Paul Alfred Newhouse MD

PubMed

• Brain cholinergic terminal density utilizing [F]-fluoroethoxybenzovesamicol PET in adults with Down's syndrome: Relationship to amyloid PET and cognitive performance.
  Jason K Russell, Alexander C Conley, Brian D Boyd, John Patrick Begnoche, Rachel Schlossberg
  Alzheimer's & Dementia. 2025-04-01
• Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [F]-fluoroethoxybenzovesamicol positron emission...
  Jason K Russell, Alexander C Conley, Brian D Boyd, J Patrick Begnoche, Rachel Schlossberg
  Neurobiology of Aging. 2025-04-01
• Treatment of Cognitive Impairment in Late Life Depression.
  Paul A Newhouse, Steven P Roose
  The American Journal of Geriatric Psychiatry. 2025-03-01

Journal Articles

• Cognition as a therapeutic target in late-life depression: potential for nicotinic therapeutics  
  Zurkovsky, L, Taylor W, Newhouse, PA, Biochemical Pharmacology, 1/1/2013
• Tamoxifen improves cholinergically-modulated cognitive performance in postmenopausal women  
  Newhouse PA, Albert K, Astur R, Johnson, J, Naylor M, Dumas JA, Neuropsychopharmacology, 1/1/2013
• Increased working memory circuitry activation in postmenopausal women with subjective cognitive complaints  
  Dumas JA, Kutz AM, McDonald BC, Naylor MR, Pfaff AC, Saykin AJ, Newhouse PA, Neurobiology of Aging, 1/1/2013
• Organizational Structure Reduces Processing Load in the Prefrontal Cortex During Discourse Processing of Written Text: Implications for High-Level Reading Issues After...  
  Cannizzaro MS, Dumas J, Prelock P, Newhouse, PA, Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, 1/1/2012
• Manipulation of nicotinic acetylcholine receptors differentially affects behavioral inhibition in volunteers with high and low baseline impulsivity  
  Potter A, Bucci DJ, Newhouse PA, Psychopharmacology, 1/1/2012
• The effects of age and estrogen on stress responsivity in older women  
  Dumas, JA, Albert KM. Naylor MR, Sites C, Benkelfat C, Newhouse PA, American Journal of Geriatric Psychiatry, 1/1/2012
• Estradiol reversal of anticholinergic-related brain activation in postmenopausal women  
  Dumas JA, Kutz A, Naylor M, Johnson J, Newhouse, PA, Neuroimage 60, 1/1/2012
• Nicotine treatment of Mild Cognitive Impairment: A six-month double blind pilot clinical trial  
  Newhouse PA, Kellar K, Aisen P, White H, Wesnes K, Coderre E, Pfaff A, Wilkins H, Howard D, Levin ED, Neurology, 1/1/2012
• Functional brain imaging of nicotinic effects on higher cognitive processes  
  Newhouse PA, Potter AS, Dumas JA, Thiel CM, Biochemical Pharmacology, 1/1/2011
• The cholinergic hypothesis of cognitive aging revisited again: the functional compensation hypothesis  
  Dumas JA, Newhouse PA, Pharmacology, Biochemistry, and Behavior, 1/1/2011
• Estrogen, menopause, and mood regulation  
  Albert K, Broadwell C, Newhouse PA, Menopausal Medicine, 1/1/2011
• Increased memory load-related frontal activation after estradiol treatment in postmenopausal women  
  Dumas J.A., Kutz A.M., Naylor M.R., Johnson, J.V., Newhouse, P.A., Hormones and Behavior, 1/1/2010
• Estrogen interacts with psychosocial stress to impair cognition in postmenopausal women  
  Newhouse P.A., Dumas J.A., Hancur-Bucci C., Naylor M., Sites C., Benkelfat C., Young S, Menopause, 1/1/2010
• Cholinergic modulation of hippocampal activity during episodic memory encoding in older women  
  Dumas, JA, McDonald, BC, Saykin, AJ, McAllister, TW, Hynes, ML, West, JD, Newhouse, PA, Menopause, 1/1/2010
• Depressive symptoms and cognitive complaints in the menopausal transition  
  Maki, PM, Freeman, EW, Greendale, G.A, Henderson, VW, Newhouse, PA, Schmidt, PJ, Scott, NF, Shively, CA,. Soares, CN, Menopause, 1/1/2010
