal of Cancer and Clinical Oncology. 23:1701-06, 1987
• Acetylation and Oxidation Phenotypes in Malignant Lymphoma.  
  Philip, P.A., Rogers, H.J., Harper, P.G, Cancer Chemotherapy and Pharmacology. 20:235:238, 1987
• Determination of Debrisoquine Metabolic Ratio From Hourly Urine Collections in Healthy Volunteers.  
  Philip, P.A., James, C.A., Rogers, H.J, British Journal of Clinical Pharmacology. 24:827- 29, 1987
• Polymorphic N-acetylation Capacity in Lung Cancer.  
  Philip, P.A., Fitzgerald, D.L., Cartwright, R.A., Peake, M.D., Rogers, H.J, Carcinogenesis. 9:491-3, 1988
• Relationship Between Ifosfamide Plasma Clearance and the Debrisoquine Oxidation Status.  
  Philip, P.A., James, C.A., Lewis, L.D., Rogers, H.J, Cancer Chemotherapy and Pharmacology. 22:321-24, 1988
• Bone Disease in Testicular and Extragonadal Germ Cell Tumors.  
  Hitchins, R.N., Philip, P.A., Wignall, B., Newlands, E.S., Begent, R.H.J., Rustin, G.J.S., Bagshawe, K.D, British Journal of Cancer. 58:793-96, 1988
• Effect of Cancer Chemotherapy on Dapsone N-acetylation in Man.  
  Philip, P.A., Rogers, H.J, Cancer Chemotherapy and Pharmacology. 23:395-96, 1989
• The Influence of Cimetidine on Debrisoquine 4-Hydroxylation in Extensive Metabolizers.  
  Philip, P.A., James, C.A., Rogers, H.J, European Journal of Clinical Pharmacology. 36:319-21, 1989
• Respiratory Failure Due to Choriocarcinoma: A Study of 103 Dyspnoeic Patients.  
  Kelly, M.P., Rustin, G.J.S., Ivory, C., Philip, P.A., Bagshawe, K.D, Gynaecologic Oncology. 38:149-154, 1990
• In Vivo Uptake of 131I-5-Iodo-2-Deoxyuridine by Malignant Tumors in Man.  
  Philip, P.A., Bagshawe, K.D., Searle, F., Newlands, E.S., Begent, R.H.J., Adam, T, British Journal of Philip A. Cancer. 63:134-35, 1991
• Convulsions and Cortical Blindness Following Therapy with Cisplatin.  
  Philip, P.A., Carmichael, J., Harris, A.L, British Medical Journal. 302:416, 1991
• Weekly Etoposide, Methotrexate, and Actinomycin D, Alternating with Cyclophosphamide Plus Vincristine (EMA/CO); A Phase II Study in Advanced Gastric Carcinoma.  
  Philip, P.A., Rustin, G.J.S., Ledermann, J.A., Begent, R.H.J., Bagshawe, K.D, Clinical Oncology. 3:214-16, 1991
• A Phase I Study on the Reversal of Multidrug Resistance (MDR) in Vivo: Nifedipine Plus Etoposide.  
  Philip, P.A., Joel, S., Monkman, S.C., Dolega-Ossowski, E., Tonkin, K., Carmichael, J., Idle, J.R., Harris, A.L, British Journal of Cancer. 65:267-270, 1992
• Phase I Study of Intravenous 4-Hydroxyanisole.  
  Rustin, J.R., Stratford, M.R., Lamont, A., Bleehen, N., Philip, P.A., Howells, N., Watfa, R.R., Slack, J.A, European Journal of Cancer. 28A(8/9): 1362-64, 1992
• High-dose Tamoxifen as an Enhancer of Etoposide Cytotoxicity. Clinical Effects and In Vitro Assessment in P-Glycoprotein Expressing Cell Lines.  
  Stuart, N.S.A., Philip, P.A., Harris, A.L., Tonkin, K., Houlbrook, S., Kirk, J., Lien, E.A., Carmichael, J, British Journal of Cancer. 66:833-39, 1992
• Hormonal Treatment of Pancreatic Carcinoma: A Phase II Study of LHRH Agonist Goserelin Plus Hydrocortisone.  
  Philip, P.A., Carmichael, J., Tonkin, K., Buamah, P.K., Britton, J., Dowsett, M., Harris, A.L, British Journal of Cancer. 67:379-82, 1993
• The Influence of High Dose Hydroxyurea on the Incorporation of 5-Iodo-2-Deoxyuridine (IUdR) by Human Bone Marrow and Tumor Cells In Vivo.  
