NezamHAfdhalMD

Gastroenterology • Boston, MA

Hepatology & Liver Transplantation

Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School

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Office
BIDMC
110 Francis St., Ste 8e
Boston, MA 02215
Phone+1 617-632-1069

Education & Training

Boston University Medical CenterFellowship, Gastroenterology, 1987 - 1989
Royal College of Surgeons IrelandClass of 1981

Certifications & Licensure

MA State Medical License 1989 - 2026

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Super Doctor SuperDoctors.com
Fellow (FACG) American College of Gastroenterology
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Clinical Trials

FibroScan in Patients With Hepatitis B and C Presenting for Liver Biopsy Start of enrollment: 2005 Mar 01
Completed
Not Applicable
Cerebral Effects of Pegylated Interferon in Hepatitis C Positive Subjects Start of enrollment: 2004 Mar 01
Completed
Study of Long-term Peg Intron vs. Colchicine in Non-responders. Start of enrollment: 2000 Jan 15
Completed
Phase 4
Timing and Duration of Acute Hepatitis C Treatment Start of enrollment: 2002 Jan 01
Completed
Phase 4
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding Start of enrollment: 2006 May 01
Completed
Phase 3
Phase I Trial of Silymarin for Chronic Liver Diseases Start of enrollment: 2006 Nov 01
Completed
Phase 1
Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Hepatitis C Patients Start of enrollment: 2008 Mar 01
Completed
Phase 2
Phase II Trial of Silymarin for Patients With Chronic Hepatitis C Who Have Failed Conventional Antiviral Treatment Start of enrollment: 2008 Apr 01
Completed
Phase 2
Phase II Trial of Silymarin for Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitis Start of enrollment: 2008 Apr 01
Completed
Phase 2
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network Start of enrollment: 2011 Nov 01
Completed
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Publications & Presentations

PubMed

140 citations
Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonser...
Saumya Jayakumar, Michael S. Middleton, Eric Lawitz, Parvez S. Mantry, Stephen H. Caldwell
Journal of Hepatology. 2019-01-01
139 citations
Accuracy of Fibroscan, Compared With Histology, in Analysis of Liver Fibrosis in Patients With Hepatitis B or C: A United States Multicenter Study
Nezam H. Afdhal, Bruce R. Bacon, Keyur Patel, Eric Lawitz, Stuart C Gordon
Clinical Gastroenterology and Hepatology. 2015-04-01
87 citations
A global view of hepatitis C: Physician knowledge, opinions, and perceived barriers to care
Christopher E. McGowan, Ali Monis, Bruce R. Bacon, Josep Mallolas, Fernando L. Gonçales
Hepatology. 2013-04-01

Lectures

MRI 2012: Clinical Update and Practical Applications
Harvard Medical School, Duck Key, Florida - 2/20/2012
Update in Internal Medicine
Harvard Medical School & Beth Israel Deacones Medical Center, Boston, Massachusetts - 12/4/2011