• Broad spectrum assessment of psychopathology and adaptive functioning with the Older Adult Behavior Checklist: A validation study  
  Brigidi, B. Achenbach, T., Dumenci, L., Newhouse, P.A., International Journal of Geriatric Psychiatry, 1/1/2010
• The effects of acute ultra-low dose mecamylamine on cognition in adult attention deficit/hyperactivity disorder (ADHD)  
  Potter, A.S., Ryan, K.K., Newhouse, P.A., Human Psychopharmacology, 1/1/2009
• Ichi, Ni, 3, 4: Neural Representation of Kana, Kanji and Arabic Numbers in Native Japanese Speakers  
  Coderre, E, Filippi, C, Newhouse, PA, Dumas, J, Brain and Cognition, 1/1/2009
• Nicotinic versus Muscarinic Blockade Alters Verbal Working Memory-Related Brain Activity in Older Women  
  Dumas, JA, Saykin, AJ, McAllister, TW, McDonald, BC, Hynes, ML, Newhouse, P.A., American Journal of Geriatric Psychiatry, 1/1/2008
• Estrogen Interacts with the Cholinergic System to Affect Verbal Memory in Post-Menopausal Women: Evidence for the Critical Period Hypothesis  
  Dumas, JA, Hancur-Bucci, C, Naylor, M, Sites, C, Newhouse, PA, Hormones and Behavior, 1/1/2008
• A Brain fMRI Study of the Stroop Effect in Native Japanese Speakers  
  Coderre, E, Filippi, C, Newhouse, PA, Dumas, J, Brain and Language, 1/1/2008
• Estrogen Replacement after Menopause: Role in Normal Cognition and Alzheimer's disease  
  Dumas, J., Edgren, C., Newhouse, P.A., Aging Health, 1/1/2006
• The role of estrogen in the development of age-related cognitive impairment and dementia  
  Dumas J., Salerno, J., Newhouse, P, Psychiatric Times, 1/1/2006
• Nicotinic treatment of Alzheimer's disease  
  Newhouse, P.A., Potter, A., Kelton, M., Corwin, J., Biological Psychiatry, 1/1/2001
• A double-blind comparison of the efficacy of sertraline and fluoxetine in depressed elderly outpatients  
  Newhouse, P.A., Krishnan, K.R.R., Doraiswamy, P.M., Richter, E., Batzar E.D., Clary, C.M., Journal of Clinical Psychiatry, 1/1/2000
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Books/Book Chapters

• Encyclopedia of Psychopharmacology. 
  Chapter: Acetylcholinesterase and Cognitive Enhancement. 
  Page 8 - 14Wilkins, H. Newhouse, PAEditors: Stolerman, IP.Springer-Verlag, Berlin, Germany2010
• Severe Dementia. 
  Chapter: Severe Dementia: Assessment and Diagnosis. 
  Page 3 - 20Newhouse, P.A., Lasek, JEditors: Winblad B.Wiley, London2006
• Manual for the Older Adult Self Report and Older Adult Behavior Check List: An Integrated System of Multi-Informant Assessment. 
  Achenbach, T., Newhouse, P., Rescorla, LUniversity of Vermont Research Center for Children, Youth, and Families, Burlington, VT2004
• Clinical Methodologies in the examination of nicotinic effects on cognition in Nicotine and the Nervous System. 
  Page 255 - 271Potter, A., Newhouse P.Editors: Levin D.CRC Press, Boca Raton, FL2001
• Refractory Mood Disorders. 
  Chapter: Treatment resistant depression in the elderly: Phenomenology and management. 
  Newhouse, P.A., Singh, J.Editors: M. Hornig-Rohan, A Nierenbeg, J Amsterdam.Cambridge Press, Cambridge, UK2001
• Handbook of Experimental Pharmacology. 
  Chapter: "Clinical Aspects of Nicotinic Agents" in Neuronal Nicotinic Receptors. 
  Newhouse, P. Kelton MCEditors: Clementi F., Cotti C., Fornasari D.Springer-Verlag, Heidelberg, Germany2000
• Nicotine in Psychiatry: Emerging Trends in Psychopathology and Emerging Therapeutics. 
  Piasecki, M., Newhouse, P. (eds)Editors: Piasecki, M., Newhouse, P..American Psychiatric Press Inc., Washington, DC2000
• Nicotine in Psychiatry: Nicotine and Nicotinic Systems in Psychiatry: Past and Future in Psychopathology and Emerging Therapeutics. 
