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Office
8700 Beverly Blvd
Los Angeles, CA 90048
Education & Training
Yale-New Haven Medical CenterResidency, Pediatrics, 2000 - 2003
Yale School of MedicineClass of 2000
Certifications & Licensure
CA State Medical License 2003 - 2027- American Board of Medical Genetics and Genomics Clinical Genetics and Genomics
Awards, Honors, & Recognition
- Fellow (FAAP) American Academy of Pediatrics
Clinical Trials
- Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia - A Start of enrollment: 2011 Feb 01
- A Phase 1, Open-label, Multicenter, Safety and Pharmacokinetic Study of EDI200 Start of enrollment: 2012 May 01
- Phase 2 Study to Evaluate Safety, Pharmacokinetics, Immunogenicity and Pharmacodynamics/Efficacy of EDI200 in Male Infants With X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Start of enrollment: 2013 Apr 01
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Publications & Presentations
PubMed
- 885 citationsA reserve stem cell population in small intestine renders Lgr5 -positive cells dispensableHua Tian, Brian Biehs, Søren Warming, Kevin G. Leong, Linda Rangell
Nature. 2011-10-13 - 26 citationsPERP regulates enamel formation via effects on cell–cell adhesion and gene expressionAndrew H. Jheon, Pasha Mostowfi, Malcolm L. Snead, Rebecca A. Ihrie, Eli D. Sone
Journal of Cell Science. 2011-03-01 - 21 citationsInhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.Andrew H. Jheon, Michaela Prochazkova, Bo Meng, Timothy Wen, Young Jun Lim
Journal of Bone and Mineral Research. 2016-01-01
Journal Articles
- Mechanoresponsive Stem Cells Acquire Neural Crest Fate in Jaw RegenerationRyan C Ransom, Michael L Lopez, Ophir D Klein, Howard Y Chang, Derrick C Wan, Michael T Longaker, Nature
- The Intestinal Epithelial Response to DamageOphir Klein, MD, Science China. Life Sciences
- Publisher Correction: Parasitic Helminths Induce Fetal-like Reversion in the Intestinal Stem Cell NicheOphir D Klein, Richard M Locksley, Nature
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Press Mentions
Setting New Research Vision for Cedars-Sinai Guerin Children’sNovember 7th, 2024- Cedars-Sinai Guerin Children’s Builds Genome Sequencing TeamOctober 25th, 2024
- Prominent Pediatric Surgeon Selected for Key Roles at Cedars-Sinai Guerin Children’sOctober 25th, 2022
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Grant Support
- The Role Of BMI1 In Regulation Of Dental Stem CellsNational Institute Of Dental &Craniofacial Research2011–2012
- The Role Of SPRY2 In Regulation Of Bone FormationNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010–2012
- The Role Of Sprouty Genes In Development Of The Circumvallate PapillaNational Institute On Deafness And Other Communication Disorders2010–2011
- An Evolutionary-Developmental Approach To Stem Cells Using Teeth As A ModelOffice Of The Director, National Institutes Of Health2010
- The Role Of Micrornas In Tooth Regeneration Using The Mouse Incisor ModelNational Institute Of Dental &Craniofacial Research2009–2010
- Analysis Of The Role Of Sprouty Genes In Tooth DevelopmentNational Institute Of Dental &Craniofacial Research2007–2009
Professional Memberships
- Fellow
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