NicholasJShaheenMD

Advanced Endoscopic Interventional, Esophagus Disease

Senior Associate Dean for Clinical Research, Bozymski-Heizer Professor of Medicine, University of North Carolina at Chapel Hill School of Medicine

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Office
101 Manning Dr
Chapel Hill, NC 27514
Phone+1 919-966-4996

Fax+1 919-843-5515

Summary

Dr. Nicholas Shaheen is a gastroenterologist in Chapel Hill, NC and is affiliated with University of North Carolina Hospitals. He received his medical degree from University of Chicago Pritzker School of Medicine and has been in practice 26 years. He specializes in advanced endoscopic interventional and esophagus disease and is experienced in general gastroenterology, pediatric gastroenterology, gastroesophageal reflux, interventional gastroenterology, and esophageal cancer.

Education & Training

University of North Carolina HospitalsFellowship, Gastroenterology, 1994 - 1997
University of ChicagoResidency, Internal Medicine, 1991 - 1994
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1991
Harvard U.AB, 1983 - 1987

Certifications & Licensure

NC State Medical License 1994 - 2025
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Master, American Society of Gastrointestinal Endoscopy ASGE, 2023
Master, American College of Gastroenterology ACG, 2020
Fellow American College of Gastroenterology
Regional Top Doctor Castle Connolly, 2014
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Fellow (AGAF) American Gastroenterological Association, 2006
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Clinical Trials

Ablation of Intestinal Metaplasia Containing Dysplasia Start of enrollment: 2006 Feb 01
Completed
Not Applicable
Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma Start of enrollment: 2005 Oct 01
Recruiting
Roles: Principal Investigator, Contact
HALO Patient Registry: Ablation of Barrett's Esophagus Start of enrollment: 2007 Jul 01
Completed
Not Applicable
Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease Start of enrollment: 2009 Sep 01
Completed
Not Applicable
Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus? Start of enrollment: 2011 Jun 01
Completed
Racial Disparity in Barrett's Esophagus Start of enrollment: 2011 Mar 01
Completed
Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese Start of enrollment: 2012 Dec 01
Terminated
Not Applicable
Prevalence of Dysplasia of the Gastric Cardia Start of enrollment: 2013 Feb 01
Completed
trūFreeze® Spray Cryotherapy Patient Registry Start of enrollment: 2013 Apr 01
Completed
A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy Start of enrollment: 2013 Apr 01
Terminated
Not Applicable
Risk Factors and Biomarkers for Diagnosis and Treatment of EoE Start of enrollment: 2011 Jul 01
Active, not recruiting
Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis Start of enrollment: 2015 Jan 01
Completed
Phase 4
Stratifying Risk in Barrett's Esophagus: A Pilot Study for Biomarker-based Patient Management Start of enrollment: 2014 Mar 01
Completed
Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy Start of enrollment: 2014 Oct 27
Completed
Not Applicable
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation Start of enrollment: 2016 Jan 15
Active, not recruiting
Phase 2
Obeticholic Acid for Prevention in Barrett's Esophagus Start of enrollment: 2024 Jan 03
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Natural course of high-grade dysplasia in Barrett's esophagus: a scoping review and case-series.
Eva P D Verheij, Sanne N van Munster, Man Wai Chan, Arjan Malekzadeh, Cary C Cotton
Gastrointestinal Endoscopy. 2025-02-19
Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation.
Robert S Bresalier, Nicholas J Shaheen, Mike Hernandez, Navtej Buttar, Norman Marcon
Digestive Diseases and Sciences. 2025-02-11
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2024.
Anne F Peery, Caitlin C Murphy, Chelsea Anderson, Elizabeth T Jensen, Sasha Deutsch-Link
Gastroenterology. 2025-02-04

Journal Articles

A Prospective Multicenter Study Using a New Multiband Mucosectomy Device for Endoscopic Resection of Early Neoplasia in Barrett’s Esophagus
Nicholas J Shaheen, Cadman L Leggett, Gastrointestinal Endoscopy
Higher Rate of Barrett’s Detection in the First Year After Successful Endoscopic Therapy: Meta-Analysis
Prasad G Iyer, Kenneth K Wang, Nicholas J Shaheen, David A Katzka, Nature
Helicobacter Pylori Infection Is Associated with Reduced Risk of Barrett’s Esophagus: An Analysis of the Barrett’s and Esophageal Adenocarcinoma Consortium
Douglas A Corley, Nicholas J Shaheen, Joel H Rubenstein, Nature

Lectures

Predicting Progression to Cancer – The Holy Grail
AGC 2018 Annual Scientific Meeting, Philadelphia, PA - 10/9/2018
Esophagus and Stomach
AGC 2018 Annual Scientific Meeting, Philadelphia, PA - 10/7/2018
Premalignant Lesions of the Esophagus
AGC 2018 Annual Scientific Meeting, Philadelphia, PA - 10/7/2018
ACG Western Regional Course
American College of Gastroenterology, Los Angeles, California - 1/25/2013
2012 AGA Spring Postgraduate Course
American Gastroenterological Association (AGA) Institute, San Diego, California - 5/19/2012
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Authored Content

A Prospective Multicenter Study Using a New Multiband Mucosectomy Device for Endoscopic Resection of Early Neoplasia in Barrett’s EsophagusJuly 2018
Tu1147 LIQUID NITROGEN SPRAY CRYOTHERAPY FOR PALLIATION OF INVASIVE ESOPHAGEAL CARCINOMA: RESULTS FROM A MULTICENTER U.S. REGISTRYMay 2018
Tu1147 LIQUID NITROGEN SPRAY CRYOTHERAPY FOR PALLIATION OF INVASIVE ESOPHAGEAL CARCINOMA: RESULTS FROM A MULTICENTER U.S. REGISTRYMay 2018

Press Mentions

Annual Scientific Meeting & Postgraduate CourseOctober 11th, 2024
ACG/ASGE Task Force Identifies 19 Indicators for Achieving Quality GI EndoscopySeptember 11th, 2024
Five Key Measures to Ensure a Quality ColonoscopySeptember 10th, 2024
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Grant Support

Genetic Determinants Of Barrett'S Esophagus And Esophageal AdenocarcinomaNational Cancer Institute2011
Racial Disparity In Barrett'S EsophagusNational Cancer Institute2010–2011
The Perception Of Cancer Risk In Patients With Barrett'S EsophagusNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Perception Of Cancer Risk In Patients With Barrett'SNational Institute Of Diabetes And Digestive And Kidney Diseases2006
Epidemiologic Case-Control Study Of Barrett'S EsophagusNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2005
Gene Prevalence Of The C282Y Mutation In Diabetic PTSNational Center For Research Resources2000