  Philip, P.A., Kaklamanis, L., Carmichael, J., Tonkin, K., Morrison, H., Gatter, K., Harris, A.L, British Journal of Cancer, 67:644-49, 1993
• A Phase I Study of the Left-Shifting Agent BW12C79 Plus Mitomycin C and the Effect on the Skeletal Muscle Metabolism Using 31P Magnetic Resonance Spectroscopy.  
  Philip, P.A., Campbell, C.H., Carmichael, J., Rea, D., Mitchell, K., Taylor, D.J., Stuart, N.S.A, Dennis, I., Rajagopalan, B., Ganesan, T., Radda, K., Harris, A.L, Cancer Research. 53:5649-53, 1993
• Phase I Study of Bryostatin 1: Assessment of Interleukin 6 and Tumor Necrosis Factor? Induction In Vivo.  
  Philip, P.A., Rea, D., Thieves, P., Carmichael, J., Stuart, N.S.A., Rockett, H., Talbot, D.C., Ganesan, T., Pettit, G.R., Balkwill, F., Harris, A.L, Journal of National Cancer Institute. 85:1812-18, 1993
• Expression of Xenobiotic-Metabolizing Enzymes in Primary and Secondary Hepatic Tumors in Man.  
  Philip, P.A., Kaklamanis, L., Ryley, N., Wolf, R., Harris, A.L., Stratford, I., Carmichael, J, International Journal of Radiation Oncology Biology Physics. 29:277-83, 1994
• A Phase II study of high-dose hydroxyurea and dacarbazine (DTIC) in the treatment of metastatic malignant melanoma.  
  Philip, P.A., Carmichael J., Tonkin T., Ganesan T.A., Harris A.L, European Journal of Cancer, 30A: 1027-1029, 1994
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Books/Book Chapters

• Chemotherapy: Concepts, Mechanisms, and New Targets for Chemotherapy. 
  Chapter: Potential for Protein Kinase C Inhibitors in Cancer Therapy 
  Page 3 - 27Philip, P.A., Harris, A.LEditors: FM Muggia.Kluwer Academic Publishers, Boston, MA
• Encyclopedia of Cancer. 
  Chapter: Erlotinib 
  El-Rayes BF, Gadgeel S, Ali S, Philip PA, Sarkar FHSpringer, Berlin
• Oxford Textbook of Medicine. 
  Chapter: Malignant Disease in Pregnancy 
  Page 1806 - 1808Philip, P.A., Harris, A.LEditors: Weatherall D., Ledingham J.G.G., Warell D.A.Oxford University Press, OxfordEdition 3,
• Treatment of Cancer. 
  Chapter: Drug Resistance 
  Page 109 - 119Talbot, D.C., Philip, P.AEditors: Price P. and Sikora K.Chapman and Hall, LondonEdition 3,
• Medical Oncology a Comprehensive Review. 
  Chapter: Gastric Cancer 
  Page 235 - 246Philip, P.A., Ajani, JEditors: Richard Pazdur.PRR, Huntington, New York
• Medical Oncology, a Comprehensive Review. 
  Chapter: Prostate Cancer 
  Page 419 - 432Philip, P.A., Milliken, REditors: Richard Pazdur.PRR, Huntington, New York
• Medical Oncology, a Comprehensive Review. 
  Chapter: Esophageal Cancer 
  Page 225 - 234Philip, P.A., Ajani, JEditors: Richard Pazdur.PRR, Huntington, New York
• Genetic Diagnosis in Medicine. 
  Chapter: Molecular Biology in the Diagnosis, Follow-up and Therapeutic Evaluation of Colorectal Cancer 
  Philip, P.AEditors: J. Garcia-Foncillas, M.E. Armengod, J.M. Echevarria, A. Blasbond.University of Navarra Press, Pamplona
• Melanoma: Biologically Targeted Therapeutics. 
  Chapter: Biochemotherapy of Melanoma 
  Page 259 - 285Flaherty, L.E., Philip, P.AEditors: Ernest C Borden.Humana Press Inc, Totowa, New Jersey
• Pancreatic Cancer. 
  Chapter: Pitfalls in Clinical Trials and Future Directions 
  Page 723 - 731Philip, P. A., Heilbrun, L. K., Abrams, JSpringer Science
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Abstracts/Posters

• Molecular Aspects of Breast Carcinoma.
  Philip, P.A., Harris, A.L, Current Medical Literature. pp 3-7, 1992, Royal Society of Medicine
• The influence of a continuous infusion of hydroxyurea (HU) on the uptake of 5-iodo-2-deoxyuridine (IUdR) by bone marrow and tumor cells in man.
  Philip P.A., Kaklamanis L., Morrison H., Gatter K.C., Carmichael J., Harris A.L, British Association of Cancer Research meeting, Manchester, England
• The effect of ifosfamide on antipyrine clearance in patients with non-small cell lung cancer.
