NicolasA.F.ChronosMDFACC, FESC, FRCP

PubMed

• 80 citations
  Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions.
  Ruxandra F. Sîrbulescu, Chloe K. Boehm, Erin Soon, Moses Q. Wilks, Iulian Ilieş
  Wound Repair and Regeneration. 2017-09-01
• 209 citations
  The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of ...
  David P. Faxon, Raymond J. Gibbons, Nicolas A.F. Chronos, Paul A. Gurbel, Florence H. Sheehan
  Journal of the American College of Cardiology. 2002-10-02
• 145 citations
  Extracellular Matrix Scaffold for Cardiac Repair
  Keith A. Robinson, Jin-Shen Li, Megumi Mathison, Alka Redkar, Jianhua Cui
  Circulation. 2005-08-30

Journal Articles

• Review of percutaneous therapy for bifurcation lesions in the era of drug-eluting stents.  
  Pendyala L, Jabara R, Hou D, Shinke T, Li J, Gadesam R, Robinson K, Chronos N, Chen JP, Minerva Cardioangiol. Feb;56(1):89-105, 2008
• Binding specificity and associated effects of platelet GP IIb/IIIa inhibitors.  
  Chronos N, Marciniak SJ, Nakada M, European Heart Journal 1(Supplement E):E11-E17, 1999
• Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: Results of a phase I open label dose escalation study.  
  Laham RJ, Chronos NA, Pike M, Leimbach ME, Udelson JE, Pearlman JD, Pettigrew RI, Whitehouse MJ, Yoshizawa C, Simons M, Journal Of The American College Of Cardiology 36:2132-2139, 2000
• Clinical trials in coronary angiogenesis – issues, problems, consensus expert panel summary.  
  Simons M, Bonow R, Chronos NA, Cohen DJ, Giordano F, Hammond K, Laham RJ, Li W, Pike M, Sellke FW, Stegmann T, Udelson JE, Rosengartt T, CIRCULATION 102:E73-86, 2000
• Intracoronary -radiation exacerbates long-term neointima formation in balloon-injured pig coronary arteries.  
  Coussement PK, De Leon H, Ueno T, Salame MY, King SB, Chronos NAF, Robinson KA, Circulation 104:2459-2464; 2001
• Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group.  
  Schwartz RS, Edelman ER, Carter A, Chronos NAF, Rogers C, Robinson KA, Waksman R, Weinberger J, Wilensky RL, Jensen DN, Zuckerman BD, Virmani R, Circulation 106:1867-73; 2002
• Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor.  
  Simons M, Annex BH, Laham RJ, Kleiman N, Henry T, Dauerman H, Udelson JE, Gervino EV, Pike M, Whitehouse MJ, Moon T, Chronos NA, Circulation 2002
• Cell therapy for the failing heart?  
  Yegin A, Goodchild T, Fischi M, Robinson K, Chronos N, King SB III, Hurst’s The Heart, 2003
• Arrhythmogenicity of catheter-based skeletal myoblast injections guided by intracardiac echo in infracted adult miniature pigs.  
  Tondato F, Robinson K, Peters N, Ebato M, Ebato B, Chronos N, Haimes H, Harvey J, Murry C, Reinecke H, Roos E, Sherman W, Cell Transplantation 12(2):148-9; 2003
• Stem cells as therapy for cardiovascular disease: lost in translation?  
  Robinson KA, Chronos NAF, Weich N, J Stem Cells 1(3):183-199; 2006
• External radiation for restenosis.  
  Robinson KA, Verheye S, Salame MY, Marijianowski M, Cui J, Chronos NAF, King SB III, Crocker IR, J Intervent Cardiol 1999;12:235-241
• Abnormal Vasomotor Functions of Coronary Artery Segments Distal to Cypher Stent Implantation Site in Swine.  
