Nolan Howard Sigal MD PhD

PubMed

• 17 citations
  Surfing the piperazine core of tricyclic farnesyltransferase inhibitors
  Laura L. Rokosz, Chia-Yu Huang, John C. Reader, Tara M. Stauffer, Daniel Chelsky
  Bioorganic & Medicinal Chemistry Letters. 2005-12-15
• 28 citations
  Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response.
  Judith A. Owen, Nolan H. Sigal, Norman R. Klinman
  Nature. 1982-01-28
• 40 citations
  Differential expression of an equivalent clonotype among BALB/c and C57BL/6 mice
  Michael P. Cancro, Nolan H. Sigal, Norman R. Klinman
  The Journal of Experimental Medicine. 1978-01-01

Journal Articles

• Differential effects of the immuno-suppressive macrolides FK-506 and rapamycin on activation-induced T-cell apoptosis.  
  Staruch, M.J., N.H. Sigal, and F.J. Dumont, Int. J. Pharmacol. 13: 677-685
• Biological screening of a large combinatorial library.  
  Appell, K.C., T. Chung, M. Ohlmeyer, N.H. Sigal, J.J. Baldwin, and D. Chelsky, J. Biomolec. Screening 1:27-31
• A paradigm for drug discovery employing encoded combinatorial libraries.  
  Burbaum, J.J., M. Ohlmeyer, J.C. Reader, I. Henderson, L.W. Dillard, G. Li, T.L. Randle, N.H. Sigal, D. Chelsky, and J.J. Baldwin, Proc. Natl. Acad. Sci. USA 92: 6027-6031
• Inhibition of calcineurin by a novel FK-506-binding protein.  
  Sewell, T.J., E. Lam, M. M. Martin, J. Leszyk, J. Weidner, J. Calaycay, P. Griffin, H. Williams, S. Hung, J. Cryan, N. H. Sigal, and G. J. Wiederrecht, J. Biol. Chem. 269: 21094-21102
• Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.  
  Lin, C.S., R.C. Boltz, J.T. Blake, M. Nguyen, A. Talento, P.A. Fischer, M. Springer, N.H. Sigal, R.S. Slaughter, M.L. Garcia, G.J. Kaczorowski, and G.C. Koo, J. Exp. Med. 177: 637-645
• A single administration of LFA-1 antibody confers prolonged allograft survival.  
  Talento, A., M. Nguyen, J.T. Blake, A. Sirotina, C. Fioravanti, D. Burkholder, R. Gibson, N.H. Sigal, M. Springer, and G.C. Koo, Transplantation 55: 418-422
• Transfection of mouse CTL with an antisense granzyme A vector reduces lytic activity.  
  Talento, A., M. Nguyen, S. Law, J.K. Wu, M. Poe, J.T. Blake, M. Patel, T.-J. Wu, C.L. Manyak, M. Silberklang, G. Mark, M. Springer, N.H. Sigal, I.L. Weissman, R.C. Ble..., J. Immunol. 149: 4009-4016
• Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506 binding protein as well as a protein complex.  
  Wiederrecht, G., S. Hung, H.K. Chan, A. Marcy, M. Martin, J. Calaycay, D. Boulton, N.H. Sigal, R.L. Kincaid, and J.J. Siekierka, J. Biol. Chem., 267: 21753-760
• The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.  
  Dumont, F.J., M.J. Staruch, S.L. Koprak, J.J. Siekierka, C. S. Lin, R. Harrison, T. Sewell, V.M. Kindt, T. Beattie, M. Wyvratt, and N.H. Sigal, J. Exp. Med. 176: 751-760
• Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein.  
  Wiederrecht, G., M.M. Martin, N.H. Sigal, and J.J. Siekierka, Biochem. Biophys Res. Comm. 185: 298-303
• Analogs of cyclosporin A modified at the D-ALA8 position.  
  Patchett, A.A., D. Taub, O.D. Hensens, R.T. Goegelman, L. Yang, F. Dumont, L. Peterson, and N.H. Sigal, J. Antibiotics 45: 94-102
