NaotoUenoMDMD, PhD(He/Him)

Oncology • Honolulu, HI

Breast Cancer

University of Hawaiʻi Cancer Center Director Professor of Medicine

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Office
701 Ilalo Street, Room 622
Honolulu, HI 96813
Phone+1 808-586-3013

Summary

I am a board-certified internist and medical oncologist. I specialize in taking care of patients with inflammatory breast cancer, triple negative breast cancer, metastatic breast cancer, and bone metastasis. I have a passion to provide the best care to my patients.

Education & Training

UT Graduate School of Biomedical SciencePhD, Cancer Biology, 1994 - 1999
University of Texas Health Science Center at HoustonFellowship, Hematology and Medical Oncology, 1993 - 1996
UPMC Medical EducationResidency, Internal Medicine, 1990 - 1993
OtherClass of 1989

Certifications & Licensure

HI State Medical License 2022 - 2026
TX State Medical License 1993 - 2026
FL State Medical License 2021 - 2023
OK State Medical License 2020 - 2021
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regents’ Outstanding Teaching Award The University of Texas System, 2013

Clinical Trials

Herceptin and GM-CSF for Metastatic Breast Cancer Start of enrollment: 2002 Aug 01
Completed
Phase 2
Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer Start of enrollment: 2007 Apr 17
Recruiting
Roles: Contact, Principal Investigator
Denosumab for Breast Cancer With Bone Mets Start of enrollment: 2015 Feb 09
Terminated
Phase 2
Pembrolizumab in Treating Patients With Stage IV Metastatic or Recurrent Inflammatory Breast Cancer or Triple-Negative Breast Cancer Who Have Achieved Clinical Response or Stable Disease to Prior Chemotherapy Start of enrollment: 2015 Jun 11
Active, not recruiting
Phase 2
Talimogene Laherparepvec in Treating Patients With Recurrent Breast Cancer That Cannot Be Removed by Surgery Start of enrollment: 2016 Aug 01
Terminated
Phase 2
Enzalutamide and Paclitaxel Before Surgery in Treating Patients With Stage I-III Androgen Receptor-Positive Triple-Negative Breast Cancer Start of enrollment: 2016 Sep 22
Completed
Phase 2
Droplet-BC Screening Test for the Detection of Breast Cancer, the DROPLET-BC Study Start of enrollment: 2020 Nov 03
Recruiting
Grapiprant and Eribulin for the Treatment of Metastatic Inflammatory Breast Cancer Start of enrollment: 2021 Nov 04
Active, not recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator
Precision Performance Status Assessment in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Start of enrollment: 2022 Aug 15
Active, not recruiting
Roles: Contact, Principal Investigator
Testing an Omega-3 Fatty Acid-Based Anti-Cancer Therapy for Patients With Triple-Negative Inflammatory Breast Cancer That Has Spread to Other Parts of the Body Start of enrollment: 2022 Nov 08
Terminated
Phase 1, Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Immune checkpoint inhibitors for patients with metastatic triple-negative inflammatory breast cancer (INCORPORATE): An international cohort study.
Carmine Valenza, Dario Trapani, Paola Zagami, Gabriele Antonarelli, Luca Boscolo Bielo
European Journal of Cancer. 2024-12-01
Targeting CDK7 enhances the antitumor efficacy of enzalutamide in androgen receptor-positive triple-negative breast cancer by inhibiting c-MYC-mediated tumorigenesis.
Xuemei Xie, Maroua Manai, Dileep R Rampa, Jon A Fuson, Elizabeth S Nakasone
Molecular Cancer Therapeutics. 2024-11-26
Genomic and transcriptomic analyses identify distinctive features of triple-negative inflammatory breast cancer.
Xiaoping Wang, Li Zhao, Xingzhi Song, Xiaogang Wu, Savitri Krishnamurthy
NPJ Precision Oncology. 2024-11-18

Journal Articles

Rates of Immune Cell Infiltration in Patients with Triple-Negative Breast Cancer by Molecular Subtype
Wendy A Woodward, Naoto T Ueno, Savitri Krishnamurthy, Bora Lim, PLoS One
Inflammatory Breast Cancer: What to Know About This Unique, Aggressive Breast Cancer
Michael C Stauder, Anthony Lucci, Wendy A Woodward, Bora Lim, Naoto T Ueno, ScienceDirect

Lectures

Phase II study of Ra-223 combined with hormonal therapy and denosumab for treatment of hormone receptor-positive breast cancer with bone-dominant metastasis.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018

Authored Content

Eicosapentaenoic Acid in Combination with EPHA2 Inhibition Shows Efficacy in Preclinical Models of Triple-Negative Breast Cancer by Disrupting Cellular Cholesterol EffluxNovember 2018
Eicosapentaenoic Acid in Combination with EPHA2 Inhibition Shows Efficacy in Preclinical Models of Triple-Negative Breast Cancer by Disrupting Cellular Cholesterol EffluxNovember 2018
Eicosapentaenoic Acid in Combination with EPHA2 Inhibition Shows Efficacy in Preclinical Models of Triple-Negative Breast Cancer by Disrupting Cellular Cholesterol EffluxNovember 2018
Eicosapentaenoic Acid in Combination with EPHA2 Inhibition Shows Efficacy in Preclinical Models of Triple-Negative Breast Cancer by Disrupting Cellular Cholesterol EffluxNovember 2018
An Oncologist-Turned-Cancer-Patient’s Plea to ColleaguesMay 2018
An Oncologist-Turned-Cancer-Patient’s Plea to ColleaguesMay 2018
My Methodology: How I Treat Inflammatory Breast CancerApril 2018
5 Items Patients (And You) Should Complete to Prepare for the End of LifeJanuary 2018
Prior Systemic Treatment Increased the Incidence of Somatic Mutations in Metastatic Breast CancerJanuary 2018
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Press Mentions

HER2-Low Breast Cancer: Despite New Data, Questions PersistOctober 24th, 2024
Five Questions with Dr. Naoto Ueno, UH Cancer Center's New DirectorJanuary 30th, 2023
MD Anderson Research Highlights for December 19, 2022December 19th, 2022
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