  Li J, Jabara R, Pendyala L, Otsuka Y, Shinke T, Hou D, Robinson K, Chronos N, Jacc Cardiovasc Interv. Jun;1(3):279-85,2008
• Phase 1b randomized study of antidote-controlled modulation of actor IXa activity in patients with stable coronary artery disease.  
  Chan MY, Cohen MG, Dyke CK, Myles SK, Aberle LG, Lin M, Walder J, Steinhubl SR, Gilchrist IC, Kleiman NS, Vorcheimer DA, Chronos N, Melloni C, Alexander JH, Harringt..., Circulation. Jun3;117(22):2865-74. Epub 2008 May 27, 2008
• A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and b...  
  Abraham WT, Burkhoff D, Nademanee K, Carson P, Bourge R, Ellenbogen KA, Parides M, Kadish A; FIX-HF-5 Investigators and Coordinators, Am Heart J. Oct; 156(4):641-648.El., 2008
• Passive and active polymer coatings for intracoronary stents: novel devices to promote arterial healing.  
  Pendyala L, Jabara R, Robinson K, Chronos N, Jour Of Interv Cardiol 22, 1;2009
• Clinical Features of Apical and Non Apical Variants of Takotsubo Cardiomyopathy in the United States.  
  Jabara R, Gadesam R, Pendyala L, Chronos N, King SB, Chen JP, J Invasive Cardiol. May;21(5):216-22;2009
• Lower dose paclitaxel elutioin by novel bioerodible sol-gel coating on stents inhibits neointima formation with low toxicity in porcine coronary model.  
  Toshiro Shinke, Sara Geva, Pendyala Lakshmana, Refat Jabara, Anna Venegoni, Ken Colley, Richard Klein, Nicolas Chronos, Keith Robinson, Dongming Hou, Int J Cardiol 2009; 135: 93-101
• Intravascular Ultrasound in the Era of Drug-Eluting Stents.  
  Takamitsu Nakamura, Jack P. Chen, Deepal Panchal, Thach Nguyen, Spencer B. King III, Nicolas Chronos, Dongming Hou, Cardiovascular & Hematological Agents In Medicine Chemistry 2010; 8:22-28
• Bioengineered Arteriovenous Grafts.  
  McAllister T, Garrido S, Velez J, Chronos N, L’Heureux N, Endovascular Today 2011; June: 1-4
• Dependence of the intensity of breathlessness on FIO2 during heavy exercise in normals.  
  Adams L, Chronos NA, Guz A, J PHYSIOL 327:51-52, 1982
• Prevention of groin vascular complications associated with percutaneous procedures.  
  Hasdai D, Holmes DR Jr., King SB III, Chronos N, J Invas Cardiol 9:119-125, 1997
• Evaluation of whole blood flow cytometric detection of platelets bound fibrinogen on normal subjects and patients with activated platelets.  
  Janes SL, Wilson DJ, Chronos N, Goodall AH, Thrombosis And Haemostasis 70:659-666, 1993
• Flow cytometric detection of the redistribution of the GP Ib-IX complex on thrombin stimulated platelets is dependent on the type of antibody conjugate used.  
  Goodall AH, Domingos MO, Chronos N, Janes SL, Wilson DJ, Blood 81:1407-1408, 1993
• Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of "-granules or lysosomes from, human platelets.  
  Chronos NAF, Wilson DJ, Janes SL, Hutton RA, Buller NP, Goodall AH, Clinical SCIENCE 87:575-580, 1994
• Electro-capsulating drugs within blood platelets: Local delivery to injured arteries during angioplasty.  
  Chronos N, Crawford N, Journal Of Local Delivery 1:1:52-64, 1995
• Join now to see all