Other

Acute cholangitis
Afdhal NH
http://www.uptodate.com/contents/acute-cholangitis
UpToDate, Wolters Kluwer Health - 2011-12-21
Pathogenesis, clinical features, and diagnosis of acute cholecystitis
Afdhal NH, Zakko SF
http://www.uptodate.com/contents/pathogenesis-clinical-features-and-diagnosis-of-acute-cholecystitis
UpToDate, Wolters Kluwer Health - 2012-12-18
Treatment of acute cholecystitis
Afdhal NH, Vollmer CM, Zakko SF
http://www.uptodate.com/contents/treatment-of-acute-cholecystitis
UpToDate, Wolters Kluwer Health - 2012-09-25
Acalculous cholecystitis
Afdhal NH
http://www.uptodate.com/contents/acalculous-cholecystitis
UpToDate, Wolters Kluwer Health - 2013-01-02
Approach to the patient with incidental gallstones
Afdhal NH
http://www.uptodate.com/contents/approach-to-the-patient-with-incidental-gallstones
UpToDate, Wolters Kluwer Health - 2012-10-11
Epidemiology of and risk factors for gallstones
Afdhal NH
http://www.uptodate.com/contents/epidemiology-of-and-risk-factors-for-gallstones
UpToDate, Wolters Kluwer Health - 2012-10-11
Clinical manifestations and diagnosis of cholangiocarcinoma
Afdhal NH, Anderson CD, Lowe RC
http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-cholangiocarcinoma
UpToDate, Wolters Kluwer Health - 2012-12-06
Epidemiology, pathogenesis, and classification of cholangiocarcinoma
Afdhal NH, Anderson CD, Lowe RC
http://www.uptodate.com/contents/epidemiology-pathogenesis-and-classification-of-cholangiocarcinoma
UpToDate, Wolters Kluwer Health - 2012-05-14
AIDS cholangiopathy
Afdhal NH
http://www.uptodate.com/contents/aids-cholangiopathy
UpToDate, Wolters Kluwer Health - 2012-11-01
Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Recognition and risk factors
Afdhal NH, Raison CL
http://www.uptodate.com/contents/neuropsychiatric-side-effects-associated-with-interferon-alfa-plus-
UpToDate, Wolters Kluwer Health - 2012-03-28
Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Treatment and prevention
Afdhal NH, Raison CL
http://www.uptodate.com/contents/neuropsychiatric-side-effects-associated-with-interferon-alfa-plus-
UpToDate, Wolters Kluwer Health - 2012-08-29
Complications of laparoscopic cholecystectomy
Afdhal NH, Vollmer CM
http://www.uptodate.com/contents/complications-of-laparoscopic-cholecystectomy
UpToDate, Wolters Kluwer Health - 2012-08-08
Gallstone ileus
Afdhal NH, Keaveny AP, Bowers S
http://www.uptodate.com/contents/gallstone-ileus
UpToDate, Wolters Kluwer Health - 2012-06-11
Noninvasive assessment of hepatic fibrosis
Afdhal NH, Curry MP
http://www.uptodate.com/contents/noninvasive-assessment-of-hepatic-fibrosis
UpToDate, Wolters Kluwer Health - 2012-12-18
Hepatic adenoma
Afdhal NH, Curry MP
http://www.uptodate.com/contents/hepatic-adenoma
UpToDate, Wolters Kluwer Health - 2012-12-18
Management of the side effects of peginterferon and ribavirin being used for treatment of chronic hepatitis C virus infection
Afdhal NH, Kelleher TB
http://www.uptodate.com/contents/management-of-the-side-effects-of-peginterferon-and-ribavirin-being
UpToDate, Wolters Kluwer Health - 2012-09-28
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Press Mentions

GI Leader to Know: Dr. Harvey Lefton of the Jefferson Health Torresdale HospitalJuly 1st, 2019
10 GI Physicians Featured in JuneJune 28th, 2019
Spring Bank Pharmaceuticals Hosts R&D Day on Pipeline of Novel Immunomodulatory TherapeuticsDecember 6th, 2018
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Grant Support

Clinical Center For Phase I/II Trials Of Silymarin In Chronic Liver DiseaseNational Center For Complementary &Alternative Medicine2006–2010
Clinical CoreNational Institute Of Allergy And Infectious Diseases2005–2009
Clinical Trial: Phase I Study Of Silymarin In Chronic Hepatitis C Or Fatty LiverNational Center For Research Resources2008
Phase I Study Of Silymarin In Chronic Hepatitis C Or Fatty Liver DiseaseNational Center For Research Resources2007
Antiviral Therapy In African Americans With HCVNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2005
NO Inhibition In Systemic/Renal Hemodynamics In Patients With CirrhosisNational Center For Research Resources2004
Proteomics And Biomarkers For Hepatocellular CancerNational Cancer Institute2003–2004
Protein Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Protein Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1999
Protein-Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1993–1995