NicholasChiorazziMD

PubMed

• 3 citations
  Mutation-specific CAR T cells as precision therapy for IGLV3-21expressing high-risk chronic lymphocytic leukemia.
  Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko
  Nature Communications. 2024-02-02
• Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia.
  Gonzalo Blanco, Edward Morris, Jodie L Morris, Hayley L Letson, Suvarna Susheel
  Annals of Case Reports. 2024-01-01
• 2 citations
  Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.
  Anita Ng, Francesca Lovat, Andrew J Shih, Yuhong Ma, Yuri Pekarsky
  Proceedings of the National Academy of Sciences of the United States of America. 2023-10-24

Journal Articles

• miRNAs Involvement in the Pathogenesis of Richter’s Syndrome  
  Nicholas Chiorazzi, Alessandra Ferrajoli, Haematologica
• BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia  
  Chen S-S, Chang BY, Chang S, Tong T, Ham S, Sherry BA, Burger JA, Rai KR, Leukemia, 1/1/2016
• Recurrent RPS15 mutations in chronic lymphocytic leukemia: a novel biomarker of clinical aggressiveness  
  Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford, Sutton L-A, Blakemore S, Stavroyianni N, Agathangelidis A, Rossi D,..., Blood, 1/1/2016
• Targeting stereotyped B cell receptors from chronic lymphocytic leukemia patients with synthetic antigen surrogates  
  Sarkar M, Liu Y, Qi J, Peng H, Morimoto J, Rader C, Chiorazzi N, Kodadek T, J Biol Chem, 1/1/2016
• Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors  
  Sutton L-A, Young E, Baliakas P, Hazidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri..., Haematologica, 1/1/2016
• Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a non-classical Th1-dependent, Bcl-6-deficient process  
  Patten PEM, Ferrer G, Chen S-S, Simone R, Marsilio S, Yan X-J, Gitto Z, Yuan C, Kolitz JE, Barrientos J, Allen SL, Rai KR, MacCarthy T, Chu CC, JCI Insight, 1/1/2016
• Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status  
  Hatzi K, Catera R, Moreno Atanasio C, Fischetti VA, Allen SL, Kolitz JE, Rai KR, Chu CC, Clin Immunol, 1/1/2016
• Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukemia  
  Xochelli1 A, Agathangelidis A, Kavakiotis J, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Pan..., Immunogenetics, 1/1/2015
• Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations  
  Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfo L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M..., Blood, 1/1/2015
• Rewiring of sIgM-mediated intracellular signaling through the CD180 Toll-like receptor  
  Porakishvili N, Vispute K, Steele AJ, Rajakaruna N, Kulikova N, Tsertsvadze T, Nathwani A, Damle RN, Clark EA, Rai KR, Chiorazzi N, Lydyard PM, Mol Med, 1/1/2015
• Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8  
  Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K, Ghia P, Blood, 1/1/2015
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  Mansouri L, Sutton L-A, Ljungström V, Bondza S, Arngården L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K, Young E, Gunnarsson R, Falk-Sörqvist E, Lönn P, Mug..., J Exp Med, 1/1/2015
• Anti-CD20CD3 T cell-independent bispecific antibody for the treatment of B cell malignancies  
  Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E, Mai E, Young J, Johnson C, Huseni M, Wang G, Wang X, Chen Y, Wang P,..., Sci Trans Med, 1/1/2015
• A spoonful of sugar helps lymphoma cells go up  
  Chiorazzi N, Blood, 1/1/2015
• TLR-9 and IL-15 synergy promotes in vitro B-CLL clonal expansion  
  Mongini PKA Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, Allen SL, Rai K, Chu CC, J Immunol, 1/1/2015
• A 7-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes  
  McCarthy BA, Yancopoulos S, Tipping M, Yan X-J, Wang XP, Bennett F, Li W, Lesser M, Paul S, Boyle E, Moreno C, Catera R, Messmer BT, Cutrona G, Ferrarini M, Kolitz JE,..., Immunol Res, 1/1/2015
• Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes  
  Sherry B, Jain P, Chiu PY, Leung L, Allen SL, Kolitz JE, Rai KR, Barrientos J, Liang S, Hawtin R, Immunol Res, 1/1/2015
• Genomic imbalance defines three prognostic groups for risk stratification of chronic lymphocytic leukemia patients  
  Houldsworth J, Guttapalli A, Thodima V, Yan XJ, Mendiratta G, Zielonka T, Nanjangud G, Chen W, Patil S, Mato A, Brown JR, Rai K, Chiorazzi N, Chaganti RSK, Leuk Lymphoma, 1/1/2014
• Effects of prostaglandin E2 on p53 mRNA transcription and p5 mutagenesis during T cell-independent human B cell clonal expansion  
  Haque S, Yan XJ, Rosen L, McCormick S, Chiorazzi N, Mongini PKA, FASEB J, 1/1/2014
• Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia  
  Chen SS, Chiorazzi N, Semin Hematol, 1/1/2014
• Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates  
  Sarkar M, Liu Y, Morimoto J, Peng H, Aquino C, Rader C, Chiorazzi N, Kodadek T, Chem Biol, 1/1/2014
• Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies  
  Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti ..., Haematologica, 1/1/2013
• Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling  
  Chen S-S, Batliwalla F, Holodick N, Yan X-J, Yancopoulos S, Croce CM, Rothstein TL, Proc Natl Acad Sci USA, 1/1/2013
• Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2  
  Leukemia, 1/1/2013
• Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability  
  Marcatili P, Ghiotto F, Tenca C, Chailyan A, Mazzarello AN, Yan X-J, Colombo M, Albesiano E, Bagnara D, Cutrona G, Morabito F, Bruno S, Ferrarini M, Chiorazzi N, Tramo..., J Immunol, 1/1/2013
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Books/Book Chapters

• Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies 
  Chapter: B-cell chronic lymphocytic leukemia/lymphoma 
  Patten PEM, Chu CCEditors: Carbone, A., and Younes, A.Future Medicine Ltd, London2013
• Essential Clinical Immunology 
  Chapter: Chronic lymphocytic leukemia 
  Chiorazzi N, Ferrarini MEditors: J. B. Zabriskie.Cambridge University Press2008
• Chronic Lymphocytic Leukemia 
  Chapter: Origin and nature of chronic lymphocytic leukemia B cells 
  Chiorazzi N, Ferrarini MEditors: S. O’Brien and J. G. Gribben.Informa Health Care, Inc.2008
• Immune Mechanisms and Disease 
  Lahita RG, Capra JD, Ferrarini M., Zabriskie JAnnals of the New York Academy of Sciences2003
• Chronic Lymphocytic Leukemia 
  Chapter: Immunoglobulin variable region gene characteristics and surface membrane phenotype define distinct subgroups of chronic lymphocytic leukemia cases with different clinical courses 
  Chiorazzi N, Ferrarini MEditors: B. Cheson.Marcel Dekker, Inc.Edition 2nd,2001
• B1 Lymphocytes in B Cell Neoplasia 
  Chapter: Chronic lymphocytic leukemia: A proliferation of B cells at two distinct stages of differentiation 
  Damle RN, Fais F, Ghiotto F, Valetto A, Albesiano E, Wasil T, Batliwalla FM, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Gregersen PK, Ferrarini MEditors: M. Potter and F. Melchers.Springer-Verlag2000
• Textbook of the Autoimmune Diseases 
  Chapter: Antibodies 
  Chiorazzi NEditors: Lahita RG, Chiorazzi N, Reeves WH.Lippincott Williams and Wilkins, Philadelphia, PA2000
• Textbook of the Autoimmune Diseases 
  Lahita RG, Chiorazzi N, Reeves WHLippincott Williams and Wilkins, Philadelphia, PA2000
• The Antibodies 
  Chapter: Immunoglobulin V gene sequence analyses distinguish two subsets of chronic lymphocytic leukemia B cells 
  Franco F, Ghiotto F, Hashimoto S, Dono M, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Ferrarini MEditors: Zanetti M and Capra JD.Harwood Academic Publishers2000
• Chemical Immunology 
  Chapter: Subepithelial B cells of the human tonsil 
  Dono M, Zupo S, Grossi CE, Chiorazzi N, Ferrarini MEditors: M. Ferrarini and F. Caligaris-Cappio, eds.S. Karger AG1997
• Clinical and Experimental Aspects of Fanconi Anemia 
  Chapter: Complementation studies in Fanconi anemia 
  Auerbach AD, Koorse RE, Ghosh R, Venkatraj VS, Zhang MEditors: Schroeder TM, Auerbach AD, Obe G.Springer Verlag, Heidelberg1988
• Systemic Lupus Erythematosus 
  Chapter: An overview of cellular immune function in systemic lupus erythematosus 
  Chiorazzi NEditors: Lahita R.J. Wiley & Sons, New York1987
• Methods in Enzymology 
  Chapter: Activation of lymphocytes by antibodies to membrane-bound antigen receptors 
  Chiorazzi NEditors: DiSabato G.1987
• The Molecular Basis of B Cell Differentiation and Function 
  Chapter: Private and shared idiotypic determinants of the human T cell antigen receptor 
  Bigler RD, Chiorazzi NEditors: Ferrarini M and Pernis B.Plenum Press, New York1987
• Leucocyte Typing II. Volume I. Human T Lymphocytes 
  Chapter: A novel disulfide-linked cell surface molecule present on resting and activated human T lymphocytes 
  Bigler RD, Chiorazzi NEditors: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID.Springer-Verlag, New York1986
• Leucocyte Typing. Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies 
  Chapter: Distinct human leucoctye activation antigens defined by murine monoclonal antibodies AA1 and AA2 
  Chiorazzi N, Bigler RD, Hatzfeld J, McCune JMEditors: Bernard A, Boumsell L, Dausett J, Milstein C, Scholssman SF, eds.Springer-Verlag, New York1984
• Human B Lymphocyte Function 
  Chapter: The influences of antibodies to cell surface immunoglobulins on human B lymphocyte activation 
  Chiorazzi NEditors: Fauci T, Ballieux R.Raven Press, New York1982
• Proceedings of the Fifth Congress of the Italian Society of Immunology and Immunopathology 
  Chapter: T-cell dependent and T-cell independent activation of human B lymphocytes. Some applications for the study of disease 
  Chiorazzi N1981
• Regulatory T Lymphocytes 
  Chapter: Activation of human B lymphocytes by MLR-derived helper factors and anti-immunoglobulins 
  Fu SM, Kunkel HGEditors: Pernis B, Vogel HJ.Academic Press, New York1980
• Antibody Production in Man: In Vitro Synthesis and Clinical Implications 
  Chapter: Generation of plaque-forming cells. Allogeneic effect and significance of monocyte removal 
  Chiorazzi N, Ferrarini M, Montazeri G, Hoffman T, Fu SMEditors: Fauci AS, Ballieux RE.Academic Press, New York1979
• B lymphocytes in the Immune Response 
  Chapter: Differentiation in vitro of human B-type leukemia cells 
  Fu SM, Hurley J, Chiorazzi N, Kunkel HGEditors: Cooper M, Mosier D, Scher I, Vitetta E, eds.Elsevier-North Holland, New York1979
• Cells of Immunoglobulin Synthesis 
  Chapter: Differentiation of leukemic B lymphocytes in man 
  Fu SM, Chiorazzi N, Hurley JN, Halper JP, Kunkel HGEditors: Vogel HJ, Pernis B.Academic Press, New York1979
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Abstracts/Posters

• Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By BrutonÍs Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrut...
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Move... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: evidence for activation induced deamina... 
  Milan, Italy - 1/23/2013
• Chronic Lymphocytic Leukemia: New Concepts for Future Therapy 
  1/1/2010
• The CD38 ectoenzyme family: advances in basic science and clinical practice 
  1/1/2006
• B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes that vary in specificity for (auto)antigens 
  1/1/2005
• Distinct sets of stereotyped antigen receptors indicate a limited primary structural diversity in antigen-binding sites of CLL B cells 
  Montreal, CA - 1/1/2004
• The human marginal zone B cell 
  1/1/2003
• Facets of Dendritic Cell Maturation: Environmental instructions lead to distinct transcriptional patterns in myeloid dendritic cells 
  1/1/2003
• Preface. Immune Mechanisms and Disease 
  1/1/2003
• B Cell Chronic Lymphocytic Leukemia. Distinct phenotypic features and replicative histories among subgroups 
  1/1/2003
• Chronic lymphocytic leukemia: a proliferation of B cells with distinct genetic and phenotypic features 
  1/1/2002
• Autoimmunity update 
  1/1/1999
• Evidence for B cell oligoclonality in the blood and joints of patients with rheumatoid arthritis 
  1/1/1997
• The accessory cell function of B-CLL B cells 
  1/1/1997
• Human B cell subsets in health and disease: Phenotypic, functional, and genetic analyses 
  1/1/1996
• Clonal heterogeneity in membrane expression of CD5 in a patient with chronic lymphocytic leukemia 
  1/1/1995
• In vivo isotype class switching in CD5+ chronic lymphocytic leukemia B cells 
  1/1/1995
• Biased usage of variable and constant region Ig genes by IgG+ CD5+ human leukemic B cells 
  1/1/1992
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