  Lind M., Philip P.A., Margison J., et al, Proceedings of AACR, 32
• Expression of drug metabolising enzymes (DME) in primary hepatic tumors in man.
  Philip P.A., et al, British Association of Cancer Research (BACR) Spring meeting, University of Southampton, Southampton, England
• A phase I/II study of left shifting agent BW12C and mitomycin C. Monitoring by magnetic resonance spectroscopy (MRS).
  Philip P.A. et al, Proceedings of the ASCO
• Gemcitabine: an active drug in advanced breast cancer.
  Carmichael J., Philip P.A., Rea D., et al, Results of a phase II study. Proceedings of ASCO
• Hormonal therapy in pancreatic carcinoma: A phase II study of LHRH agonist goserelin plus hydrocortisone.
  Philip P.A., et al, British Association of Cancer Research (BACR) spring meeting, University of Southampton, Southampton, England
• Modulation of drug resistance with antimetabolites: the influence of high-dose hydroxyurea (HU) on the repair of cisplatin induced DNA damage.
  Philip P.A, British Association of Cancer (BACR) spring meeting, University of Southampton, Southampton, England
• Essential fatty acids in the treatment of metastatic carcinoma of the colon.
  Rea D., Harris A.L., Philip P.A., et al, British Association of Cancer Research (BACR) spring meeting, University of Southampton, Southampton, England
• Phase I trial of bryostatin-1. Influence on the plasma concentrations of interleukin-6 and tumor necrosis factor-a.
  Philip P.A., et al, Proceedings of the AACR, 34
• High-dose hydroxyurea increases the formation of O6-methylguanine but not N7-methylguanine DNA adducts in lymphocytes from melanoma patients treated with dacarbazine w...
  Philip P.A., et al, EORTC/PAMM winter meeting, Brest, France
• Hydroxyurea increases the formation of O6-methylguanine (OMG) DNA adducts in lymphocytes from melanoma patients treated with dacarbazine (DTIC).
  Philip P.A., et al, Proceedings of ASCO
• Difluorodeoxycytidine (gemcitabine): A phase II study in patients with advanced breast cancer.
  Carmichael J., Possinger K., Philip P.A., et al, Proceedings of ASCO
• Expression of xenobiotic-metabolizing enzymes (XMEs) by primary and secondary hepatic tumors in man.
  Philip P.A., et al, Eighth International Congress on Chemical Modifiers, Kyoto, Japan
• Phase I study of protein kinase C partial agonist, bryostative-1.
  Philip P.A., Talbot D., Rea D., et al, EORTC Early Drug Development Meeting, Rotterdam, the Netherlands
• Phase I study of the mitomycin C analogue BMY 25067.
  Talbot D.C., Green J.A., Mitchell K., Smith K., Philip P.A., Stuart N., et al, European Journal of Cancer. 29A
• 5-fluorouracil, a-interferon, cisplatin (FAP) and methotrexate (MTX) in patients (pts) with transitional cell carcinoma (TCC): results of a phase I trial.
  Philip P.A., et al, Proceedings of ASCO 13, A796
• Increased dose-intensity of epirubicin and ifosfamide in small cell lung cancer using r-metHuG-CSF.
  O'Byrne K.J., Philip P.A., Stuart N.S.A. et al, British Journal of Cancer, Supplement XXI, Vol 69
• Multidrug resistance reversal with toremifene in renal cell cancer.
  Vallis K., Philip P.A., Rockett H., et al, British Journal of Cancer, Supplement XXI, Vol 69
• Correlation between an apoptosis-associated gene (TRPM-2) and apoptotic cell death induced by Adriamycin in a rat prostatic epithelial cell line (NbE).
  Philip P.A., and Hsieh J.T, AACR special conference in cancer research: Basic and clinical aspects of prostate cancer, Palm Springs, CA
• 5-Fluorouracil and folinic acid modulation with hydroxyurea in the treatment of metastatic colorectal cancer.
  O'Byrne K.J., Philip P.A., et al, British Journal of Cancer, Supplement, p. 10, A3.1, BACR Spring meeting, Nottingham, England
• Modulation of 5-Fluorouracil and folinic acid with hydroxyurea in the treatment of metastatic colorectal cancer.
  O'Byrne K.J., Philip P.A., et al, Proceedings of ASCO, 14:172, 372A
• In vitro metabolism of cytotoxic drugs using V79 cells stably transfected with human cytochrome P-450 cDNAs.
  Philip P.A., Ali-Sadat, S., Kocarek, T., Doehmer, J, Proceedings of AACR, Abstract #2515
• The use of the V79 cells stably transfected with cytochrome P-450 cDNAs in studying the metabolism of cyclophosphamide and ifosfamide.
