NealStuartYoungMD

Hematology • Washington, DC

Chief, Hematology Branch, NHLBI

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Office
Hatfield CRC, NIH
3E-5140
Washington, DC 20011
Phone+1 301-496-9604

Education & Training

Massachusetts General HospitalResidency, Internal Medicine, 1971 - 1973
Johns Hopkins University School of MedicineClass of 1971

Certifications & Licensure

DC State Medical License 1978 - 2024
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1985
Member American Association of Physicians

Clinical Trials

Collection of Blood From Patients With Pancytopenia Start of enrollment: 1986 Apr 30
Completed
Comparing Therapies for the Treatment of Severe Aplastic Anemia Start of enrollment: 1997 Jun 02
Completed
Phase 2
Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes Start of enrollment: 1997 Jul 08
Completed
Combination Therapy of Severe Aplastic Anemia Start of enrollment: 2000 Mar 17
Completed
Phase 2
Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia Start of enrollment: 2003 Mar 10
Completed
Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia Start of enrollment: 2003 Jun 26
Completed
Phase 2
Cytokine Gene Polymorphisms in Bone Marrow Failure Start of enrollment: 2005 Feb 11
Completed
Telomere Repair Gene Mutation in Inflammatory Bowel Disease Start of enrollment: 2006 May 15
Completed
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers Start of enrollment: 2007 Mar 03
Recruiting
Safety of ON 01910.Na in Patients With Myelodysplasia Start of enrollment: 2007 Sep 14
Completed
Phase 1
Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Protocols Start of enrollment: 2009 Aug 06
Completed
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies Start of enrollment: 2009 Sep 09
Completed
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines Start of enrollment: 2009 Sep 18
Completed
Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies Start of enrollment: 2010 Jul 01
Terminated
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers Start of enrollment: 2011 Jan 21
Completed
Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy Start of enrollment: 2011 Jul 01
Completed
Phase 2
Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant Start of enrollment: 2012 Mar 20
Completed
Phase 1, Phase 2
Low-Dose Danazol for the Treatment of Telomere Related Diseases Start of enrollment: 2018 Feb 08
Recruiting
Phase 2
CHIP/CCUS Natural History Protocol Start of enrollment: 2020 Mar 03
Recruiting
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) Start of enrollment: 2020 May 07
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

156 citations
The Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease)
Terence Chorba, Peter F. Coccia, Robert C. Holman, P. Tattersall, Larry J. Anderson
The Journal of Infectious Diseases. 1986-09-01
179 citations
Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition
Carmine Selleri, Jaroslaw P. Maciejewski, Tadatsugu Sato, Neal S. Young
Blood. 1996-05-15
84 citations
Limited heterogeneity of T cell receptor BV usage in aplastic anemia.
Weihua Zeng, Jaroslaw P. Maciejewski, Guibin Chen, Neal S. Young
The Journal of Clinical Investigation. 2001-09-01

Abstracts/Posters

Outcomes in Pediatric Patients with Severe Aplastic Anemia Treated with Standard Immunosuppression and Eltrombopag
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Deficit of Circulating CD19+CD24hiCD38hi Regulatory B Cells in Severe Aplastic Anemia
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Macrophage TNF-Α Licenses Donor T Cells in Murine Bone Marrow Failure and Can Be Implicated in Human Aplastic Anemia
Neal Young, MD, Blood, Orlando, FL, 12/9/2019
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Lectures

Bone Marrow Failure: Fanconi Anemia and Aplastic Anemia
60th American Society of Hematology Annual Meeting - 12/3/2018
Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome(MDS)
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Mutations and Manifestations: What’s Known About VEXASAugust 16th, 2024

Grant Support

Viruses And HematopoiesisNational Heart, Lung, And Blood Institute2010–2011
Telomeres DiseasesNational Heart, Lung, And Blood Institute2010–2011
MyelodysplasiaNational Heart, Lung, And Blood Institute2010–2011
Immune Pathophysiology Of Aplastic Anemia And Immunosuppressive TreatmentsNational Heart, Lung, And Blood Institute2010–2011
Pathogenesis And Treatment Of Aplastic AnemiaNational Heart, Lung, And Blood Institute2009
Pathogenesis And Treatment Of Aplastic AnemiaNational Heart, Lung, And Blood Institute1990–2008
Viruses And HematopoeiesisNational Heart, Lung, And Blood Institute1996–1997
B19 Parvovirus And Adeno-Associated VirusNational Heart, Lung, And Blood Institute1994–1995
Parovirus (HUMAN) B19National Heart, Lung, And Blood Institute1988–1993
Lymphocytes And Lmyphokines In Aplastic AnemiaNational Heart, Lung, And Blood Institute1985–1988
ParovirusNational Heart, Lung, And Blood Institute1987
Viruses And Bone Marrow FailureNational Heart, Lung, And Blood Institute1986