NathanAPennellMDPhD, FASCO

PubMed

• Long-term safety of selpercatinib for Rearranged during transfection (RET)-activated advanced solid tumors in LIBRETTO-001: differing patterns of adverse events over t...
  Luis E Raez, Ashish C Massey, Scott S Barker, Patrick M Peterson, Katherine Liming
  The Oncologist. 2024-12-06
• 2 citations
  CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
  Ferdinandos Skoulidis, Haniel A Araujo, Minh Truong Do, Yu Qian, Xin Sun
  Nature. 2024-11-01
• Outcomes for pembrolizumab stratified by pemetrexed maintenance post pembrolizumab-platinum-pemetrexed induction in metastatic non-small-cell lung cancer.
  Jerome H Goldschmidt, Srinivas Annavarapu, Divea Venkatasetty, Yunfei Wang, Melissa L Santorelli
  Immunotherapy. 2024-04-01

Journal Articles

• Adjuvant Targeted Therapy for Patients with Epidermal Growth Factor Receptor–Mutant Lung Cancer  
  Nathan Pennell, MD, JAMA Oncology
• ALK Status Testing in Non-small Cell Lung Carcinoma by FISH on ThinPrep Slides with Cytology Material  
  Minca EC, Lanigan C, Reynolds JP, Wang Z, Ma PC, Cicenia J, Almeida FA, Pennell NA, Tubbs RR, J Thor Onc, 1/1/2014
• EGFR Mutational Genotyping of Liquid Based Cytology Samples Obtained via Fine Needle Aspiration (FNA) at Endobronchial Ultrasound Guided Fine Needle Aspiration of Non-...  
  Tubbs RR, Minca E, MacNamarra S, Reynolds J, Almeida F, Ma P, Pennell N, Cicenia J, Lung Cancer, 1/1/2014
• RET-Rearranged Lung Adenocarcinomas with Lymphangitic Spread, Psammoma Bodies, and Clinical Responses to Cabozantinib  
  Mukhopadhyay S, Pennell NA, Ma PM, Ali SM, Ross JS, Velcheti V, J Thor Onc, 1/1/2014
• (The Cancer Genome Atlas Network) Comprehensive Molecular Profiling of Lung Adenocarcinoma  
  Meyerson M, Collisson E, et al., Nature, 1/1/2014
• High MET Receptor Expression but not Gene Amplification in ALK 2p23 Rearrangement Positive Non-Small Cell Lung Cancer  
  Feng Y, Minca EC, Lanigan C, Liu A, Zhang W, Yin L, Pennell NA, Farver C, Tubbs R, Ma PC, J Thor Onc, 1/1/2014
• A Stereotactic Body Radiotherapy-Based Treatment Model for Stage I Medically Inoperable Small Cell lung Cancer  
  Videtic GM, Stephans KL, Woody NM, Pennell NA, Shapiro M, Reddy CA, Djemil T, Practical Radiation Oncology, 1/1/2013
• EGFR Molecular Testing in African-American Non-Small Cell Lung Cancer Patients - A Review of Discrepant Data  
  Clifford BT, Fu P, Pennell NA, Halmos B, Leidner RS, Trans Lung Cancer Res, 1/1/2013
• ALK Gene Rearrangement Testing in Non-small Cell Lung Carcinoma: Correlation between Ultrasensitive IHC and FISH  
  Minca EC, Portier BP, Wang Z, Lanigan C, Farver C, Feng Y, Ma PC, Arrossi V, Pennell N, Tubbs RR, J Mol Diagn, 1/1/2013