Books/Book Chapters

• Cost Effective Diagnosis And Treatment Of Coronary Artery Disease. 
  Chapter: Management of the Coronary Care Unit 
  Page 79 - 89Chronos, NAF, Grosswald REditors: Talley JD, Mauldin PD, Becker ER.Williams & Wilkins, Maryland
• Interventional Cardiology. 
  Chapter: Preclinical Laboratory Functions 
  Page 735 - 741Robinson KA, Chronos NAF, Schwartz RSEditors: King SB, Yeung A.McGraw-Hill, New York, NYEdition 1,
• Cardiovascular Magnetic Resonance. 
  Lardo A, Fayad Z, Chronos N, Fuster VMartin Dunitz, Ltd, London
• Antiplatelet Therapy In Clinical Practice. 
  Ferguson, J, Chronos, NAF, Harrington, RAMartin Dunitz, Ltd, London
• Cardiology In Primary Care. 
  Chapter: Anticoagulation and Antiplatelet Therapy in Heart Disease 
  Salame MY, Chronos NAFEditors: Alexander RW, Branch WT Jr..
• Comtemporary Cardiology: Platelet Glycoprotein Iib/Iiia Inhibitors In Cardiovascular Disease. 
  Chapter: Tirofiban In Coronary Intervention – The RESTORE Trial 
  Page 127 - 142Salame MY, King SB III, Chronos NAFEditors: Lincoff AM, Topol EJ.Humana Press Inc, Totowa, NJ
• Current Concepts In The Role Of Thrombosis In Interventional Cardiology: Focus On Contrast Agents. 
  Chapter: In vitro effects of contrast media (ioxaglate vs iodixanol) on platelet functions 
  Page 26 - 32Cove CS, Chronos N, Sabattier VEditors: Marco J, King SB III.Apex.edt. editions medicales, France
• Current Concepts In The Role Of Thrombosis In Interventional Cardiology: Focus On Contrast Agents. 
  Chapter: Economic perspectives on the utilization of contrast agents in coronary intervention 
  Page 49 - 52Chronos N, Grosswald REditors: Marco J, King SB III.Apex.edt. editions medicales, France
• Current Concepts In The Role Of Thrombosis In Interventional Cardiology: Focus On Contrast Agents. 
  Chapter: Implication of Clinical Contrast Media Selection in Interventional Cardiology 
  Page 33 - 44Chronos NEditors: Marco J, King SB III.Apex.edt. editions medicales, France
• Current Therapy And Diagnosis. 
  Chapter: Dyslipoproteinaemias and risk factor modification 
  Winder AF, Chronos NAFEditors: Pounder RE, Hamilton.
• Women & Heart Disease. 
  Chapter: Percutaneous Transluminal Coronary Angioplasty in Women 
  Page 183 - 192Chronos NAF, Ewing HL, McGorisk GM, King SBEditors: Julian DG, Wenger NK.Martin Dunitz Ltd, London
• Coronary Stenting. 
  Chapter: Phosporylcholine as a novel stent coating 
  Hanson S, Chronos NAFEditors: Sigwart U.
• Endoluminal Stenting. 
  Chapter: Efficient Endoluminal Drug Delivery for Stent Thrombosis 
  Page 123 - 128Hanson SR, Chronos NAFEditors: Sigwart U.W.B. Saunders Company Ltd, Great Britain
• Textbook Of Cardiology. 
  Chapter: Percutaneous interventions for chronic coronary occlusions 
  Chronos NAF, King SB
• Textbook Of Cardiology. 
  Chapter: Restenosis, a clinical perspective 
  Chronos NAF, King SB
• Current Review Of Interventional Cardiology. 
  Chapter: Implications of contrast media selection in interventional cardiology 
  Page 279 - 293Chronos NAFEditors: Topol E, Serruys P.Current Medicine, Philadelphia
• Current Therapy And Diagnosis. 
  Chapter: Cardiac Resuscitation 
  Chronos NAF, Wynne GEditors: Pounder RE, Hamilton.
• Join now to see all