  Philip P.A., Ali-Sadat, S., Kocarek, T., Doehmer, J, Proc. ASCO, Abstract #A1588
• Influence of differential metabolism of cyclophosphamide (CPA) on cytotoxicity in MCF-7 and V-79 cells.
  Philip P.A., Ali-Sadat S, Chen, K.K., Kocarek, T., Doehmer, J, Proc. AACR
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Lectures

• Phase II Study of Gemzar and Cisplatin in Advanced or Metastatic Pancreatic Cancer. 
  Seminar, U.S. Gemzar Investigator’s Meeting, Memphis, TN
• Phase II Study of Carboplatin and Paclitaxel in Gastric and Esophageal Cancer. 
  Seminar, Fox Chase and Free University Symposium, St. Thomas, Virgin Islands
• Protein Kinase C Modulators in Cancer Therapy: Bryostatin 1. 
  Iowa Oncology Society Annual Meeting, Des Moines
• Molecular Biology in the Diagnosis and Treatment of Colo-Rectal Cancer. 
  2nd International Symptom on Molecular Diagnosis in Medicine, Madrid, Spain
• Colo-Rectal Cancer. 
  Multiple Locations 1997, 1998, 1999, 2000
• Update on Carboplatin and Taxol in Upper GI and Unknown Primary Cancers. 
  Fox Chase Cancer Center meeting, Lanai, Hawaii
• Phase I Study of Gemzar and Orzel. 
  Gemzar Investigators Meeting, New Orleans
• Phase II Study of Gemcitabine and Cisplatin in Advanced Pancreatic Cancer. 
  Gemzar Investigators' Meeting, New Orleans
• Advances in the Treatment of Pancreas Cancer. 
  Dr Cobau’s Group in Toledo
• Updates on the Treatment of Advanced Breast Cancer. 
  Tumor Board, Bixby Medical Center, Adrian, Ohio
• Role of Bisphosphonates in Management of Cancer Pain 
  Somerville College, University of Oxford, United Kingdom
• Colo-rectal and Primary Hepatic Cancers. 
  St. Joseph Hospital, Pontiac, MI
• Clinical Dilemmas. 
  Division of Hematology and Oncology, Detroit, MI
• Expression of Xenobiotic-Metabolizing Enzymes in Tonsilar Tissues. 
  Institute of Chemical Toxicology, Detroit, MI
• Mechanisms of Drug Resistance in Human Breast Cancer. 
  Breast Multidisciplinary Conference. Detroit, MI
• Advances in Colo-Rectal Cancer. 
  Harper Hospital, Detroit, MI
• Drug-Metabolizing Enzymes. 
  Mechanisms of Drug Resistance Group, Barbara Ann Karmanos Cancer Institute, Detroit, MI
• Pancreatic Cancer. 
  Multiple Loactions, 1998, 2000, 2001, 2004, 2005, 2006, 2008
• Role of Cytochrome P450 3A4 Enzyme in the Pharmacogenetics of Cyclophosphamide. 
  Kresge Eye Institute, Detroit, MI
• Mechanisms of Drug Resistance Group. 
  Karmanos Cancer Institute
• Advances in the Therapy of Pancreatic Cancer. 
  Department of Medicine, Hutzel Hospital
• Bryostatin and Gemcitabine. 
• Phase II Study of Gemcitabine and Cisplatin. 
  Pancreas Group at Karmanos Cancer institute
• Updates on the Treatment of Pancreas Cancer. 
  Drug Discovery Program, Karmanos Cancer Institute
• Role of Carcinogen Metabolizing Enzymes in Susceptibility and Response to Therapy. 
  Breast Program, Karmanos Cancer Institut
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Other

• Current Strategies in Previously Untreated Patients with Advanced Colorectal Cancer. 
  Philip PA, Physicians Education Resource, 7(3): 3-6, 2003
• Experience with Docetaxel in the Treatment of Gastric Cancer. 
  Philip PA, Seminars in Oncology. 32(suppl 4): S24-S38
• Liver Directed Therapies in Hepatocellular Cancer. 
  Choi M and Philip PA, Community Oncology
• Targeted Therapies for Pancreatic Cancer. 
  Philip PA, Gastrointestinal Cancer Research, 2(4): S16-S19
• Improvements in Gastric Cancer Therapy Options. 
  Philip, PA, Medscape Conference Coverage
  http://www.medscape.com/viewarticle/457605
• Update on the GI ASCO Symposium, Pancreas Cancer. 
  Philip, PA
  http://www.medscape.com/viewarticle/468972
• Key Practical Strategies in Pancreatic Cancer: Improving Treatment Disparities and Clinical Trial Accrual. 
  Philip PA, MedscapeCME Oncology
  http://www.medscape.com
• Top Oncology Stories for 2010, Pancreas Cancer. 
  Philip PA, Lee Schwartzberg and Axel Grothey
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