• ZEPHYR Illustrates the Perils of Testing Targeted Treatments in Unselected Non-Small-Cell Lung Cancer Patients  
  Bagai, R. and Pennell, N.A., Trans Lung Cancer Res, 1/1/2013
• Superior Vena Cava Syndrome in Lung Cancer  
  Feng, Y. and Pennell, N.A., Lung Cancer Management, 1/1/2012
• Superior Vena Cava Syndrome  
  Pennell, N., 1/1/2012
• Selection of Chemotherapy for Patients with Advanced Non-small Cell Lung Cancer  
  Pennell, N.A., Cleveland Clinic Journal of Medicine, 1/1/2012
• Treating ALK+ Lung Cancer in the Weeks after the FDA Approval of Crizotinib  
  Pennell, N.A., Journal of Oncology Practice, 1/1/2012
• Treating Acquired Resistance to EGFR-tyrosine Kinase Inhibitors: Still a Work in Progress  
  Pennell, N.A., Trans Lung Cancer Res, 1/1/2012
• Advanced Non-Small Cell Lung Cancer (NSCLC): Maintenance Therapy For All?  
  Hashemi-Sadraei, N. and Pennell, N.A., Curr Treat Options Oncol, 1/1/2012
• Two Generations of Light/Never-smokers with Advanced Adenocarcinoma of the Lung with Durable Responses to Erlotinib  
  Pennell, N. A., Yin, L., Keshtgarpour, M., and Ma, P.C., J Thor Onc, 1/1/2012
• Expert Insight on Tsuchiya et al, Clinical Lung Cancer 2012  
  Pennell, N.A., Clinical Oncology News, 1/1/2012
• Perspective on Kratz JR et al Lancet 2012  
  Pennell, N.A., HemOnc Today, 1/1/2012
• XL647, a Multi-Targeted Tyrosine Kinase Inhibitor: Results of a Phase II Study in Subjects with Non-Small Cell Lung Cancer who have Progressed after Responding to Tre...  
  Pietanza MC, Lynch TJ, Lara PN, Cho J, Yanagihara RH, Vrindavanam N, Chowhan N, Gadgeel SM, Pennell NA, Funke R, Mitchell B, Wakalee HA, and Miller VA., J Thor Onc, 1/1/2012
• Integration of EGFR Inhibitors and Conventional Chemotherapy in the Treatment of NSCLC  
  Pennell, N.A., Clin Lung Cancer, 1/1/2011
• BAC: Time to Move beyond Clinical and Pathologic Classification  
  Pennell, N.A. and Govindan, R, Oncology (Williston Park), 1/1/2010
• Targeting Angiogenesis in Non-Small Cell Lung Cancer: Agents in Practice and Clinical Development  
  Barzi, A. and Pennell, N.A., European Journal of Clinical & Medical Oncology, 1/1/2010
• Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non-Small Cell Lung Cancer  
  Zhu, C., Ding, K., Strumpf, D., Weir, B.A., Meyerson, M., Naoki, K., Pennell, N., Ladd-Acosta, C., Thomas, R.K., Liu, N., Pintilie, M., Der, S., Seymour, L., Jurisica1..., J Clin Onc, 1/1/2010
• Combined Inhibition of the VEGFR and EGFR Signalling Pathways in the Treatment of NSCLC  
  Pennell, N.A. and Lynch, T.J., Oncologist, 1/1/2009
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Books/Book Chapters