Abstracts/Posters

• Harnessing the Response to Hypoxia: Use of a Constitutively Active Hypoxia-Inducible Factor 1-a Transgene in No-Option Critical Limb Ischemia.
  Nicolas Chronos, American Heart Association 76th Scientific Session, Orlando, FL
• Follow-Up of a Phase 1 Study of Skeletal Myoblasts for Congestive Heart Failure.
  Nicolas Chronos, M.D. & Warren Sherman, M.D, ACC Poster Session Presentation, Atlanta, Georgia
• Breathlessness during different ventilatory drives in normal subjects.
  Adams L, Chronos NA, Guz A, J PHYSIOL 324:33-34, 1981
• Maintenance of VE/VCO2 induced hypopnoea in heavy exercise in man.
  Adams L, Chronos NA, Guz A, A J PYSIOL 334:101, 1982
• The dyspnogenic effect of hypoxia, dissociation from the ventilatory response.
  Adams L, Chronos NA, Guz A, Clinical Science 63:17, 1982
• 24 hour intragastric ph and 24 hour plasma gastrin concentration in healthy volunteers and patients with pernicious anemia.
  Lanzon-Miller S, Pounder RE, Chronos NA, Ball S, Hamilton M, Neame R, Mercia J, GUT 27(a):611, 1986
• 24 hour intragastric acidity and plasma gatrin concentration before and during treatment with either Ranitidine or Omeprazole.
  Lanzon-Miller S, Pounder RE, Ball S, Hamilton M, Chronos N, Raymond F, GUT 27(a):1255, 1986
• Can high dose oral ranitidine eliminate intragastric acid and what does it do to plasma gastrin?
  Lanzon-Miller S, Pounder RE, Chronos NAF, Ball S, Raymond F, GASTROENTEROLOGY 92(A):1491, 1987
• 24 hour intragastric acidity and plasma gastrin in healthy volunteers taking Nizatidine 150 mg, Nizatidine 300 mg, Ranitidine 300 mg, or placebo at 21.15 hours.
  Lanzon-Miller S, Pounder RE, Raymond F, Hamilton MR, Chronos NA, Dalgliesh D, GASTROENTEROLOGY 92(a):1492, 1987
• Platelet activation: An important side effect of contrast media of relevance to coronary angiography and intervention.
  Chronos N, Goodall A, Mookerjee RP, Sigwart U, Rickards A, Buller N, British Heart Journal 68:1:80, 1992
• Flow cytometry of whole blood a method for analyzing platelet activation in cardiovascular disease.
  Chronos N, Mookerjee R, Buller N, Goodall A, British Heart Journal 68:1:100, 1992
• Randomized evaluation of a new inflatable femoral artery compression device after coronary angiography.
  Nordrehaug JE, Chronos NA, Foram J, Wainwright R, Rickards AF, Buller NP, Sigwart U, Circulation 86:I-382, 1992
• Contrast media induced platelet activation, an important factor in thrombosis and restenosis following angioplasty?
  Chronos NAF, Rickards AF, Sigwart U, Goodall AH, Buller NP, Circulation 86:I-445, 1992
• Assessment of intracoronary platelet activation using a novel sampling technique.
  Chronos N, Goodall A, Sigwart U, Rickards A, Buller N, European Heart Journal 13:255, 1992
• The effect of aspirin on the expression of neoantigens on the platelet surface membrane in response to physiological agonists.
  Chronos N, Wilson DJ, Goodall AH, Sigwart U, Buller N, European Heart Journal 13:299, 1992
• Results of stent implantation for the management of aorta-ostial stenosis.
  Nordrehaug JE, Chronos N, Priestley K, Denne L, Rickards AF, Buller N, Sigwart U, British Heart Journal 68:154, 1992
• Safety efficacy and patient toleration of a new inflatable device for compressing the femoral artery after cardiac angiography.
  Nordrehaug JE, Chronos N, Priestley K, Denne L, Rickards AF, Buller N, Sigwart U, British Heart Journal 68:154, 1992
• Immediate and late results of emergency stenting for acute occlusion after coronary angioplasty.
  Nordrehaug JE, Chronos N, Gunnes P, Rickards AF, Culler N, Sigwart U, British Heart Journal 68:154:82, 1992
• Regional left ventricular long axis function during dobutamine stress in controls and patients with ischemic heart disease pre and post angioplasty.
  Karwatowski SP, Forbat SM, Mohiaddin R, Chronos NA, Yang GZ, Firmin DN, Buller NB, Underwood R, Longmore DB, Circulation 88:I-83, 1993
• . Heparin and aspirin fail to abolish platelet activation in patients undergoing PTCA.
  Chronos NAF, Wilson DJ, Gibbs JSR, Goodall AH, Sigwart U, Buller NP, European Heart Journal 14:181, 1993
• A new method for the direct measurement of intracoronary platelet activation during PTCA.
  Chronos, NAF, Wilson DJ, Goodall AH, Sigwart U, Buller NP, European Heart Journal 14:227, 1993
• A novel biocompatible coating applied to coronary stents.
  Nordrehaug JE, Chronos NAF, Sigwart U, European Heart Journal 14:321, 1993
• Platelet activation and platelet hyper-responsiveness in stable angina.
  Chronos NAF, Wilson DJ, Goodall AH, Buller NP, European Heart Journal 14:412, 1993
• Contrast media induced platelet degranulation is dose dependent.
  Chronos N, Sigwart U, Goodall A, Buller N, J Am Coll Cardiol 21:99a, 1993
• The effect of aspirin on the expression of neoantigens on the platelet surface membrane in response to physiological agonists.
  Chronos N, Wilson D, Goodall AH, Sigwart U, Buller N, J Am Coll Cardiol 21:361a, 1993
• Join now to see all

