PasiAnteroJanneMDMD, PhD

Oncology • Boston, MA

Associate Professor of Medicine, Dana-Farber Cancer Institute

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Office
44 Binney St
# Dana
Boston, MA 02115
Phone+1 617-632-6049

Fax+1 617-632-5786

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1998 - 2001
Brigham and Women's HospitalInternship, Internal Medicine, 1996 - 1997
Perelman School of Medicine at the University of PennsylvaniaClass of 1996

Certifications & Licensure

MA State Medical License 1998 - 2024
NH State Medical License 2024 - 2024
RI State Medical License 2020 - 2020

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Elected Member The American Society for Clinical Investigation, 2008

Clinical Trials

Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma. Start of enrollment: 2004 Oct 01
Completed
Phase 2
Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer Start of enrollment: 2005 Aug 15
Completed
Phase 2
Study of OSI-774 (Tarceva) in Previously Untreated Elderly Lung Cancer Patients Start of enrollment: 2003 Feb 01
Completed
Phase 2
Bevacizumab (Avastin) and Erlotinib (Tarceva) in Previously Treated Mesothelioma Start of enrollment: 2004 Feb 01
Completed
Phase 2
Erlotinib in Women With Previously Untreated Adenocarcinoma of the Lung Start of enrollment: 2004 Nov 01
Completed
Phase 2
Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer Start of enrollment: 2005 Jun 01
Completed
Phase 2
Epidermal Growth Factor Receptor and K-ras Mutations in Patients With Stage III Non-Small Cell Lung Cancer Start of enrollment: 2005 Nov 01
Completed
Assess Efficacy and Safety of AZD6244 in Combination With Docetaxel in Patients Receiving Second Line Non Small Cell Lung Cancer Treatment. Start of enrollment: 2012 Dec 18
Completed
Phase 2
A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants Start of enrollment: 2013 Aug 01
Completed
Phase 2
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) Start of enrollment: 2014 Sep 26
Recruiting
Not Applicable
A Phase 2 Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer Start of enrollment: 2018 Jan 31
Active, not recruiting
Phase 2
Osimertinib In EGFR Mutant Lung Cancer Start of enrollment: 2018 Aug 13
Recruiting
Phase 2
Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1) Start of enrollment: 2019 Jul 09
Active, not recruiting
Phase 1, Phase 2
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations Start of enrollment: 2020 Jan 10
Active, not recruiting
Phase 3
Roles: Principal Investigator
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Publications & Presentations

PubMed

7632 citations
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee, Sean Tracy, Heidi Greulich
Science. 2004-06-04
263 citations
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
Kari J. Kurppa, Yao Liu, Ciric To, Tinghu Zhang, Mengyang Fan
Cancer Cell. 2020-01-13
515 citations
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
Pasi A. Jänne, Alice T. Shaw, José Rodrigues Pereira, Gaelle Jeannin, Johan Vansteenkiste
The Lancet. Oncology. 2013-01-01

Journal Articles

Genomic Correlates of Response to Immune Checkpoint Blockade in Microsatellite-Stable Solid Tumors
Jeffrey A Engelman, David A Barbie, Nicole G Chau, Glenn J Hanna, Natalie I Vokes, Sabina Signoretti, Pasi A Janne, Robert I Haddad, Lynette M Sholl, Rizwan Haq, Peter..., Nature

Lectures

Safety and preliminary antitumor activity of U3-1402: A HER3-targeted antibody drug conjugate in EGFR TKI-resistant, EGFRm NSCLC.
2019 ASCO Annual Meeting - 6/1/2019
Antitumor activity of TAK-788 in NSCLC with EGFR exon 20 insertions.
2019 ASCO Annual Meeting - 6/1/2019
Phase 1 study of the anti-HER3 antibody drug conjugate U3-1402 in metastatic or unresectable EGFR-mutant NSCLC.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018

Press Mentions

Erasca Announces Trial to Evaluate ERAS-007 in Combination with KRAS G12C Inhibitor in KRAS-Driven CancersJune 2nd, 2022
Takeda Pharmaceutical : EXKIVITY (Mobocertinib) Approved by U.S. FDA as the First Oral Therapy Specifically Designed for Patients with EGFR Exon20 Insertion+ NSCLCSeptember 20th, 2021
WCLC 2021: KRAS Drugs May Do Best in Tough SubtypeFebruary 2nd, 2021
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Grant Support

The Use Of Whole-Exome Sequencing To Guide The Care Of Cancer PatientsNational Human Genome Research Institute2012
EML4-ALK: A Potential Therapeutic Target In Lung CancerNational Cancer Institute2009–2012
Drug Resistance In Lung CancerNational Cancer Institute2008–2011
Mechanisms Of Acquired Resistance To Egfr-Targeted AgentsNational Cancer Institute2008–2009