NathanielMyerWeathingtonMD

PubMed

• 60 citations
  Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome.
  Georgios D Kitsios, L. Yang, Dimitris V. Manatakis, Mehdi Nouraie, John Evankovich
  Critical Care Medicine. 2019-12-01
• 24 citations
  The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions
  Shuang Li, Dan Wang, Jing Zhao, Nathaniel M. Weathington, Dong Shang
  FASEB Journal. 2018-01-01
• 383 citations
  A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.
  Nathaniel M. Weathington, Anneke H. van Houwelingen, Brett D. Noerager, Patricia L. Jackson, Aletta D. Kraneveld
  Nature Medicine. 2006-02-12

Journal Articles

• Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells  
  Wang D, Zhao J, Li S, Nan L, Weathington NM, Ma H, Zhao Y, J Mol Cell Biol, 1/1/2017
• Post-translational modification of the interferon gamma receptor alters its stability and signaling  
  Londino JD, Gullick DL, Lear TB, Suber TL, Weathington NM, Masa LS, Chen BB, Mallampalli RK, Biochem J, 1/1/2017
• APO-9'-Fucoxanthinone extracted from undariopsis peteseniana protects oxidative stress-mediated apoptosis in cigarette smoke-exposed human airway epithelial cells  
  Jang JH, Lee JH, Chand HS, Lee JS, Lin Y, Weathington NM, Mallampalli R, Jeon YJ, Nyunoya T, Marine Drugs, 1/1/2016
• Novel PDE4 inhibitors derived from Chinese medicine forsythia  
  Coon TA, McKelvey AC, Weathington NM, Birru RL, Lear T, Leikauf GD, Chen BB, PLoS One, 1/1/2014
• Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation  
  Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK, Respir Res, 1/11/2017
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Abstracts/Posters

• IL-4 dependent IL17Rb gene transcription requires coordinate autocrine Il-25 signaling in monocytes and alveolar macrophages
  Kanth S, Gong Q, Tedrow J, Wenzel SW, Mallampalli R, Weathington NM, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• Small molecule inhibition of the CHIP E3 ligase stabilizes deltaf508 CFTR in HEK cell lines
  Franz J, Londino JD, Chen B, Myerburg M, Weathington NM, Straub A, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• Azithromycin decreases NALP3 expression in THP-1 cells
  Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• IL-4 as a driver of the IL-25 signaling axis in alveolar macrophages and monocytes
  Weathington NM, Kanth S, Gong Q, Mallampalli, RK, Pittsburgh Munich International Lung Conference, Pittsburgh, PA, 1/1/2016
• The IL-25 signaling Axis is Induced by Th2 cytokine IL-4 in Human Monocytes and Macrophages
  Kanth S, Gong Q, Mallampalli RK, and Weathington NM, University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 1/1/2016
• Human Ex-Vivo Lung Preparations for Testing the Anti-Inflammatory Small Molecule BC1215
  Weathington NM, Alvarez DA, Sembrat J, Cardenes N, Noda K, Mallampalli RK, D’Cuhna J, Chen BB, Rojas M, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Induction of Il-17rb And Il-25 In Human Monocytes and Macrophages Through the Action of Th2 Cytokine Il-4
  Kanth S, Gong Q, Mallampalli RK, and Weathington NM, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Inhibition of NALP7 Inflammasome Activity with A Novel Small Molecule Antagonist of The Deubiquitinase STAMBP
  Bednash JS, Weathington NM, Fort RJ, Mckelvey A, Chen BB, Mallampalli RK, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Human Ex Vivo Ventilated and Perfused Lung Preparations as a Platform for Drug Development
  Nathaniel Weathington, Diana Alvarez, John Sembrat, Nayra Cardenes, Kentaro Noda, Rama K Mallampalli, Jonathan D’Cuhna, Bill Chen, Mauricio Rojas, Munich Pittsburgh international lung conference, Munich, Germany, 1/1/2015
• Therapeutic targeting of the deubiquitinase STAMBP as a novel inhibitor of NALP7 inflammasome activity
  Joseph Bednash, Nathaniel Weathington, Robert Fort, Bill Chen Rama Mallampalli, Munich Pittsburgh International lung conference, Munich, Germany, 1/1/2015
• Il-22 Receptor Modulation By The E3 Ligase Subunit Fbxw12 Modulates Epithelial Proliferation And Host Defense Signaling
  Joseph Franz, Jake Jerome, Qiaoke Gong, Travis Lear, Nathaniel Weathington, American Thoracic Society International scientific meeting, Denver, CO, 1/1/2015
• Nalp7 Protein Expression Is Regulated by Ubiquitination In Response To LPS In Human Monocytes
  Joseph Bednash, Nathaniel Weathington, Robert Fort, Bill Chen Rama Mallampalli, American Thoracic Society International scientific meeting, Denver, CO, 1/1/2015
• The E3 Ligase Subunit FBXW12 Modulates the IL-22 Receptor Abundance and Host-Protective Epithelial Proliferation
  Nathaniel Weathington, Joseph Franz, Courtney Snavely, Jake Jerome, Qiaoke Gong, Travis Lear, Rama Mallampalli, American Society of Clinical Investigators Young Investigator Awards Poster Presentation, Chicago, IL, 1/1/2015
• The IL-22 Receptor is coordinately Regulated by the Ubiquitin Proteasome System and Glycogen Synthase Kinase-3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, American Thoracic Society International scientific meeting, San Diego, CA, 1/1/2014
• Interleukin 22 receptor abundance and signaling is regulated by the ubiquitin proteasome and glycogen synthase kinase 3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, IMMUNOLOGY 2014, Pittsburgh, PA, 1/1/2014
• The IL-22 receptor regulation by the ubiquitin proteasome
  Nathaniel Weathington, Mark Geraci for the pulmonary fellow’s retreat, Pittsburgh, PA, 1/1/2013
• Regulation of the IL-22 Receptor by the Ubiquitin-Proteasome System with IL22 Ligation via Glycogen Synthase Kinase 3beta actitvity
  Nathaniel Weathington et al, University of Pittsburgh Department of Medicine research day, Pittsburgh, Pennsylvania, 1/1/2013
• Molecular and medhanistic characterization of the anti-inflammatory activity of Traditional Chinese medicinal plant Forsythia suspensa
  Tiffany A Coon, Nathaniel Weathington, Bill B Chen, Pittsburgh International Lung conference, 1/1/2013
• The IL-22 Receptor, an Essential Component of Host Defense to Pneumonia, is Regulated by the Ubiquitin Proteasome System, and Stabilized by GSK-3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, Pittsburgh International Lung Conference, 1/1/2013
• The IL-22 Receptor, An Essential Component of Host Defense to Pneumonia, is Regulated by the Ubiquitin-Proteasome System, and Depleted After IL22 Ligation
  Nathaniel Weathington, Courtney Snavely, Yutong Zhao, Rama Mallampalli, Meeting of the American Thoracic Society, Philadelphia, PA, 1/1/2013
• Matrix Metalloprotease (MMP)-9 Modulates Surfactant Protein-D (SP-D) Functions In Vitro
  Preston Bratcher, Nathaniel Weathington, et al, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2012
• Matrix metalloproteinase-9 cleaves Surfactant Protein-D, and impairs its innate immune function in bacterial agglutination and opsonophagocytosis
  Peston Bratcher, Nathaniel Weathington, et al, Pittsburgh International Lung Conference, Pittsburgh, PA, 1/1/2011
• Matrix metalloproteinase-9 cleaves Surfactant Protein-D, impairing collectin function as a bacterial agglutinin and opsonin in vitro, and such cleavage is seen during ...
  Nathaniel M Weathington, Amit Gaggar, Xin Xu, and Robert Snelgrove, American Thoracic Society annual scientific conference, 1/1/2010
• Surfactant Protein D is cleaved by matrix metalloproteinase-9, resulting in disruption of collectin function
  Nathaniel M Weathington, Patricia L Jackson, Landon Wilson, Matthew Hardison, and Amit Gaggar, American Association of Immunologists annual scientific conference, 1/1/2009
• PGP, a peptide PMN chemoattractant, is released during airway inflammation and causes pulmonary neutrophilia and disease
  Nathaniel M Weathington, Brett D Noerager et al, American Thoracic Society international meeting, San Diego, CA, 1/1/2006
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Lectures

