PeterWStacpooleMD

Endocrinology • Gainesville, FL

Diabetes, Lipid Metabolism

Professor, Medicine, University of Florida College of Medicine

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Office
1600 SW Archer Rd
Gainesville, FL 32610

Education & Training

Vanderbilt University Medical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1978 - 1980
Vanderbilt University Medical CenterResidency, Internal Medicine, 1976 - 1978
Vanderbilt University School of MedicineClass of 1976
UC San FranciscoPhD, Pharmacology, 1968 - 1972

Certifications & Licensure

CA State Medical License 1980 - Present
FL State Medical License 1981 - 2025
TN State Medical License 1978 - 1984

Awards, Honors, & Recognition

Elected Member Royal Society of Physicians, 2000
Elected Member The American Society for Clinical Investigation, 1985

Clinical Trials

Prevention of Dichloroacetate Toxicity Start of enrollment: 2001 Sep 01
Completed
Not Applicable
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease Start of enrollment: 2007 Jan 01
Completed
Phase 3
Pharmacotoxicology of Trichloroethylene Metabolites Start of enrollment: 2011 Aug 01
Terminated
Not Applicable
Pharmacotoxicology of Trichloroethylene Metabolites Start of enrollment: 2009 Aug 01
Completed
Not Applicable
Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors Start of enrollment: 2010 Apr 01
Completed
Phase 1
Vitamin B6 Effects for Women Taking Birth Control Pills Start of enrollment: 2010 Apr 01
Completed
Phase 2, Phase 3
Pharmacotoxicology of Trichloroethylene Metabolites Start of enrollment: 2010 Apr 01
Completed
Phase 1, Phase 2
Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
No longer available
13C-Pyruvate Breath Test Start of enrollment: 2013 Mar 01
Completed
Phase 1
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Start of enrollment: 2020 Jul 14
Active, not recruiting
Phase 3
A Pilot Study of Rapid Haplotyping Procedure for Personalized Dosing of Dichloroacetate (DCA) in Healthy Volunteers Start of enrollment: 2016 Mar 01
Completed
Phase 1
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM) Start of enrollment: 2022 Jul 01
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation.
Peter W Stacpoole, Carolyn O Dirain
Molecular Genetics and Metabolism. 2024-07-16
1 citations
Clinical physiology and pharmacology of GSTZ1/MAAI.
Peter W Stacpoole
Biochemical Pharmacology. 2023-11-01
17 citations
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.
Peter W Stacpoole, Charles E McCall
Mitochondrion. 2023-05-01

Grant Support

Phase 3 Trial Of Coenzyme In Mitochondrial DiseaseFood And Drug Administration2006–2011
Planning Grant For Phase 3 Trial Of Dichloroacetate In PDH DeficiencyEunice Kennedy Shriver National Institute Of Child Health &Human Development2010
Pharmacotoxicology Of Trichloroethylene MetabolitesNational Institute Of Environmental Health Sciences2006–2010
UF Clinical And Translational Science AwardNational Center For Research Resources2009
Pilot Study Of DCA Effects On Human Tyrosine MetabolismNational Center For Research Resources2009
Dichloroacetate Treatment Of CLA Presenting In InfancyNational Center For Research Resources2009
CTSA Infrastructure For Pediatric ResearchNational Center For Research Resources2009
CTSA Infrastructure For Clinical TrialsNational Center For Research Resources2009
CTSA Infrastructure For AIDS ResearchNational Center For Research Resources2009
Clinical Trial: The Effect Of Dichloroacetate On Aerobic Function And Work CapacNational Center For Research Resources2008–2009
Clinical Trial: Dichloroacetate Treatment Of Congenital Lactic AcidosisNational Center For Research Resources2008–2009
Pharmacotoxicology Of Trichloroethylene MetabolitesNational Center For Research Resources2005–2009
Dichloroacetate Kinetics, Metabolism And ToxicologyNational Institute Of Environmental Health Sciences1995–2009
The Effect Of Dichloroacetate On Aerobic Function And Work Capacity InNational Center For Research Resources2005–2007
Dichloroacetate Treatment Of Congenital Lactic AcidosisNational Center For Research Resources1997–2007
Institutional CTSA Planning GrantNational Center For Research Resources2006
Prevention Of Dichloroacetate ToxicityNational Center For Research Resources2004–2005
Dichloroacetate Treatment Of Congenital Lactic Acidosis*National Center For Research Resources2004–2005
Dichloroacetate Kinetics And MetabolismNational Center For Research Resources1996–2004
Pharmacology Of Trichloroethylene MetabolitesNational Institute Of Environmental Health Sciences2000–2002
Pathobiology &Treatment Of Malaria In AfricaNational Center For Research Resources1999–2001
Physiology/Cognition--Ritalin In Sleep Deprived StudentNational Center For Research Resources2000
Treatment Of Congenital Lactic Acidosis With Sodium DichloroacetateNational Center For Research Resources1998–2000
Evaluation Of DCA As Adjunct Therapy In Severe MalariaNational Institute Of Allergy And Infectious Diseases1997–1999
Dichloroacetate Kinetics, Metabolism And Human ToxicologyNational Institute Of Environmental Health Sciences1995–1999
Natural History And Course Of Cerebrotendonous Xanthomatosis (CTX)National Center For Research Resources1995–1997
Treatment Of Mitochondrial Myopathies With Dichloroacetic AcidNational Center For Research Resources1995–1996
Nutritional Control Of Intermediary MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1988–1991
Treatment Of Lactic Acidosis With DichloroacetateNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1990
Regulation Of Human HMG Coa ReductaseNational Heart, Lung, And Blood Institute1985–1988
Regulation Of Human HMG Coa ReductaseNational Heart, Lung, And Blood Institute1985–1986

Industry Relationships

Chief Scientific Officer, Praesidio Pharma, LLCFocus on research involving dichloroacetate (DCA) and related compounds2018 - Present