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Office
Cook Children's Dodson Specialty Clinics
1500 Cooper St 2nd Floor
Fort Worth, TX 76104Phone+1 817-470-0169
Summary
- Paul Stephen Thornton, M.B., B.Ch., M.R.C.P.I., is Medical Director, Distinguished Consultant of the Endocrinology/Diabetes Clinic and the Hyperinsulinism Center at Cook Children's Medical Center, in Fort Worth, Texas.
His recent awards include the Cook Children's Clinical Scholar Award 2012-2014 and recipient of the 2012 Cook Children's Health Care System Endowed Chair Award. Dr. Thornton received a Bachelor of Medicine and Bachelor of Surgery degree from University College, in Dublin, Ireland. He interned at the Mater Misericordiae Hospital, Dublin, with residencies at the Children's Hospital, Dublin, the Hospital for Sick Children Great Ormond Street, London, England, and Children's Hospital of Philadelphia. Dr. Thornton was a fellow in endocrinology at the Children's Hospital of Philadelphia, Pennsylvania. He then became Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia. He is board certified in Pediatric Endocrinology.
As an expert in the evaluation and management of congenital hyperinsulinism, Dr. Thornton is frequently invited to lecture on congenital hyperinsulinism and hypoglycemia in infants and children. He has coauthored more than a dozen book chapters and over 80 journal articles. He presents his research at international and national meetings. Paul is the lead author of the
Pediatric Endocrine Society's Recommendations and Management of Persistent Hypoglycemia in neonates, infants and children. He also leads the Pediatric Endocrine Society's Rare Disease working group on hyperinsulinism and is the senior Author on the International guidelines for the diagnosis and management of hyperinsulinism.
Dr. Thornton is a member of the Pediatric Endocrine Society, Society for Pediatric Research and The Endocrinology Society.
Education & Training
- Children's Hospital of PhiladelphiaFellowship, Pediatric Endocrinology, 1990 - 1995
- University College of Dublin National Univ SOMClass of 1984
Certifications & Licensure
- AZ State Medical License 2023 - 2026
- GA State Medical License 2023 - 2026
- CO State Medical License 2023 - 2025
- KS State Medical License 2023 - 2024
- LA State Medical License 2023 - 2024
- OK State Medical License 2023 - 2024
- TX State Medical License 2003 - 2024
- American Board of Pediatrics Pediatric Endocrinology
- Royal College of Physicians, IrelandMRCPI
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Awards, Honors, & Recognition
- Endowed Chair Cook Children's Health Care System, 2012-2024
- Texas Super Doctors
- Regional Top Doctor Castle Connolly, 2014, 2017, 2020
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Clinical Trials
- Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma Start of enrollment: 2013 Oct 09
- CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital Hyperinsulinism Start of enrollment: 2016 Oct 01
- An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism Start of enrollment: 2020 Feb 24
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Publications & Presentations
PubMed
- Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome.Maiko Matsui, Lauren E Lynch, Isabella Distefano, Allison Galante, Aravind R Gade
Nature Communications. 2024-10-17 - The Birth Prevalence of Congenital Hyperinsulinism: A Narrative Review of the Epidemiology of a Rare Disease.David Lapidus, Diva D De León, Paul S Thornton, Davelyn Hood, Jeffrey Breit
Hormone Research in Paediatrics. 2024-06-17 - 1 citationsIdiopathic Pathological Ketotic Hypoglycemia: Finding the Needle in a Haystack.Joseph I Wolfsdorf, Terry G J Derks, Danielle Drachmann, Pratik Shah, Paul S Thornton
Hormone Research in Paediatrics. 2024-03-21
Journal Articles
- Correction: “Congenital Hyperinsulinism as the Presenting Feature of Kabuki Syndrome: Clinical and Molecular Characterization of 10 Affected Individuals”Lindsay C Burrage, Sara Halbach, Paul Thornton, Andrew C Edmondson, Alejandro Diaz, Lisa Truong, Darrel Waggoner, Nature
- Congenital Hyperinsulinism as the Presenting Feature of Kabuki Syndrome: Clinical and Molecular Characterization of 10 Affected IndividualsAlejandro Diaz, Darrel Waggoner, Lindsay C Burrage, Sara Halbach, Andrew C Edmondson, Lisa Truong, Paul Thornton, Nature
Books/Book Chapters
Abstracts/Posters
- Duration of Fasting Studies Required to Demonstrate a Cure for Patients with Focal Congenital HyperinsulinismLisa Truong, Courtney Reynolds and Paul Thornton, Poster Presentation at ESPE, 9/22/2021
- Outcomes of Feeding Interventions on Patients with Genetic HICourtney Reynolds, Lisa Truong, and Paul Thornton., Presentation at Congenital Hyperinsulinism Research Conference, 9/18/2021
- The Effectiveness of Low Dose Glucagon Infusion (<5 mcg/kg/hr) in Preventing Hypoglycemia.Courtney Reynolds, Lisa Truong, and Paul Thornton., Presentation at Congenital Hyperinsulinism Research Conference, 9/18/2021
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Lectures
- Novel use of a pump post pancreatectomy for congenital hyperinsulinism.The 47th annual conference of the International Society for Pediatric and Adolescent Diabetes - 10/2021
- Controversies in Neonatal Hypoglycemia.The 2021 annual meeting of the British Society of Pediatric Endocrinology and Diabetes - 9/2021
- Mapping the source of HI.National Association of Neonatal Nurses 37th Annual Conference. - 9/2021
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Press Mentions
- FDA Approves First Once-Weekly Injection for Pediatric GH DeficiencyAugust 26th, 2021
- Baby Cured of Rare Disease Goes Home for ChristmasDecember 15th, 2017
- World Health Organization Declares Babies Dying from Breastfeeding Complications Are “Not a Priority”October 19th, 2017
Grant Support
- NIH/NIDDK 1R44DK-105691-01 Prestrelski Co-PI, Thornton Co-PI 4/2015-3/2018 CSI Glucagon for Treatment of Congenital HyperinsulinismNIH/NIDDK2015–2018
- Somatostatin Therapy In HyperinsulinismNational Center For Research Resources1996
- Determination Of Role Of Vitamin D Binding Protein In Actin ScavengingNational Center For Research Resources1996
Committees
- Board Member, JDRF 2020 - Present
- Board member, Pediatric Endocrine Society 2019 - Present
- Member, PES Drug & Therapeutic committee 2017 - Present
- Chairman, Hyperinsulinism Rare Disease Group of the PES 2016 - Present
- Chairman, PES Practice Management Committee 2010 - 2018
Research History
- Cook Children's Endowed Chair2012 - Present
- Use of subcutaneous Glucagon in congenital hyperinsuliniusm Co-PI2015 - 2018
Professional Memberships
- Pediatric Endocrine SocietyMember
- Member
- Society for Pediatric ResearchMember
External Links
- If you missed Grand rounds and want to hear the latest on neonatal hypoglycemia, listen herehttps://cookchildrens.rev.vbrick.com/#/videos/85fce4a4-3760-4ac5-8409-ae79a45b1662
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