  Page 253 - 256Piasecki, M. and Newhouse P.A, (eds)Editors: Piasecki, M. and Newhouse P.A..American Psychiatric Press, Washington, DC2000
• Nicotine in Psychiatry: Emerging Trends in Psychopathology and Emerging Therapeutics. 
  Chapter: Nicotinic cholinergic systems in Alzheimer's and Parkinson's Disease. 
  Page 149 - 182Newhouse, P.A., Whitehouse, PEditors: Piasecki M. and Newhouse P.American Psychiatric Press, Washington, DC2000
• Pharmacotherapy of Mood and Cognition (Hormones, Brain and Neuropsychopharmacology). 
  Chapter: Nicotinic approaches to cognitive enhancement in the dementias. 
  Page 559 - 580Newhouse, PEditors: S. Montgomery and U. Halbreich.APPI, Washington, DC2000
• Progress in Alzheimer's Disease and Similar Conditions (American Psychopathological Association Annual Series). 
  Chapter: Alzheimer's disease and the cholinergic system: An introduction to clinical pharmacological research. 
  Newhouse, P.A.Editors: Heston LL.American Psychiatric Press, Washington, DC1997
• War Psychiatry Part 1: Warfare, Weaponry and the Casualty; Textbook of Military Medicine. 
  Chapter: Neuropsychiatric casualties of nuclear, biological, and chemical warfare. 
  Page 85 - 112Jones, F.D., Newhouse PA, Stokes, J., Belenky, G.L.Editors: Jones, F.D., Sparacino, L.R., Wilcox, V.L., Rothberg, J.M., Stokes, J.W..Office of the Surgeon General, TMM Publications, Washington, DC1995
• The Effects of Nicotine on Biologic System (II). 
  Chapter: Nicotinic modulation of cognitive functioning in human. 
  Page 345 - 351Newhouse, P.A., Potter, A., Piasecki, M., Geelmuyden, J., Corwin, J., Lenox, REditors: Clark, P.B.S., Quik, M., Thuran, K., Adlkofer, F.Birkhauser, Boston, MA1995
• Alzheimer's Disease: Therapeutic Strategies. 
  Chapter: The role of nicotinic systems in the cognitive disorder of Alzheimer's disease. 
  Page 191 - 195Newhouse, P.A., Potter, A., Corwin, J., Lenox, REditors: Giacobini, E., and Becker, R.Birkhauser, Boston, MA1995
• Contemporary Studies in Combat Psychiatry. 
  Chapter: Neuropsychiatric aspects of chemical warfare. 
  Page 185 - 202Newhouse PEditors: Belenky G.Greenwood Press, New York, NY1987
• Psychopharmacology, a Third Generation of Progress. 
  Chapter: Diagnosis and assessment of cognitive dysfunctions in the elderly. 
  Page 909 - 919Weingartner H, Cohen R, Sunderland T, Tariot PN, Thompson K, and Newhouse PAEditors: Meltzer H.Raven Press, New York, NY1987
• Advancing Frontiers in Alzheimer's Disease. 
  Chapter: Towards a taxonomy of cognitive impairments. 
  Page 249 - 262Weingartner H, Grafman J, Newhouse PEditors: Glenner G, and Wurtman R.University of Texas Press, Austin, TX1987
• Psychiatry: The State of the Art. 
  Chapter: Neuropsychiatric casualties of chemical, biological and nuclear warfare. 
  Page 539 - 543Jones FD, Stokes J, Newhouse PA, Belenky GL, Crocq LEditors: Berner P and Pichot P.Plenum Press, New York, NY1985
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Abstracts/Posters

• Cognitive complaints after menopause correlate with functional connectivity of the frontal cortex and medial temporal lobe.
  Zurkovsky L, Dumas JA, Woodward ND, Newhouse PA, Society for Neuroscience annual meeting, San Diego, CA, 11/1/2013
• Menstrual phase is associated with differences in brain activity during psychosocial stress.
  Albert K, Pruessner J, Rabinowitz T, Newhouse PA, Society for Neuroscience annual meeting, San Diego, CA, 11/1/2013
• Tamoxifen produces estrogen-like agonist effects on cholinergically-mediated learning in postmenopausal women.
