NicoleLSimoneMD

Breast Cancer

Professor and Vice Chair of Research, Faculty Affairs and DEI, Radiation Oncology, SKCC Program Leader, Cancer Risk and Control Program, Director, Breast Radiation Oncology, Thomas Jefferson University

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Office
111 S. 11th Street
Bodine Center For Cancer Treatment
Philadelphia, PA 19107
Phone+1 215-955-6702

Fax+1 215-955-5331

Summary

Adding a healthy diet to the fight against cancer

Absolutely. We know that some foods in our diet have been shown to actually promote cancer growth, such as processed sugars and fats. There's something about th

Education & Training

National Capital ConsortiumResidency, Radiation Oncology, 2004 - 2008
Rutgers Health/New Jersey Medical SchoolInternship, Internal Medicine, 2003 - 2004
Rutgers New Jersey Medical SchoolClass of 2003

Certifications & Licensure

PA State Medical License 2010 - 2026
NJ State Medical License 2017 - 2021
MD State Medical License 2004 - 2011
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2013
CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012

Clinical Trials

Comparison of Surgeries, With or Without Radiation Therapy, in Treating Women With Stage I or Stage II Breast Cancer Start of enrollment: 1979 Sep 01
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy Start of enrollment: 2013 Mar 08
Completed
Not Applicable
Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy Start of enrollment: 2013 Nov 11
Completed
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jul 22
Completed
Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer Start of enrollment: 2015 Feb 05
Completed
Phase 1
Telehealth in Improving Quality of Life in Patients During Post Radiation Therapy Visits Start of enrollment: 2016 Mar 23
Completed
Not Applicable
CAREFOR: Precision Medicine Driving Precision Nutrition for the Treatment of NeoAdjuvant Breast Cancer Start of enrollment: 2016 Jun 16
Completed
Not Applicable
Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer Start of enrollment: 2016 Jun 08
Active, not recruiting
Phase 2
Prospective Breast Cancer Biospecimen Collection Start of enrollment: 2018 May 10
RECRUITING
NA
Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer Start of enrollment: 2021 Aug 23
RECRUITING
NA
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Publications & Presentations

PubMed

Improved survival with elevated BMI following immune checkpoint inhibition across various solid tumor cancer types.
Eric V Mastrolonardo, Pablo Llerena, Emma De Ravin, Kathryn Nunes, Praneet C Kaki
Cancer. 2025-03-15
Patient-Reported Outcomes: Comparing Functional Avoidance and Standard Thoracic Radiation Therapy in Lung Cancer.
Spencer J Poiset, Joseph Lombardo, Edward Castillo, Richard Castillo, Bernard Jones
JCO Clinical Cancer Informatics. 2025-02-01
1 citations
Genomic Determinants Associated with Modes of Progression and Patterns of Failure in Metachronous Oligometastatic Castration-sensitive Prostate Cancer.
Philip Sutera, Yang Song, Amol C Shetty, Keara English, Kim Van der Eecken
European Urology Oncology. 2025-02-01

Press Mentions

Low-Calorie Diet Helps Prevent Aggressive Breast Cancer from SpreadingMay 28th, 2014
Fighting Cancer with Dietary ChangesMay 26th, 2014
Dieting on Radiation Therapy May Improve Outcomes for Breast Cancer Patients: New Clinical Trial to BeginFebruary 4th, 2013

Grant Support

Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET) CenterUNIVERSITY OF MARYLAND BALTIMORE2022–2027
Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET) CenterUNIVERSITY OF MARYLAND BALTIMORE2022–2027
Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET) CenterUNIVERSITY OF MARYLAND BALTIMORE2022–2027
Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatmentsTHOMAS JEFFERSON UNIVERSITY2018–2025
(11) Diet Modification to Augment Radiation for Breast Cancer Brain MetastasesTHOMAS JEFFERSON UNIVERSITY2018–2025
Underlying Cause Of Radiation-Induced FibrosisNational Cancer Institute2010–2011
Mechanism Of Radiation Affects On MicrornaNational Cancer Institute2010–2011
Underlying Cause Of Radiation-Induced FibrosisDivision Of Basic Sciences - Nci2009
Mechanism Of Radiation Affects On MicrornaDivision Of Basic Sciences - Nci2009
Underlying Cause Of Radiation-Induced FibrosisNational Cancer Institute2008