• Blockade of the voltage gated potassium channel Kv1.3 inhibits immune responsiveness in vivo.  
  Koo, G.C., T. Blake, A. Talento, M. Nguyen, S. Lin, A. Sirotina, K. Shah, K. Mulvany, D. Hora, P. Cunningham, D. Wunderler, O. McManus, R. Slaughter, R. Bugianesi, J. ..., J. Immunol 158:5120-5128
• FKBP, the binding protein for the immunosuppressive drug FK-506, is not an inhibitor of protein kinase C activity.  
  Cryan, J., S.H.Y. Hung, G. Wiederrecht, N.H. Sigal and J.J. Siekierka, Biochem. Biophys Res. Comm. 180: 846-852
• FK-506 and cyclosporin A selectively inhibit calcium inonophore induced polymorphonuclear leukocyte degranulation.  
  Forrest, M.J., M.E. Jewell, G.C. Koo, and N.H. Sigal, Biochem. Pharmacol. 42: 1221-1228
• Unexpected up-regulation of gene expression by cyclosporine A and FK-506 in a T cell lymphoma: Both immunosuppressants augment Ly-6E antigen induction by interferon-? ...  
  Altmeyer, A., M.J. Staruch, P.A. Fischer, P.L. Durrette, M.J. Tocci, N.H. Sigal and F. J. Dumont, Int. J. Pharmacol. 13: 1187-99
• Inhibition of human T-cell activation by FK-506, rapamycin and cyclosporin A. Transplant.  
  Sigal, N.H., C.S. Lin and J.J. Siekierka, Proc. 23: 1-5
• Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?  
  Sigal, N.H., F. Dumont, P. Durette, J.J. Siekierka, L. Peterson, D.H. Rich, B.E. Dunlap, M.J. Staruch, M.R. Melino, S.L. Koprak, D. Williams, B. Witzel, and J. Pisano, J. Exp. Med. 133: 619-629
• Cloning of the S. cerevisiae FK-506 binding protein gene and comparison to its homologs reveals a conserved amino acid sequence shared with the cyclophilins.  
  Wiederrecht, G., L. Brizuela, K. Elliston, N.H. Sigal, and J.J. Siekierka, Proc. Natl. Acad. Sci. USA 88: 1029-1033
• FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human lymphocytes.  
  Lin, C.S., R.C. Boltz, J.J. Siekierka, and N.H. Sigal, Cell Immunol. 133: 269-284
• The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease,...  
  Poe, M., J.K. Wu, J.T. Blake, H.J. Zweerink, and N.H. Sigal, Arch. Biochem. Biophys. 284: 215-218
• Human cytotoxic lymphocyte granzyme B: Its purification from granules and the characterization of substrate and inhibitor specificity.  
  Poe, M., J.T. Blake, D.A. Boulton, M. Gammon, N.H. Sigal, J.K. Wu, and H.J. Zweerink, J. Biol. Chem. 266: 98-103
• Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK-506?  
  Sigal, N.H., F.J. Dumont, J.J. Siekierka, G. Wiederrecht, S.A. Parent and L. Brizuela, Transplant. Proc. 23: 2859-62
• Applying Informatics to High Throughput Screening and Analysis.  
  Gund, P.A., and N.H. Sigal, Trends in Pharmainformatics, 1:25-29
• Field Format Assays of Combinatorial Libraries on Solid Supports.  
  Burbaum, J.J., C. Dianni-Carroll, M. Traversari, T. Nichols, D. Chelsky, and N.H. Sigal, Biotechnology International, 2:213-216
• New technologies for high throughput screening.  
  Burbaum, J.J. and N.H. Sigal, Curr. Opinion in Chemical Biology, 1: 72-78
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Books/Book Chapters

