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Office
8700 Beverly Blvd
Los Angeles, CA 90048
Summary
- Dr. Ophir Klein serves as the inaugural executive director of Cedars-Sinai Guerin Children’s and Executive Vice Dean for Children’s Services at Cedars-Sinai. He is the David and Meredith Kaplan Distinguished Chair in Children’s Health and is also an Adjunct Professor of Orofacial Sciences and Pediatrics at the University of California, San Francisco (UCSF), where he was previously the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies and the Charles J. Epstein Professor of Human Genetics. Until 2022, he served as Director of the Institute for Human Genetics, Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, and Director of the Program in Craniofacial Biology at UCSF. Dr. Klein was educated at the University of California, Berkeley, where he earned a B.A. in Spanish Literature. He subsequently attended Yale University School of Medicine, where he received a Ph.D. in Genetics and an M.D. He then completed residencies at Yale-New Haven Hospital in Pediatrics and at UCSF in Clinical Genetics. Dr. Klein has received several honors, including a New Innovator Award from the NIH and the E. Mead Johnson Award from the Society for Pediatric Research. Dr. Klein was elected to the American Society for Clinical Investigation, the American Association of Physicians, and the National Academy of Medicine, and he is a Fellow of the American Association for the Advancement of Science. Dr. Klein’s research focuses on understanding how organs form in the embryo and how they regenerate in the adult, with a particular emphasis on the processes underlying craniofacial and dental development and renewal as well as understanding how stem cells in the intestinal epithelium enable renewal and regeneration.
Education & Training
- University of California (San Francisco)Residency, Medical Genetics and Genomics, 2003 - 2007
- Yale-New Haven Medical CenterResidency, Pediatrics, 2000 - 2003
- Yale School of MedicineClass of 2000
- Yale University School of MedicinePhD, Genetics, 1995 - 1999
- University of California, BerkeleyBA, Spanish, Cum Laude, 1989 - 1993
Certifications & Licensure
- CA State Medical License 2003 - 2027
- American Board of Medical Genetics and Genomics Clinical Genetics and Genomics
Awards, Honors, & Recognition
- Fellow (FAAP) American Academy of Pediatrics
Clinical Trials
- Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia - A Start of enrollment: 2011 Feb 01
- A Phase 1, Open-label, Multicenter, Safety and Pharmacokinetic Study of EDI200 Start of enrollment: 2012 May 01
- Phase 2 Study to Evaluate Safety, Pharmacokinetics, Immunogenicity and Pharmacodynamics/Efficacy of EDI200 in Male Infants With X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Start of enrollment: 2013 Apr 01
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Publications & Presentations
PubMed
- 2 citationsSynthetic organizer cells guide development via spatial and biochemical instructions.Toshimichi Yamada, Coralie Trentesaux, Jonathan M Brunger, Yini Xiao, Adam J Stevens
Cell. 2025-02-06 - YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution.Farhoud Faraji, Sydney I Ramirez, Lauren M Clubb, Kuniaki Sato, Valeria Burghi
Nature Communications. 2025-01-08 - 1 citationsSyndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population.Michiel Vanneste, Hanne Hoskens, Seppe Goovaerts, Harold Matthews, Jay Devine
Nature Communications. 2024-12-02
Journal Articles
- Mechanoresponsive Stem Cells Acquire Neural Crest Fate in Jaw RegenerationRyan C Ransom, Michael L Lopez, Ophir D Klein, Howard Y Chang, Derrick C Wan, Michael T Longaker, Nature
- The Intestinal Epithelial Response to DamageOphir Klein, MD, Science China. Life Sciences
- Publisher Correction: Parasitic Helminths Induce Fetal-like Reversion in the Intestinal Stem Cell NicheOphir D Klein, Richard M Locksley, Nature
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Press Mentions
- Towards Tissue Regeneration: Scientists Engineer Self -Organizing CellsJanuary 2nd, 2025
- Stem Cells 'Instructed' to Form Specific Tissues and OrgansDecember 26th, 2024
- Cedars-Sinai, UCSF Experts Steer the Development of Stem Cells to Regenerate and Repair OrgansDecember 20th, 2024
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Grant Support
- The Role Of BMI1 In Regulation Of Dental Stem CellsNational Institute Of Dental &Craniofacial Research2011–2012
- The Role Of SPRY2 In Regulation Of Bone FormationNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010–2012
- The Role Of Sprouty Genes In Development Of The Circumvallate PapillaNational Institute On Deafness And Other Communication Disorders2010–2011
- An Evolutionary-Developmental Approach To Stem Cells Using Teeth As A ModelOffice Of The Director, National Institutes Of Health2010
- The Role Of Micrornas In Tooth Regeneration Using The Mouse Incisor ModelNational Institute Of Dental &Craniofacial Research2009–2010
- Analysis Of The Role Of Sprouty Genes In Tooth DevelopmentNational Institute Of Dental &Craniofacial Research2007–2009
Professional Memberships
- Fellow
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