PaulaRuthClemensMD

Neurology • Pittsburgh, PA

Associate Professor, Neurology, University of Pittsburgh School of Medicine

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Office
3471 5th Ave
Ste 810
Pittsburgh, PA 15213
Phone+1 412-692-4920

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Residency, Neurology, 1988 - 1990
Dartmouth-Hitchcock/Mary Hitchcock Memorial HospitalResidency, Neurology, 1985 - 1988
Dartmouth-Hitchcock/Mary Hitchcock Memorial HospitalInternship, Internal Medicine, 1984 - 1985
MCP-Hahnemann College of MedicineClass of 1984

Certifications & Licensure

PA State Medical License 1995 - 2026
TX State Medical License 1993 - 1995
MN State Medical License 1988 - 1993
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011

Clinical Trials

Longitudinal Study of the Natural History of Duchenne Muscular Dystrophy (DMD) Start of enrollment: 2005 Dec 01
Unknown status
Cardiac Magnetic Resonance in Children With Muscular Dystrophy Start of enrollment: 2010 Apr 01
Completed
Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies Start of enrollment: 2010 Feb 01
Completed
Phase 2, Phase 3
Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping Start of enrollment: 2012 Apr 01
Unknown status
Duchenne Muscular Dystrophy Tissue Bank for Exon Skipping Start of enrollment: 2012 Sep 01
Unknown status
First-In-Human Study to Evaluate Safety, Tolerability, and PK of Intravenous ATB200 Alone and When Co-Administered With Oral AT2221
COMPLETED
PHASE1, PHASE2
A Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD) Start of enrollment: 2016 Jun 01
Completed
Phase 2
An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD) Start of enrollment: 2016 Jul 28
Completed
Phase 2
Long-term Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD) Start of enrollment: 2017 Feb 02
Completed
Phase 2
A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD) Start of enrollment: 2018 Jun 29
Completed
Phase 2
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Publications & Presentations

PubMed

Association ofGene Variant Classes With Motor Outcomes in a Drug Registration Clinical Trial Setting.
Yuan Fang, Utkarsh J Dang, Katherine I Illei, Paula Clemens, Eric P Hoffman
Neurology. Genetics. 2025-04-01
Analysis of human urinary extracellular vesicles reveals disordered renal metabolism in myotonic dystrophy type 1.
Preeti Kumari, Lauren M Sullivan, Zhaozhi Li, E Parker Conquest, Elizabeth Cornforth
Nature Communications. 2025-03-05
A Parent Project Muscular Dystrophy-sponsored International Workshop Report on Endocrine and Bone Issues in Patients with Duchenne Muscular Dystrophy: An Ever-changing...
Leanne M Ward, David R Weber, Sze Choong Wong, Susan Apkon, Paula R Clemens
Journal of Neuromuscular Diseases. 2025-02-20

Journal Articles

Safety, Tolerability, and Efficacy of Viltolarsen in Boys with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping
Paula R Clemens, Vamshi K Rao, Craig M Zaidman, JAMA Neurology

Authored Content

Safety, Tolerability, and Efficacy of Viltolarsen in Boys with Duchenne Muscular Dystrophy Amenable to Exon 53 SkippingMay 2020

Press Mentions

Spinal Cord Stimulation Restores Neural Function, Targets Key Feature of Progressive Neurodegenerative DiseaseFebruary 5th, 2025
ReveraGen and Santhera Announce FDA Orphan Grant Funding for Clinical Trial with Vamorolone in Becker Muscular DystrophySeptember 27th, 2021
Long-Term Viltepso Prevents Motor Function Decline in DMD BoysJuly 13th, 2021
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Grant Support

Network of Excellence in Neuroscience Clinical Trials (University of Pittsburgh CRS)UNIVERSITY OF PITTSBURGH AT PITTSBURGH2018–2028
Network of Excellence in Neuroscience Clinical Trials (University of Pittsburgh CRS)UNIVERSITY OF PITTSBURGH AT PITTSBURGH2018–2028
Pilot Trial of Vamorolone for the Treatment of Becker Muscular DystrophyUNIVERSITY OF PITTSBURGH AT PITTSBURGH2020–2025
Pilot Trial of Vamorolone for the Treatment of Becker Muscular DystrophyUNIVERSITY OF PITTSBURGH AT PITTSBURGH2020–2025
Vamorolone trial in Becker muscular dystrophyREVERAGEN BIOPHARMA, INC.2021–2024
Vamorolone trial in Becker muscular dystrophyREVERAGEN BIOPHARMA, INC.2021–2024
Network Of Excellence In Neuroscience Clinical Trials (Univ Of Pittsburgh Crs)National Institute Of Neurological Disorders And Stroke2011
Becker Muscular Dystrophy: A Natural History Study To Predict Efficacy Of EXON SKNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
Genetic Rescue Of Dystrophic Muscle In UteroNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2008
Genetic Rescue Of Dystrophic Mucle In UteroNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2005–2006
Core--Training ProgramNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2003
Analysis And Modulation Of Immunity In Gene TherapyNational Institute Of Allergy And Infectious Diseases1999–2003
Longterm Rescue Of Muscle Function By Dystrophin Delivery--Adenoviral VectorsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1999–2002
Core--Mouse BreedingNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1999–2002
Gene Therapy For Duchenne Muscular DystrophyNational Institute Of Neurological Disorders And Stroke1996–2000
Gene Therapy For Duchenne Muscular DystrophyNational Institute Of Neurological Disorders And Stroke1993–1995