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Ophir Klein, MD, Medical Genetics, Los Angeles, CA

Ophir David Klein MD

Medical Genetics•Los Angeles, CA

Clinical Genetics, Ph.D. Medical Genetics

Executive Director, Cedars-Sinai Guerin Children’s Executive Vice Dean for Children’s Services David and Meredith Kaplan Distinguished Chair in Children’s Health

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  • 8700 Beverly BlvdLos Angeles, CA 90048

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Summary

  • Dr. Ophir Klein serves as the inaugural executive director of Cedars-Sinai Guerin Children’s and Executive Vice Dean for Children’s Services at Cedars-Sinai. He is the David and Meredith Kaplan Distinguished Chair in Children’s Health and is also an Adjunct Professor of Orofacial Sciences and Pediatrics at the University of California, San Francisco (UCSF), where he was previously the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies and the Charles J. Epstein Professor of Human Genetics. Until 2022, he served as Director of the Institute for Human Genetics, Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, and Director of the Program in Craniofacial Biology at UCSF. Dr. Klein was educated at the University of California, Berkeley, where he earned a B.A. in Spanish Literature. He subsequently attended Yale University School of Medicine, where he received a Ph.D. in Genetics and an M.D. He then completed residencies at Yale-New Haven Hospital in Pediatrics and at UCSF in Clinical Genetics. Dr. Klein has received several honors, including a New Innovator Award from the NIH and the E. Mead Johnson Award from the Society for Pediatric Research. Dr. Klein was elected to the American Society for Clinical Investigation, the American Association of Physicians, and the National Academy of Medicine, and he is a Fellow of the American Association for the Advancement of Science. Dr. Klein’s research focuses on understanding how organs form in the embryo and how they regenerate in the adult, with a particular emphasis on the processes underlying craniofacial and dental development and renewal as well as understanding how stem cells in the intestinal epithelium enable renewal and regeneration.

Education & Training

  • University of California (San Francisco)
    University of California (San Francisco)Residency, Medical Genetics and Genomics, 2003 - 2007
  • Yale-New Haven Medical Center
    Yale-New Haven Medical CenterResidency, Pediatrics, 2000 - 2003
  • Yale School of Medicine
    Yale School of MedicineClass of 2000
  • Yale University School of Medicine
    Yale University School of MedicinePhD, Genetics, 1995 - 1999
  • University of California, Berkeley
    University of California, BerkeleyBA, Spanish, Cum Laude, 1989 - 1993

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 2003 - 2027
  • Clinical Genetics and Genomics
    American Board of Medical Genetics and Genomics Clinical Genetics and Genomics

Awards, Honors, & Recognition

  • Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Mechanoresponsive Stem Cells Acquire Neural Crest Fate in Jaw Regeneration  
    Ryan C Ransom, Michael L Lopez, Ophir D Klein, Howard Y Chang, Derrick C Wan, Michael T Longaker, Nature
  • The Intestinal Epithelial Response to Damage  
    Ophir Klein, MD, Science China. Life Sciences
  • Publisher Correction: Parasitic Helminths Induce Fetal-like Reversion in the Intestinal Stem Cell Niche  
    Ophir D Klein, Richard M Locksley, Nature
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Press Mentions

  • Towards Tissue Regeneration: Scientists Engineer Self -Organizing Cells
    Towards Tissue Regeneration: Scientists Engineer Self -Organizing CellsJanuary 2nd, 2025
  • Stem Cells 'Instructed' to Form Specific Tissues and Organs
    Stem Cells 'Instructed' to Form Specific Tissues and OrgansDecember 26th, 2024
  • Cedars-Sinai, UCSF Experts Steer the Development of Stem Cells to Regenerate and Repair Organs
    Cedars-Sinai, UCSF Experts Steer the Development of Stem Cells to Regenerate and Repair OrgansDecember 20th, 2024
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Grant Support

  • Mechanisms of hyperactive Ras signaling in craniofacial and dental diseasesCEDARS-SINAI MEDICAL CENTER2025–2030
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
  • Developmental and molecular basis for a craniofacial metabolic syndromeUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2025–2027
  • How Patterned Mesenchymal-Epithelial interactions Shape Intestinal CryptsUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2022–2026
  • How Patterned Mesenchymal-Epithelial interactions Shape Intestinal CryptsUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2022–2026
  • 2024 Epithelial Stem Cells and Niches Gordon Research Conference and SeminarGORDON RESEARCH CONFERENCES2024–2025
  • Enamel atlas: systems-level amelogenesis tools at multiple scalesUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2021–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The physical and molecular mechanisms of intestinal villus morphogenesis and repairUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2020–2025
  • The Role Of BMI1 In Regulation Of Dental Stem CellsNational Institute Of Dental &Craniofacial Research2011–2012
  • The Role Of SPRY2 In Regulation Of Bone FormationNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010–2012
  • The Role Of Sprouty Genes In Development Of The Circumvallate PapillaNational Institute On Deafness And Other Communication Disorders2010–2011
  • An Evolutionary-Developmental Approach To Stem Cells Using Teeth As A ModelOffice Of The Director, National Institutes Of Health2010
  • The Role Of Micrornas In Tooth Regeneration Using The Mouse Incisor ModelNational Institute Of Dental &Craniofacial Research2009–2010
  • Analysis Of The Role Of Sprouty Genes In Tooth DevelopmentNational Institute Of Dental &Craniofacial Research2007–2009

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