PennyLSappingtonMD

Internal Medicine • Morgantown, WV

Critical Care Medicine, Infectious Disease

Associate Professor, Department of Cardiovascular and Thoracic Surgery Medical Director of Transplant Critical Care WVU Heart & Vascular Institute West Virginia University

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Office
1 Medical center Drive
Morgantown, WV 26506

Education & Training

UPMC Medical Education/Presbyterian Shadyside HospitalFellowship, Critical Care Medicine, 1999 - 2000
Howard UniversityFellowship, Infectious Disease, 1997 - 1999
Howard UniversityResidency, Internal Medicine, 1994 - 1997
Pennsylvania State University College of MedicineClass of 1994

Certifications & Licensure

WV State Medical License 2020 - 2025
PA State Medical License 1999 - 2021
DC State Medical License 1996 - 2002
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine

Clinical Trials

Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients Start of enrollment: 2008 Jan 01
Withdrawn
Phase 2

Publications & Presentations

PubMed

259 citations
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice
Penny L. Sappington, Runkuan Yang, Huan Yang, Kevin J. Tracey, Russell L. Delude
Gastroenterology. 2002-09-01
89 citations
Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers.
Penny L. Sappington, Xiaonan Han, Runkuan Yang, Russell L. Delude, Mitchell P. Fink
The Journal of Pharmacology and Experimental Therapeutics. 2003-01-01
122 citations
HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers.
Shiguang Liu, Donna B. Stolz, Penny L. Sappington, Carlos A Macias, Meaghan E. Killeen
American Journal of Physiology. Cell Physiology. 2006-04-01

Grant Support

HMGB1 Alteration Tight Junction Structure And FunctionNational Institute Of General Medical Sciences2004–2008