• IASLC Multidisciplinary Approach to Thoracic Oncology 
  Chapter: The Role of Palliative Care in Lung Cancer 
  Davis, M and Pennell, NA.LWW, NY2014

Abstracts/Posters

• Molecular Subtyping to Predict Risk of Venous Thromboembolism in Patients with Advanced Lung Adenocarcinoma: A Cohort Study
  Nathan A Pennell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Study of Hsp90 Inhibitor AT13387 Alone and in Combination with Crizotinib (CZT) in the Treatment of Non-Small Cell Lung Cancer (NSCLC).
  B Besse, E Bertino, NA Pennell, A Wozniak, D Mahadevan, A Spira, A Oganesian, L Manlapaz-Espiritu, H Keer, J-C Soria, DR Camidge, ESMO, 1/1/2014
• SELECT: A Multicenter Phase II Trial of Adjuvant Erlotinib in Resected Early-stage EGFR Mutation-positive NSCLC
  NA Pennell, JW Neal, JE Chaft, CG Azzoli, PA Janne, R Govindan, TL Evans, DB Costa, RPG Rosovsky, HA Wakelee, R Suk Heist, AT Shaw, JS Temel, MA Shapiro, A Muzikansky,..., Proc Amer Soc Clin Onc, 1/1/2014
• Treatment (Trmt) Outcome in Lung Transplant (LTx) Recipients Who Develop Lung Cancer (LC): A Cleveland Clinic (CC) Experience
  L Du, NA Pennell, P Elson, N Hashemi, Proc Amer Soc Clin Onc, 1/1/2014
• Circulating Tumor Cells Enrichment and Characterization in ALK-translocation Positive Lung Cancer
  PC Ma, L Yin, P Joshi, Y Feng, B Jacobs, W Zhang, M Shapiro, M McNamara, N Hashemi Sadraei, N Pennell, E B, M Zborowski, Proc Amer Soc Clin Onc, 1/1/2014
• EGFR Mutational Analysis by Allele Specific PCR on Fine Needle Aspiration and Biopsy Derived Samples of Non-Small Cell Lung Carcinoma
  Minca EC, Brainard J, MacNamara S, Farver C, Ma PC, Arrossi V, Pennell N, Tubbs RR, USCAP Annual Meeting, 1/1/2014
• Dowlati. Erlotinib beyond Progression Study: Randomized Phase II Study Comparing Chemotherapy plus Erlotinib with Chemotherapy Alone in EGFR Tyrosine Kinase Inhibitor ...
  B. Halmos, N.A. Pennell, G.A. Otterson, S.M. Gadgeel, T. Mekhail, M.R. Snell, J.P. Kuebler, P. Fu, N. Sharma, A., Proc Amer Soc Clin Onc, 1/1/2013
• Clinical Implications of Routine Testing for Epidermal Growth Factor Receptor (EGFR) Mutations in Patients with Nonsquamous Non-small Cell Lung Cancer (NSCLC).
  Zhu H, Arrossi AV, Elson P, Farver C, Tubbs R, Murthy S, Mason D, Mazzone P, Pennell NA, Proc Amer Soc Clin Onc, 1/1/2013
• The Impact of Bevacizumab on the Occurrence and Recurrence of Intracranial Brain Metastases in Non-small Cell Lung Cancer (NSCLC) Patients
  ME Salem, N Szerlip, NA Pennell, KB Ali, D Altshuler, S Taylor, A Hallock, A Sukari, SM Gadgeel, AJ Wozniak, Proc Amer Soc Clin Onc, 1/1/2012
• Clinical Profile and Molecular Detection of ALK 2p23 Fusion Driven Lung Cancer at Cleveland Clinic
  Y. Feng, L. Yin, J. Samsa, C. Lanigan, E. Borden, A. Arrossi, C. Farver, N. Pennell, R. Tubbs, P. C. Ma., ASTRO/IASLC Multidisciplinary Symposium in Thoracic Oncology, 1/1/2012
• Dowlati. Final Report of an Open-Label Phase II Trial of Bevacizumab Plus Docetaxel and Gemcitabine in Metastatic, Previously Untreated Non-squamous Non-small Cell Lun...
  N. A. Pennell, S. R. Kalmadi, M. Shapiro, H. Daw, C. Rodriguez, A. Haddad, J. Samsa, P. Elson, P. Ma, A., ASTRO/IASLC Multidisciplinary Symposium in Thoracic Oncology, 1/1/2012
• The SELECT Study: A Multicenter Phase II Trial of Adjuvant Erlotinib in Resected Epidermal Growth Factor Receptor (EGFR) Mutation-positive Non-small Cell Lung Cancer (...