• The Biology of the Interferon System. 
  Chapter: Antagonistic effect of alpha and beta interferon on Ia-induction by gamma interferon 
  Page 351 - 354Manyak, C.L., N.H. Sigal, H.C. Passmore, and G.C. KooEditors: W.E. Stewart II and H. Schellekens.Elsevier Science Publishers, New York
• Combinatorial Chemistry and Molecular Diversity in Drug Discovery. 
  Chapter: Approaches and technologies for screening large combinatorial libraries 
  Page 433 - 445Sigal, N.H. and D. ChelskyEditors: E.M. Gordon and J.F. Kerwin.John Wiley & Sons, New York
• Immunopharmaceuticals. 
  Chapter: FK-506: Preclinical and clinical studies 
  Page 1 - 30Parsons, W.H. and N.H. SigalEditors: E.S. Kimball.CRC Press, Boca Raton
• Perspectives in Drug Discovery and Design: Immunosuppressive Agents. 
  Sigal, N.HEditors: Sigal, N.H. and M.J. Wyvratt.ESCOM Publishers, Leiden, Netherlands
• Fundamental Immunology. 
  Chapter: Immunosuppression 
  Page 903 - 916Sigal, N.H. and F.J. DumontEditors: W.E. Paul.Raven Press, New York
• Adv. Medicinal Chemistry. 
  Chapter: Chemistry and biology of the immunosuppressant FK-506 
  Page 55 - 108Shinkai, I. and N.H. SigalEditors: B.E. Maryanoff and C.A. Maryanoff.JAI Press, Greenwich
• Report of the NIAID Task Force on Immunology and Allergy.s. 
  Chapter: Nonspecific immunosuppressive drugs: CsA and FK-506 
  Page 43 - 48Sigal, N.HEditors: S. Burakoff and C. Carpenter.U.S. Department of Health and Human Services
• Idiotypes and Diseases. 
  Chapter: Effects of immunization with syngeneic monoclonal anti-idiotype antibody on antibody responses to influenza viruses 
  Page 143 - 149Schulman, J.L., T.M. Moran, M. Monestier, M. Reale, Y. Beilin, N.H. Sigal, and C.A. BonaEditors: M. Zanetti, C. Bona and F. Celada.Karger, Basel
• Idiotypes and Diseases. 
  Chapter: Idiotypic analysis of the influenza virus-specific human B cell repertoire 
  Page 134 - 142Sigal, N.H., M. Chan, M.A. Reale, T. Moran, J.L. Schulman, and C. BonaEditors: M. Zanetti, C. Bona, and F. Celada.Karger, Basel
• The Generation of Diversity: A New Look. 
  Chapter: The acquisition of the B cell specificity repertoire: The germ-line theory of predetermined permutation of genetic information 
  Page 127 - 149Klinman, N.R., J.L. Press, N.H. Sigal, and P.J. GearhartEditors: A. J. Cunningham.Academic Press, London
• Investigation of Cell-Mediated Immunity. 
  Chapter: Lymphocyte activation 
  Page 135 - 146Sigal, N.HEditors: T. Yoshida.Churchill Livingstone, New York
• Regulation of the Immune System. 
  Chapter: The development and diversity of B cells 
  Page 441 - 444Sigal, N.H., and L.S. WickerEditors: H. Cantor, L. Chess, and E. Sercarz.Alan R. Liss, Inc, New York
• Human B Lymphocyte Function, Activation and Immunoregulation. 
  Chapter: Hapten-carrier-induced PFC responses in humans 
  Page 61 - 71Dosch, H.M., N.H. Sigal, and E.W. GelfandEditors: A.S. Fauci and R.E. Ballieux.Raven Press, New York
• Human B Lymphocyte Function, Activation and Immunoregulation. 
  Chapter: Parallel quantitation in individual microcultures of antigen- and class-specific immunoglobulins 
  Page 103 - 118Sigal, N.H., and H.M. DoschEditors: A.S. Fauci and R.E. Ballieux.Raven Press, New York
• Developmental Immunobiology. 
  Chapter: Control of the expression of the B-cell specificity repertoire 
  Page 179 - 193Klinman, N.R., M.P. Cancro, S.K. Pierce, J.A. Owen, E.S. Metcalf, and N.H. SigalEditors: G.W. Siskind, S.D. Litwin, and M.E. Wecksler.Academic Press, New York
• Regulation of the Immune System: Genes and the Cells in Which They Function. 
  Chapter: The significance of minor clonotypes in the dissection of B-cell diversification 
  Page 217 - 224Sigal, N.H., M.P. Cancro, and N.R. KlinmanEditors: E.E. Sercarz and L.A. Herzenberg.Academic Press, New York
• Development of Host Defenses. 
  Chapter: Functional analysis of B cell maturation at the clonotype level 
  Page 93 - 106Klinman, N.R., E.S. Metcalf, and N.H. SigalEditors: M.D. Cooper and D.H. Dayton.Raven Press, New York
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Abstracts/Posters

• The interplay of evolution and environment in B-cell diversification.
  Klinman, N.R., N.H. Sigal, E.S. Metcalf, S.K. Pierce, and P.J. Gearhart, Cold Spring Harbor Symp. Quant. Biol. 41: 165-173

Other

• Novel 6-position analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin. 
  N.H. Sigal, U.S. patent number 4,914,188
• Process for identifying and assaying L-679,934 immunosuppressive agents. 
  N.H. Sigal, U.S. patent number 5,109,112