NathanIvanShapiroMD

Emergency Medicine • Boston, MA

Associate Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School

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Office
330 Brookline Ave
CC2W
Boston, MA 02215
Phone+1 617-754-2343

Education & Training

Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical SchoolResidency, Emergency Medicine, 1997 - 2000
Lewis Katz School of Medicine at Temple UniversityClass of 1996

Certifications & Licensure

MA State Medical License 1999 - 2025
PA State Medical License 2002 - 2006
RI State Medical License 2005 - 2006
American Board of Emergency Medicine Emergency Medicine

Clinical Trials

The Utility of Ischemia Modified Albumin (IMA) in Sepsis Start of enrollment: 2007 Mar 01
Completed
Endothelium in Severe Sepsis
COMPLETED
Assessment of Acute Disease to Reduce Imaging Costs Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Near Infrared Spectroscopy (St02)
COMPLETED
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock
WITHDRAWN
NA
Preemptive Resuscitation for Eradication of Septic Shock Start of enrollment: 2011 Sep 01
Completed
Not Applicable
Procalcitonin Monitoring Sepsis Study Start of enrollment: 2011 Dec 01
Completed
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure Start of enrollment: 2012 Jul 01
Completed
Phase 3
Rapid Administration of Carnitine in sEpsis Start of enrollment: 2013 Jan 01
Completed
Phase 2
Reoxygenation After Cardiac Arrest (REOX Study) Start of enrollment: 2013 Jun 01
Completed
Hematoma Block for Distal Radius Fracture Start of enrollment: 2014 Aug 01
Recruiting
Not Applicable
Biomarkers in Infection
RECRUITING
Reoxygenation After Cardiac Arrest II (REOX II Study) Start of enrollment: 2016 Apr 01
Completed
Phase 1
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients Start of enrollment: 2018 Nov 10
TERMINATED
Early Identification of SEPsis SIGNs in Emergency Department Start of enrollment: 2020 Jul 06
Completed
Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 Start of enrollment: 2020 Jun 01
Completed
Phase 2
Novel Experimental COVID-19 Therapies Affecting Host Response Start of enrollment: 2021 Jul 15
COMPLETED
PHASE2, PHASE3
Roles: Contact
Pragmatic Trial Examining Oxygenation Prior to Intubation Start of enrollment: 2022 Mar 10
COMPLETED
NA
Roles: Contact
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Publications & Presentations

PubMed

1 citations
Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
Rombout B E van Amstel, Brian Bartek, Alexander P J Vlaar, Elizabeth Gay, Lonneke A van Vught
American Journal of Respiratory and Critical Care Medicine. 2025-03-01
COVID-19 and influenza vaccine Hesitancy among adults hospitalized in the United States, 2019-2022.
Akram Khan, Yuwei Zhu, Hilary M Babcock, Laurence W Busse, Abhijit Duggal
Vaccine. 2025-02-27
Lactated Ringer's or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension.
Georg Gelbenegger, Nathan I Shapiro, Markus Zeitlinger, Bernd Jilma, Ivor S Douglas
Critical Care Medicine. 2025-02-19

Journal Articles

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19
Matthew W Semler, Lindsay M Leither, Derek C Angus, Roy G Brower, Steven Y Chang, John C Eppensteiner, Michael R Filbin, Adit A Ginde, Michelle N Gong, Douglas L Hayde..., JAMA

Press Mentions

For Septic Shock, Another Toss-up Between Emphasizing Vasopressors vs FluidsJanuary 21st, 2023
Symptoms and Recovery Among Adult Outpatients with and Without COVID‐19 at 11 Healthcare Facilities—July 2020, United StatesJanuary 6th, 2021
More About COVID-19: Where Are We Now and Where Are We Headed?November 10th, 2020
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Grant Support

Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2026
Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2026
Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2026
Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2026
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisMASSACHUSETTS GENERAL HOSPITAL2023–2025
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisMASSACHUSETTS GENERAL HOSPITAL2023–2025
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisMASSACHUSETTS GENERAL HOSPITAL2023–2025
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic ShockBETH ISRAEL DEACONESS MEDICAL CENTER2019–2025
Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2024
Endothelial Cell Signaling And Microcirculatory Flow In Severe SepsisNational Heart, Lung, And Blood Institute2008–2011