  JW Neal, NA Pennell, R Govindan, M Lanuti, R Rosovsky, R Suk Heist, AT Shaw, JS Temel, A Muzikansky, PA Janne, TJ Lynch, CG Azzoli, LV Sequist, Proc Amer Soc Clin Onc, 1/1/2012
• Pilot Study to Measure Circulating Endothelial Cells (CECs) in Patients with Non-small Cell Lung Cancer (NSCLC).
  Pennell NA, Hashemi Sadraei N, Samsa J, Henderson L, Grane R, Borden E, World Conf on Lung Cancer, Amsterdam, 1/1/2011
• Phase II Trial of Carboplatin, Abraxane, and Bevacizumab in NSCLC
  RS Heist, DG Duda, DV Sahani, M Ancukiewicz, P Fidias, LV Sequist, A Shaw, J Temel, I Lennes, J Neal, N Pennell, TJ Lynch, JA Engelman, RK Jain, Proc Amer Soc Clin Onc, 1/1/2011
• Erlotinib beyond Progression Study: Randomized Phase II Study Comparing Chemotherapy plus Erlotinib with Chemotherapy Alone in EGFR TKI-responsive, Advanced Non-small ...
  B. Halmos, P. Fu, N. A. Pennell, G. A. Otterson, T. Mekhail, M. R. Snell, J. P. Kuebler, S. M. Gadgeel, A. Conrad, A. T. Stefanski, A. Dowlati., Proc Amer Soc Clin Onc, 1/1/2011
• In Vivo Assessment of the Effects of Bevacizumab in Advanced Non-small Cell Lung Cancer (NSCLC).
  R. S. Heist, G. D. Duda, D. Sahani, N. A. Pennell, J. W. Neal, M. Ancukiewicz, J. A. Engelman, T. J. Lynch, R. K. Jain., Proc Amer Soc Clin Onc, 1/1/2010
• A Multicenter Phase II Trial of Adjuvant Erlotinib in Patients with Resected Non-small Cell Lung Cancer (NSCLC) And Mutations in the Epidermal Growth Factor Receptor (...
  Neal, J.W.; Pennell, N.A.; Goodgame, B.W.; Lanuti, M.; Heist, R.S.; Shaw, A.T.; Temel, J.S.; Janne, P.A.; Azzoli, C.G.; Sequist, L.V., Proc Amer Soc Clin Onc, 1/1/2010
• ERCC1 Protein Expression Is Not Associated with Survival after Platinum-based Chemotherapy in Patients with Metastatic Non-small Cell Lung Cancer (NSCLC).
  Pennell, N.A., Chireac, L., El Karak, F., Lynch, T.J., Heist, R.S., Christiani, D.C., ERCC1 Protein Expression Is Not Associated with Survival after Platinum-based Chemotherapy in Patients with Metastatic Non-small Cell Lung Cancer (NSCLC)., 1/1/2010
• Patient Compliance with Prolonged Erlotinib (E) Treatment: Experience from a Phase I/II Trial of Perioperative Concurrent Chemoradiotherapy (CRT) And E Followed by 2 Y...
  Pennell, N.A., Videtic, G.M., Murthy, S., Mason, D., Rice, T.W., Mazzone, P., Samsa, J., Rich, T., Shapiro, M., Mekhail, T., 13th World Lung Conference, 1/1/2009
• The Serial Effects of Multimodality Therapy for Stage III Non-small Cell Carcinoma on Lung Function
  Mazzone, P.J., Videtic, G., Murthy, S., Mason, D., Rice, T., Pennell, N., Rich, T., Machuzak, M., Mekhail, T., Proc Amer Soc Clin Onc, 1/1/2009
• A Phase I/II Trial of Perioperative Paclitaxel (P), Carboplatin (C) And Erlotinib (E) With Concurrent Accelerated Hyperfractionated Radiation (HFRT) Followed by Mainte...
  Pennell, N.A., Videtic, G.M., Murthy, S., Mason, D., Rice, T.W., Mazzone, P., Samsa, J., Rich, T., Shapiro, M., Mekhail, T., Proc Amer Soc Clin Onc, 1/1/2009
• A Phase II Trial of the Dual Farnesyl Transferase and Geranylgeranyl Transferase Inhibitor L-778,123 in Previously Untreated Patients with Advanced Non-small Cell Lung...
  Pennell, N.A., Johnson, B., Moore, M.R., Garcia, M., Aisner, J., Pramanik, B., Morrison, B., Lynch, T.J., IASLC 7th Annual Targeted Therapies of the Treatment of Lung Cancer, 1/1/2007
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Lectures