• Interstitial Lung Disease 
  1/1/2017
• The physiologic, molecular and genetic basis of Protease-driven emphysematous COPD. From Gene SNPs to respiratory mechanics 
  1/1/2017
• Understanding and Treating Shock 
  1/1/2017
• Hypoxemia Causes and Therapy 
  1/1/2017
• Pulmonary Artery Catheterization and Interpretation 
  1/1/2017
• Acute Hemoptysis Management 
  1/1/2017
• Pulmonary Function Tests interpretation and relevance 
  1/1/2017
• Tipping Points and Moving Targets-Examining Molecular Switches and Homeostatic Control of Lung Inflammation 
  University of Pittsburgh School of Medicine - 1/1/2016
• Ex Vivo Ventilated Perfused Lungs as a relevant human system to model injury and test the novel anti-inflammatory 
  1/1/2016
• IL-4 as a driver of the IL-25 signaling axis in alveolar macrophages and monocytes 
  1/1/2016
• Mixed Signals and Molecular Switches for Innate Inflammatory Signaling in the Lung 
  Stanford University - 1/1/2016
• New molecular therapeutics targeting Integrin-TGF signaling in the pathophysiology of fibrotic disease 
  1/1/2015
• The cytokine receptor for IL22 is degraded through action of novel E3 Ubiquitin Ligase FBXW12, which acts as an epithelial growth suppressor 
  Washington, DC - 1/1/2014
• Cellular Regulation of IL-22R expression in pneumonia 
  Pittsburgh, PA - 1/1/2013
• A 56-year old man with acute onset dyspnea 
  Pittsburgh, PA - 1/1/2012
• Collagen breakdown as a driver of inflammation: PGP peptides in lung disease 
  1/1/2007
• Characterization of the molecular mechanism of the neutrophil chemoattractant PGP and its role in lung disease 
  University of Alabama Department of Medicine, Birmingham, AL - 1/1/2006
• Characterization of the CXCL activity of the collagen-liberated PGP peptide 
  University of Alabama Birmingham - 1/1/2006
• Variable EJP amplitude in stomatogastric muscles of Panulirus 
  Woods Hole, MA - 1/1/1999
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