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Office
Duke-NUS Medical School Cardiovascular and Metabolic Disorders Program
8 College Road Level 8D Singapore, 589663 Singapore. Duke University SOM Dept Medicine
Durham, NC 27708
Summary
- 8 College Road, Level 8D14
Singapore 589663
SINGAPORE
Education & Training
- National Institutes of Health Clinical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1986 - 1989
- University of ChicagoResidency, Internal Medicine, 1982 - 1985
- Johns Hopkins University School of MedicineClass of 1982
- Amherst CollegeB.A., Chemistry, 1978
Certifications & Licensure
- MA State Medical License 1989 - 2024
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Endocrinology, Diabetes and Metabolism
Awards, Honors, & Recognition
- Abbott Clinical Thyroid Research Mentor Award (Endocrine Society), 2001
- Boots Clinical Fellowship Mentor Award for outstanding thyroid research (Endocrine Society), 1993
- New Investigator Award Nichols Institute (Endocrine Society), 1992
Clinical Trials
- Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD) Start of enrollment: 2014 Mar 28
Publications & Presentations
PubMed
- 116 citationsEstrogen and thyroid hormone interaction on regulation of gene expression.Yuan-Shan Zhu, Paul M. Yen, William W. Chin, Donald W. Pfaff
Proceedings of the National Academy of Sciences of the United States of America. 1996-10-29 - 135 citationsThyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Winifred W. Yau, Brijesh K. Singh, Ronny Lesmana, Jin Zhou, Rohit A. Sinha
Autophagy. 2019-01-01 - 9 citationsMTORC1 inhibition drives crinophagic degradation of glucagon.Sangam Rajak, Sherwin Xie, Archana Tewari, Sana Raza, Yajun Wu
Molecular Metabolism. 2021-07-02
Journal Articles
- Hepatic FOXO1 target genes are co-regulated by thyroid hormone via RICTOR deacetylation and MTORC2-AKT inhibitionSingh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM, J Biol Chem, 1/1/2016
- Caffeine stimulates hepatic lipid metabolism via autophagy-lysosomal pathwaySinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM, Hepatology, 1/1/2014
- Beta-Adrenergic agonist and antagonist regulation of hepatic autophagyFarah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM, PLOS One, 1/1/2014
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Press Mentions
- A New Twist on an Old Hormone Leads to First Drug for a Type of Liver DiseaseAugust 12th, 2024
Professional Memberships
- Member
- Member
- Asia Oceanic Thyroid AssociationCouncil Member
- Endocrine and Metabolic Society of SingaporeMember
- Iodine Global Network (formerly International Council for the Control of Iodine Deficiency Disorders)Singapore Representative
- World Thyroid FederationRepresentative for Asia
Other Languages
- Chinese (Mandarin), French
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