• Guidelines, Barriers, Access to Molecular Testing in NSCLC 
  ASCO Annual Meeting 2019 - Chicago, IL - 5/31/2019
• Assessment and Diagnostics of Newly Diagnosed Patients With Advanced Non-Small Cell Lung Cancer 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018
• Circulating Tumor Cells Detection and Molecular Characterization of ALK(2p23)-Fusion Non-Small Cell Lung Cancer 
  Sydney - 1/1/2013
• Management of Stage III Non-small Cell Lung Cancer 
  Dana Farber Cancer Institute, Boston, MA - 1/1/2008
• Update on Lung Cancer in 2012 
  Akron General Hospital, Akron, OH - 1/7./2012
• New Agents and Clinical Strategies in the Management of NSCLC - Research to Practice 
  Novant Health, Winston-Salem, NC, 2014; White Plains, NY, 2014 - 1/19/2014
• Lung Cancer End of the Year Review 
  NY, NY - 1/11/2014
• Use of Off-targeted Therapies in Targeted Populations 
  Boston, MA - 1/6./2014
• Management of Advanced NSCLC 
  Alliance, OH - 1/1./2014
• The New Landscape for Targeted Agents in NSCLC 
  Northside Hospital, Youngstown, OH - 1/1./2013
• Treating Patients with Common Molecular Subtypes of NSCLC in 2013 
  Cleveland, OH - 1/27/2013
• Molecular Testing in NSCLC: How Soon is Now? 
  Chicago, IL - 1/2./2013
• Palliative Treatment for Advanced NSCLC 
  The Gathering Place, Beachwood, OH - 1/1./2013
• Lung Cancer: Molecular Findings and Targeted Therapies 
  Boston, MA - 1/4./2012
• Advances: EGFR/ALK and Lung Cancer 
  Key Largo, Florida - 1/24/2012
• Clinical Management: Chemotherapy in NSCLC 
  Cleveland Clinic Florida, Weston, FL - 1/8./2011
• Selection of Chemotherapy for Patients with Advanced NSCLC 
  Cleveland, OH - 1/30/2011
• Lung Cancer: Updates on Chemotherapy and Targeted Treatments 
  Westlake, OH - 1/6./2011
• Circulating Tumor Cells (CTCs) and Circulating Endothelial Cells (CECs) in Patients with Lung Cancer 
  1/8./2011
• Advances in Chemotherapy for Non-small Cell Lung Cancer 
  1/29/2010
• Impact of Histology on Response and Patient Selection 
  Washington, DC - 1/10/2009
• Lung Cancer Update 2009 
  Rocky River, OH - 1/5./2009
• Targeting the Epidermal Growth Factor Receptor in Non-small Cell Lung Cancer 
  Cleveland, OH - 1/8./2009
• Malignant Mesothelioma: Non-surgical Options 
  Cleveland, OH - 1/18/2009
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Other

• Treatment of a Patient with Metastatic Non-Small-Cell Lung Cancer and Adenocarcinoma Histology 
  Pennell, N.A. and Perez-Soler, R., Oncology Consultations
  http://www.cancerlearning.com/index.cfm/fuseaction/publication.showOverview/id/9/publication_id/330
  1/1/2009
• Study Guide for "Voices from the Lived World of Illness", an Interactive DVD about Terminal Cancer Patients Created by the Institute of Medical Humanism 
  Schapira, L., Pennell, N.A., Bandman, B.M., Bandman, C.
  Burlington, VT - 1/1/2006