Lectures

• Thrombosis in PTCA patients. 
  Norwegian Heart Association, Norway
• Novel Antithrombotic Strategies. 
  New York Heart Association, New York
• The Role of Platelets in Acute Coronary Syndromes. 
  German Society of Thrombosis and Hemostasis, Berlin
• Electroporation: A potential method of increasing local drug cellular penetration at the site of the vessel wall injury. 
  Prevention of Restenosis Conference, New Orlean, LA
• Stent Coatings. 
  Atlanta, GA
• Stent Coatings in the 1990’s. 
  Thoraxcenter Stent Summit, Rotterdam
• Heparin Stent Coatings. 
  Washington, DC
• Antithrombotic coatings for endovascular stents. 
  Washington, DC
• Contrast media choices for interventional procedures. 
  Washington, DC
• Clinical Implications and Cost Considerations. 
  Washington, DC
• Stent Coatings, Molecular Vascular Biology. 
  XVIIIth Congress of the European Society of Cardiology
• GP IIb/IIIa antagonists and local drug delivery. 
  American College of Cardiology, Santa Barbara, CA
• Stent Coatings and the RESTORE Trial. 
  New York Heart Association, New York
• Stent Coatings, Heparin vs. Phosphorylcholine. 
  Local Drug Delivery Summit, Rotterdam
• GP IIb/IIIa inhibitors. 
  International Roundtable Discussion, Davos
• Endoluminal Drug Delivery for Angioplasty and Stents. 
  Interventional Cardiology, Toward the Third Millennium, Atlanta
• IIb/IIIa Inhibitor Therapy in Interventional Cardiology. 
  Challenges for the Interventional Cardiologist, Atlanta
• Is there a logic for adjunctive medical therapy in coronary interventions? 
  London
• Current Concepts on the role of thrombosis in interventional cardiology – focus on contrast agents. 
  5th Alpe-Adria Cardiology Meeting in Austria, Graz
• Clinical Impact of Contrast Media in Interventional Cardiology. 
  Endovascular Therapy Course, Coronary and Peripheral, Paris
• Antithrombotic drugs: the significance for acute and chronic outcome after coronary interventions. 
  Frontiers in Interventional Cardiology, Germany
• IIb/IIIa inhibitors interaction: data from the ERASER trial. 
  2nd International Meeting on Interventional Cardiology, Eilat and Jerusalem
• Adjunctive pharmacology: an alternative or addition to stenting. 
  Eilat and Jerusalem
• Therapeutic applications of local drug delivery. 
  XIXth Congress of the European Society of Cardiology, Stockholm
• Understanding the new anti-thrombotic agents: from experimental models to clinical applications. 
  Transcatheter Cardiovascular Therapeutics IX, Washington, DC
• Join now to see all

Other

• Contrast Imaging in Interventional Cardiology. 
  Nicolas A. F. Chronos, M.D, GEMS-TV Productions
• Thrombosis in Coronary Intervention: Influence of Angiographic Contrast Media. 
  Nicolas A. F. Chronos, CD ROM, Conceptis Technologies
• Futuristic Treatments of the Nonrevascularized Patient. 
  Nicolas Chronos, M.B.B.S., C. Richard Conti, M.D, ACCEL (American College of Cardiology Extended Learning); 33:6, 2001
• Myoblast Transplant: Novel Cell Therapy for Heart Failure-Transplanted Leg Muscle Cells into the Heart. 
  Nicolas Chronos, WSB Atlanta-Channel 2 Live Action News
• Cardiac Research, Saint Joseph’s Research Institute, Atlanta-Our work in cardiac research to include numerous cardiac clinical trials, autologous myoblast transplants,... 
  Nicolas Chronos, Georgia Public Television. The Georgia Weekly Show- Live Presentation
  Atlanta, Georgia
• Patient Charlie Hoff’s Cutting Edge Cell Therapy that Can Help Repair Damaged Hearts and Perhaps Save Countless Lives. 
  Nicolas Chronos, M.D, CNN American Morning, Heart Health on “House Call” with Dr. Sanjay Gupta
• Heart & Vascular Research Institute: The Anatomy of Research. 
  Nicolas Chronos, A Mission to Heal TV Show – Holy Cross Hospital – Jim Moran
• Join now to see all