  Newhouse PA, Albert K, Astur R, Johnson J, Naylor M, Dumas J, Society for Neuroscience annual meeting, San Diego, CA, 11/1/2013
• Decreased gray matter volume in post-menopausal women who report cognitive complaints.
  Zurkovsky L, Dumas JA, Valiquette CM, McDonald BC, Saykin AJ, Taylor WD, Naylor MR, Newhouse PA, Alzheimer's Association International Conference, Boston, MA, 7/1/2013
• Menstrual Phase is Associated with Differences in Brain Activity During Psychosocial Stress.
  Albert K, Pruessner J, Rabinowitz T, Newhouse PA, Society of Biological Psychiatry, San Francisco, CA, 4/1/2013
• Cognitive Complaints After Menopause Correlate with Decreased Functional Connectivity of the Medial Temporal Lobe.
  Zurkovsky L, Dumas, J, Woodward N, Newhouse PA, Society of Biological Psychiatry, San Francisco, CA, 4/1/2013
• Estradiol reversal of anticholinergic-related brain activation in postmenopausal women.
  Dumas JA, Kutz AM, Naylor MR, Johnson JV, Newhouse PA, Biological Psychiatry, 5/1/2011
• Responsivity of postmenopausal women to estradiol-induced brain activation changes in emotional circuitry.
  Newhouse, PA, Kutz, AM, Dumas, JA, Biological Psychiatry, 5/1/2011
• Working memory-related brain activity increases following breast cancer chemotherapy.
  Albert K, Dumas JA, Ditus K, Kelly B, Newhouse PA, Biological Psychiatry, 5/1/2011
• Working memory and emotional processing in geriatric depression: an fMRI study.
  Dumas JA, Newhouse PA, Biological Psychiatry, 5/1/2011
• Changes in neural activity associated with response inhibition during acute nicotine administration.
  Mazzulla EC, Newhouse PA, Dube SL, Potter AS, Biological Psychiatry, 5/1/2011
• Estradiol increases cortical gray matter in healthy postmenopausal women.
  Newhouse, PA, Kutz A, Pfaff A, McDonald B, Saykin A, West J, Casson P, Devins R, Naylor M, Dumas J, Society for Neuroscience Annual Meeting, Washington, DC, 3/1/2011
• Nicotine increases activation in the anterior insular cortex during emotional encoding task in non-smoking adults.
  Carstens K, Potter A, Newhouse P, Dumas J, Society for Neuroscience Annual Meeting, Washington, DC, 3/1/2011
• Increased frontal activation during working memory performance in postmenopausal women with cognitive complaints.
  Dumas J, Kutz A, Pfaff A, Naylor M, Casson P, Newhouse PA, Society for Neuroscience Annual Meeting, Washington, DC, 3/1/2011
• Gender differences in the effect of acute nicotine on impulsivity in ADHD.
  Ryan, K. Newhouse, P. Potter, AS, Society for Neuroscience Annual Meeting, San Diego, CA, 11/2/2010
• Breast cancer chemotherapy alters brain activity during working memory.
  Albert K, Dumas JA, Kelly BK, Dittus KL, Newhouse, PA, Annual Meeting of the Cognitive Neuroscience Society, San Diego, CA, 10/1/2010
• Changes in neural activity associated with response inhibition during acute nicotine administration.
  Mazzulla EC, Newhouse PA, Locke SM, Potter AS, Society for Neuroscience Annual Meeting, San Diego, CA, 10/1/2010
• Novel nicotinic agonist AZD3480 improves cognition in a randomized control trial of adults with attention-deficit/hyperactivity disorder.
  Locke SM, Newhouse PA, Mazzulla E, Wilkins H, Potter AS, Society for Neuroscience Annual Meeting, San Diego, CA, 10/1/2010
• Estradiol treatment alters brain activation following nicotinic blockade in postmenopausal women.
  Newhouse, PA, Kutz AM, Pfaff AC, Naylor MR, Johnson JV, Dumas JA, Society for Neuroscience Annual Meeting, San Diego, CA, 10/1/2010
• Estradiol decreases scopolamine-induced activation in the frontal lobes during a working memory task in postmenopausal women.
  Dumas JA, Kutz AM, Pfaff AC, Naylor MR, Johnson JV, Newhouse PA, Society for Neuroscience Annual Meeting, San Diego, CA, 10/1/2010
• Estradiol modulation of frontal lobe and amygdala activity across the menstrual cycle in young women.
  Pfaff A, Broadwell C, Kutz A, Wilkins H, Newhouse PA, Dumas JA, Society for Neuroscience annual meeting, San Diego, CA, 10/1/2010
• Acute Nicotine Effects on Response Inhibition: An fMRI study of the Stop Signal Task.
  Potter AS, Mazzulla E, Newhouse PA, Society of Biological Psychiatry, New Orleans, LA, 5/1/2010
• The Effects of Hormone Variation During the Menstrual Cycle on Emotional Memory.
  Broadwell CE, Wilkins H, Kutz A, Newhouse PA, Dumas JA, President's Presenters Award Winner at the annual meeting of the Society for Gynecologic Investigation, Orlando, FL, 1/1/2010
• Acute Nicotine Effects on Impulsivity in Adult ADHD and Control Subjects.
  Potter AS, Ryan KK, Newhouse PA, Society for Research on Nicotine and Tobacco, Dublin, Ireland, 1/1/2010
• Estradiol Modulates Emotional Memory Encoding in Young Women.
  Kutz AM, Broadwell C, Wilkins HL, Pfaff AC, Newhouse PA, Dumas JA, Annual Meeting of the Cognitive Neuroscience Society, Montreal, QC, Canada, 1/1/2010
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Lectures

• Nicotinic Effects on Cognitive Operations and Late-Life Cognitive Impairment: Alzheimer's Disease and Beyond. 
  San Diego, CA - 11/6/2013
• Estrogen and the Brain: Studies in Cognitive Aging. 
  9/23/2013
• Estrogen and the Brain: Studies in Cognitive and Emotional Aging. 
  5/12/2013
• Nicotinic Modulation of Age-Related Cognitive Impairment: Human Translational Studies from Models to Multi-Center Trials. 
  1/13/2013
• Nicotinic Mechanisms in Age-Related Cognitive Impairment: Human Translational Studies from Models to Multi-Center Trials. 
  Berlin, Germany - 11/12/2012
• Cognitive Medicine: Human Translational Modeling of Development and Disease. 
  11/30/2011
• Nicotinic Receptor Systems and Cognitive Function in Development and Aging. 
  San Diego, CA - 10/31/2007
• Sex Hormones and Cognitive Aging: New Insights Regarding Cognition and Emotion. 
  La Jolla, CA - 10/30/2007
• Challenges in the Care of the Late Stage Alzheimer's Patient. 
  Plattsburgh, NY - 12/7/2006
• Behavioral and Psychological Disturbances in Alzheimer's Disease: Phenomenology, Management, and Pharmacotherapy. 
  Copenhagen, Denmark - 4/20/2006
• Estrogen-Cholinergic System Interactions and Cognitive Aging. 
  Copenhagen, Denmark - 4/20/2006
• Estrogen and Cholinergic Systems: Implications for Cognitive Aging and Psychopathology. 
  Pittsburgh, PA - 4/12/2006
• Estrogen and the Brain: The Good, the Bad, and the Questions. 
  New Haven, CT - 2/12/2006
• Estrogen and the Brain. 
  Lebanon, NH - 6/20/2005
• Dysfunction of Reward Systems in Psychopathology: Clinical and Research Implications. 
  Atlanta, GA - 5/20/2005
• What's a Woman to Do? Estrogen, Menopause, and the Brain. 
  5/17/2005
• The Treatment of Alzheimer's Disease: Where have We Been and Where are We Going? 
  Little Rock, AK - 2/11/2005
• Combat Stress and the Management of Acute Stress Reactions. 
  9/14/2001
• The Treatment of Geriatric Depression. 
  5/10/2001
• Nicotinics Effect in Neurodegenerative Disorders. 
  10/10/2000
• Nicotinic Treatment of Alzheimer's Disease. 
  Fajardo, PR - 3/16/2000
• Nicotinic Systems in Central Nervous System Disease. 
  Camerino, Italy - 9/5/1999
• Pharmaceutical Treatment of Alzheimer's Disease - Strategies and Clinical Experience. 
  Copenhagen, Denmark - 9/1/1998
• Management of Behavioral Problems in Alzheimer's Disease. 
  Istanbul, Turkey - 5/1/1998
• Drug Treatment of Alzheimer's Disease. 
  Odense, Denmark - 4/1/1998
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